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M. ulcerans Agy99 MUL_0939 (aldA_1)

annotation: NAD-dependent aldehyde dehydrogenase, AldA_1
coordinates: 985483 - 986949
length: 488

MAERALPESLVDTYQLYIDGRWVEPENGRYDDVSPSTGMVIATAPDASVSQVGDAVDAARRAFDAGPWPA
MSHQERGHCLAQLGAALQDYADAYFTLSQVEWGCTANERRLQIDASASAARRAGHLASTLGDQPIQSASG
AAVLCHEPLGVVSILTPWNFPHSLNVMKLSRALAGGNTVVLKPSPLTPLAGLALARIIHEHTDIPPGVVN
VVTPGGIEASKVLTVDPRIDMVSFTGSSAVGCEVMAAAAGTMKRVLLECGGKSASIVLDDAECSDELLAR
MLFESCLLHAGQACILHSRLLLPEAMHDEIVDRLVALARAVRVGDPADPDVQMGPLISAAQRSRVEDQVA
RALRDGATLAAGGRRPATPEAGFYYEPTILTGVTPDAHIAQNEVFGPVLSVLRYRDDDDAVAIANNSQYG
LSGAVWGGDADRAVRVARRIRTGQIAVNGFGPGDAPFGGFKQSGLGREGGGIAGLHQYMEPKAIGMPG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_0939aldA_1-100% (488)NAD-dependent aldehyde dehydrogenase, AldA_1
M. ulcerans Agy99MUL_0477aldAe-10144.14% (478) NAD-dependent aldehyde dehydrogenase, AldA
M. ulcerans Agy99MUL_1122-1e-8839.46% (479) aldehyde dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0791aldA1e-11046.17% (483) aldehyde dehydrogenase NAD dependant AldA
M. gilvum PYR-GCKMflv_2502-1e-10648.74% (478) aldehyde dehydrogenase
M. tuberculosis H37RvRv0768aldA1e-11046.17% (483) aldehyde dehydrogenase NAD dependent AldA
M. leprae Br4923MLBr_02573gabD11e-5432.21% (444) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_1218-1e-10343.75% (480) aldehyde dehydrogenase AldA
M. marinum MMMAR_4246aldA_10.099.18% (488) NAD-dependent aldehyde dehydrogenase, AldA_1
M. avium 104MAV_1340-0.072.20% (482) aldehyde dehydrogenase
M. smegmatis MC2 155MSMEG_5859-1e-10544.47% (479) aldehyde dehydrogenase (NAD) family protein
M. thermoresistible (build 8)TH_4242-0.066.11% (481) PUTATIVE aldehyde dehydrogenase
M. vanbaalenii PYR-1Mvan_4156-1e-10147.17% (477) aldehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


MUL_0939|M.ulcerans_Agy99           ---MAERALPESLVDT------YQLYIDGRWVEPENGRYDDVSPSTGMVI
MMAR_4246|M.marinum_M               ---MAERALPESLVDT------YQLYIDGRWVEPENGRYDDVSPSTGMVI
MAV_1340|M.avium_104                ---MAD---PPALVQT------YQLYIDGQWVEPQDGRYDDLSPCTEAVI
TH_4242|M.thermoresistible__bu      ---MTR---SHALVET------YGHYINGEWVDPDSGRYEDVDPATGETF
Mb0791|M.bovis_AF2122/97            ---MALWGDGIS-----------ALLIDGKLSDGRAGTFPTVNPATEEVL
Rv0768|M.tuberculosis_H37Rv         ---MALWGDGIS-----------ALLIDGKLSDGRAGTFPTVNPATEEVL
MAB_1218|M.abscessus_ATCC_1997      ---MTVLSDGDS-----------ELFIDGKLLPGGAGRFPTVNPATEEVL
MSMEG_5859|M.smegmatis_MC2_155      ---MPLLADRQS-----------QLLIDGKLVAGRKGVFDTVNPATEEVL
Mflv_2502|M.gilvum_PYR-GCK          MQETVTIPDATSGTETADRRAARRLLIGGQLVDTER-TFASLNPATGDVL
Mvan_4156|M.vanbaalenii_PYR-1       MQETATISDERSGAGQAAQRAERHLLIGGQLLETER-TFPSLNPATGEVL
MLBr_02573|M.leprae_Br4923          ------------------------------------MSIATINPATGETV
                                                                             :.*.*  ..

MUL_0939|M.ulcerans_Agy99           ATAPDASVSQVGDAVDAARRAFDAGPWPAMSHQERGHCLAQLGAALQDYA
MMAR_4246|M.marinum_M               ATAPDASVSQVGDAVDAARRAFDAGPWPAMSHQERGHCLAQLGAALQDYA
MAV_1340|M.avium_104                ATAPDASVAQVDDAIAAARRAFDSGPWGRISAEQRARCLNQLGEALTKHA
TH_4242|M.thermoresistible__bu      AAAPDASTAQVDRAIAAAREAFDSGRWTGLTPEERAKCLQQLGAALLEHA
Mb0791|M.bovis_AF2122/97            GVAADADAEDMGRAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHV
Rv0768|M.tuberculosis_H37Rv         GVAADADAEDMGRAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHV
MAB_1218|M.abscessus_ATCC_1997      GTAADADSDDMSDAIEAARRAFDDSGWSRDV-ALRVHCIRQLRDGMKTHI
MSMEG_5859|M.smegmatis_MC2_155      GVAADATAEDMGDAIEAARRAFDDTDWSTDT-ELRVRCIRQLRDALREHV
Mflv_2502|M.gilvum_PYR-GCK          GYAPDASVADAEAAVAAARAAFDTGDWATDT-ELRIRCLEQLHAALVEHR
Mvan_4156|M.vanbaalenii_PYR-1       GYAPDATVADAEAAVAAARRAFDAGVWATDT-ELRIRCLEQFHAALVEHR
MLBr_02573|M.leprae_Br4923          KTFTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEA
                                       . :   :   *:  *   **   :       * :        :    

MUL_0939|M.ulcerans_Agy99           DAYFTLSQVEWG-----CTANERRLQIDASASAARRAGHLASTLGDQPIQ
MMAR_4246|M.marinum_M               DAYFALSQVEWG-----CTANERRLQIDASASAARRAGHLAGTLGDQPIQ
MAV_1340|M.avium_104                DDFFALSQTEWG-----CIGNERIMQIDGAGFMSMHAAQLATQLVDQEVA
TH_4242|M.thermoresistible__bu      DDFFALAQLEWG-----CSANERMFHVEGPAVMTTHAGELALEPVEQPID
Mb0791|M.bovis_AF2122/97            EELRELTISEVGAPRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEAS
Rv0768|M.tuberculosis_H37Rv         EELRELTISEVGAPRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEAS
MAB_1218|M.abscessus_ATCC_1997      EELRELTIAEVGAPRMLTAGAQLEGPVDDLQFAADTAESFDWTSDLGVAS
MSMEG_5859|M.smegmatis_MC2_155      EELRDLTIAEVGAPRMLTSGAQLEGPIDDLAFSADTAENYPWRTDLGHAT
Mflv_2502|M.gilvum_PYR-GCK          DELAALTIAEVGATPALCQGAQLDQPIEIVRYYADLLKTYPLTEDLGNIE
Mvan_4156|M.vanbaalenii_PYR-1       DELAALTVAEVGATPALCQGAQLDQPIEIVRYYADLLKTYPLTEDLGNIE
MLBr_02573|M.leprae_Br4923          NQSAALMTLEMG-KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAA
                                    :    *   * *         :           :                

MUL_0939|M.ulcerans_Agy99           SASG--AAVLCHEPLGVVSILTPWNFPHSLNVMKLSRALAGGNTVVLKPS
MMAR_4246|M.marinum_M               SASG--AAVLCHEPLGVVSILTPWNFPHSLNVMKLSRALAGGNTVVLKPS
MAV_1340|M.avium_104                GISAG-TTLLRHVPLGVVAVLTPWNFPHCLNVMKLNHALAAGNTVVLKPS
TH_4242|M.thermoresistible__bu      AWGAGGTTLLRYEPLGVVSVLTPWNFPHTLNAMKIGSALAAGNTVVLKPS
Mb0791|M.bovis_AF2122/97            PLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPA
Rv0768|M.tuberculosis_H37Rv         PLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPA
MAB_1218|M.abscessus_ATCC_1997      PMGIKTRRTLAREAVGVVGAVTPWNFPHQINLAKVGPALAAGNTLVLKPA
MSMEG_5859|M.smegmatis_MC2_155      PQGIPTDRVIAREAVGVVGAITPWNFPHQINLAKVGPALAAGNTLVLKPA
Mflv_2502|M.gilvum_PYR-GCK          SRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAKLAPALAAGCTVVLKSA
Mvan_4156|M.vanbaalenii_PYR-1       SRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAKLAPALAAGCTVVLKSA
MLBr_02573|M.leprae_Br4923          VGAS--KALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHA
                                      .          . ***  : .:*:*          ** .* . :** :

MUL_0939|M.ulcerans_Agy99           PLTPLAGLALARIIHEHTDIPPGVVNVVTPGGIEASKVLTVDPRIDMVSF
MMAR_4246|M.marinum_M               PLTPLAGLALARIIHEHTDIPPGVVNVVTPGGIEASKVLAVDPRIDMVSF
MAV_1340|M.avium_104                PLTPLAGLALARLIDEHTDIPPGVVNVVTPSGVEAAKLLTTDPRIDMVSF
TH_4242|M.thermoresistible__bu      PLTPLAGFALARMIDEHTDIPPGVVNVVTPSGLDGSKMLTTDPRIDMVSF
Mb0791|M.bovis_AF2122/97            PDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISF
Rv0768|M.tuberculosis_H37Rv         PDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISF
MAB_1218|M.abscessus_ATCC_1997      PDTPWCAAVLGRIIAEHTDFPPGVVNIVTSSDHRIGAQLSTDPRVDMVSF
MSMEG_5859|M.smegmatis_MC2_155      PDTPWAAAVLGQIITEHTDFPPGVINIVTSSDHSVGALLSKDPRVDMVSF
Mflv_2502|M.gilvum_PYR-GCK          PDTPLITLALGELIAEHTDIPPGVVNVLSGADPQVGAALTTSPDVDMVTF
Mvan_4156|M.vanbaalenii_PYR-1       PDTPLVTLALGELIAKHTDIPAGVVNVLSGADPAVGAALTTSPDVDMVTF
MLBr_02573|M.leprae_Br4923          SNVPQCALYLADVIARG-GFPEDCFQTLLISANGVEAILR-DPRVAAATL
                                    . .*     *. :* .  .:* . .: :  .       *  .* :   ::

MUL_0939|M.ulcerans_Agy99           TGSSAVGCEVMAAAAGTMKRVLLECGGKSASIVLDD-AECSDELLARMLF
MMAR_4246|M.marinum_M               TGSSAVGREVMAAAAGTMKRVLLECGGKSASIVLDD-AECSDELLARMLF
MAV_1340|M.avium_104                TGSSAVGRQVMSAAGDTIKRILLELGGKSASIVLDD-ANVTDEMLEQMLF
TH_4242|M.thermoresistible__bu      TGSSAVGREVMAGAAGGMKRILLECGGKSASIVLDD-LEVTDELLETILF
Mb0791|M.bovis_AF2122/97            TGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSA
Rv0768|M.tuberculosis_H37Rv         TGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSA
MAB_1218|M.abscessus_ATCC_1997      TGSTATGRAVMTDAAATVKKVFLELGGKSAFIVLDDLDEAALGSACSVAA
MSMEG_5859|M.smegmatis_MC2_155      TGSTATGRAVMTDAALTIKKVFLELGGKSAFLVLDD---ADLTGACSMAA
Mflv_2502|M.gilvum_PYR-GCK          TGSTPTGRAIMAAASGTLKKVFLELGGKSAAIVLDD---ADFSTAALFSA
Mvan_4156|M.vanbaalenii_PYR-1       TGSTPTGRAIMAAASGTLKKVFLELGGKSAAIVLDD---ADFNTAAMFSA
MLBr_02573|M.leprae_Br4923          TGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS---ADLDAAVATAV
                                    *** ..*  : : *.  :*  .** **... :*: .              

MUL_0939|M.ulcerans_Agy99           ESCLLHAGQACILHSRLLLPEAMHDEIVDRLVALARAVRVGDPADPDVQM
MMAR_4246|M.marinum_M               ESCLLHAGQACILHSRLLLPEAMHDEIVDRLVALARAVRVGDPADPDVQM
MAV_1340|M.avium_104                QSCSLHAGQACILHSRLLLPDSLHDDVVDRLAALARDVKVGDPTDPDVQM
TH_4242|M.thermoresistible__bu      ECLTMHAGQACILNSRLVVPEAMHDDVVARLGELARKVVVGNPVDPAVQM
Mb0791|M.bovis_AF2122/97            FSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVC
Rv0768|M.tuberculosis_H37Rv         FSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVC
MAB_1218|M.abscessus_ATCC_1997      FTAAMHAGQGCAITTRLVVPRERYDDAVAAAAATMGSLKPGDPAKPGTIC
MSMEG_5859|M.smegmatis_MC2_155      FTVAMHAGQGCAITTRLVVPRARYDEAVEIAAGTLGSIKPGDPTSKRTVC
Mflv_2502|M.gilvum_PYR-GCK          FSMVTHAGQGCALTSRLLVPRKHKDEIVELVKNNFGLVRLGDPADPSTYM
Mvan_4156|M.vanbaalenii_PYR-1       FSMVTHAGQGCALTSRLLVPKKHKDELVELVKNNFGLVRYGDPTAAGTYM
MLBr_02573|M.leprae_Br4923          TGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDV
                                         : **.*   .*::      :: *         :  *:*    .  

MUL_0939|M.ulcerans_Agy99           GPLISAAQRSRVEDQVARALRDGATLAAGGRRPATPEAGFYYEPTILTGV
MMAR_4246|M.marinum_M               GPLISAAQRSRVEDQVARALRDGATLAAGGRRPATPEAGFYYEPTILTGV
MAV_1340|M.avium_104                GPLISAAQRDRVEAHIAGARSDGATLVTGGGRPAGLDVGYYVEPTILSGV
TH_4242|M.thermoresistible__bu      GPLISRAHLERVEGFVERAVADGATVVAGGSRPAHLDRGFFYEPTILTDV
Mb0791|M.bovis_AF2122/97            GPLISARQRDRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGL
Rv0768|M.tuberculosis_H37Rv         GPLISARQRDRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGL
MAB_1218|M.abscessus_ATCC_1997      GPVISARQRDRVQSYLDLAVAEGGSFACGGGRPEGKDRGFFIEPTVVAGL
MSMEG_5859|M.smegmatis_MC2_155      GPVISARQRDRVQSYLDLAIKEGGRFACGGGRPADMDKGFWIEPTVIAGL
Mflv_2502|M.gilvum_PYR-GCK          GPLISEKQRDKVDGMVKRAVEAGATLVTGGEK---VDPGYFYTPTLLADV
Mvan_4156|M.vanbaalenii_PYR-1       GPLISEKQRDKVDGMVKRAVEAGATLVTGGEK---VDPGYFYTPTLLADV
MLBr_02573|M.leprae_Br4923          GPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPD--RPGWFYPPTVITDI
                                    **: :     :*:  :  *   *. .  ** :      *::  **:::.:

MUL_0939|M.ulcerans_Agy99           TPDAHIAQNEVFGPVLSVLRYRDDDDAVAIANNSQYGLSGAVWGGDADRA
MMAR_4246|M.marinum_M               TPDAHIAQNEVFGPVLSVLRYRDDDDAVAIANNSQYGLSGAVWGGDADRA
MAV_1340|M.avium_104                EPNSTVAQEEVFGPVLSVLRYRDDDDAVAIANNSRYGLSGAVWGDDVDRA
TH_4242|M.thermoresistible__bu      APDDFIAQEEVFGPVLTVLRCRDDDEAVDIANNSRYGLGGAVYAADVDRA
Mb0791|M.bovis_AF2122/97            TNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRA
Rv0768|M.tuberculosis_H37Rv         TNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRA
MAB_1218|M.abscessus_ATCC_1997      TNAARVAREEIFGPVLVVIAHDGDEDAVRIANDSPYGLSGTVFGDDDERS
MSMEG_5859|M.smegmatis_MC2_155      DNNARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSGDDARA
Mflv_2502|M.gilvum_PYR-GCK          DPDSEIAQEEVFGPVLTVIAYEDDDDAVRIANNSIYGLSGAVFGSQD-RA
Mvan_4156|M.vanbaalenii_PYR-1       DPDSEIAQEEVFGPVLVVIAYEDDDDAVRIANNSIYGLSGAVFGSQD-RA
MLBr_02573|M.leprae_Br4923          TKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQ
                                         :  :*:****  *    . ::*: *** : :**.. .:  :  . 

MUL_0939|M.ulcerans_Agy99           VRVARRIRTGQIAVNG--FGPGDAPFGGFKQSGLGREGGGIAGLHQYMEP
MMAR_4246|M.marinum_M               VRVARRIRTGQIAVNG--FGPGDAPFGGFKQSGLGREGGGIAGLHQYMEP
MAV_1340|M.avium_104                VGVARRIRTGQIAVNG--ISPAGAPFGGFRLSGLGREGGGIGGLHQYMEP
TH_4242|M.thermoresistible__bu      LGVARRIRSGQVSING--CIAGDAPFGGFGQSGIGREGG-LLGLRSYMEP
Mb0791|M.bovis_AF2122/97            ARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMG-LLGFEEYLEA
Rv0768|M.tuberculosis_H37Rv         ARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMG-LLGFEEYLEA
MAB_1218|M.abscessus_ATCC_1997      ARVASRLRVGTVNVNGGVWYSADAPFGGYKQSGNGREMG-VAGFEEYLET
MSMEG_5859|M.smegmatis_MC2_155      QAVASRMRVGTVNVNGGIWYSADAPFGGYKQSGVGREMG-LAGFEEYTEI
Mflv_2502|M.gilvum_PYR-GCK          LGVARRIRTGTFSINGGNYFSPDSPFGGYKQSGIGREMG-RAGLEEFLES
Mvan_4156|M.vanbaalenii_PYR-1       LAVARRIRTGTFSINGGNYFAPDSPFGGYKQSGIGREMG-RAGLEEFLES
MLBr_02573|M.leprae_Br4923          RHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELS-THGIREFCNI
                                      .  .:  * . :**        ****   ** *** .   *:..: : 

MUL_0939|M.ulcerans_Agy99           KAIGMPG-------
MMAR_4246|M.marinum_M               KAIGMPG-------
MAV_1340|M.avium_104                MAIGVPA-------
TH_4242|M.thermoresistible__bu      KAIGVPA-------
Mb0791|M.bovis_AF2122/97            KLIATAAN------
Rv0768|M.tuberculosis_H37Rv         KLIATAAN------
MAB_1218|M.abscessus_ATCC_1997      KVIATAVK------
MSMEG_5859|M.smegmatis_MC2_155      KLIATLAG------
Mflv_2502|M.gilvum_PYR-GCK          KTFATVAG------
Mvan_4156|M.vanbaalenii_PYR-1       KTYAVVVPEAGGQA
MLBr_02573|M.leprae_Br4923          KTVWIA--------