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M. avium 104 MAV_2429 (-)

annotation: PPE family protein
coordinates: 2450761 - 2452413
length: 550

MTAPVWIAFPPEVHSTLLSSGPGPAPLLAAATAWSSMSTEYAAAAAELDGLLAAAHAGAWEGPSAEQYVA
AHAPYQAWLLESAAKSSTAASLHETAAGAYTAALAAMPTLGELATNHAVHGALVATNFFGINTIPIAVNE
ADYARMWVQAATTMSTYQAVSQSALAAVPPTTPAPTIVAPGTEAGTATAAAVQSAAAAPATDSGSNLNHA
DTSSTQQQASTAAQSYPSWQDQLTAWLKQYTQNFAWPVSKDLNPGGWPFPPVPFVNGLASFFGQLGFSPA
LSTALGWAIFHTLMIFWPFMQAAIQMAVVLAPVVVAAIGAAAAGGAAAAVTAISVAAPLSMAAPVPVAAA
PAPVATVPAPTIAGAPAGVSHVPTTASAPAPTMAGSAGGGPVGGGPGVGFGPTATDGIGAGMSDALYAVG
LSGLSARGSASSRARRKSEEPAPDDLDAPAAAAAAAAGSKKARARRRRRGTATDRAYRYEYMDLDTDSGP
EDGGPDDGPVASEASAGQLGFAGAATKSDAARPAGLATLTRDGSSEGPGVPMMPSTWDRD
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_2429--100% (550)PPE family protein
M. avium 104MAV_4872-e-10644.75% (552) PPE family protein
M. avium 104MAV_4879-e-10243.71% (572) PPE family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0288PPE31e-10041.84% (576) PPE family protein
M. gilvum PYR-GCKMflv_0325-7e-8837.94% (564) PPE protein
M. tuberculosis H37RvRv0280PPE31e-10041.84% (576) PPE family protein
M. leprae Br4923MLBr_01828PPE5e-7935.18% (577) PPE-family protein
M. abscessus ATCC 19977MAB_4783-2e-9843.06% (569) PPE family protein
M. marinum MMMAR_0538-1e-10643.92% (567) PPE family protein, PPE3
M. smegmatis MC2 155MSMEG_0619-1e-10042.40% (559) PPE family protein
M. thermoresistible (build 8)TH_3569-7e-7546.59% (352) PUTATIVE PPE protein
M. ulcerans Agy99MUL_1202-1e-10543.69% (563) PPE family protein
M. vanbaalenii PYR-1Mvan_0415-5e-9541.13% (564) PPE protein

CLUSTAL 2.0.9 multiple sequence alignment


MAV_2429|M.avium_104                ----------MTAPVWIAFPPEVHSTLLSSGPGPAPLLAAATAWSSMSTE
MAB_4783|M.abscessus_ATCC_1997      ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
Mflv_0325|M.gilvum_PYR-GCK          MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1       ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155      ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu      ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mb0288|M.bovis_AF2122/97            ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
Rv0280|M.tuberculosis_H37Rv         ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
MMAR_0538|M.marinum_M               ----------MVAPVWFASPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MUL_1202|M.ulcerans_Agy99           --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MLBr_01828|M.leprae_Br4923          ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
                                                  :*:: ******::** ***...:: .. .* .:*: 

MAV_2429|M.avium_104                YAAAAAELDGLLAAAHAGAWEGPSAEQYVAAHAPYQAWLLESAAKSSTAA
MAB_4783|M.abscessus_ATCC_1997      YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
Mflv_0325|M.gilvum_PYR-GCK          YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1       YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155      YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu      YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mb0288|M.bovis_AF2122/97            YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
Rv0280|M.tuberculosis_H37Rv         YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
MMAR_0538|M.marinum_M               YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MUL_1202|M.ulcerans_Agy99           YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MLBr_01828|M.leprae_Br4923          YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
                                    *:  * **   *  .  . *:* ::  *  *: **  ** . :  .:  *

MAV_2429|M.avium_104                SLHETAAGAYTAALAAMPTLGELATNHAVHGALVATNFFGINTIPIAVNE
MAB_4783|M.abscessus_ATCC_1997      AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK          VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1       AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155      VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu      GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mb0288|M.bovis_AF2122/97            ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
Rv0280|M.tuberculosis_H37Rv         ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
MMAR_0538|M.marinum_M               AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MUL_1202|M.ulcerans_Agy99           AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MLBr_01828|M.leprae_Br4923          AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
                                       :: * **  ::* ***: **: *:. * .*: ***:******** .*

MAV_2429|M.avium_104                ADYARMWVQAATTMSTYQAVSQSALAAVPPTTPAP-TIVAPGT-------
MAB_4783|M.abscessus_ATCC_1997      ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAP-PVLSP---------
Mflv_0325|M.gilvum_PYR-GCK          ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAP-SVLLPGVG------
Mvan_0415|M.vanbaalenii_PYR-1       ADYVRMWIQAATTMATYQAVSGAALAATPTATPAP-FVLAPGVG------
MSMEG_0619|M.smegmatis_MC2_155      ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAP-FLLKPGVG------
TH_3569|M.thermoresistible__bu      ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAP-LLLAPGVS------
Mb0288|M.bovis_AF2122/97            ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADDDHDHD
Rv0280|M.tuberculosis_H37Rv         ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADDDHDHD
MMAR_0538|M.marinum_M               ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAA--HDHD
MUL_1202|M.ulcerans_Agy99           ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAA--HDHD
MLBr_01828|M.leprae_Br4923          IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
                                     ** *** :**  *.*** *:   : :.* : .**  :            

MAV_2429|M.avium_104                -EAGTATAAAVQSAAAAPATDSGSNLNHADTSSTQQQAST--AAQSYPSW
MAB_4783|M.abscessus_ATCC_1997      -DSGAAARTAAQDATKPPPIVP-------DPNDPIEMLLK--NSQHFLGM
Mflv_0325|M.gilvum_PYR-GCK          -EAGRAAADMSAFAAQPMAAQAGAAFD--VSNIIADIIRL--YGEVLRFL
Mvan_0415|M.vanbaalenii_PYR-1       -EAGRAAADVTAFAAQAQAAEAGSALD--LSNIIADLIRA--YGELLRFL
MSMEG_0619|M.smegmatis_MC2_155      -EAGSASASVQQMSAQATAAESGSSLD--LSSIISDLLNQ--YLQGVPGG
TH_3569|M.thermoresistible__bu      -EAADAMATTQQIGSQATAADSGTALN--LSDLIANLLQY--YQDYLDQL
Mb0288|M.bovis_AF2122/97            HDHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIP---FEDYTDAA
Rv0280|M.tuberculosis_H37Rv         HDHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIP---FEDYTDAA
MMAR_0538|M.marinum_M               HDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIP---YDDYVNAA
MUL_1202|M.ulcerans_Agy99           HDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIP---YDDYVNAA
MLBr_01828|M.leprae_Br4923          SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
                                       .                           .            :     

MAV_2429|M.avium_104                QDQLTAWLKQYTQNFAWPVSKDLNPGGWPFPPVPFVNGLASFFGQLGFSP
MAB_4783|M.abscessus_ATCC_1997      YRALKGLITDPVGTIVR-IIIDFSTN----PAAAIVTWTPLFY-------
Mflv_0325|M.gilvum_PYR-GCK          FEPIFNFLRDPIGNTFA-LITDFLTN----PVQALITWGPFLL-------
Mvan_0415|M.vanbaalenii_PYR-1       FEPIFDFLRDPLGNTIK-LITDFLTN----PAQALITWGPFLA-------
MSMEG_0619|M.smegmatis_MC2_155      Q-AILDFLKDPLGNLGR-LLTDFMTN----PAGALATWWPFLF-------
TH_3569|M.thermoresistible__bu      FGPIVDFLRDPIGNLFQ-LIDDFLTN----PAGALVTWWPLLF-------
Mb0288|M.bovis_AF2122/97            QPIWWVVRAIEFSKDFETFVQELFVN----PVEAFQFYFELLLFDYP---
Rv0280|M.tuberculosis_H37Rv         QPIWWVVRAIEFSKDFETFVQELFVN----PVEAFQFYFELLLFDYP---
MMAR_0538|M.marinum_M               QPIWWLVRALEFGQDFQTFIKELFTN----PIGAIEFMVELVLFDWP---
MUL_1202|M.ulcerans_Agy99           QPIWWLVRALEFGQDFQTFIKELFTN----PIGAIEFMVELVLFDWP---
MLBr_01828|M.leprae_Br4923          FDPWLPSLGNPLSFLSPFNIAFALGTP--MDIGSYVGYLSQTFAFIGADL
                                                                     .                

MAV_2429|M.avium_104                ALSTALGWAIFHTLMIFWPFMQAAIQMAVVLAPVVV---------AAIGA
MAB_4783|M.abscessus_ATCC_1997      VFAYAATFAVMGTP-IYAAIMGPAAGISIPLAITLA---------SLSQM
Mflv_0325|M.gilvum_PYR-GCK          AVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVG---------QHLLS
Mvan_0415|M.vanbaalenii_PYR-1       AVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVG---------AYLLE
MSMEG_0619|M.smegmatis_MC2_155      GVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITG---------LVLLI
TH_3569|M.thermoresistible__bu      AVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAG---------LVMIA
Mb0288|M.bovis_AF2122/97            THIVQIVEALSQSPQLLAVALGSVISNLGAVTGFAG---------LSGLA
Rv0280|M.tuberculosis_H37Rv         THIVQIVEALSQSPQLLAVALGSVISNLGAVTGFAG---------LSGLA
MMAR_0538|M.marinum_M               THIAQIIQALAQSPQLLAVALGGVVANLGAISGLAG---------LSGLA
MUL_1202|M.ulcerans_Agy99           THIAQIIQALAQSPQLLAVALGGVVANLGAISGLAG---------LSGLA
MLBr_01828|M.leprae_Br4923          AAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMIL
                                             :                                        

MAV_2429|M.avium_104                AAAGGAAAAVTAISVAAPLSMAAPVPVAAAPAPVATVPAPTIAGAPAGVS
MAB_4783|M.abscessus_ATCC_1997      PEAP--PVDAPAETVPARIDQPHAVAMGGAPAPTASTAAPTPTTTSP---
Mflv_0325|M.gilvum_PYR-GCK          LLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTV
Mvan_0415|M.vanbaalenii_PYR-1       NLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTV
MSMEG_0619|M.smegmatis_MC2_155      DHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPA
TH_3569|M.thermoresistible__bu      DQAQP-----PAEEAAPEEDVAAP-------------------VRAEPQN
Mb0288|M.bovis_AF2122/97            GMQPA-AIPALAPVAAAPPTLPAVAMAPTMAAPGAAVASAAAPASAPAAS
Rv0280|M.tuberculosis_H37Rv         GMQPA-AIPALAPVAAAPSTLPAVAMAPTMAAPGAAVASAAAPASAPAAS
MMAR_0538|M.marinum_M               GLHSA-ALPA-AIAPIAPPMPPGVALAPTVATSVAAPTPPSAPPSA--TS
MUL_1202|M.ulcerans_Agy99           GLHSA-ALPA-AIAPIAPPMPPGVALAPTVAASVAAPTPPSAPPSA--AS
MLBr_01828|M.leprae_Br4923          PLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPP
                                               *    .    .                       .    

MAV_2429|M.avium_104                HVPTTASAPAPTMAGSAGGG--PVGGGPGVGFGPTATDGIGAGMSDALYA
MAB_4783|M.abscessus_ATCC_1997      ATPGSAPAPTPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGA--------
Mflv_0325|M.gilvum_PYR-GCK          SAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGA--------
Mvan_0415|M.vanbaalenii_PYR-1       ATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSA--------
MSMEG_0619|M.smegmatis_MC2_155      PAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQV--------
TH_3569|M.thermoresistible__bu      PLPLTXXX------------------------------------------
Mb0288|M.bovis_AF2122/97            TVASATPAPPPAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQR----
Rv0280|M.tuberculosis_H37Rv         TVASATPAPPPAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQR----
MMAR_0538|M.marinum_M               TVANAAPPPPPAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARR----
MUL_1202|M.ulcerans_Agy99           TVANAAPPPPPAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARR----
MLBr_01828|M.leprae_Br4923          SMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFG--
                                                                                      

MAV_2429|M.avium_104                VGLSGLSARGSASSRARRKSEEPAPDDLDAPAAAAAAAAGSKKARARRRR
MAB_4783|M.abscessus_ATCC_1997      ------TAHAPSS----------------AVSAAAALACNPATGKSRRRR
Mflv_0325|M.gilvum_PYR-GCK          --------KAPAGT---------------IPAAASGIAASAAERRKRRRR
Mvan_0415|M.vanbaalenii_PYR-1       --------KAPASG---------------IPAAASGVAASAAERRKRRRR
MSMEG_0619|M.smegmatis_MC2_155      --------AAPASG---------------VPAAASGVAASLASRRKRRRK
TH_3569|M.thermoresistible__bu      --------------------------------------------------
Mb0288|M.bovis_AF2122/97            --------KAPQPDS--------------AAAAAAAAAVRDQARARRRRR
Rv0280|M.tuberculosis_H37Rv         --------KAPQPDS--------------AAAAAAAAAVRDQARARRRRR
MMAR_0538|M.marinum_M               --------KAPEPD---------------SAALAAAAAAREEARRRRRKR
MUL_1202|M.ulcerans_Agy99           --------KAPEPD---------------SAALAAAAAVREEARRRRRKR
MLBr_01828|M.leprae_Br4923          ----YLVGRLPSTARG-------------VVGTSVRQQSSAPDRIEAPDA
                                                                                      

MAV_2429|M.avium_104                RG-TATDRAYRYEYMDLDTDSGPED-GGPDDGPVASEASAGQLGFAGAAT
MAB_4783|M.abscessus_ATCC_1997      RR-TIDDRGYRHEYATMDDHTPTGP-QDP-VTAVASGTGAGRLGFAGVHT
Mflv_0325|M.gilvum_PYR-GCK          QKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVS
Mvan_0415|M.vanbaalenii_PYR-1       QKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVS
MSMEG_0619|M.smegmatis_MC2_155      KGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVT
TH_3569|M.thermoresistible__bu      --------------------------------------------------
Mb0288|M.bovis_AF2122/97            VTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLGFAGTAR
Rv0280|M.tuberculosis_H37Rv         VTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLGFAGTAR
MMAR_0538|M.marinum_M               KTERGYGEEFMDV--EVDPDWGGPRDDEP----VASTQGAGRLGFAGTVH
MUL_1202|M.ulcerans_Agy99           KTERGYGEEFMDV--EVDPDWGGPLDDEP----VASTQGAGRLGFAGTVH
MLBr_01828|M.leprae_Br4923          AATPQEQARSRWRRRAKVTPFDSSGSPNPKAAPTASDQGAGTLGLAGTAR
                                                                                      

MAV_2429|M.avium_104                KSDAARPAGLATLTRDGSSEGPGVPMMPSTWDRD----------------
MAB_4783|M.abscessus_ATCC_1997      ATTAVEATGLSTL--DGDAENRTIPMLPGTWDVTDDDR------------
Mflv_0325|M.gilvum_PYR-GCK          R-GDEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGH
Mvan_0415|M.vanbaalenii_PYR-1       R-DAAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHH
MSMEG_0619|M.smegmatis_MC2_155      R-HDVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDP
TH_3569|M.thermoresistible__bu      --------------------------------------------------
Mb0288|M.bovis_AF2122/97            REAVADAAGMTTLAGDDFGDGPTTPMVPGSWDPDRDAPGSAEPGDRG---
Rv0280|M.tuberculosis_H37Rv         REAVADAAGMTTLAGDDFGDGPTTPMVPGSWDPDRDAPGSAEPGDRG---
MMAR_0538|M.marinum_M               SESAATAAGLTTLVADEFGGGPKMPMLPGTWDTDSDAPSD----------
MUL_1202|M.ulcerans_Agy99           SESAATAAGLTTLVADEFGGGPKMPMLPGTWDTDSDAPSD----------
MLBr_01828|M.leprae_Br4923          QASSGPATGLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGGW
                                                                                      

MAV_2429|M.avium_104                ------
MAB_4783|M.abscessus_ATCC_1997      ------
Mflv_0325|M.gilvum_PYR-GCK          DGKEKP
Mvan_0415|M.vanbaalenii_PYR-1       DGKDSQ
MSMEG_0619|M.smegmatis_MC2_155      EGGPRR
TH_3569|M.thermoresistible__bu      ------
Mb0288|M.bovis_AF2122/97            ------
Rv0280|M.tuberculosis_H37Rv         ------
MMAR_0538|M.marinum_M               ------
MUL_1202|M.ulcerans_Agy99           ------
MLBr_01828|M.leprae_Br4923          DDE---