For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RSRPRALVTAPLRGSGLDKLRQLVDVVYDPWIGGLEGGPLRIYSAEQLAERITSESVDIVVVEADSVSGA VLQLGLRAIFSTRGDPNNVDIAGATAAGIPVLNTPARNADAVAEMTVALLLASTRHLLTADADVRSGNIF RDGTIPYQRFRGWEIAGRTAGLVGLGAVGRATAWRLTGLGLWVIAHDPYCADARHGLAELLAESDIVSLH APVTDDTVGMIGAQQFASMRDGAVFLNTARAQLHDTDALVQALRAGKVAAAGLDHFVGEWLPTDHPLASM PNVVLTPHIGGATWNTEARQAQMVADGLQALLSGTRPTHILNPEVLAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0823 | serA2 | - | 100% (329) | D-3-phosphoglycerate dehydrogenase SerA2 |
| M. ulcerans Agy99 | MUL_1952 | serA1 | 1e-40 | 35.58% (312) | D-3-phosphoglycerate dehydrogenase |
| M. ulcerans Agy99 | MUL_1195 | serA3 | 3e-36 | 39.08% (261) | D-3-phosphoglycerate dehydrogenase SerA3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0749c | serA2 | 1e-146 | 79.51% (327) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0334 | - | 5e-41 | 40.80% (250) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0728c | serA2 | 1e-145 | 79.20% (327) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 4e-41 | 36.54% (312) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 3e-41 | 37.78% (270) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_1065 | serA2 | 0.0 | 99.09% (329) | D-3-phosphoglycerate dehydrogenase SerA2 |
| M. avium 104 | MAV_4438 | - | 1e-154 | 82.98% (329) | 2-hydroxyacid dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2378 | serA | 3e-41 | 34.67% (323) | D-3-phosphoglycerate dehydrogenase |
| M. thermoresistible (build 8) | TH_2037 | serA | 6e-42 | 35.91% (323) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. vanbaalenii PYR-1 | Mvan_2128 | - | 7e-41 | 35.29% (323) | D-3-phosphoglycerate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2378|M.smegmatis_MC2_155 -MSLPVVLIADKLAESTVAALGDEVEVRWVDGP----------DRAKLLA
Mvan_2128|M.vanbaalenii_PYR-1 -MSLPVVLIADKLAQSTVEALGDQVEVRWVDGP----------DREKLLA
MAB_3304c|M.abscessus_ATCC_199 ------MLIADKLAPSTVEALGDGVEVRWVDGP----------DRPALLA
MLBr_01692|M.leprae_Br4923 -MDLPVVLIADKLAQSTVAALGDQVEVRWVDGP----------DRTKLLA
TH_2037|M.thermoresistible__bu -VSLPVVLIADKLAESTVAALGDQVEVRWVDGP----------DREKLLA
Mflv_0334|M.gilvum_PYR-GCK -MRVLAHFLPGPKVTEFLSPHTDWLDIRYCAED----------DDETFYR
MUL_0823|M.ulcerans_Agy99 MRSRPRALVTAPLRGSGLDKLRQLVDVVYDPWIGGLEGGPLRIYSAEQLA
MMAR_1065|M.marinum_M MRSRPRALVTAPLRGSGLDKLRQLVDVVYDPWIGELEGGPLRIYSAEQLA
MAV_4438|M.avium_104 MTSKPRALVTAPLRGPGLDKLRALAEVVYDPWI---EQRPLRIYSAEQLA
Mb0749c|M.bovis_AF2122/97 MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWI---DQRPLRIYSAEQLA
Rv0728c|M.tuberculosis_H37Rv MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWI---DQRPLRIYSAEQLA
::. . :: :
MSMEG_2378|M.smegmatis_MC2_155 AVPEADALLVRSATTVDAEVIAAAPKLKIVARAGVGLDNVDVDAATARGV
Mvan_2128|M.vanbaalenii_PYR-1 AVADADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGV
MAB_3304c|M.abscessus_ATCC_199 AVPEADALLVRSATTVDAEVLAAGTKLKIVARAGVGLDNVDVKAATARGV
MLBr_01692|M.leprae_Br4923 AVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGV
TH_2037|M.thermoresistible__bu AVADADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVEAATARGV
Mflv_0334|M.gilvum_PYR-GCK ELPDAEVIWH-VLRPISGDDLSKAPKLRLVHKLGAGVNTVDVDTATARGI
MUL_0823|M.ulcerans_Agy99 ERITSESVDIVVVEADSVSGAVLQLGLRAIFSTRGDPNNVDIAGATAAGI
MMAR_1065|M.marinum_M ERITSESVDIVVVEADSVSGAVLQLGLRAIFSTRGDPNNVDIAGATAAGI
MAV_4438|M.avium_104 ERIAAEEAEIVVVESDSVRGPVFELGVRAIAATRGDPNNVDIDGATAAGI
Mb0749c|M.bovis_AF2122/97 DRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGI
Rv0728c|M.tuberculosis_H37Rv DRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGI
: . . :: : . ..**: *** *:
MSMEG_2378|M.smegmatis_MC2_155 LVVNAPTSNIHSAAEHAIALLLATARQIPAADATLRE-RSWKRSSFSGT-
Mvan_2128|M.vanbaalenii_PYR-1 LVVNAPTSNIHSAAEHALALLLAAARQIPAADATLRE-HSWKRSSFSGT-
MAB_3304c|M.abscessus_ATCC_199 LVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLKA-HTWKRSSFNGT-
MLBr_01692|M.leprae_Br4923 LVVNAPTSNIHSAAEHALALLLAASRQIAEADASLRA-HIWKRSSFSGT-
TH_2037|M.thermoresistible__bu LVVNAPTSNIHSAAEHAIALLLAAARQIPAADATLRQ-RTWKRSEFSGV-
Mflv_0334|M.gilvum_PYR-GCK AVANMPGANAPSVAEGTLLLMLAALRRLPELDRATRTGNGWPSDPTLGES
MUL_0823|M.ulcerans_Agy99 PVLNTPARNADAVAEMTVALLLASTRHLLTADADVRSGNIFRDGTIPYQR
MMAR_1065|M.marinum_M PVLNTPARNADAVAEMTVALLLASTRHLLTADADVRSGNIFHDGTIPYQR
MAV_4438|M.avium_104 PVLNTPGRNADAVAEMTVALLLAATRHLLPADADVRGGNIFRDGSIPYQR
Mb0749c|M.bovis_AF2122/97 PVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQR
Rv0728c|M.tuberculosis_H37Rv PVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQR
* : * * :.** :: *:** *:: * : . : .
MSMEG_2378|M.smegmatis_MC2_155 ----EIFGKTVGVVGLGRIGQLVAQRLAAFGAHIVAYDPYVSQARAAQLG
Mvan_2128|M.vanbaalenii_PYR-1 ----EIFGKTVGVVGLGRIGQLVAQRLAAFGAHITAYDPYVSHARAAQLG
MAB_3304c|M.abscessus_ATCC_199 ----EIFGKTVGVVGLGRIGQLFAQRLAAFGTHIVAYDPYVSAARAAQLG
MLBr_01692|M.leprae_Br4923 ----EIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLG
TH_2037|M.thermoresistible__bu ----EIYDKTVGVVGLGRIGQLVAQRLAAFGTHLIAYDPYVSPARAAQLG
Mflv_0334|M.gilvum_PYR-GCK VR--DLGGCTVGLVGYGNIAKQVERILLAIGAEVVHTSTRDDGLPGWRT-
MUL_0823|M.ulcerans_Agy99 FRGWEIAGRTAGLVGLGAVGRATAWRLTGLGLWVIAHDPYCADAR-----
MMAR_1065|M.marinum_M FRGWEIAGRTAGLVGLGAVGRATAWRLTGLGLRVIAHDPYCADAR-----
MAV_4438|M.avium_104 FRGGEIAGLTAGLVGLGAVGRATRWRLSGLGLRVIAHDPYHPEAR-----
Mb0749c|M.bovis_AF2122/97 FRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAG-----
Rv0728c|M.tuberculosis_H37Rv FRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAG-----
:: . *.*:** * :.: : .:* : ..
MSMEG_2378|M.smegmatis_MC2_155 IELLPLDDLLARADFISVHLPKTKETAGLLGKEALAKTKKGVIIVNAARG
Mvan_2128|M.vanbaalenii_PYR-1 IELLTLDELLGRADFISVHLPKTKETAGLIGKEALAKTKPGVIIVNAARG
MAB_3304c|M.abscessus_ATCC_199 IELLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARG
MLBr_01692|M.leprae_Br4923 IELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARG
TH_2037|M.thermoresistible__bu IELVDLDELLGRADIISVHLPKTPETAGLIGADALAKVKPGVIIVNAARG
Mflv_0334|M.gilvum_PYR-GCK -----LPDLLSESDIVSLHLPLTGATEGLLGRKALAQMKTDAVLVNTSRG
MUL_0823|M.ulcerans_Agy99 ---HGLAELLAESDIVSLHAPVTDDTVGMIGAQQFASMRDGAVFLNTARA
MMAR_1065|M.marinum_M ---HGLAELLAESDIVSLHAPVTDDTVGMIGAQQFASMRDGAVFLNTARA
MAV_4438|M.avium_104 ---HGLDELLAESDVVSLHAPVTDETTGMIGAEQFAAMRDGVVFLNTARA
Mb0749c|M.bovis_AF2122/97 ---HSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARS
Rv0728c|M.tuberculosis_H37Rv ---HSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARS
: :**..:*.:*:* . * * *::. . :* : ..:::*::*.
MSMEG_2378|M.smegmatis_MC2_155 GLIDEQALADAITSGHVRGAGLDVYATEPCT-DSPLFDLPQVVVTPHLGA
Mvan_2128|M.vanbaalenii_PYR-1 GLIDEAALADAINSGHVRGAGLDVFSTEPCT-DSPLFELPQVVVTPHLGA
MAB_3304c|M.abscessus_ATCC_199 GLIDEAALADAIRSGHVRGAGLDVFSTEPCT-DSPLFELDQVVVTPHLGA
MLBr_01692|M.leprae_Br4923 GLVDEVALADAVRSGHVRAAGLDVFATEPCT-DSPLFELSQVVVTPHLGA
TH_2037|M.thermoresistible__bu GLIDEQALADAIISGRVRAAGIDVFAKEPCT-DSPLFDLPQVVVTPHLGA
Mflv_0334|M.gilvum_PYR-GCK AIVDEAALVDALRAGTLAAAGLDVFAVEPVPSDNPLLGLPNVVLTPHVTW
MUL_0823|M.ulcerans_Agy99 QLHDTDALVQALRAGKVAAAGLDHFVGEWLPTDHPLASMPNVVLTPHIGG
MMAR_1065|M.marinum_M QLHDTDALVQALRAGKVAAAGLDHFVGEWLPTDHPLASMPNVVLTPHIGG
MAV_4438|M.avium_104 QLHDTDALVEALRAGKVAAAGLDHFVGEWLPTDHPLVGMPNVVLTPHIGG
Mb0749c|M.bovis_AF2122/97 QLHDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGG
Rv0728c|M.tuberculosis_H37Rv QLRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGG
: * **.:*: .* : .**:* : * . * ** : :**:***:
MSMEG_2378|M.smegmatis_MC2_155 STAEAQDRAGTDVAASVKLALAGEFVPDAVNVGGGVVGEEVAPWLELVRK
Mvan_2128|M.vanbaalenii_PYR-1 STVEAQDRAGTDVAASVKLALAGEFVPDAVNVGGGAVGEEVAPWLDLVRK
MAB_3304c|M.abscessus_ATCC_199 STSEAQDRAGTDVAASVQLALAGEFVPDAVNVGGGVVSEEVAPWLEVVRK
MLBr_01692|M.leprae_Br4923 STAEAQDRAGTDVAESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLVCK
TH_2037|M.thermoresistible__bu STVEAQDRAGTDVAASVKLALAGEFVPDAVNVGAGEVSEEVAPWVDLARK
Mflv_0334|M.gilvum_PYR-GCK YTADTMRRYLEFALDNCERLRDGRALAHVVNDPSG---------------
MUL_0823|M.ulcerans_Agy99 ATWNTEARQAQMVADGLQALLSGTRPTHILNPEVLAR-------------
MMAR_1065|M.marinum_M ATWNTEARQAQMVADGLQALLSGTRPTHILNPEVLAR-------------
MAV_4438|M.avium_104 ATWNTEARQAQLVADDLEALLAGATPAHIVNPEVLAR-------------
Mb0749c|M.bovis_AF2122/97 ATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS-------------
Rv0728c|M.tuberculosis_H37Rv ATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS-------------
* :: * . . * .. :*
MSMEG_2378|M.smegmatis_MC2_155 LGLLVGALADAPPVSLQVQVRGELASEDVEILKLSALRGLFSAVVDEQVT
Mvan_2128|M.vanbaalenii_PYR-1 LGLLVGVLSSEPPVSLQVQVQGELASEEVEVLKLSALRGLFSAVIEHPVT
MAB_3304c|M.abscessus_ATCC_199 LGVLIGAVSEQLPTSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQVT
MLBr_01692|M.leprae_Br4923 LGVLVAALSDELPASLSVHVRGELASEDVEILRLSALRGLFSTVIEDAVT
TH_2037|M.thermoresistible__bu LGLLVGTLSGEPTATLQVRVAGELASEDVEVLRLSALRGLFSTLTDQQVT
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2378|M.smegmatis_MC2_155 FVNAPALAADRGVTAEISTATESPNHRSVVDVRAVHADGSSINVAGTLSG
Mvan_2128|M.vanbaalenii_PYR-1 FVNAPALASERGVEASITTATESANHRSVVDVRAVAADGSTVNVAGTLTG
MAB_3304c|M.abscessus_ATCC_199 FVNAPSIAEERGVSAEITTATESPNHRSVVDVRAVYADGSVINVAGTLSG
MLBr_01692|M.leprae_Br4923 FVNAPALAAERGVSAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTLSG
TH_2037|M.thermoresistible__bu YVNAPTLAAERGMQAELEKVSESPNYRSVVDVRAVSTDGTVTNVAGTLSG
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2378|M.smegmatis_MC2_155 PQLVEKIVQINGRNFDLRAEGHNLIVNYSDKPGALGKIGTLLGGANVNIL
Mvan_2128|M.vanbaalenii_PYR-1 PQLVEKIVQINGRNLELRAEGVNLIINYDDQPGALGKIGTLLGGAAVNIL
MAB_3304c|M.abscessus_ATCC_199 PQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQ
MLBr_01692|M.leprae_Br4923 PQLVQKIVQVNGRNFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVNIQ
TH_2037|M.thermoresistible__bu PQQVEKIVQINGRNFDLRAEGVNLVMHYVDRPGALGKIGTLLGAADVNIL
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2378|M.smegmatis_MC2_155 AAQLSQDASGDHATVMLRVDTDVPDDVRAAIADAVGASTLEVVDLS
Mvan_2128|M.vanbaalenii_PYR-1 AAQLSQDADGIGATVMLRLDREVPGEVLAAIGRDVNAVTLEVVDLT
MAB_3304c|M.abscessus_ATCC_199 AAQLSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
MLBr_01692|M.leprae_Br4923 AAQLSEDTEGPGATILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
TH_2037|M.thermoresistible__bu AAQLSQDISGDGATLMLRVNRDVPADVRDAIGAAVGASTLEVVDLS
Mflv_0334|M.gilvum_PYR-GCK ----------------------------------------------
MUL_0823|M.ulcerans_Agy99 ----------------------------------------------
MMAR_1065|M.marinum_M ----------------------------------------------
MAV_4438|M.avium_104 ----------------------------------------------
Mb0749c|M.bovis_AF2122/97 ----------------------------------------------
Rv0728c|M.tuberculosis_H37Rv ----------------------------------------------