For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MADPPALVQTYQLYIDGQWVEPQDGRYDDLSPCTEAVIATAPDASVAQVDDAIAAARRAFDSGPWGRISA EQRARCLNQLGEALTKHADDFFALSQTEWGCIGNERIMQIDGAGFMSMHAAQLATQLVDQEVAGISAGTT LLRHVPLGVVAVLTPWNFPHCLNVMKLNHALAAGNTVVLKPSPLTPLAGLALARLIDEHTDIPPGVVNVV TPSGVEAAKLLTTDPRIDMVSFTGSSAVGRQVMSAAGDTIKRILLELGGKSASIVLDDANVTDEMLEQML FQSCSLHAGQACILHSRLLLPDSLHDDVVDRLAALARDVKVGDPTDPDVQMGPLISAAQRDRVEAHIAGA RSDGATLVTGGGRPAGLDVGYYVEPTILSGVEPNSTVAQEEVFGPVLSVLRYRDDDDAVAIANNSRYGLS GAVWGDDVDRAVGVARRIRTGQIAVNGISPAGAPFGGFRLSGLGREGGGIGGLHQYMEPMAIGVPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1340 | - | - | 100% (486) | aldehyde dehydrogenase |
| M. avium 104 | MAV_0713 | - | e-108 | 44.89% (479) | aldehyde dehydrogenase (NAD) family protein |
| M. avium 104 | MAV_0944 | - | e-107 | 47.26% (493) | aldehyde dehydrogenase (NAD) family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-109 | 45.47% (486) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_1600 | - | 1e-106 | 43.89% (483) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 1e-109 | 45.47% (486) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-53 | 32.21% (444) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 1e-107 | 45.51% (490) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4246 | aldA_1 | 0.0 | 72.41% (482) | NAD-dependent aldehyde dehydrogenase, AldA_1 |
| M. smegmatis MC2 155 | MSMEG_5859 | - | 1e-109 | 45.80% (476) | aldehyde dehydrogenase (NAD) family protein |
| M. thermoresistible (build 8) | TH_4242 | - | 0.0 | 67.01% (482) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0939 | aldA_1 | 0.0 | 72.20% (482) | NAD-dependent aldehyde dehydrogenase, AldA_1 |
| M. vanbaalenii PYR-1 | Mvan_5157 | - | 1e-107 | 43.53% (487) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4246|M.marinum_M MAERALPESLVDTYQLYIDGRWVEPENGRYDDVSPSTGMVIATAPDASVS
MUL_0939|M.ulcerans_Agy99 MAERALPESLVDTYQLYIDGRWVEPENGRYDDVSPSTGMVIATAPDASVS
MAV_1340|M.avium_104 MAD---PPALVQTYQLYIDGQWVEPQDGRYDDLSPCTEAVIATAPDASVA
TH_4242|M.thermoresistible__bu MTR---SHALVETYGHYINGEWVDPDSGRYEDVDPATGETFAAAPDASTA
Mflv_1600|M.gilvum_PYR-GCK -----MAILADRDSKLLIDGKLVAGSAGTFPTVNPATEETLGVAADAGAD
Mvan_5157|M.vanbaalenii_PYR-1 -----MAILADRESRLLIDGKLVAGSSGTFTTVNPATEETLGVAADASAE
MSMEG_5859|M.smegmatis_MC2_155 -----MPLLADRQSQLLIDGKLVAGRKGVFDTVNPATEEVLGVAADATAE
MAB_1218|M.abscessus_ATCC_1997 -----MTVLSDGDSELFIDGKLLPGGAGRFPTVNPATEEVLGTAADADSD
Mb0791|M.bovis_AF2122/97 -----MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAE
Rv0768|M.tuberculosis_H37Rv -----MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAE
MLBr_02573|M.leprae_Br4923 ---------------------------MSIATINPATGETVKTFTPTTQD
:.*.* .. . . :
MMAR_4246|M.marinum_M QVGDAVDAARRAFDAGPWPAMSHQERGHCLAQLGAALQDYADAYFALSQV
MUL_0939|M.ulcerans_Agy99 QVGDAVDAARRAFDAGPWPAMSHQERGHCLAQLGAALQDYADAYFTLSQV
MAV_1340|M.avium_104 QVDDAIAAARRAFDSGPWGRISAEQRARCLNQLGEALTKHADDFFALSQT
TH_4242|M.thermoresistible__bu QVDRAIAAAREAFDSGRWTGLTPEERAKCLQQLGAALLEHADDFFALAQL
Mflv_1600|M.gilvum_PYR-GCK DMDAAIGAARRAFDETGWSTDT-ALRVRCIRQLQNAMRAHVEELRELTIA
Mvan_5157|M.vanbaalenii_PYR-1 DMSAAIGAARRSFDETDWATNT-DLRVRCIRQLQQAMRDHVEELRELTIA
MSMEG_5859|M.smegmatis_MC2_155 DMGDAIEAARRAFDDTDWSTDT-ELRVRCIRQLRDALREHVEELRDLTIA
MAB_1218|M.abscessus_ATCC_1997 DMSDAIEAARRAFDDSGWSRDV-ALRVHCIRQLRDGMKTHIEELRELTIA
Mb0791|M.bovis_AF2122/97 DMGRAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHVEELRELTIS
Rv0768|M.tuberculosis_H37Rv DMGRAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHVEELRELTIS
MLBr_02573|M.leprae_Br4923 EVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTL
:: *: * ** : * : : : *
MMAR_4246|M.marinum_M EWGCT-----ANERRLQIDASASAARRAGHLAGTLGDQPIQSASG--AAV
MUL_0939|M.ulcerans_Agy99 EWGCT-----ANERRLQIDASASAARRAGHLASTLGDQPIQSASG--AAV
MAV_1340|M.avium_104 EWGCI-----GNERIMQIDGAGFMSMHAAQLATQLVDQEVAGISAG-TTL
TH_4242|M.thermoresistible__bu EWGCS-----ANERMFHVEGPAVMTTHAGELALEPVEQPIDAWGAGGTTL
Mflv_1600|M.gilvum_PYR-GCK EVGAPRMLTAAAQLEGPVDDLSFCADTAESYRWSTDLGIASPMGIKTRRT
Mvan_5157|M.vanbaalenii_PYR-1 EVGAPRMLTSAAQLEGPVEDLSFCADTAESYAWTTDLGIASPMGIKTHRT
MSMEG_5859|M.smegmatis_MC2_155 EVGAPRMLTSGAQLEGPIDDLAFSADTAENYPWRTDLGHATPQGIPTDRV
MAB_1218|M.abscessus_ATCC_1997 EVGAPRMLTAGAQLEGPVDDLQFAADTAESFDWTSDLGVASPMGIKTRRT
Mb0791|M.bovis_AF2122/97 EVGAPRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRT
Rv0768|M.tuberculosis_H37Rv EVGAPRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRT
MLBr_02573|M.leprae_Br4923 EMGKT---LQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKAL
* * . :
MMAR_4246|M.marinum_M LCHEPLGVVSILTPWNFPHSLNVMKLSRALAGGNTVVLKPSPLTPLAGLA
MUL_0939|M.ulcerans_Agy99 LCHEPLGVVSILTPWNFPHSLNVMKLSRALAGGNTVVLKPSPLTPLAGLA
MAV_1340|M.avium_104 LRHVPLGVVAVLTPWNFPHCLNVMKLNHALAAGNTVVLKPSPLTPLAGLA
TH_4242|M.thermoresistible__bu LRYEPLGVVSVLTPWNFPHTLNAMKIGSALAAGNTVVLKPSPLTPLAGFA
Mflv_1600|M.gilvum_PYR-GCK VTREAIGVVGAITPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWAAAV
Mvan_5157|M.vanbaalenii_PYR-1 IAREAVGVVGAITPWNFPHQINLAKIGPALAAGNTLVLKPAPDTPWAAAV
MSMEG_5859|M.smegmatis_MC2_155 IAREAVGVVGAITPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWAAAV
MAB_1218|M.abscessus_ATCC_1997 LAREAVGVVGAVTPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWCAAV
Mb0791|M.bovis_AF2122/97 LAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAA
Rv0768|M.tuberculosis_H37Rv LAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAA
MLBr_02573|M.leprae_Br4923 ARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALY
.:*** : ***** . ** .**. :** :. .* ..
MMAR_4246|M.marinum_M LARIIHEHTDIPPGVVNVVTPGGIEASKVLAVDPRIDMVSFTGSSAVGRE
MUL_0939|M.ulcerans_Agy99 LARIIHEHTDIPPGVVNVVTPGGIEASKVLTVDPRIDMVSFTGSSAVGCE
MAV_1340|M.avium_104 LARLIDEHTDIPPGVVNVVTPSGVEAAKLLTTDPRIDMVSFTGSSAVGRQ
TH_4242|M.thermoresistible__bu LARMIDEHTDIPPGVVNVVTPSGLDGSKMLTTDPRIDMVSFTGSSAVGRE
Mflv_1600|M.gilvum_PYR-GCK LGELITEHTDFPAGVINIVTSSDHGVGALLSKDPRVDMVSFTGSTNTGRA
Mvan_5157|M.vanbaalenii_PYR-1 LGELIAEHTDFPAGVINIVTSSDHGVGALLSKDPRVDMVSFTGSTNTGRA
MSMEG_5859|M.smegmatis_MC2_155 LGQIITEHTDFPPGVINIVTSSDHSVGALLSKDPRVDMVSFTGSTATGRA
MAB_1218|M.abscessus_ATCC_1997 LGRIIAEHTDFPPGVVNIVTSSDHRIGAQLSTDPRVDMVSFTGSTATGRA
Mb0791|M.bovis_AF2122/97 LGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRA
Rv0768|M.tuberculosis_H37Rv LGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRA
MLBr_02573|M.leprae_Br4923 LADVIARG-GFPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQA
*. :* . .:* . .: : . * ***: ::*** .*
MMAR_4246|M.marinum_M VMAAAAGTMKRVLLECGGKSASIVLDD-AECSDELLARMLFESCLLHAGQ
MUL_0939|M.ulcerans_Agy99 VMAAAAGTMKRVLLECGGKSASIVLDD-AECSDELLARMLFESCLLHAGQ
MAV_1340|M.avium_104 VMSAAGDTIKRILLELGGKSASIVLDD-ANVTDEMLEQMLFQSCSLHAGQ
TH_4242|M.thermoresistible__bu VMAGAAGGMKRILLECGGKSASIVLDD-LEVTDELLETILFECLTMHAGQ
Mflv_1600|M.gilvum_PYR-GCK VMADGAATLTKVFLELGGKSAFLVLDD---ADLAGACSMAAFTASMHAGQ
Mvan_5157|M.vanbaalenii_PYR-1 VMADGAATLKKVFLELGGKSAFLVIDD---ADLAGACSMAAFTASMHAGQ
MSMEG_5859|M.smegmatis_MC2_155 VMTDAALTIKKVFLELGGKSAFLVLDD---ADLTGACSMAAFTVAMHAGQ
MAB_1218|M.abscessus_ATCC_1997 VMTDAAATVKKVFLELGGKSAFIVLDDLDEAALGSACSVAAFTAAMHAGQ
Mb0791|M.bovis_AF2122/97 VMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSAFSACMHAGQ
Rv0768|M.tuberculosis_H37Rv VMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSAFSACMHAGQ
MLBr_02573|M.leprae_Br4923 VGAIAGNEIKPTVLELGGSDPFIVMPS---ADLDAAVATAVTGRVQNNGQ
* : .. :. .** **... :*: . : **
MMAR_4246|M.marinum_M ACILHSRLLLPEAMHDEIVDRLVALARAVRVGDPADPDVQMGPLISAAQR
MUL_0939|M.ulcerans_Agy99 ACILHSRLLLPEAMHDEIVDRLVALARAVRVGDPADPDVQMGPLISAAQR
MAV_1340|M.avium_104 ACILHSRLLLPDSLHDDVVDRLAALARDVKVGDPTDPDVQMGPLISAAQR
TH_4242|M.thermoresistible__bu ACILNSRLVVPEAMHDDVVARLGELARKVVVGNPVDPAVQMGPLISRAHL
Mflv_1600|M.gilvum_PYR-GCK GCAITTRLLVPRARYDEAVEAAAATMGGLKPGDPDKPGTICGPVISARQR
Mvan_5157|M.vanbaalenii_PYR-1 GCAITTRLVVPRDRYDEAVEAAAATMGGLKAGDPTKPGTVCGPLISERQR
MSMEG_5859|M.smegmatis_MC2_155 GCAITTRLVVPRARYDEAVEIAAGTLGSIKPGDPTSKRTVCGPVISARQR
MAB_1218|M.abscessus_ATCC_1997 GCAITTRLVVPRERYDDAVAAAAATMGSLKPGDPAKPGTICGPVISARQR
Mb0791|M.bovis_AF2122/97 GCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQR
Rv0768|M.tuberculosis_H37Rv GCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQR
MLBr_02573|M.leprae_Br4923 SCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGR
.* .*:: ::: * : *:* . . **: :
MMAR_4246|M.marinum_M SRVEDQVARALRDGATLAAGGRRPATPEAGFYYEPTILTGVTPDAHIAQN
MUL_0939|M.ulcerans_Agy99 SRVEDQVARALRDGATLAAGGRRPATPEAGFYYEPTILTGVTPDAHIAQN
MAV_1340|M.avium_104 DRVEAHIAGARSDGATLVTGGGRPAGLDVGYYVEPTILSGVEPNSTVAQE
TH_4242|M.thermoresistible__bu ERVEGFVERAVADGATVVAGGSRPAHLDRGFFYEPTILTDVAPDDFIAQE
Mflv_1600|M.gilvum_PYR-GCK DRIQSYLDSAVAEGGRFACGGGRPADRDTGFFIEPTVIAGLDNNAKVARE
Mvan_5157|M.vanbaalenii_PYR-1 ERVQGYLDSAIAEGGRFACGGGRPADRDTGFFIDPTVIAGLDNNAKVARE
MSMEG_5859|M.smegmatis_MC2_155 DRVQSYLDLAIKEGGRFACGGGRPADMDKGFWIEPTVIAGLDNNARVARE
MAB_1218|M.abscessus_ATCC_1997 DRVQSYLDLAVAEGGSFACGGGRPEGKDRGFFIEPTVVAGLTNAARVARE
Mb0791|M.bovis_AF2122/97 DRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGLTNDARVARE
Rv0768|M.tuberculosis_H37Rv DRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGLTNDARVARE
MLBr_02573|M.leprae_Br4923 AQVEQQVDAAAAAGAVIRCGGKRPDRP--GWFYPPTVITDITKDMALYTD
::: : * *. . ** ** *:: **:::.: : :
MMAR_4246|M.marinum_M EVFGPVLSVLRYRDDDDAVAIANNSQYGLSGAVWGGDADRAVRVARRIRT
MUL_0939|M.ulcerans_Agy99 EVFGPVLSVLRYRDDDDAVAIANNSQYGLSGAVWGGDADRAVRVARRIRT
MAV_1340|M.avium_104 EVFGPVLSVLRYRDDDDAVAIANNSRYGLSGAVWGDDVDRAVGVARRIRT
TH_4242|M.thermoresistible__bu EVFGPVLTVLRCRDDDEAVDIANNSRYGLGGAVYAADVDRALGVARRIRS
Mflv_1600|M.gilvum_PYR-GCK EIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSPDLERANGVAARLRV
Mvan_5157|M.vanbaalenii_PYR-1 EIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSADPERAAGIAARMRV
MSMEG_5859|M.smegmatis_MC2_155 EIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVFSGDDARAQAVASRMRV
MAB_1218|M.abscessus_ATCC_1997 EIFGPVLVVIAHDGDEDAVRIANDSPYGLSGTVFGDDDERSARVASRLRV
Mb0791|M.bovis_AF2122/97 EIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRV
Rv0768|M.tuberculosis_H37Rv EIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRV
MLBr_02573|M.leprae_Br4923 EVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVA
*:**** * . ::*: *** : :**.. .: : . . .:
MMAR_4246|M.marinum_M GQIAVNG--FGPGDAPFGGFKQSGLGREGGGIAGLHQYMEPKAIGMPG-
MUL_0939|M.ulcerans_Agy99 GQIAVNG--FGPGDAPFGGFKQSGLGREGGGIAGLHQYMEPKAIGMPG-
MAV_1340|M.avium_104 GQIAVNG--ISPAGAPFGGFRLSGLGREGGGIGGLHQYMEPMAIGVPA-
TH_4242|M.thermoresistible__bu GQVSING--CIAGDAPFGGFGQSGIGREGG-LLGLRSYMEPKAIGVPA-
Mflv_1600|M.gilvum_PYR-GCK GTVNINGGVWYSADMPFGGYKQSGIGREMG-LAGFEEYLEIKAIATAVN
Mvan_5157|M.vanbaalenii_PYR-1 GTVNVNGGVWYSADMPFGGYKQSGIGREMG-LAGFEEYLEIKAIATAAN
MSMEG_5859|M.smegmatis_MC2_155 GTVNVNGGIWYSADAPFGGYKQSGVGREMG-LAGFEEYTEIKLIATLAG
MAB_1218|M.abscessus_ATCC_1997 GTVNVNGGVWYSADAPFGGYKQSGNGREMG-VAGFEEYLETKVIATAVK
Mb0791|M.bovis_AF2122/97 GTVNVNGGVWYCADAPFGGYKQSGIGREMG-LLGFEEYLEAKLIATAAN
Rv0768|M.tuberculosis_H37Rv GTVNVNGGVWYCADAPFGGYKQSGIGREMG-LLGFEEYLEAKLIATAAN
MLBr_02573|M.leprae_Br4923 GQVFINGMTVSYPELPFGGIKRSGYGRELS-THGIREFCNIKTVWIA--
* : :** **** ** *** . *:..: : :