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MQETVTIPDATSGTETADRRAARRLLIGGQLVDTERTFASLNPATGDVLGYAPDASVADAEAAVAAARAA FDTGDWATDTELRIRCLEQLHAALVEHRDELAALTIAEVGATPALCQGAQLDQPIEIVRYYADLLKTYPL TEDLGNIESRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAKLAPALAAGCTVVLKSAPDTPLITLALGE LIAEHTDIPPGVVNVLSGADPQVGAALTTSPDVDMVTFTGSTPTGRAIMAAASGTLKKVFLELGGKSAAI VLDDADFSTAALFSAFSMVTHAGQGCALTSRLLVPRKHKDEIVELVKNNFGLVRLGDPADPSTYMGPLIS EKQRDKVDGMVKRAVEAGATLVTGGEKVDPGYFYTPTLLADVDPDSEIAQEEVFGPVLTVIAYEDDDDAV RIANNSIYGLSGAVFGSQDRALGVARRIRTGTFSINGGNYFSPDSPFGGYKQSGIGREMGRAGLEEFLES KTFATVAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2502 | - | - | 100% (498) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1600 | - | e-137 | 53.72% (484) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4119 | - | e-121 | 49.08% (491) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-139 | 53.35% (478) | aldehyde dehydrogenase NAD dependant AldA |
| M. tuberculosis H37Rv | Rv0768 | aldA | 1e-139 | 53.35% (478) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-55 | 33.84% (461) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 1e-131 | 51.83% (465) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4714 | - | 0.0 | 78.25% (492) | NAD-dependent aldehyde dehydrogenase |
| M. avium 104 | MAV_0944 | - | 0.0 | 77.35% (499) | aldehyde dehydrogenase (NAD) family protein |
| M. smegmatis MC2 155 | MSMEG_4799 | - | 0.0 | 87.10% (496) | aldehyde dehydrogenase (NAD) family protein |
| M. thermoresistible (build 8) | TH_2504 | - | 0.0 | 84.68% (496) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0477 | aldA | 1e-136 | 53.55% (465) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. vanbaalenii PYR-1 | Mvan_4156 | - | 0.0 | 92.14% (496) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0791|M.bovis_AF2122/97 ------------MALWGD-------------------GISALLIDGKLSD
Rv0768|M.tuberculosis_H37Rv ------------MALWGD-------------------GISALLIDGKLSD
MUL_0477|M.ulcerans_Agy99 ------------MALLAD-------------------GVSSLFIDGKRCE
MAB_1218|M.abscessus_ATCC_1997 ------------MTVLSD-------------------GDSELFIDGKLLP
Mflv_2502|M.gilvum_PYR-GCK ------------MQETVTIPD-----ATSGTETADRRAARRLLIGGQLVD
Mvan_4156|M.vanbaalenii_PYR-1 ------------MQETATISD-----ERSGAGQAAQRAERHLLIGGQLLE
MSMEG_4799|M.smegmatis_MC2_155 ------------MQETSTIA-------------AGQRADRKLLIGGELRE
TH_2504|M.thermoresistible__bu -----------MMRETSTLPG-----EEQRSNGAGQHVDRRLLIDGQLLT
MMAR_4714|M.marinum_M ----------MSSQDTAQTIA--DARSGVAEAPAASRAQRRLLIGGRLIS
MAV_0944|M.avium_104 MTATTSGGTGMPAQDTAEPVTGSSATAATADAAPAAHVDRRLLIDGRLVT
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mb0791|M.bovis_AF2122/97 GRAGTFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTEL
Rv0768|M.tuberculosis_H37Rv GRAGTFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTEL
MUL_0477|M.ulcerans_Agy99 GAAGTFATVNPATEETLGVAADAVAGDMDRAIEAARRAFDDTDWSRNTEL
MAB_1218|M.abscessus_ATCC_1997 GGAGRFPTVNPATEEVLGTAADADSDDMSDAIEAARRAFDDSGWSRDVAL
Mflv_2502|M.gilvum_PYR-GCK TER-TFASLNPATGDVLGYAPDASVADAEAAVAAARAAFDTGDWATDTEL
Mvan_4156|M.vanbaalenii_PYR-1 TER-TFPSLNPATGEVLGYAPDATVADAEAAVAAARRAFDAGVWATDTEL
MSMEG_4799|M.smegmatis_MC2_155 TSR-TFPSVNPATAEVLGYAPDATVADAEAAVAAARTAFDTTSWSTDTEF
TH_2504|M.thermoresistible__bu TAR-TFPSLNPATGQVLGYAPDATVAEAQAAVAAARRAFDTTDWATNVEL
MMAR_4714|M.marinum_M TDR-TFPSVNPATGAVLGCAPDAGVPEAEAAVAAARRAFDTTEWSTDVEL
MAV_0944|M.avium_104 AGT-TFPSINPATGAVIGHAPDAGTAEAEAAIAAARRAFDGTGWATDVEL
MLBr_02573|M.leprae_Br4923 ---MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDN-YRHTTFTQ
:.::**** .: . : : *: * **
Mb0791|M.bovis_AF2122/97 RVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGDLSFAA
Rv0768|M.tuberculosis_H37Rv RVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGDLSFAA
MUL_0477|M.ulcerans_Agy99 RVRCVRQLRDAMREHIEELRALTISEVGAPRMLTAAAQLEGPVNDLAFSA
MAB_1218|M.abscessus_ATCC_1997 RVHCIRQLRDGMKTHIEELRELTIAEVGAPRMLTAGAQLEGPVDDLQFAA
Mflv_2502|M.gilvum_PYR-GCK RIRCLEQLHAALVEHRDELAALTIAEVGATPALCQGAQLDQPIEIVRYYA
Mvan_4156|M.vanbaalenii_PYR-1 RIRCLEQFHAALVEHRDELAALTVAEVGATPALCQGAQLDQPIEIVRYYA
MSMEG_4799|M.smegmatis_MC2_155 RVHCLEQFHRALLEHRDELAALTTAEVGATAALCAGAQLDQPIDIVRYYA
TH_2504|M.thermoresistible__bu RIRCLDQLHRALVEHRDELADLTVAEVGATPALCAGAQLDQPIAIVRYYA
MMAR_4714|M.marinum_M RIRCLDQLHRALVDHAEELRELTIAEVGATHALTQGAQLDEPIGIVRFYA
MAV_0944|M.avium_104 RIRCLDQLHRALLEHADELRELTIAEVGATRALTHGAQLDEPIGIVRFYA
MLBr_02573|M.leprae_Br4923 RAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYA
* : : . :: * *:* . :. . . : *
Mb0791|M.bovis_AF2122/97 DTAESYPWKQDLGEASPLGIATRRTLAREAVGVVGAITPWNFPHQINLAK
Rv0768|M.tuberculosis_H37Rv DTAESYPWKQDLGEASPLGIATRRTLAREAVGVVGAITPWNFPHQINLAK
MUL_0477|M.ulcerans_Agy99 DTAESYSWKQDLGAAAPMGIPTRRTVVREAVGVVGAITPWNFPHQINLAK
MAB_1218|M.abscessus_ATCC_1997 DTAESFDWTSDLGVASPMGIKTRRTLAREAVGVVGAVTPWNFPHQINLAK
Mflv_2502|M.gilvum_PYR-GCK DLLKTYPLTEDLGNIESRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAK
Mvan_4156|M.vanbaalenii_PYR-1 DLLKTYPLTEDLGNIESRGMQHHRWVEKEAGGVVAAIIAYNYPNQLALAK
MSMEG_4799|M.smegmatis_MC2_155 ELLATYPLTEDLGNIESRGMQHHRWVEKEAAGVVAAIIAYNYPNQLALAK
TH_2504|M.thermoresistible__bu DLLRRYPMTEDLGNAEIRGMQHHRWVEKEAAGVVAAIIAYNYPNQLALAK
MMAR_4714|M.marinum_M DLLSRYEFSEDLGEKESRGMRHHRWVEKEAAGVVAAIIAYNYPNQLALAK
MAV_0944|M.avium_104 DLLRSYPFTEDLGEKESRGLRHHRWVEKEAAGVVGAIIAYNYPNQLALAK
MLBr_02573|M.leprae_Br4923 EKAETLLADEPAEAAAVG--ASKALARYQPLGVVLAVMPWNFPLWQTVRF
: . : :. *** *: .:*:* :
Mb0791|M.bovis_AF2122/97 LGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHA
Rv0768|M.tuberculosis_H37Rv LGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHA
MUL_0477|M.ulcerans_Agy99 LGPALAAGNTVVLKPAPDTPWCAAVLGELIADCTDIPPGVVNIVTSSEHG
MAB_1218|M.abscessus_ATCC_1997 VGPALAAGNTLVLKPAPDTPWCAAVLGRIIAEHTDFPPGVVNIVTSSDHR
Mflv_2502|M.gilvum_PYR-GCK LAPALAAGCTVVLKSAPDTPLITLALGELIAEHTDIPPGVVNVLSGADPQ
Mvan_4156|M.vanbaalenii_PYR-1 LAPALAAGCTVVLKSAPDTPLVTLALGELIAKHTDIPAGVVNVLSGADPA
MSMEG_4799|M.smegmatis_MC2_155 LAPALAAGCTVVLKAAPDTPLITLALGELIAHHTDIPPGVVNVISGADPE
TH_2504|M.thermoresistible__bu LGPALAAGCTVVLKGAPDTPLVTLALGELIAEHTDIPAGVVNVLSGADPD
MMAR_4714|M.marinum_M LAPALAAGCTVVLKGAPDTPLVTLALGELIANHTDIPAGVVNVLSSSDPA
MAV_0944|M.avium_104 LAPALAAGCTVVLKGAPDTPLVTLALGELIANHTDIPAGVVNVLSSSDPA
MLBr_02573|M.leprae_Br4923 AAPALMAGNVGLLKHASNVPQCALYLADVIARG-GFPEDCFQTLLISANG
.*** ** . :** *.:.* : *. :*. .:* . .: : :
Mb0791|M.bovis_AF2122/97 LGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVL
Rv0768|M.tuberculosis_H37Rv LGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVL
MUL_0477|M.ulcerans_Agy99 LGALLAKDPRVDMVSFTGSTATGRSVMADGAATIKRMFLELGGKSAFIVL
MAB_1218|M.abscessus_ATCC_1997 IGAQLSTDPRVDMVSFTGSTATGRAVMTDAAATVKKVFLELGGKSAFIVL
Mflv_2502|M.gilvum_PYR-GCK VGAALTTSPDVDMVTFTGSTPTGRAIMAAASGTLKKVFLELGGKSAAIVL
Mvan_4156|M.vanbaalenii_PYR-1 VGAALTTSPDVDMVTFTGSTPTGRAIMAAASGTLKKVFLELGGKSAAIVL
MSMEG_4799|M.smegmatis_MC2_155 VGAVLTTSPDVDMVTFTGSTPTGRRIMAAASETLKKVFLELGGKSAAIIL
TH_2504|M.thermoresistible__bu VGAALTTSPDVDMVTFTGSTQTGRRIMAAASETLKKVFLELGGKSAAIVL
MMAR_4714|M.marinum_M VGEVLTTSPDVDVVTFTGSTATGRRIMAAASQTVKRVFLELGGKSAVIML
MAV_0944|M.avium_104 AGVALTTSPDVDVITFTGSTAVGREIMAAASQTVKRVFLELGGKSAAIIL
MLBr_02573|M.leprae_Br4923 VEAILR-DPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVM
* .* * ::*** .*: : : .. :* .*****... :::
Mb0791|M.bovis_AF2122/97 DD---ADLAAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAAT
Rv0768|M.tuberculosis_H37Rv DD---ADLAAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAAT
MUL_0477|M.ulcerans_Agy99 DD---ADLAAASSVSAFTASMHAGQGCAITTRLVVPRARYDEAVAIAAGT
MAB_1218|M.abscessus_ATCC_1997 DDLDEAALGSACSVAAFTAAMHAGQGCAITTRLVVPRERYDDAVAAAAAT
Mflv_2502|M.gilvum_PYR-GCK DD---ADFSTAALFSAFSMVTHAGQGCALTSRLLVPRKHKDEIVELVKNN
Mvan_4156|M.vanbaalenii_PYR-1 DD---ADFNTAAMFSAFSMVTHAGQGCALTSRLLVPKKHKDELVELVKNN
MSMEG_4799|M.smegmatis_MC2_155 DD---ADFNTAALFSAFSMVTHAGQGCALTSRLLVPAAHKDEIVELIKNN
TH_2504|M.thermoresistible__bu DD---ADFTMAALFTAFSMVTHAGQGCALTSRLLVPRTHHDEIVVLVKNN
MMAR_4714|M.marinum_M DD---ADFAGAAMFAAFSMVTHAGQGCALTSRLLVPRAHHDEIVELIAQN
MAV_0944|M.avium_104 DD---ADFAGAALFAAFSMVTHAGQGCALTSRLLVPRSHHDEIVELIAQN
MLBr_02573|M.leprae_Br4923 PS---ADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVAR
. * : * :. : **.* :.*::. :: *
Mb0791|M.bovis_AF2122/97 MSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGARPA
Rv0768|M.tuberculosis_H37Rv MSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGARPA
MUL_0477|M.ulcerans_Agy99 MSSIKPGDPDDARTVCGPLISQRQRDRVEGYLDLAIAEGGTFACGGGRPA
MAB_1218|M.abscessus_ATCC_1997 MGSLKPGDPAKPGTICGPVISARQRDRVQSYLDLAVAEGGSFACGGGRPE
Mflv_2502|M.gilvum_PYR-GCK FGLVRLGDPADPSTYMGPLISEKQRDKVDGMVKRAVEAGATLVTGGEK--
Mvan_4156|M.vanbaalenii_PYR-1 FGLVRYGDPTAAGTYMGPLISEKQRDKVDGMVKRAVEAGATLVTGGEK--
MSMEG_4799|M.smegmatis_MC2_155 FAMVRYGDPADPKTYMGPLISEKQRDKVDGMVKRAVAAGATLVTGGEK--
TH_2504|M.thermoresistible__bu FGLVKYGDPTDPQTYMGPLISEKQRDKVHGMVQRAVAAGATLVTGGQK--
MMAR_4714|M.marinum_M FARVRHGDPADPKTYMGPLINERQRDKVDAMVGRAVAAGATLVTGGKR--
MAV_0944|M.avium_104 FAKVRHGDPADPKTYMGPLINERQRDKVDGMVRRAVAAGATLVTGGKR--
MLBr_02573|M.leprae_Br4923 METLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRP-
: :: *** . * **: . * :*. : * *. : ** :
Mb0791|M.bovis_AF2122/97 DREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDGDDDAVRIANDS
Rv0768|M.tuberculosis_H37Rv DREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDGDDDAVRIANDS
MUL_0477|M.ulcerans_Agy99 GRQVGYFIEPTVIAGLTTDARPAREEIFGPVLTVLAHDGDDDAVRIANDS
MAB_1218|M.abscessus_ATCC_1997 GKDRGFFIEPTVVAGLTNAARVAREEIFGPVLVVIAHDGDEDAVRIANDS
Mflv_2502|M.gilvum_PYR-GCK -VDPGYFYTPTLLADVDPDSEIAQEEVFGPVLTVIAYEDDDDAVRIANNS
Mvan_4156|M.vanbaalenii_PYR-1 -VDPGYFYTPTLLADVDPDSEIAQEEVFGPVLVVIAYEDDDDAVRIANNS
MSMEG_4799|M.smegmatis_MC2_155 -VDPGYFYTPTLLADVDPDSEIAQEEVFGPVLAVISYTDDDDAVRIANNS
TH_2504|M.thermoresistible__bu -VDPGFFYQPTLLTGVDPDSEIAQEEVFGPVLAVIAYDDDDDAVRIANNS
MMAR_4714|M.marinum_M -LDPGFFYAPTLLTNVDPDSEIAQDEVFGPVLVVIAFDDDDDAVRIANNS
MAV_0944|M.avium_104 -LDPGFFYAPTLLTNVDPDSEIAQEEIFGPVLVVIAFDDDDDAVRIANNS
MLBr_02573|M.leprae_Br4923 -DRPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANAT
*:: **:::.: :*:**** * . . :**:.*** :
Mb0791|M.bovis_AF2122/97 PYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGI
Rv0768|M.tuberculosis_H37Rv PYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGI
MUL_0477|M.ulcerans_Agy99 PYGLSGTVYGGDPQRAADVAARLRVGAVNVNGGVWYCADAPFGGYKQSGI
MAB_1218|M.abscessus_ATCC_1997 PYGLSGTVFGDDDERSARVASRLRVGTVNVNGGVWYSADAPFGGYKQSGN
Mflv_2502|M.gilvum_PYR-GCK IYGLSGAVFG-SQDRALGVARRIRTGTFSINGGNYFSPDSPFGGYKQSGI
Mvan_4156|M.vanbaalenii_PYR-1 IYGLSGAVFG-SQDRALAVARRIRTGTFSINGGNYFAPDSPFGGYKQSGI
MSMEG_4799|M.smegmatis_MC2_155 IYGLSGAVFG-SQERALAVSRRIRTGTFSINGGNYFSPDSPFGGYKQSGI
TH_2504|M.thermoresistible__bu IYGLSGAVFG-SEERAIAVARRIRTGTFSINGGNYFSPDVPFGGYKQSGI
MMAR_4714|M.marinum_M IYGLAGAVFSRDQERALALARRIRTGSFSINGGNYFGADSPFGGFKQSGV
MAV_0944|M.avium_104 IYGLAGAVFSGDQERALAVARRIRTGSFSINGGNYFGADSPFGGFKQSGV
MLBr_02573|M.leprae_Br4923 PFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGY
:**.. .: . .. . .: .* . :** .: **** *:**
Mb0791|M.bovis_AF2122/97 GREMGLLGFEEYLEAKLIATAAN----------
Rv0768|M.tuberculosis_H37Rv GREMGLLGFEEYLEAKLIATAAN----------
MUL_0477|M.ulcerans_Agy99 GREMGLAGFEEYLETKLIATAAN----------
MAB_1218|M.abscessus_ATCC_1997 GREMGVAGFEEYLETKVIATAVK----------
Mflv_2502|M.gilvum_PYR-GCK GREMGRAGLEEFLESKTFATVAG----------
Mvan_4156|M.vanbaalenii_PYR-1 GREMGRAGLEEFLESKTYAVVVPEAGGQA----
MSMEG_4799|M.smegmatis_MC2_155 GREMGTAGLEEFLESKTFATVVA----------
TH_2504|M.thermoresistible__bu GREMGVAGLEEFLESKTFARVLTEVPA------
MMAR_4714|M.marinum_M GREMGVAGLEEFLERKTFAVPVMPAVPAGEARA
MAV_0944|M.avium_104 GREMGVAGLEEFLERKTFAVVAGPAEGALA---
MLBr_02573|M.leprae_Br4923 GRELSTHGIREFCNIKTVWIA------------
***:. *:.*: : *