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PTAMITGASGGLGSALADALAPTHTLFLAGRPSPRLDAVAERLGATTWPVDLADPDAMAAVVEPIVELDV LIHNAGVAYPGRVAESHVDEWRSTMAVNVVGAVALTLELLPALRAARGHVVFINSGAGINASPGLASYTA SKFALRGFADSLRADEPTLRVTSVHPGRIATAMQEDLVAYEGRPYEPDRFLSPQTVARLTVDAINAPADA HVHEVIIRPSPAPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0854 | - | - | 100% (225) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0295 | - | 8e-20 | 37.08% (178) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1472 | - | 2e-18 | 34.04% (188) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0494c | - | 1e-20 | 31.00% (229) | putative short-chain type oxidoreductase |
| M. tuberculosis H37Rv | Rv0484c | - | 6e-21 | 31.44% (229) | short-chain type oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 3e-20 | 30.89% (246) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4922 | - | 3e-78 | 63.01% (219) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0058 | - | 1e-78 | 64.55% (220) | short-chain type oxidoreductase |
| M. avium 104 | MAV_0056 | - | 4e-83 | 66.97% (221) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6916 | - | 9e-87 | 70.00% (220) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0508 | - | 4e-85 | 68.64% (220) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_0057 | - | 3e-77 | 63.64% (220) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_6051 | - | 1e-113 | 91.36% (220) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0494c|M.bovis_AF2122/97 MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALAN
Rv0484c|M.tuberculosis_H37Rv MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALAN
Mflv_0854|M.gilvum_PYR-GCK -------MPTAMITGASGGLGSALADALAPT-HTLFLAGRPSPRLDAVAE
Mvan_6051|M.vanbaalenii_PYR-1 -------MPTAMITGASGGVGSALADALAPT-HTLFLAGRPSPRLDAVAE
MMAR_0058|M.marinum_M -------MPTALITGASRGIGAAIAAALAPT-HTLLLAGRPSSQLDAVAD
MUL_0057|M.ulcerans_Agy99 -------MPTALITGASRGIGAAIAAALAPT-HTLLLAGRPSAQLDAVAD
MAV_0056|M.avium_104 -------MPNALITGAGGGIGSAIATALAPT-HTLLLAGRPSDRLDAVAQ
MSMEG_6916|M.smegmatis_MC2_155 -------MPTALITGASGAIGSAIAAALAPT-HTLLLAGRPSARLDEVAE
TH_0508|M.thermoresistible__bu -------MPTAMITGAAGGLGSALTAALAPT-HTLFLAGRASDRLDDLAQ
MAB_4922|M.abscessus_ATCC_1997 -------MPHALITGAAGGLGAAIARALAAT-HSLLLGGRPSLRLDTLAD
MLBr_01094|M.leprae_Br4923 --MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQTEG
*::***. .:* * : ** : . :
Mb0494c|M.bovis_AF2122/97 QIGGT-----AIVADVTDDAAVEALARALSR----VDVLVNNAGGAKGLQ
Rv0484c|M.tuberculosis_H37Rv QIGGT-----AIVADVTDDAAVEALARALSR----VDVLVNNAGGAKGLQ
Mflv_0854|M.gilvum_PYR-GCK RLGAT-----TWPVDLADPDAMAAVVEPIVE----LDVLIHNAG-VAYPG
Mvan_6051|M.vanbaalenii_PYR-1 RLGAT-----TWPVDLADPDAIPAVVEPIVE----LDVLIHNAG-VAYPG
MMAR_0058|M.marinum_M QFGAT-----TFPLDLTDDESIETSCEIVDE----LDVLIHNAG-LSIPG
MUL_0057|M.ulcerans_Agy99 QFGAT-----TFPLDLTDDESIETSCEIVDE----LDVLIHNAG-LSIPG
MAV_0056|M.avium_104 RLGAT-----TFPLDLTDGGDIEAACEVVDE----LDVLVHNAG-LSIPG
MSMEG_6916|M.smegmatis_MC2_155 RLGAP-----TWPLDLTDADSIESSTEVLAE----LDVLVHNAG-VLFPG
TH_0508|M.thermoresistible__bu RYGAT-----TWPVDFTDLEALPAVVEPIDE----LDVLIHNAG-VTHPA
MAB_4922|M.abscessus_ATCC_1997 ELDAT-----PWPVDLSDQDAILAAVAGIDA----LDVLVHNAG-VSYPA
MLBr_01094|M.leprae_Br4923 QLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAG-IAFTG
. . . *.:: . : : :: : :***
Mb0494c|M.bovis_AF2122/97 FVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAALE
Rv0484c|M.tuberculosis_H37Rv FVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAAIE
Mflv_0854|M.gilvum_PYR-GCK RVAESHVDEWRSTMAVNVVGAVALTLELLPALR-AARGHVVFINSGAGIN
Mvan_6051|M.vanbaalenii_PYR-1 RVAESDVDQWRATMAVNVVGAVALTLELLPALR-SAGGHVVFINSGAGIN
MMAR_0058|M.marinum_M HFGDSHVDEWRATFNVNLFGAVALTLALLPALR-SARGQVVFINSGAGRN
MUL_0057|M.ulcerans_Agy99 HFGDSHVDEWRATFNVNLFGAVALTLALLPAPR-SARGQVVFINSGAGRN
MAV_0056|M.avium_104 NVADSNVDEWRATFAVNVFGPVELTLALLPALR-RARGQVVFINSGAGRN
MSMEG_6916|M.smegmatis_MC2_155 RVGESTADEWRASFEVNVTGAVALTLALLPALR-AARGHVVFINSGAGRK
TH_0508|M.thermoresistible__bu DFADSTVEEWRNSFDVNVIGPVALTQALLPALR-QRRGHVVIINSGSGLR
MAB_4922|M.abscessus_ATCC_1997 TIADSTLADWRKTLDVNVLAPVALTQALLPALR-AAQGDVVFINSGAGIN
MLBr_01094|M.leprae_Br4923 DVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFGLF
. : . . .: . : * :** * :: :.* .
Mb0494c|M.bovis_AF2122/97 VYDGGAGYTAAKHAQGALHRTLRGELLGK--PVRLTEIAPGAVETEFS--
Rv0484c|M.tuberculosis_H37Rv VYDGGAGYTAAKHAQGALHRTLRGELLGK--PVRLTEIAPGAVETEFS--
Mflv_0854|M.gilvum_PYR-GCK ASPGLASYTASKFALRGFADSLRADEP----TLRVTSVHPGRIATAMQED
Mvan_6051|M.vanbaalenii_PYR-1 ASPGLASYSASKFALRAFADSLRADEP----GLRVTSVHPGRIATAMQED
MMAR_0058|M.marinum_M VSAGMASYSASKFALRAFADSLRTDEP----TLRVTTVYPGRTDTDMQRE
MUL_0057|M.ulcerans_Agy99 VSAGMASYSASKFALRAFADSLRTDES----TLRVTTVYPGRTDTDMQRE
MAV_0056|M.avium_104 VSPGMASYSASKFALRAFADSLRNDEP----ELRVTTVYPGRTDTGMQRE
MSMEG_6916|M.smegmatis_MC2_155 VSAGMASYSASKFALRAFADSLRADEP----SLRVTSVFPGRTDSDMQRE
TH_0508|M.thermoresistible__bu AHAGMASYSASKFAARAFADALREEEP----LLRVTSVFPGRIDTAMQQK
MAB_4922|M.abscessus_ATCC_1997 AHPGIGSYSVSKFALRGFADVLRAEEP----ALRVTSVHPGRISTPMQQE
MLBr_01094|M.leprae_Br4923 SVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTAIARN
* ..*. :*.* .: ** : :.:* : ** : :
Mb0494c|M.bovis_AF2122/97 LVRFDGDQQRADAV--YAGMTPLVAADVAEVIGFVATRP-------SHVN
Rv0484c|M.tuberculosis_H37Rv LVRFDGDQQRADAV--YAGMTPLVAADVAEVIGFVATRP-------SHVN
Mflv_0854|M.gilvum_PYR-GCK LVAYEGRP--------YEPDRFLSPQTVARLTVDAINAP-------ADAH
Mvan_6051|M.vanbaalenii_PYR-1 LVAYEGRP--------YDPAQFLSPQTVAQVTADAINAP-------ADAH
MMAR_0058|M.marinum_M LVDFEGGT--------YDPARFMRADTVAAVVANVVATP-------PDGH
MUL_0057|M.ulcerans_Agy99 LVDFEGGT--------YDPARFMRADTVAEVVANVVATP-------PDGH
MAV_0056|M.avium_104 LIAFEGGS--------YDPDRFLKPETVAAAVANVVATP-------PDGH
MSMEG_6916|M.smegmatis_MC2_155 LIAYEGRE--------YDPGSFLRPETVAGLVASAVNTP-------RDGH
TH_0508|M.thermoresistible__bu LVAYEGRQ--------YNPDEFLRPETVAKIVADAVNTP-------PDAH
MAB_4922|M.abscessus_ATCC_1997 LTEHEGRE--------YNPDDYMRPESVAQLVADAVNLP-------RDAR
MLBr_01094|M.leprae_Br4923 ATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRKKKARVLVGPDAK
:* . .* . . .
Mb0494c|M.bovis_AF2122/97 LDQIVIRPRDQASASRRATHPVR-------
Rv0484c|M.tuberculosis_H37Rv LDQIVIRPRDQASASRRATHPVR-------
Mflv_0854|M.gilvum_PYR-GCK VHEVIIRPSPAPR-----------------
Mvan_6051|M.vanbaalenii_PYR-1 IHEVIVRPR---------------------
MMAR_0058|M.marinum_M VHEVVIRPR---------------------
MUL_0057|M.ulcerans_Agy99 VHEVVIRPR---------------------
MAV_0056|M.avium_104 VHEVVLRPARR-------------------
MSMEG_6916|M.smegmatis_MC2_155 VHEIVVRPG---------------------
TH_0508|M.thermoresistible__bu LHEIVVRPYQ--------------------
MAB_4922|M.abscessus_ATCC_1997 VHQIVVRQN---------------------
MLBr_01094|M.leprae_Br4923 VANVVVRFSGGAGYQRLFAQVASRLILNQR
: ::::*