For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TNFAMLPPEINSSLMFSGAGSAPMLDAAAAWEGLASELGTAASSSSSVTSGLVSDAWQGAASAAMNAVAT PYAQFLSAASTQAAGAASQAKAVAGAFEVARAAMIHPLEVLANRNVFVQLIRTNLFGLNAPAIMAAEGQY EQMWAQDVAAMVSYHGGASSAAASLPSGLQQILQSLPNLGLGNKGNANLGSGNTGIGNIGVGNSGEGNSA LVPPQSGNYNIGGGNNGNNNLGAGNIGNFNFGFGNNGTGNFGFGNAGPADLSNPNLFTFHVTPGENNIGI GNTGNGNFGLGNTGDGNIGGGNTGIGNIGFGLNGNNLVGVGGAYYDTAAGQFHFDGLNTGSGNIGIGNSG SNNIGFFNSGDGNIGAFSSGTNSVFPGQLNSFGVGNSGTGNLGFGNAGSGNAGFGNSGLLNTGFGNAGST NTGGFNGNNLNTGFLNSGEVNTGIGNSGHINTGFLNAGNVNTGIGNATDAGEVGLTATDSSGFFNTGYGV SGFGNAADESSYGHGVSAFGNTAVGTAFEVGVSSGFFNTGYSEAIGPFALGQVSGFNSGFFNWGTANSGL FSLSKLAIKS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0890 | - | - | 100% (571) | PPE family protein |
| M. ulcerans Agy99 | MUL_0902 | - | e-151 | 50.96% (626) | PPE family protein |
| M. ulcerans Agy99 | MUL_0964 | - | e-145 | 49.52% (620) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3588 | PPE64 | 1e-175 | 58.55% (579) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-25 | 31.72% (186) | PPE protein |
| M. tuberculosis H37Rv | Rv3558 | PPE64 | 1e-175 | 58.55% (579) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-28 | 39.11% (179) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 3e-24 | 34.38% (160) | PPE family protein |
| M. marinum M | MMAR_1129 | - | 0.0 | 98.95% (571) | PPE family protein |
| M. avium 104 | MAV_4704 | - | 8e-47 | 54.30% (186) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-25 | 34.97% (183) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-23 | 35.16% (182) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-26 | 33.70% (184) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MUL_0890|M.ulcerans_Agy99 ----------MT--NFAMLPPEINSSLMFSGAGSAPMLDAAAAWEGLASE
MMAR_1129|M.marinum_M ----------MT--NFAMLPPEINSSLMFSGAGSAPMLDAAAAWEGLASE
Mb3588|M.bovis_AF2122/97 ----------MA--HFSVLPPEINSLRMYLGAGSAPMLQAAAAWDGLAAE
Rv3558|M.tuberculosis_H37Rv ----------MA--HFSVLPPEINSLRMYLGAGSAPMLQAAAAWDGLAAE
MAV_4704|M.avium_104 ----------MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :* : *.*...: *. * *. .
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MUL_0890|M.ulcerans_Agy99 LGTAASSSSSVTSGLVSDAWQGAASAAMNAVATPYAQFLSAASTQAAGAA
MMAR_1129|M.marinum_M LGTAASSFSSVTSGLVSDAWQGAASAAMNAVATPYAQFLSAASTQAAGAA
Mb3588|M.bovis_AF2122/97 LGTAASSFSSVTTGLTGQAWQGPASAAMAAAAAPYAGFLTTASAQAQLAA
Rv3558|M.tuberculosis_H37Rv LGTAASSFSSVTTGLTGQAWQGPASAAMAAAAAPYAGFLTTASAQAQLAA
MAV_4704|M.avium_104 LASSAQSFSSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVS
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
::* : ::.* .: * :* : . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MUL_0890|M.ulcerans_Agy99 SQAKAVAGAFEVARAAMIHPLEVLANRNVFVQLIRTNLFGLNAPAIMAAE
MMAR_1129|M.marinum_M SQAKAVAGAFEVARAAMIHPLEVLANRNVFVQLIRTNLFGLNAPAIMAAE
Mb3588|M.bovis_AF2122/97 GQAKAVASVFEAAKAAIVPPAAVAANREAFLALIRSNWLGLNAPWIAAVE
Rv3558|M.tuberculosis_H37Rv GQAKAVASVFEAAKAAIVPPAAVAANREAFLALIRSNWLGLNAPWIAAVE
MAV_4704|M.avium_104 HQASAIATAFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* . * .. * : : *: * :* :* *: * *
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPT---------SAPAPSVLLPG
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPT---------ATPAPFVLAPG
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPV---------SAPAPFLLKPG
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPP---------STPPPSILHD-
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPR---------TVAPPPILGAG
MUL_0890|M.ulcerans_Agy99 GQYEQMWAQDVAAMVSYHGGASSAAASLPS--GLQQILQSLPNLGLGNKG
MMAR_1129|M.marinum_M GQYEQMWAQDVAAMVGYHGGASSAAASLPS--GLQQILQSLPNLGLGNKG
Mb3588|M.bovis_AF2122/97 SLYEEYWAADVAAMTGYHAGASQAAAQLPLPAGLQQFLNTLPNLGIGNQG
Rv3558|M.tuberculosis_H37Rv SLYEEYWAADVAAMTGYHAGASQAAAQLPLPAGLQQFLNTLPNLGIGNQG
MAV_4704|M.avium_104 AAYEQMWASDVAAMFGYHADASAAVAKLPP------WNEVLQNLGFSNAS
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKA--------FTAPPLGVNEVG
. * . * .::* *. * . .
Mflv_0325|M.gilvum_PYR-GCK VGEAGRAAADMSAFAAQPMAAQA--------------GAAFDVSNIIADI
Mvan_0415|M.vanbaalenii_PYR-1 VGEAGRAAADVTAFAAQAQAAEA--------------GSALDLSNIIADL
MSMEG_0619|M.smegmatis_MC2_155 VGEAGSASASVQQMSAQATAAES--------------GSSLDLSSIISDL
MAB_0809c|M.abscessus_ATCC_199 -----------HDHGHDDHDHEH--------------GHDDDHG------
TH_3113|M.thermoresistible__bu TGESATAAITGAHVTAELRAAES--------------RTLLDEINELIDR
MUL_0890|M.ulcerans_Agy99 NANLGSGNTGIGNIGVGNSGEGNSALVPPQSGNYNIGGGNNGNNNLGAGN
MMAR_1129|M.marinum_M NANLGSGNTGIGNIGVGNSGEGNSALVPPQSGNYNIGGGNNGNNNLGAGN
Mb3588|M.bovis_AF2122/97 NANLGGGNTGSGNIGNGNKGSSN------------LGGGNIGNNNIGSGN
Rv3558|M.tuberculosis_H37Rv NANLGGGNTGSGNIGNGNKGSSN------------LGGGNIGNNNIGSGN
MAV_4704|M.avium_104 TAVTRP--AGSGAVARGYT------------------------SRIAG--
MLBr_01182|M.leprae_Br4923 LAQEVVEEVVEEVVEEVVEAEQA---------------------------
Mflv_0325|M.gilvum_PYR-GCK IRLYGEVLRFLFEPIFNFLR--------------DPIGNTFALITDFLTN
Mvan_0415|M.vanbaalenii_PYR-1 IRAYGELLRFLFEPIFDFLR--------------DPLGNTIKLITDFLTN
MSMEG_0619|M.smegmatis_MC2_155 LNQYLQGVPGG-QAILDFLK--------------DPLGNLGRLLTDFMTN
MAB_0809c|M.abscessus_ATCC_199 ---HGDLDPTDPEWWVHVAG--------------EMVEHFELLLNNLLTD
TH_3113|M.thermoresistible__bu LFAPLFPPGFADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSN
MUL_0890|M.ulcerans_Agy99 IGNFNFGFGNNGTGNFGFGNAGPADLSNPNLFTFHVTPGENNIGIGNTGN
MMAR_1129|M.marinum_M IGNFNFGFGNNGTGNFGFGNAGPADLSNPNLFTFHVTPGENNIGIGNTGN
Mb3588|M.bovis_AF2122/97 RGSDNFGAGNVGTGNIGFGNQGPIDVN------LLATPGQNNVGLGNIGN
Rv3558|M.tuberculosis_H37Rv RGSDNFGAGNVGTGNIGFGNQGPIDVN------LLATPGQNNVGLGNIGN
MAV_4704|M.avium_104 ---------------------------------FLAPRAPQ---------
MLBr_01182|M.leprae_Br4923 ---------------------------------ISQAALDQAVNEGMEAT
Mflv_0325|M.gilvum_PYR-GCK PVQALITWGPFLLAVVYQA----VSWVGASILYPSLFLLPLLATT---LA
Mvan_0415|M.vanbaalenii_PYR-1 PAQALITWGPFLAAVAYQA----VSWVGASILYPSLLLLPLVATT---LA
MSMEG_0619|M.smegmatis_MC2_155 PAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGI-TG
MAB_0809c|M.abscessus_ATCC_199 PAALLTNLPMVLADVAFHA----AQLASTIGQFAPALIQPALALAIANLG
TH_3113|M.thermoresistible__bu PAYLFPVLVYLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAG
MUL_0890|M.ulcerans_Agy99 GNFGLGNTGDGNIGGGNTGIGNIGFGLNGNNLVGVG---------GAYYD
MMAR_1129|M.marinum_M GNFGLGNTGDGNIGGGNTGIGNIGFGLNGNNLVGVG---------GAYYD
Mb3588|M.bovis_AF2122/97 NNMGFGNTGDANTGGGNTGNGNIGGGNTGNNNFGFGNTGNNNIGIGLTGN
Rv3558|M.tuberculosis_H37Rv NNMGFGNTGDANTGGGNTGNGNIGGGNTGNNNFGFGNTGNNNIGIGLTGN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 VVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFA--------------
Mflv_0325|M.gilvum_PYR-GCK IVAGVG--QHLLSLL-NTPPAEEAAEEPAPAQSAPSRPDQQSFPATMSAP
Mvan_0415|M.vanbaalenii_PYR-1 IVLGVG--AYLLENL-PAPAEDAPAEEPAASSPAPTRADQPSPAIAVSAP
MSMEG_0619|M.smegmatis_MC2_155 LVLLID--HVLNNPV-DVPAEDEAPQEVAAAP----RTDQP-LAVGISPA
MAB_0809c|M.abscessus_ATCC_199 WAAGFAGLAGIQPSP-EILAVEPGSVEDAPMAASAGTALAPSPPASAAAP
TH_3113|M.thermoresistible__bu VWAGLSGLAGLAGLT-AVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGS
MUL_0890|M.ulcerans_Agy99 TAAGQFHFDGLNTGSGNIGIGNSGSNNIGFFNSGDGNIGAFSSGTNSVFP
MMAR_1129|M.marinum_M TAAGQFHFDGLNTGSGNIGIGNSGSNNIGFFNSGDGNIGAFSSGTNSVFP
Mb3588|M.bovis_AF2122/97 NQMGINLAGLLNSGSGNIGIGNSGTNNIGLFNSGSGNIGVFNTGANTLVP
Rv3558|M.tuberculosis_H37Rv NQMGINLAGLLNSGSGNIGIGNSGTNNIGLFNSGSGNIGVFNTGANTLVP
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 -QHLSPINDTLSMINNHAGMANAG---LSLVNGMGSAMKSLAPTTTKAAE
Mflv_0325|M.gilvum_PYR-GCK PPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRD-PYEGFSPTV
Mvan_0415|M.vanbaalenii_PYR-1 PPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRD-PGTGFSPTV
MSMEG_0619|M.smegmatis_MC2_155 GVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRD-PGEGFTPTL
MAB_0809c|M.abscessus_ATCC_199 AAPASAPAPTASGTAPAPPSP-PPVGDPGFSFPYAVGGGPRLGTGLALAA
TH_3113|M.thermoresistible__bu AAPTTGTAPGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVA
MUL_0890|M.ulcerans_Agy99 GQLNSFG--VGNSGTGNLGFGNAGSGNAGFGNSGLLNTGFGNAGSTNTGG
MMAR_1129|M.marinum_M GQLNSFG--VGNSGTGNLGFGNAGSGNAGFGNSGLLNTGFGNAGSINTGG
Mb3588|M.bovis_AF2122/97 GDLNNLG--VGNSGNANIGFGNAGVLNTGFGNASILNTGLGNAGELNTGF
Rv3558|M.tuberculosis_H37Rv GDLNNLG--VGNSGNANIGFGNAGVLNTGFGNASILNTGLGNAGELNTGF
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 SAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGS-LRVPQTWTTAS
Mflv_0325|M.gilvum_PYR-GCK RDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADY
Mvan_0415|M.vanbaalenii_PYR-1 RDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADY
MSMEG_0619|M.smegmatis_MC2_155 GNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDY
MAB_0809c|M.abscessus_ATCC_199 QVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG-----IEY
TH_3113|M.thermoresistible__bu RRSAGARRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHG-------
MUL_0890|M.ulcerans_Agy99 FNGNNLNTGFLNSGEVNTGIGNSGHINTGFLNAGNVNTGIGNATDAGEVG
MMAR_1129|M.marinum_M FNGNNLNTGFLNSGQVNTGIGNSGHINTGFLNAGNVNTGIGNATDAGEVG
Mb3588|M.bovis_AF2122/97 GNAGFVNTGFDNSGNVNTGNGNSGNINTGSWNAGNVNTGFGIITDS---G
Rv3558|M.tuberculosis_H37Rv GNAGFVNTGFDNSGNVNTGNGNSGNINTGSWNAGNVNTGFGIITDS---G
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 QPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGG----------
Mflv_0325|M.gilvum_PYR-GCK EELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTTLA-GDS
Mvan_0415|M.vanbaalenii_PYR-1 EPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTTLP-GDP
MSMEG_0619|M.smegmatis_MC2_155 EE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTTLT-GDT
MAB_0809c|M.abscessus_ATCC_199 MDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGLAMLSRDDD
TH_3113|M.thermoresistible__bu -HRHEHQQPASMSAATAPSAAGIRVLGGAGRISRTRGSVPHAEITP-GDP
MUL_0890|M.ulcerans_Agy99 LTATDSSGFFNTGYGVSGFGNAADESSYGHGVSAFGNTAVGTAFEVGVSS
MMAR_1129|M.marinum_M LTATDSSGFFNTGYGVSGFGNAADESSYGHGVSGFGNTAVGTAFGVGVSS
Mb3588|M.bovis_AF2122/97 LTN---SGFGNTGTDVSGFFNTP-TGPLAVDVSGFFNTASGGTVINGQTS
Rv3558|M.tuberculosis_H37Rv LTN---SGFGNTGTDVSGFFNTP-TGPLAVDVSGFFNTASGGTVINGQTS
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 ------------GSGTGGVNTALRLQPRAFVMP--RNPAAG---------
Mflv_0325|M.gilvum_PYR-GCK FGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-------
Mvan_0415|M.vanbaalenii_PYR-1 FGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-------
MSMEG_0619|M.smegmatis_MC2_155 FDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPRR-------
MAB_0809c|M.abscessus_ATCC_199 LFEGVRAPMVPNTWDP------------EHGRQD------------
TH_3113|M.thermoresistible__bu TEPSSPTDRAHRPAEPN-----------------------------
MUL_0890|M.ulcerans_Agy99 GFFNTGYSEAIGPFALGQVSGFNSGFFNWGTANSGLFSLSKLAIKS
MMAR_1129|M.marinum_M GFFNTGYSEAIGPFALGQVSGFNSGFFNWGTANSGLFSLSKLAIKS
Mb3588|M.bovis_AF2122/97 GIGNIG---VPGTLFGSVRSGLNTGLFNMGTAISGLFNLRQLLG--
Rv3558|M.tuberculosis_H37Rv GIGNIG---VPGTLFGSVRSGLNTGLFNMGTAISGLFNLRQLLG--
MAV_4704|M.avium_104 ----------------------------------------------
MLBr_01182|M.leprae_Br4923 ----------------------------------------------