For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTAPVWIAFPPEVHSTLLSSGPGPAPLLAAATAWSSMSTEYAAAAAELDGLLAAAHAGAWEGPSAEQYVA AHAPYQAWLLESAAKSSTAASLHETAAGAYTAALAAMPTLGELATNHAVHGALVATNFFGINTIPIAVNE ADYARMWVQAATTMSTYQAVSQSALAAVPPTTPAPTIVAPGTEAGTATAAAVQSAAAAPATDSGSNLNHA DTSSTQQQASTAAQSYPSWQDQLTAWLKQYTQNFAWPVSKDLNPGGWPFPPVPFVNGLASFFGQLGFSPA LSTALGWAIFHTLMIFWPFMQAAIQMAVVLAPVVVAAIGAAAAGGAAAAVTAISVAAPLSMAAPVPVAAA PAPVATVPAPTIAGAPAGVSHVPTTASAPAPTMAGSAGGGPVGGGPGVGFGPTATDGIGAGMSDALYAVG LSGLSARGSASSRARRKSEEPAPDDLDAPAAAAAAAAGSKKARARRRRRGTATDRAYRYEYMDLDTDSGP EDGGPDDGPVASEASAGQLGFAGAATKSDAARPAGLATLTRDGSSEGPGVPMMPSTWDRD
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_2429 | - | - | 100% (550) | PPE family protein |
M. avium 104 | MAV_4872 | - | e-106 | 44.75% (552) | PPE family protein |
M. avium 104 | MAV_4879 | - | e-102 | 43.71% (572) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0288 | PPE3 | 1e-100 | 41.84% (576) | PPE family protein |
M. gilvum PYR-GCK | Mflv_0325 | - | 7e-88 | 37.94% (564) | PPE protein |
M. tuberculosis H37Rv | Rv0280 | PPE3 | 1e-100 | 41.84% (576) | PPE family protein |
M. leprae Br4923 | MLBr_01828 | PPE | 5e-79 | 35.18% (577) | PPE-family protein |
M. abscessus ATCC 19977 | MAB_4783 | - | 2e-98 | 43.06% (569) | PPE family protein |
M. marinum M | MMAR_0538 | - | 1e-106 | 43.92% (567) | PPE family protein, PPE3 |
M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-100 | 42.40% (559) | PPE family protein |
M. thermoresistible (build 8) | TH_3569 | - | 7e-75 | 46.59% (352) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_1202 | - | 1e-105 | 43.69% (563) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-95 | 41.13% (564) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment MAV_2429|M.avium_104 ----------MTAPVWIAFPPEVHSTLLSSGPGPAPLLAAATAWSSMSTE MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE Mb0288|M.bovis_AF2122/97 ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE Rv0280|M.tuberculosis_H37Rv ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE MMAR_0538|M.marinum_M ----------MVAPVWFASPPEVHSALLSSGPGPASLLSGAAAWAGLSTE MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV :*:: ******::** ***...:: .. .* .:*: MAV_2429|M.avium_104 YAAAAAELDGLLAAAHAGAWEGPSAEQYVAAHAPYQAWLLESAAKSSTAA MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA Mb0288|M.bovis_AF2122/97 YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA Rv0280|M.tuberculosis_H37Rv YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA MMAR_0538|M.marinum_M YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA *: * ** * . . *:* :: * *: ** ** . : .: * MAV_2429|M.avium_104 SLHETAAGAYTAALAAMPTLGELATNHAVHGALVATNFFGINTIPIAVNE MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE Mb0288|M.bovis_AF2122/97 ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE Rv0280|M.tuberculosis_H37Rv ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE MMAR_0538|M.marinum_M AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE :: * ** ::* ***: **: *:. * .*: ***:******** .* MAV_2429|M.avium_104 ADYARMWVQAATTMSTYQAVSQSALAAVPPTTPAP-TIVAPGT------- MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAP-PVLSP--------- Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAP-SVLLPGVG------ Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAP-FVLAPGVG------ MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAP-FLLKPGVG------ TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAP-LLLAPGVS------ Mb0288|M.bovis_AF2122/97 ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADDDHDHD Rv0280|M.tuberculosis_H37Rv ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADDDHDHD MMAR_0538|M.marinum_M ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAA--HDHD MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAA--HDHD MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP ** *** :** *.*** *: : :.* : .** : MAV_2429|M.avium_104 -EAGTATAAAVQSAAAAPATDSGSNLNHADTSSTQQQAST--AAQSYPSW MAB_4783|M.abscessus_ATCC_1997 -DSGAAARTAAQDATKPPPIVP-------DPNDPIEMLLK--NSQHFLGM Mflv_0325|M.gilvum_PYR-GCK -EAGRAAADMSAFAAQPMAAQAGAAFD--VSNIIADIIRL--YGEVLRFL Mvan_0415|M.vanbaalenii_PYR-1 -EAGRAAADVTAFAAQAQAAEAGSALD--LSNIIADLIRA--YGELLRFL MSMEG_0619|M.smegmatis_MC2_155 -EAGSASASVQQMSAQATAAESGSSLD--LSSIISDLLNQ--YLQGVPGG TH_3569|M.thermoresistible__bu -EAADAMATTQQIGSQATAADSGTALN--LSDLIANLLQY--YQDYLDQL Mb0288|M.bovis_AF2122/97 HDHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIP---FEDYTDAA Rv0280|M.tuberculosis_H37Rv HDHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIP---FEDYTDAA MMAR_0538|M.marinum_M HDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIP---YDDYVNAA MUL_1202|M.ulcerans_Agy99 HDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIP---YDDYVNAA MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG . . : MAV_2429|M.avium_104 QDQLTAWLKQYTQNFAWPVSKDLNPGGWPFPPVPFVNGLASFFGQLGFSP MAB_4783|M.abscessus_ATCC_1997 YRALKGLITDPVGTIVR-IIIDFSTN----PAAAIVTWTPLFY------- Mflv_0325|M.gilvum_PYR-GCK FEPIFNFLRDPIGNTFA-LITDFLTN----PVQALITWGPFLL------- Mvan_0415|M.vanbaalenii_PYR-1 FEPIFDFLRDPLGNTIK-LITDFLTN----PAQALITWGPFLA------- MSMEG_0619|M.smegmatis_MC2_155 Q-AILDFLKDPLGNLGR-LLTDFMTN----PAGALATWWPFLF------- TH_3569|M.thermoresistible__bu FGPIVDFLRDPIGNLFQ-LIDDFLTN----PAGALVTWWPLLF------- Mb0288|M.bovis_AF2122/97 QPIWWVVRAIEFSKDFETFVQELFVN----PVEAFQFYFELLLFDYP--- Rv0280|M.tuberculosis_H37Rv QPIWWVVRAIEFSKDFETFVQELFVN----PVEAFQFYFELLLFDYP--- MMAR_0538|M.marinum_M QPIWWLVRALEFGQDFQTFIKELFTN----PIGAIEFMVELVLFDWP--- MUL_1202|M.ulcerans_Agy99 QPIWWLVRALEFGQDFQTFIKELFTN----PIGAIEFMVELVLFDWP--- MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTP--MDIGSYVGYLSQTFAFIGADL . MAV_2429|M.avium_104 ALSTALGWAIFHTLMIFWPFMQAAIQMAVVLAPVVV---------AAIGA MAB_4783|M.abscessus_ATCC_1997 VFAYAATFAVMGTP-IYAAIMGPAAGISIPLAITLA---------SLSQM Mflv_0325|M.gilvum_PYR-GCK AVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVG---------QHLLS Mvan_0415|M.vanbaalenii_PYR-1 AVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVG---------AYLLE MSMEG_0619|M.smegmatis_MC2_155 GVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITG---------LVLLI TH_3569|M.thermoresistible__bu AVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAG---------LVMIA Mb0288|M.bovis_AF2122/97 THIVQIVEALSQSPQLLAVALGSVISNLGAVTGFAG---------LSGLA Rv0280|M.tuberculosis_H37Rv THIVQIVEALSQSPQLLAVALGSVISNLGAVTGFAG---------LSGLA MMAR_0538|M.marinum_M THIAQIIQALAQSPQLLAVALGGVVANLGAISGLAG---------LSGLA MUL_1202|M.ulcerans_Agy99 THIAQIIQALAQSPQLLAVALGGVVANLGAISGLAG---------LSGLA MLBr_01828|M.leprae_Br4923 AAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMIL : MAV_2429|M.avium_104 AAAGGAAAAVTAISVAAPLSMAAPVPVAAAPAPVATVPAPTIAGAPAGVS MAB_4783|M.abscessus_ATCC_1997 PEAP--PVDAPAETVPARIDQPHAVAMGGAPAPTASTAAPTPTTTSP--- Mflv_0325|M.gilvum_PYR-GCK LLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTV Mvan_0415|M.vanbaalenii_PYR-1 NLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTV MSMEG_0619|M.smegmatis_MC2_155 DHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPA TH_3569|M.thermoresistible__bu DQAQP-----PAEEAAPEEDVAAP-------------------VRAEPQN Mb0288|M.bovis_AF2122/97 GMQPA-AIPALAPVAAAPPTLPAVAMAPTMAAPGAAVASAAAPASAPAAS Rv0280|M.tuberculosis_H37Rv GMQPA-AIPALAPVAAAPSTLPAVAMAPTMAAPGAAVASAAAPASAPAAS MMAR_0538|M.marinum_M GLHSA-ALPA-AIAPIAPPMPPGVALAPTVATSVAAPTPPSAPPSA--TS MUL_1202|M.ulcerans_Agy99 GLHSA-ALPA-AIAPIAPPMPPGVALAPTVAASVAAPTPPSAPPSA--AS MLBr_01828|M.leprae_Br4923 PLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPP * . . . MAV_2429|M.avium_104 HVPTTASAPAPTMAGSAGGG--PVGGGPGVGFGPTATDGIGAGMSDALYA MAB_4783|M.abscessus_ATCC_1997 ATPGSAPAPTPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGA-------- Mflv_0325|M.gilvum_PYR-GCK SAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGA-------- Mvan_0415|M.vanbaalenii_PYR-1 ATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSA-------- MSMEG_0619|M.smegmatis_MC2_155 PAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQV-------- TH_3569|M.thermoresistible__bu PLPLTXXX------------------------------------------ Mb0288|M.bovis_AF2122/97 TVASATPAPPPAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQR---- Rv0280|M.tuberculosis_H37Rv TVASATPAPPPAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQR---- MMAR_0538|M.marinum_M TVANAAPPPPPAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARR---- MUL_1202|M.ulcerans_Agy99 TVANAAPPPPPAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARR---- MLBr_01828|M.leprae_Br4923 SMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFG-- MAV_2429|M.avium_104 VGLSGLSARGSASSRARRKSEEPAPDDLDAPAAAAAAAAGSKKARARRRR MAB_4783|M.abscessus_ATCC_1997 ------TAHAPSS----------------AVSAAAALACNPATGKSRRRR Mflv_0325|M.gilvum_PYR-GCK --------KAPAGT---------------IPAAASGIAASAAERRKRRRR Mvan_0415|M.vanbaalenii_PYR-1 --------KAPASG---------------IPAAASGVAASAAERRKRRRR MSMEG_0619|M.smegmatis_MC2_155 --------AAPASG---------------VPAAASGVAASLASRRKRRRK TH_3569|M.thermoresistible__bu -------------------------------------------------- Mb0288|M.bovis_AF2122/97 --------KAPQPDS--------------AAAAAAAAAVRDQARARRRRR Rv0280|M.tuberculosis_H37Rv --------KAPQPDS--------------AAAAAAAAAVRDQARARRRRR MMAR_0538|M.marinum_M --------KAPEPD---------------SAALAAAAAAREEARRRRRKR MUL_1202|M.ulcerans_Agy99 --------KAPEPD---------------SAALAAAAAVREEARRRRRKR MLBr_01828|M.leprae_Br4923 ----YLVGRLPSTARG-------------VVGTSVRQQSSAPDRIEAPDA MAV_2429|M.avium_104 RG-TATDRAYRYEYMDLDTDSGPED-GGPDDGPVASEASAGQLGFAGAAT MAB_4783|M.abscessus_ATCC_1997 RR-TIDDRGYRHEYATMDDHTPTGP-QDP-VTAVASGTGAGRLGFAGVHT Mflv_0325|M.gilvum_PYR-GCK QKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVS Mvan_0415|M.vanbaalenii_PYR-1 QKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVS MSMEG_0619|M.smegmatis_MC2_155 KGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVT TH_3569|M.thermoresistible__bu -------------------------------------------------- Mb0288|M.bovis_AF2122/97 VTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLGFAGTAR Rv0280|M.tuberculosis_H37Rv VTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLGFAGTAR MMAR_0538|M.marinum_M KTERGYGEEFMDV--EVDPDWGGPRDDEP----VASTQGAGRLGFAGTVH MUL_1202|M.ulcerans_Agy99 KTERGYGEEFMDV--EVDPDWGGPLDDEP----VASTQGAGRLGFAGTVH MLBr_01828|M.leprae_Br4923 AATPQEQARSRWRRRAKVTPFDSSGSPNPKAAPTASDQGAGTLGLAGTAR MAV_2429|M.avium_104 KSDAARPAGLATLTRDGSSEGPGVPMMPSTWDRD---------------- MAB_4783|M.abscessus_ATCC_1997 ATTAVEATGLSTL--DGDAENRTIPMLPGTWDVTDDDR------------ Mflv_0325|M.gilvum_PYR-GCK R-GDEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGH Mvan_0415|M.vanbaalenii_PYR-1 R-DAAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHH MSMEG_0619|M.smegmatis_MC2_155 R-HDVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDP TH_3569|M.thermoresistible__bu -------------------------------------------------- Mb0288|M.bovis_AF2122/97 REAVADAAGMTTLAGDDFGDGPTTPMVPGSWDPDRDAPGSAEPGDRG--- Rv0280|M.tuberculosis_H37Rv REAVADAAGMTTLAGDDFGDGPTTPMVPGSWDPDRDAPGSAEPGDRG--- MMAR_0538|M.marinum_M SESAATAAGLTTLVADEFGGGPKMPMLPGTWDTDSDAPSD---------- MUL_1202|M.ulcerans_Agy99 SESAATAAGLTTLVADEFGGGPKMPMLPGTWDTDSDAPSD---------- MLBr_01828|M.leprae_Br4923 QASSGPATGLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGGW MAV_2429|M.avium_104 ------ MAB_4783|M.abscessus_ATCC_1997 ------ Mflv_0325|M.gilvum_PYR-GCK DGKEKP Mvan_0415|M.vanbaalenii_PYR-1 DGKDSQ MSMEG_0619|M.smegmatis_MC2_155 EGGPRR TH_3569|M.thermoresistible__bu ------ Mb0288|M.bovis_AF2122/97 ------ Rv0280|M.tuberculosis_H37Rv ------ MMAR_0538|M.marinum_M ------ MUL_1202|M.ulcerans_Agy99 ------ MLBr_01828|M.leprae_Br4923 DDE---