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AMNLVHRLCCDSDRWANEVKGQVFPWVLADVDLGDNALEIGPGYGAFLRVLVDKTPKLTAVEIDPAMARR LQERYGEQARIINGDGTDTGLPAEEFSSVVSFTMLHHVPTTELQDELFAEAYRVLRPGGVFAGSDGIPSL LFSILHFRDTCNPIPPTDLPDRLRAAGFHDVEVEVQAGRQRWRAQKPKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1534 | - | - | 100% (190) | hypothetical protein MUL_1534 |
| M. ulcerans Agy99 | MUL_4869 | - | 2e-07 | 34.02% (97) | methyltransferase/methylase |
| M. ulcerans Agy99 | MUL_1900 | - | 8e-07 | 35.51% (107) | hypothetical protein MUL_1900 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3862c | - | 2e-65 | 61.58% (190) | hypothetical protein Mb3862c |
| M. gilvum PYR-GCK | Mflv_2862 | - | 2e-10 | 39.42% (104) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3832c | - | 2e-65 | 61.58% (190) | hypothetical protein Rv3832c |
| M. leprae Br4923 | MLBr_01723 | - | 4e-08 | 37.38% (107) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_2704 | - | 1e-60 | 62.21% (172) | hypothetical protein MAB_2704 |
| M. marinum M | MMAR_2358 | - | 1e-108 | 98.94% (189) | hypothetical protein MMAR_2358 |
| M. avium 104 | MAV_0196 | - | 4e-68 | 63.30% (188) | hypothetical protein MAV_0196 |
| M. smegmatis MC2 155 | MSMEG_2329 | - | 2e-07 | 36.45% (107) | methyltransferase, UbiE/COQ5 family protein |
| M. thermoresistible (build 8) | TH_2189 | - | 2e-08 | 36.79% (106) | CONSERVED HYPOTHETICAL PROTEIN |
| M. vanbaalenii PYR-1 | Mvan_2318 | - | 7e-41 | 47.43% (175) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1534|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2358|M.marinum_M --------------------------------------------------
Mb3862c|M.bovis_AF2122/97 --------------------------------------------------
Rv3832c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0196|M.avium_104 --------------------------------------------------
MAB_2704|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2318|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1534|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2358|M.marinum_M --------------------------------------------------
Mb3862c|M.bovis_AF2122/97 --------------------------------------------------
Rv3832c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0196|M.avium_104 --------------------------------------------------
MAB_2704|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2318|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1534|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2358|M.marinum_M --------------------------------------------------
Mb3862c|M.bovis_AF2122/97 --------------------------------------------------
Rv3832c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0196|M.avium_104 --------------------------------------------------
MAB_2704|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2318|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1534|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2358|M.marinum_M --------------------------------------------------
Mb3862c|M.bovis_AF2122/97 --------------------------------------------------
Rv3832c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0196|M.avium_104 --------------------------------------------------
MAB_2704|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2318|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1534|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2358|M.marinum_M --------------------------------------------------
Mb3862c|M.bovis_AF2122/97 --------------------------------------------------
Rv3832c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0196|M.avium_104 --------------------------------------------------
MAB_2704|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2318|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 ------------------------------------------MTEIRDAA
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MLBr_01723|M.leprae_Br4923 ------------------------------------------MTRSTEIS
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1534|M.ulcerans_Agy99 ----------------------MAMNLVHRLCCDSDRWANEVKGQVFPWV
MMAR_2358|M.marinum_M ----------------------MAMNLVHRLCCDSDRWANEVKGQVLPWV
Mb3862c|M.bovis_AF2122/97 ----------------------MAMNLLHRRHCSSAGWEKAVANQLLPWA
Rv3832c|M.tuberculosis_H37Rv ----------------------MAMNLLHRRHCSSAGWEKAVANQLLPWA
MAV_0196|M.avium_104 -------------------MIAMAMNLLHRHRCSSAGWAKEVADELLPWA
MAB_2704|M.abscessus_ATCC_1997 ------------------------------------MWARKTESQLLPWA
Mvan_2318|M.vanbaalenii_PYR-1 ------------------------MNEAHR-LCGSDQWRQMIRDVILPWA
MSMEG_2329|M.smegmatis_MC2_155 D--------PAPNPHATAEEVEAAMHDSKLAQVLYHDWEAETYDEKWSIS
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPNPHATAEQVEAAMRDSKLAQILYHDWEAESYDDKWSIS
MLBr_01723|M.leprae_Br4923 AN-------AVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSIS
Mflv_2862|M.gilvum_PYR-GCK ----------------------MNMAETALINSAPRRWLQRVYEVPVLLR
*
MUL_1534|M.ulcerans_Agy99 LADVDLG--------------------DNALEIGPGYGAFLRVLVDK--T
MMAR_2358|M.marinum_M LADVDLG--------------------DNVLEIGPGYGAFLRVLVDK--T
Mb3862c|M.bovis_AF2122/97 LQHVELG--------------------PRTLEIGPGYGATLQALLGL--T
Rv3832c|M.tuberculosis_H37Rv LQHVELG--------------------PRTLEIGPGYGATLQALLGL--T
MAV_0196|M.avium_104 LDGVELG--------------------SRTLEIGPGYGATLSALLDR--T
MAB_2704|M.abscessus_ATCC_1997 LQGVELG--------------------ADTLEIGPGYGANLRVLTNR--T
Mvan_2318|M.vanbaalenii_PYR-1 MGDHRLG--------------------DDVLEVGPGYGATTDVLCTE--V
MSMEG_2329|M.smegmatis_MC2_155 YDQRCIDYARGRFDAIVPEDEQRKLPYDRALELGCGTGFFLLNLIQSG-V
TH_2189|M.thermoresistible__bu YDQRCVDYARGRFDAIVPDHVQRELPYDNALELGCGTGFFLLNLIQSG-V
MLBr_01723|M.leprae_Br4923 YDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQSG-V
Mflv_2862|M.gilvum_PYR-GCK FGGRLVP-------------------DTQALEIGCGSGYGTQLILERFGA
: .**:* * * : .
MUL_1534|M.ulcerans_Agy99 PKLTAVEIDPAMARRLQE---RYGEQ--ARIIN--GDGTDTGLPAEEFSS
MMAR_2358|M.marinum_M PKLTAVEIDPAMARRLQE---RYGEQ--ARIIN--GDGTDTGLPAEEFSS
Mb3862c|M.bovis_AF2122/97 ASLTAVEVDNSMVERLNR---RYGQR--ARIIR--GDGTQTGLPDDHFTS
Rv3832c|M.tuberculosis_H37Rv ASLTAVEVDNSMVERLNR---RYGQR--ARIIR--GDGTQTGLPDDHFTS
MAV_0196|M.avium_104 ASLTAVELDPVMADRLQR---RYGDR--ARVIQ--ASGTETGLPANHFTS
MAB_2704|M.abscessus_ATCC_1997 PQLTAVEIDETMATRLQR---LYGDR--ATVMQ--GDGTKLGFDNDRFSS
Mvan_2318|M.vanbaalenii_PYR-1 ARLTAVEIDPDLAAMLID---RFADQPSVQIVN--GDAAALDYPDGRFTG
MSMEG_2329|M.smegmatis_MC2_155 ARRGSVTDLSPGMVKVAT---RNGQSLGLDIDGRVADAEGIPYEDDTFDL
TH_2189|M.thermoresistible__bu ARRGSVTDLSPGMVRVAT---RNGRSLGLDVDGRVADAEGIPYDDNTFDL
MLBr_01723|M.leprae_Br4923 ARRGSVTDLSPGMVKIAT---RNGQSLGLDINGRVADAEGIPYDDNTFDL
Mflv_2862|M.gilvum_PYR-GCK ATVDAVDLDPAMIRRAGERLARYGNRVRLVQGSATDLSTALDAGDGSYGA
. :* . . :
MUL_1534|M.ulcerans_Agy99 VVSFTMLHHVPTTELQDELFAEAYRVLRPGG--VFAGS------------
MMAR_2358|M.marinum_M VVSFTMLHHVPTTELQDELFAEAYRVLRPGG--VFAGS------------
Mb3862c|M.bovis_AF2122/97 VVCFTMLHHVASAQLQDQLFAEAYRVLQPGG--VFAGS------------
Rv3832c|M.tuberculosis_H37Rv VVCFTMLHHVASAQLQDQLFAEAYRVLQPGG--VFAGS------------
MAV_0196|M.avium_104 VVCFTMLHHVPSPQLQDQLFAEALRVLQPGG--TFAGS------------
MAB_2704|M.abscessus_ATCC_1997 VVCFTMLHHVPTADLQDQLFAQAHRVLAPGG--VFAGS------------
Mvan_2318|M.vanbaalenii_PYR-1 AACFTMLHHVEPSQRQDRLFAEIARVLRPGA--VLVAS------------
MSMEG_2329|M.smegmatis_MC2_155 VVGHAVLHHIPDVELS---LREVVRILKPGGRFVFAGEPTTVGNRYAREL
TH_2189|M.thermoresistible__bu VVGHAVLHHIPDVELS---LREVVRVLRPGGRFVFAGEPTTVGNSYARAL
MLBr_01723|M.leprae_Br4923 VVGHAVLHHIPDVELS---LREVLRVLKPGGRFVFAGEPTDVGNRYARVF
Mflv_2862|M.gilvum_PYR-GCK VFDFGIVHHIPDWRNA---VAEVARVLAPGGRFYFDEVT-----------
. . ::**: . : *:* **. :
MUL_1534|M.ulcerans_Agy99 ----------------------------DGIPSLLFSILHFRDTCNPIPP
MMAR_2358|M.marinum_M ----------------------------DGIPSLLFSILHFRDTCNPIPP
Mb3862c|M.bovis_AF2122/97 ----------------------------DGVPSLPFRLIHIADTYTPIAP
Rv3832c|M.tuberculosis_H37Rv ----------------------------DGVPSLPFRLIHIADTYTPIAP
MAV_0196|M.avium_104 ----------------------------DGVPSWVFRLLHVADTYNPIAP
MAB_2704|M.abscessus_ATCC_1997 ----------------------------DGVHSTFFRLLHIGDTYNPVPT
Mvan_2318|M.vanbaalenii_PYR-1 ----------------------------DSLASEPLQQMHDGDTYNPVDP
MSMEG_2329|M.smegmatis_MC2_155 STLTWHATTNLTKLPFLSGWRRPQEELDESSRAAALEAVVDLHTFDPADL
TH_2189|M.thermoresistible__bu STLTWHVATTVTRLPGLQGWRRPQAELDESSRAAALEAVVDLHTFEPSDL
MLBr_01723|M.leprae_Br4923 ADLTWKVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVL
Mflv_2862|M.gilvum_PYR-GCK ---------------------------AHALARPSYKRLFDHPTEDRFSA
. : *
MUL_1534|M.ulcerans_Agy99 TDLPDRLRAAGFHDVEVEVQAGRQRWRAQKPKA-----------------
MMAR_2358|M.marinum_M TDLPDRLRAAGFHDVEVEVQAGRQRWRAQKPKV-----------------
Mb3862c|M.bovis_AF2122/97 ADLPGRLRAVGFTDIHVDVAGARLRWRATKPVAA----------------
Rv3832c|M.tuberculosis_H37Rv ADLPGRLRAVGFTDIHVDVAGARLRWRATKPVAA----------------
MAV_0196|M.avium_104 KDLPGRLAAAGFADIHADARGGRQRWRAVKPID-----------------
MAB_2704|M.abscessus_ATCC_1997 TSLPDRLRAAGFTDIEHHLDGGNQRWRAVKAA------------------
Mvan_2318|M.vanbaalenii_PYR-1 QTLPGRLEAAGFTDVEVQTN--EFGWSAVAHRA-----------------
MSMEG_2329|M.smegmatis_MC2_155 ERMATNAGAVEVRTASEEFTAAMLGWPVRTFEAAVPPGRLGWGWAKFAFN
TH_2189|M.thermoresistible__bu ERMARNAGAVEVATASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAKFAFG
MLBr_01723|M.leprae_Br4923 ETMATNAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFT
Mflv_2862|M.gilvum_PYR-GCK EQFSDELAHHGLVVLGSRTRIQGDYLLGVAAKPLPTGCE-----------
:. . .
MUL_1534|M.ulcerans_Agy99 ---------------------------------
MMAR_2358|M.marinum_M ---------------------------------
Mb3862c|M.bovis_AF2122/97 ---------------------------------
Rv3832c|M.tuberculosis_H37Rv ---------------------------------
MAV_0196|M.avium_104 ---------------------------------
MAB_2704|M.abscessus_ATCC_1997 ---------------------------------
Mvan_2318|M.vanbaalenii_PYR-1 ---------------------------------
MSMEG_2329|M.smegmatis_MC2_155 SWTTLSWVDANVWRKVVPKGWFYNVMVTGVKPS
TH_2189|M.thermoresistible__bu SWTALSWVDANVWRRVMPKGWFYNVMVTGVKPS
MLBr_01723|M.leprae_Br4923 SWKTLSWVDANVWRRVIPKSWFYNIIITGVKPS
Mflv_2862|M.gilvum_PYR-GCK ---------------------------------