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MAERALPESLVDTYQLYIDGRWVEPENGRYDDVSPSTGMVIATAPDASVSQVGDAVDAARRAFDAGPWPA MSHQERGHCLAQLGAALQDYADAYFTLSQVEWGCTANERRLQIDASASAARRAGHLASTLGDQPIQSASG AAVLCHEPLGVVSILTPWNFPHSLNVMKLSRALAGGNTVVLKPSPLTPLAGLALARIIHEHTDIPPGVVN VVTPGGIEASKVLTVDPRIDMVSFTGSSAVGCEVMAAAAGTMKRVLLECGGKSASIVLDDAECSDELLAR MLFESCLLHAGQACILHSRLLLPEAMHDEIVDRLVALARAVRVGDPADPDVQMGPLISAAQRSRVEDQVA RALRDGATLAAGGRRPATPEAGFYYEPTILTGVTPDAHIAQNEVFGPVLSVLRYRDDDDAVAIANNSQYG LSGAVWGGDADRAVRVARRIRTGQIAVNGFGPGDAPFGGFKQSGLGREGGGIAGLHQYMEPKAIGMPG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_0939 | aldA_1 | - | 100% (488) | NAD-dependent aldehyde dehydrogenase, AldA_1 |
M. ulcerans Agy99 | MUL_0477 | aldA | e-101 | 44.14% (478) | NAD-dependent aldehyde dehydrogenase, AldA |
M. ulcerans Agy99 | MUL_1122 | - | 1e-88 | 39.46% (479) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-110 | 46.17% (483) | aldehyde dehydrogenase NAD dependant AldA |
M. gilvum PYR-GCK | Mflv_2502 | - | 1e-106 | 48.74% (478) | aldehyde dehydrogenase |
M. tuberculosis H37Rv | Rv0768 | aldA | 1e-110 | 46.17% (483) | aldehyde dehydrogenase NAD dependent AldA |
M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-54 | 32.21% (444) | succinic semialdehyde dehydrogenase |
M. abscessus ATCC 19977 | MAB_1218 | - | 1e-103 | 43.75% (480) | aldehyde dehydrogenase AldA |
M. marinum M | MMAR_4246 | aldA_1 | 0.0 | 99.18% (488) | NAD-dependent aldehyde dehydrogenase, AldA_1 |
M. avium 104 | MAV_1340 | - | 0.0 | 72.20% (482) | aldehyde dehydrogenase |
M. smegmatis MC2 155 | MSMEG_5859 | - | 1e-105 | 44.47% (479) | aldehyde dehydrogenase (NAD) family protein |
M. thermoresistible (build 8) | TH_4242 | - | 0.0 | 66.11% (481) | PUTATIVE aldehyde dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_4156 | - | 1e-101 | 47.17% (477) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment MUL_0939|M.ulcerans_Agy99 ---MAERALPESLVDT------YQLYIDGRWVEPENGRYDDVSPSTGMVI MMAR_4246|M.marinum_M ---MAERALPESLVDT------YQLYIDGRWVEPENGRYDDVSPSTGMVI MAV_1340|M.avium_104 ---MAD---PPALVQT------YQLYIDGQWVEPQDGRYDDLSPCTEAVI TH_4242|M.thermoresistible__bu ---MTR---SHALVET------YGHYINGEWVDPDSGRYEDVDPATGETF Mb0791|M.bovis_AF2122/97 ---MALWGDGIS-----------ALLIDGKLSDGRAGTFPTVNPATEEVL Rv0768|M.tuberculosis_H37Rv ---MALWGDGIS-----------ALLIDGKLSDGRAGTFPTVNPATEEVL MAB_1218|M.abscessus_ATCC_1997 ---MTVLSDGDS-----------ELFIDGKLLPGGAGRFPTVNPATEEVL MSMEG_5859|M.smegmatis_MC2_155 ---MPLLADRQS-----------QLLIDGKLVAGRKGVFDTVNPATEEVL Mflv_2502|M.gilvum_PYR-GCK MQETVTIPDATSGTETADRRAARRLLIGGQLVDTER-TFASLNPATGDVL Mvan_4156|M.vanbaalenii_PYR-1 MQETATISDERSGAGQAAQRAERHLLIGGQLLETER-TFPSLNPATGEVL MLBr_02573|M.leprae_Br4923 ------------------------------------MSIATINPATGETV :.*.* .. MUL_0939|M.ulcerans_Agy99 ATAPDASVSQVGDAVDAARRAFDAGPWPAMSHQERGHCLAQLGAALQDYA MMAR_4246|M.marinum_M ATAPDASVSQVGDAVDAARRAFDAGPWPAMSHQERGHCLAQLGAALQDYA MAV_1340|M.avium_104 ATAPDASVAQVDDAIAAARRAFDSGPWGRISAEQRARCLNQLGEALTKHA TH_4242|M.thermoresistible__bu AAAPDASTAQVDRAIAAAREAFDSGRWTGLTPEERAKCLQQLGAALLEHA Mb0791|M.bovis_AF2122/97 GVAADADAEDMGRAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHV Rv0768|M.tuberculosis_H37Rv GVAADADAEDMGRAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHV MAB_1218|M.abscessus_ATCC_1997 GTAADADSDDMSDAIEAARRAFDDSGWSRDV-ALRVHCIRQLRDGMKTHI MSMEG_5859|M.smegmatis_MC2_155 GVAADATAEDMGDAIEAARRAFDDTDWSTDT-ELRVRCIRQLRDALREHV Mflv_2502|M.gilvum_PYR-GCK GYAPDASVADAEAAVAAARAAFDTGDWATDT-ELRIRCLEQLHAALVEHR Mvan_4156|M.vanbaalenii_PYR-1 GYAPDATVADAEAAVAAARRAFDAGVWATDT-ELRIRCLEQFHAALVEHR MLBr_02573|M.leprae_Br4923 KTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEA . : : *: * ** : * : : MUL_0939|M.ulcerans_Agy99 DAYFTLSQVEWG-----CTANERRLQIDASASAARRAGHLASTLGDQPIQ MMAR_4246|M.marinum_M DAYFALSQVEWG-----CTANERRLQIDASASAARRAGHLAGTLGDQPIQ MAV_1340|M.avium_104 DDFFALSQTEWG-----CIGNERIMQIDGAGFMSMHAAQLATQLVDQEVA TH_4242|M.thermoresistible__bu DDFFALAQLEWG-----CSANERMFHVEGPAVMTTHAGELALEPVEQPID Mb0791|M.bovis_AF2122/97 EELRELTISEVGAPRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEAS Rv0768|M.tuberculosis_H37Rv EELRELTISEVGAPRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEAS MAB_1218|M.abscessus_ATCC_1997 EELRELTIAEVGAPRMLTAGAQLEGPVDDLQFAADTAESFDWTSDLGVAS MSMEG_5859|M.smegmatis_MC2_155 EELRDLTIAEVGAPRMLTSGAQLEGPIDDLAFSADTAENYPWRTDLGHAT Mflv_2502|M.gilvum_PYR-GCK DELAALTIAEVGATPALCQGAQLDQPIEIVRYYADLLKTYPLTEDLGNIE Mvan_4156|M.vanbaalenii_PYR-1 DELAALTVAEVGATPALCQGAQLDQPIEIVRYYADLLKTYPLTEDLGNIE MLBr_02573|M.leprae_Br4923 NQSAALMTLEMG-KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAA : * * * : : MUL_0939|M.ulcerans_Agy99 SASG--AAVLCHEPLGVVSILTPWNFPHSLNVMKLSRALAGGNTVVLKPS MMAR_4246|M.marinum_M SASG--AAVLCHEPLGVVSILTPWNFPHSLNVMKLSRALAGGNTVVLKPS MAV_1340|M.avium_104 GISAG-TTLLRHVPLGVVAVLTPWNFPHCLNVMKLNHALAAGNTVVLKPS TH_4242|M.thermoresistible__bu AWGAGGTTLLRYEPLGVVSVLTPWNFPHTLNAMKIGSALAAGNTVVLKPS Mb0791|M.bovis_AF2122/97 PLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPA Rv0768|M.tuberculosis_H37Rv PLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPA MAB_1218|M.abscessus_ATCC_1997 PMGIKTRRTLAREAVGVVGAVTPWNFPHQINLAKVGPALAAGNTLVLKPA MSMEG_5859|M.smegmatis_MC2_155 PQGIPTDRVIAREAVGVVGAITPWNFPHQINLAKVGPALAAGNTLVLKPA Mflv_2502|M.gilvum_PYR-GCK SRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAKLAPALAAGCTVVLKSA Mvan_4156|M.vanbaalenii_PYR-1 SRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAKLAPALAAGCTVVLKSA MLBr_02573|M.leprae_Br4923 VGAS--KALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHA . . *** : .:*:* ** .* . :** : MUL_0939|M.ulcerans_Agy99 PLTPLAGLALARIIHEHTDIPPGVVNVVTPGGIEASKVLTVDPRIDMVSF MMAR_4246|M.marinum_M PLTPLAGLALARIIHEHTDIPPGVVNVVTPGGIEASKVLAVDPRIDMVSF MAV_1340|M.avium_104 PLTPLAGLALARLIDEHTDIPPGVVNVVTPSGVEAAKLLTTDPRIDMVSF TH_4242|M.thermoresistible__bu PLTPLAGFALARMIDEHTDIPPGVVNVVTPSGLDGSKMLTTDPRIDMVSF Mb0791|M.bovis_AF2122/97 PDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISF Rv0768|M.tuberculosis_H37Rv PDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISF MAB_1218|M.abscessus_ATCC_1997 PDTPWCAAVLGRIIAEHTDFPPGVVNIVTSSDHRIGAQLSTDPRVDMVSF MSMEG_5859|M.smegmatis_MC2_155 PDTPWAAAVLGQIITEHTDFPPGVINIVTSSDHSVGALLSKDPRVDMVSF Mflv_2502|M.gilvum_PYR-GCK PDTPLITLALGELIAEHTDIPPGVVNVLSGADPQVGAALTTSPDVDMVTF Mvan_4156|M.vanbaalenii_PYR-1 PDTPLVTLALGELIAKHTDIPAGVVNVLSGADPAVGAALTTSPDVDMVTF MLBr_02573|M.leprae_Br4923 SNVPQCALYLADVIARG-GFPEDCFQTLLISANGVEAILR-DPRVAAATL . .* *. :* . .:* . .: : . * .* : :: MUL_0939|M.ulcerans_Agy99 TGSSAVGCEVMAAAAGTMKRVLLECGGKSASIVLDD-AECSDELLARMLF MMAR_4246|M.marinum_M TGSSAVGREVMAAAAGTMKRVLLECGGKSASIVLDD-AECSDELLARMLF MAV_1340|M.avium_104 TGSSAVGRQVMSAAGDTIKRILLELGGKSASIVLDD-ANVTDEMLEQMLF TH_4242|M.thermoresistible__bu TGSSAVGREVMAGAAGGMKRILLECGGKSASIVLDD-LEVTDELLETILF Mb0791|M.bovis_AF2122/97 TGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSA Rv0768|M.tuberculosis_H37Rv TGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSA MAB_1218|M.abscessus_ATCC_1997 TGSTATGRAVMTDAAATVKKVFLELGGKSAFIVLDDLDEAALGSACSVAA MSMEG_5859|M.smegmatis_MC2_155 TGSTATGRAVMTDAALTIKKVFLELGGKSAFLVLDD---ADLTGACSMAA Mflv_2502|M.gilvum_PYR-GCK TGSTPTGRAIMAAASGTLKKVFLELGGKSAAIVLDD---ADFSTAALFSA Mvan_4156|M.vanbaalenii_PYR-1 TGSTPTGRAIMAAASGTLKKVFLELGGKSAAIVLDD---ADFNTAAMFSA MLBr_02573|M.leprae_Br4923 TGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS---ADLDAAVATAV *** ..* : : *. :* .** **... :*: . MUL_0939|M.ulcerans_Agy99 ESCLLHAGQACILHSRLLLPEAMHDEIVDRLVALARAVRVGDPADPDVQM MMAR_4246|M.marinum_M ESCLLHAGQACILHSRLLLPEAMHDEIVDRLVALARAVRVGDPADPDVQM MAV_1340|M.avium_104 QSCSLHAGQACILHSRLLLPDSLHDDVVDRLAALARDVKVGDPTDPDVQM TH_4242|M.thermoresistible__bu ECLTMHAGQACILNSRLVVPEAMHDDVVARLGELARKVVVGNPVDPAVQM Mb0791|M.bovis_AF2122/97 FSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVC Rv0768|M.tuberculosis_H37Rv FSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVC MAB_1218|M.abscessus_ATCC_1997 FTAAMHAGQGCAITTRLVVPRERYDDAVAAAAATMGSLKPGDPAKPGTIC MSMEG_5859|M.smegmatis_MC2_155 FTVAMHAGQGCAITTRLVVPRARYDEAVEIAAGTLGSIKPGDPTSKRTVC Mflv_2502|M.gilvum_PYR-GCK FSMVTHAGQGCALTSRLLVPRKHKDEIVELVKNNFGLVRLGDPADPSTYM Mvan_4156|M.vanbaalenii_PYR-1 FSMVTHAGQGCALTSRLLVPKKHKDELVELVKNNFGLVRYGDPTAAGTYM MLBr_02573|M.leprae_Br4923 TGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDV : **.* .*:: :: * : *:* . MUL_0939|M.ulcerans_Agy99 GPLISAAQRSRVEDQVARALRDGATLAAGGRRPATPEAGFYYEPTILTGV MMAR_4246|M.marinum_M GPLISAAQRSRVEDQVARALRDGATLAAGGRRPATPEAGFYYEPTILTGV MAV_1340|M.avium_104 GPLISAAQRDRVEAHIAGARSDGATLVTGGGRPAGLDVGYYVEPTILSGV TH_4242|M.thermoresistible__bu GPLISRAHLERVEGFVERAVADGATVVAGGSRPAHLDRGFFYEPTILTDV Mb0791|M.bovis_AF2122/97 GPLISARQRDRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGL Rv0768|M.tuberculosis_H37Rv GPLISARQRDRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGL MAB_1218|M.abscessus_ATCC_1997 GPVISARQRDRVQSYLDLAVAEGGSFACGGGRPEGKDRGFFIEPTVVAGL MSMEG_5859|M.smegmatis_MC2_155 GPVISARQRDRVQSYLDLAIKEGGRFACGGGRPADMDKGFWIEPTVIAGL Mflv_2502|M.gilvum_PYR-GCK GPLISEKQRDKVDGMVKRAVEAGATLVTGGEK---VDPGYFYTPTLLADV Mvan_4156|M.vanbaalenii_PYR-1 GPLISEKQRDKVDGMVKRAVEAGATLVTGGEK---VDPGYFYTPTLLADV MLBr_02573|M.leprae_Br4923 GPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPD--RPGWFYPPTVITDI **: : :*: : * *. . ** : *:: **:::.: MUL_0939|M.ulcerans_Agy99 TPDAHIAQNEVFGPVLSVLRYRDDDDAVAIANNSQYGLSGAVWGGDADRA MMAR_4246|M.marinum_M TPDAHIAQNEVFGPVLSVLRYRDDDDAVAIANNSQYGLSGAVWGGDADRA MAV_1340|M.avium_104 EPNSTVAQEEVFGPVLSVLRYRDDDDAVAIANNSRYGLSGAVWGDDVDRA TH_4242|M.thermoresistible__bu APDDFIAQEEVFGPVLTVLRCRDDDEAVDIANNSRYGLGGAVYAADVDRA Mb0791|M.bovis_AF2122/97 TNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRA Rv0768|M.tuberculosis_H37Rv TNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRA MAB_1218|M.abscessus_ATCC_1997 TNAARVAREEIFGPVLVVIAHDGDEDAVRIANDSPYGLSGTVFGDDDERS MSMEG_5859|M.smegmatis_MC2_155 DNNARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSGDDARA Mflv_2502|M.gilvum_PYR-GCK DPDSEIAQEEVFGPVLTVIAYEDDDDAVRIANNSIYGLSGAVFGSQD-RA Mvan_4156|M.vanbaalenii_PYR-1 DPDSEIAQEEVFGPVLVVIAYEDDDDAVRIANNSIYGLSGAVFGSQD-RA MLBr_02573|M.leprae_Br4923 TKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQ : :*:**** * . ::*: *** : :**.. .: : . MUL_0939|M.ulcerans_Agy99 VRVARRIRTGQIAVNG--FGPGDAPFGGFKQSGLGREGGGIAGLHQYMEP MMAR_4246|M.marinum_M VRVARRIRTGQIAVNG--FGPGDAPFGGFKQSGLGREGGGIAGLHQYMEP MAV_1340|M.avium_104 VGVARRIRTGQIAVNG--ISPAGAPFGGFRLSGLGREGGGIGGLHQYMEP TH_4242|M.thermoresistible__bu LGVARRIRSGQVSING--CIAGDAPFGGFGQSGIGREGG-LLGLRSYMEP Mb0791|M.bovis_AF2122/97 ARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMG-LLGFEEYLEA Rv0768|M.tuberculosis_H37Rv ARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMG-LLGFEEYLEA MAB_1218|M.abscessus_ATCC_1997 ARVASRLRVGTVNVNGGVWYSADAPFGGYKQSGNGREMG-VAGFEEYLET MSMEG_5859|M.smegmatis_MC2_155 QAVASRMRVGTVNVNGGIWYSADAPFGGYKQSGVGREMG-LAGFEEYTEI Mflv_2502|M.gilvum_PYR-GCK LGVARRIRTGTFSINGGNYFSPDSPFGGYKQSGIGREMG-RAGLEEFLES Mvan_4156|M.vanbaalenii_PYR-1 LAVARRIRTGTFSINGGNYFAPDSPFGGYKQSGIGREMG-RAGLEEFLES MLBr_02573|M.leprae_Br4923 RHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELS-THGIREFCNI . .: * . :** **** ** *** . *:..: : MUL_0939|M.ulcerans_Agy99 KAIGMPG------- MMAR_4246|M.marinum_M KAIGMPG------- MAV_1340|M.avium_104 MAIGVPA------- TH_4242|M.thermoresistible__bu KAIGVPA------- Mb0791|M.bovis_AF2122/97 KLIATAAN------ Rv0768|M.tuberculosis_H37Rv KLIATAAN------ MAB_1218|M.abscessus_ATCC_1997 KVIATAVK------ MSMEG_5859|M.smegmatis_MC2_155 KLIATLAG------ Mflv_2502|M.gilvum_PYR-GCK KTFATVAG------ Mvan_4156|M.vanbaalenii_PYR-1 KTYAVVVPEAGGQA MLBr_02573|M.leprae_Br4923 KTVWIA--------