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MKYVDVDGVGRLSRIGLGTWQFGSREWGYGDSYAAGAAGDIVRRALALGVTLFDTAEIYGFGKSERILGD ALGEQRAEVAVASKIMPVAPFPAVVRQRARASARRLGLDRIPLYQVHQPNPVFPDSVIMPGMRDLLDSGE IGAAGVSNYSLQRWRKADAALGRPVISNQVHFSLAYPKALKNLVPFAERENRIVIAYSPLEQGLLGGKYG VDNRPGGVRAVNALFGTENLRRIEPLLQLLRDVAAQVDAKPAQVALAWLISYPGVVAIPGASSVEQLEFN VAAADIELPAESRDALTDAALAFRPTSAARFLTDLARERIPGRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4098 | - | - | 100% (324) | aldo/keto reductase |
| M. avium 104 | MAV_3334 | - | 2e-33 | 33.33% (309) | general stress protein 69 |
| M. avium 104 | MAV_2496 | - | 1e-29 | 32.69% (312) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 1e-153 | 82.35% (323) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_1329 | - | 2e-11 | 27.73% (321) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 1e-153 | 82.35% (323) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 3e-20 | 29.47% (302) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 3e-30 | 32.88% (295) | aldo/keto reductase |
| M. marinum M | MMAR_3520 | - | 1e-151 | 82.35% (323) | hypothetical protein MMAR_3520 |
| M. smegmatis MC2 155 | MSMEG_2920 | - | 1e-28 | 32.65% (294) | aldo/keto reductase |
| M. thermoresistible (build 8) | TH_1525 | - | 9e-08 | 23.29% (292) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 1e-150 | 82.04% (323) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 3e-22 | 31.37% (271) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3520|M.marinum_M ----------------------MKHLEVDGIGNVSRIGLGTWQFGSREWG
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSREWG
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSREWG
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSREWG
MAV_4098|M.avium_104 ----------------------MKYVDVDGVGRLSRIGLGTWQFGSREWG
MAB_4120c|M.abscessus_ATCC_199 ----------------------MKHTWLG-ELSVSRIGLGAMSMSAY---
MSMEG_2920|M.smegmatis_MC2_155 ----------------------MTVAPL--RTDRRRLGSGGPEVSAIGLG
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKGVW
Mvan_2555|M.vanbaalenii_PYR-1 ----------MTSGSS----RTAPTFLLGGELPVNRLGFGAMRLTGPGVW
Mflv_1329|M.gilvum_PYR-GCK ----------------------MDTFPLG-SHTVGRVGFGAMQLPGPGVF
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPD---
: ::* * .
MMAR_3520|M.marinum_M YGDRYASGAAR------DIVARARALGVTLFDTAEVYGLGKSERILGEAL
MUL_2745|M.ulcerans_Agy99 YGDRYASGAAR------DIVARACALGVTLFDTAEVYGLGKSERILGEAL
Mb2320|M.bovis_AF2122/97 YGDRYATGAAR------DIVKRARALGVTLFDTAEIYGLGKSERILGEAL
Rv2298|M.tuberculosis_H37Rv YGDRYATGAAR------DIVKRARALGVTLFDTAEIYGLGKSERILGEAL
MAV_4098|M.avium_104 YGDSYAAGAAG------DIVRRALALGVTLFDTAEIYGFGKSERILGDAL
MAB_4120c|M.abscessus_ATCC_199 YRAIGSESGPD-EATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAI
MSMEG_2920|M.smegmatis_MC2_155 FMSFRAGSGPDDEKQAKDIVDAAIDLGVTLFDTADIYGPEHSEVLLGKAI
MLBr_00458|M.leprae_Br4923 GPPVDRYEAVR-------VLRRAVELGVNFIDTADSYGPYVSEEIIAEAL
Mvan_2555|M.vanbaalenii_PYR-1 GPPADRDECLR-------VLRRAVDLGVDFIDTADSYGPYISEDLIREAL
Mflv_1329|M.gilvum_PYR-GCK GPPRDHDQALA-------VLRRVVELGINHIDTAQIYGPNVANELIREAL
TH_1525|M.thermoresistible__bu ----QTAAAVR----------TALDAGYRHIDTAQMYGNERGVAEGIRDA
. * :***: **
MMAR_3520|M.marinum_M GDERAEVVVASKIM------------PVAPFPAVVKQRERASARRLQLD-
MUL_2745|M.ulcerans_Agy99 GDERAEVVVASKIM------------PVAPFPAVVKQRERASARRLQLD-
Mb2320|M.bovis_AF2122/97 GDDRTEVVVASKVF------------PVAPFPAVIKNRERASARRLQLN-
Rv2298|M.tuberculosis_H37Rv GDDRTEVVVASKVF------------PVAPFPAVIKNRERASARRLQLN-
MAV_4098|M.avium_104 GEQRAEVAVASKIM------------PVAPFPAVVRQRARASARRLGLD-
MAB_4120c|M.abscessus_ATCC_199 AGRRDEVVLATKFG-LVSHGNGAS-QVLDSTPGNISTAVEGSLRRLGVD-
MSMEG_2920|M.smegmatis_MC2_155 RGRRDSLVIATKFGNRLDRGTSTDGRALDGRPEYVRSAIEGSLRRLGVD-
MLBr_00458|M.leprae_Br4923 HPY-KGLVIATKAG---LLRTGRDVWIPLGNPSYLRQELEMSLRRLNVD-
Mvan_2555|M.vanbaalenii_PYR-1 HPY-DGVVIATKAG---LLRTAPDVWEPLGFPAYLRQECEMSLRRLGTD-
Mflv_1329|M.gilvum_PYR-GCK HPYADGLALVSKVG---GRRDEQGNWLPAQDPDDLRRQLEENLSTLDTDR
TH_1525|M.thermoresistible__bu GLDRGEVFITSKLN------------NPYHRPDDARRAFDRTLTELGSD-
: :.:* * . * :
MMAR_3520|M.marinum_M --RIPLYQIHQPNPVVP-------DSVIMPGMRELLDTGRIGAAGVSNYS
MUL_2745|M.ulcerans_Agy99 --RIPLYQIHQPNPVVP-------DSVIMPGIRELLDIGRIGAAGVSNYS
Mb2320|M.bovis_AF2122/97 --RIPLYQIHQPNPVVP-------DSVIMPGMRDLLDSGDIGAAGVSNYS
Rv2298|M.tuberculosis_H37Rv --RIPLYQIHQPNPVVP-------DSVIMPGMRDLLDSGDIGAAGVSNYS
MAV_4098|M.avium_104 --RIPLYQVHQPNPVFP-------DSVIMPGMRDLLDSGEIGAAGVSNYS
MAB_4120c|M.abscessus_ATCC_199 --HIDLYYQHRVDPNVA-------IEDTIGAVAELVQQGKVRYIGLSEAA
MSMEG_2920|M.smegmatis_MC2_155 --HVDLYYQHRVDPQVP-------IEDTVGALAELVQAGKVRHIGLSEPG
MLBr_00458|M.leprae_Br4923 --TIDLFQLHRIDPNFP-------LADQVGELFTLKNEGKIRHIGLSEIN
Mvan_2555|M.vanbaalenii_PYR-1 --TIDLFQLHRIAPKFP-------AEDQIGELAKLQQEGKVRHIGLSEVS
Mflv_1329|M.gilvum_PYR-GCK LAAVNLRAFNHDDPSLPAVLDRDLFDRQLTAMIAARDEGLIAGIGLSNVS
TH_1525|M.thermoresistible__bu --YVDLFLIHWPLPMHYDG----DFVSTWKTLEEFAADGRARSIGVSNFE
: * : * : * *:*:
MMAR_3520|M.marinum_M LARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPL
MUL_2745|M.ulcerans_Agy99 LARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPL
Mb2320|M.bovis_AF2122/97 LARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPL
Rv2298|M.tuberculosis_H37Rv LARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPL
MAV_4098|M.avium_104 LQRWRKADAALGRPVISNQVHFSLAYPKALKNLVPFAERENRIVIAYSPL
MAB_4120c|M.abscessus_ATCC_199 AGTIRRAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPL
MSMEG_2920|M.smegmatis_MC2_155 PQTLRRAHAVH--PVAAIQNEWSLFTRDIEDETVPIARELGIGIVPYSPL
MLBr_00458|M.leprae_Br4923 LDQLTAAQQIT--EIVSVQNMYNLSAR-AAEPLLDAVTSRGIGFIPWSPL
Mvan_2555|M.vanbaalenii_PYR-1 VDQLTAARAVA--PIVSVQNMYNLTMR-AAEPVLDACEADGIAFIPWFPL
Mflv_1329|M.gilvum_PYR-GCK ADHLRVALERT--EIVCVQNAYNLLDR-TSQPVLDLSAEHGIAFVPFFPL
TH_1525|M.thermoresistible__bu PAHLDLLAAET--STVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAWAPI
.: . . . .: *:
MMAR_3520|M.marinum_M AQGLLGGKYGVDNRPAG--VRAVNPLFGTENLRRIEPLLQTLRAVATDVD
MUL_2745|M.ulcerans_Agy99 AQGLLGGKYGVDNRPAG--VRAVNPLFGTENLRRIEPLLQTLRAVAIDVD
Mb2320|M.bovis_AF2122/97 AQGLLGGKYGLENRPGG--VRALNPLFGTENLRRIEPLLATLRAIAVDVD
Rv2298|M.tuberculosis_H37Rv AQGLLGGKYGLENRPGG--VRALNPLFGTENLRRIEPLLATLRAIAVDVD
MAV_4098|M.avium_104 EQGLLGGKYGVDNRPGG--VRAVNALFGTENLRRIEPLLQLLRDVAAQVD
MAB_4120c|M.abscessus_ATCC_199 GRGFLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIG
MSMEG_2920|M.smegmatis_MC2_155 GRGWLTGRVQSRDNISG--THRDHPRFSDEAFDRNRALADTVVTVAGELG
MLBr_00458|M.leprae_Br4923 AAGPLAAP------------------------------DGPLQRIAVNHH
Mvan_2555|M.vanbaalenii_PYR-1 AAGPLAAA------------------------------DGPLHRIAAEHH
Mflv_1329|M.gilvum_PYR-GCK GSGFVADNPVLK--------------------------HPAVVREAEKLG
TH_1525|M.thermoresistible__bu AKGRVADD-------------------------------PVIAGIADRLG
* : : *
MMAR_3520|M.marinum_M AKPAQVALAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSADARAALT
MUL_2745|M.ulcerans_Agy99 AKPAQVALAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSADARAALT
Mb2320|M.bovis_AF2122/97 AKPAQVALAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSAQSRDALT
Rv2298|M.tuberculosis_H37Rv AKPAQVALAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSAQSRDALT
MAV_4098|M.avium_104 AKPAQVALAWLISYPG-VVAIPGASSVEQLEFNVAAADIELPAESRDALT
MAB_4120c|M.abscessus_ATCC_199 ATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIELLPEHLVRLE
MSMEG_2920|M.smegmatis_MC2_155 VQPGQVALAWVLSRGQDVVPIPGTRHVGFLRENLCAVGIELSDDHLRRLE
MLBr_00458|M.leprae_Br4923 ATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEISLSDDEFEMLS
Mvan_2555|M.vanbaalenii_PYR-1 ATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQIDLTDAEFETLG
Mflv_1329|M.gilvum_PYR-GCK RTPAQIVLAWTLSVAPNVLLIPGTSSVAHLEQNTAVRDITLDDDTRRDLD
TH_1525|M.thermoresistible__bu RTPAQVTLRWHIQRGD--IVLPKSVTPERVRSNIALFDFELSDADMAAIS
..*:.* * : : :* : :. * : * :
MMAR_3520|M.marinum_M EAARAFHPVSARRFLTDTVREKLGRR-----
MUL_2745|M.ulcerans_Agy99 EAARAFHPVSARRFLTDTVREKLGRR-----
Mb2320|M.bovis_AF2122/97 DAARAFRPVSTGRFLTDMVREKVSRR-----
Rv2298|M.tuberculosis_H37Rv DAARAFRPVSTGRFLTDMVREKVSRR-----
MAV_4098|M.avium_104 DAALAFRPTSAARFLTDLARERIPGRG----
MAB_4120c|M.abscessus_ATCC_199 CLA-AAAGDRYN-AEHLARLEG---------
MSMEG_2920|M.smegmatis_MC2_155 GIAGQVAGHRSARPEHLGTEAPQADSGVQNR
MLBr_00458|M.leprae_Br4923 AAGAQ--------------------------
Mvan_2555|M.vanbaalenii_PYR-1 NAGAAAS------------------------
Mflv_1329|M.gilvum_PYR-GCK AAA----------------------------
TH_1525|M.thermoresistible__bu ALDKGEAGRMGPHPDKFDMI-----------