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M. thermoresistible (build 8) TH_2037 (serA)

annotation: PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH)
coordinates: 4002574 - 4004160
length: 529

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2037serA-100% (529)PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH)
M. thermoresistible (build 8)TH_3809-2e-4238.85% (260) PUTATIVE putative D-3-phosphoglycerate dehydrogenase
M. thermoresistible (build 8)TH_3383-2e-4134.92% (295) PUTATIVE D-isomer specific 2-hydroxyacid dehydrogenase,

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3020cserA10.080.11% (528) D-3-phosphoglycerate dehydrogenase
M. gilvum PYR-GCKMflv_4234-0.082.39% (528) D-3-phosphoglycerate dehydrogenase
M. tuberculosis H37RvRv2996cserA10.080.11% (528) D-3-phosphoglycerate dehydrogenase
M. leprae Br4923MLBr_01692serA0.079.55% (528) D-3-phosphoglycerate dehydrogenase
M. abscessus ATCC 19977MAB_3304c-0.078.78% (523) D-3-phosphoglycerate dehydrogenase
M. marinum MMMAR_1715serA10.079.73% (528) D-3-phosphoglycerate dehydrogenase SerA1
M. avium 104MAV_3847serA0.083.52% (528) D-3-phosphoglycerate dehydrogenase
M. smegmatis MC2 155MSMEG_2378serA0.082.95% (528) D-3-phosphoglycerate dehydrogenase
M. ulcerans Agy99MUL_1952serA10.079.73% (528) D-3-phosphoglycerate dehydrogenase
M. vanbaalenii PYR-1Mvan_2128-0.082.01% (528) D-3-phosphoglycerate dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4234|M.gilvum_PYR-GCK          MSLPVVLIADKLAQSTVEALGDQVEVRWVDGPDREKLLAAVADADALLVR
Mvan_2128|M.vanbaalenii_PYR-1       MSLPVVLIADKLAQSTVEALGDQVEVRWVDGPDREKLLAAVADADALLVR
MAB_3304c|M.abscessus_ATCC_199      -----MLIADKLAPSTVEALGDGVEVRWVDGPDRPALLAAVPEADALLVR
MSMEG_2378|M.smegmatis_MC2_155      MSLPVVLIADKLAESTVAALGDEVEVRWVDGPDRAKLLAAVPEADALLVR
Mb3020c|M.bovis_AF2122/97           MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVR
Rv2996c|M.tuberculosis_H37Rv        MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVR
MLBr_01692|M.leprae_Br4923          MDLPVVLIADKLAQSTVAALGDQVEVRWVDGPDRTKLLAAVPEADALLVR
MMAR_1715|M.marinum_M               MNLPVVLIADKLAQSTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVR
MUL_1952|M.ulcerans_Agy99           MNLPVVLIADKLAQSTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVR
MAV_3847|M.avium_104                MNLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVR
TH_2037|M.thermoresistible__bu      VSLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVADADALLVR
                                         :******* *** **** ***********  *****.:*******

Mflv_4234|M.gilvum_PYR-GCK          SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
Mvan_2128|M.vanbaalenii_PYR-1       SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
MAB_3304c|M.abscessus_ATCC_199      SATTVDAEVLAAGTKLKIVARAGVGLDNVDVKAATARGVLVVNAPTSNIH
MSMEG_2378|M.smegmatis_MC2_155      SATTVDAEVIAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
Mb3020c|M.bovis_AF2122/97           SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
Rv2996c|M.tuberculosis_H37Rv        SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
MLBr_01692|M.leprae_Br4923          SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
MMAR_1715|M.marinum_M               SATTVDAEVLAAATKLKIVARAGVGLDNVDVDAATTRGVLVVNAPTSNIH
MUL_1952|M.ulcerans_Agy99           SATTVDAEVLAAATKLKIVARAGVGLDNVDVDAATTRGVLVVNAPTSNIH
MAV_3847|M.avium_104                SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATERGVLVVNAPTSNIH
TH_2037|M.thermoresistible__bu      SATTVDAEVLAAAPKLKIVARAGVGLDNVDVEAATARGVLVVNAPTSNIH
                                    *********:**..*****************.*** **************

Mflv_4234|M.gilvum_PYR-GCK          SAAEHALALLLSTARQIPAADATLREHTWKRSAFSGTEIFGKTVGVVGLG
Mvan_2128|M.vanbaalenii_PYR-1       SAAEHALALLLAAARQIPAADATLREHSWKRSSFSGTEIFGKTVGVVGLG
MAB_3304c|M.abscessus_ATCC_199      SAAEHAVTLLLATARQIPAADASLKAHTWKRSSFNGTEIFGKTVGVVGLG
MSMEG_2378|M.smegmatis_MC2_155      SAAEHAIALLLATARQIPAADATLRERSWKRSSFSGTEIFGKTVGVVGLG
Mb3020c|M.bovis_AF2122/97           SAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLG
Rv2996c|M.tuberculosis_H37Rv        SAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLG
MLBr_01692|M.leprae_Br4923          SAAEHALALLLAASRQIAEADASLRAHIWKRSSFSGTEIFGKTVGVVGLG
MMAR_1715|M.marinum_M               SAAEHAMALLLAAARQIPAADASLREHTWKRSSFSGAEIFGKTVGVVGLG
MUL_1952|M.ulcerans_Agy99           SAAEHAMALLLAAARQIPAADASLREHTWKRSSFSGAEIFGKTVGVVGLG
MAV_3847|M.avium_104                SAAEHALALLLAAAREIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLG
TH_2037|M.thermoresistible__bu      SAAEHAIALLLAAARQIPAADATLRQRTWKRSEFSGVEIYDKTVGVVGLG
                                    ******::***:::*:*. ***:*: : **** *.*.**:.*********

Mflv_4234|M.gilvum_PYR-GCK          RIGQLVAQRLAAFGAHITAYDPYVSHARAAQLGIELLTLDELLSRADFIS
Mvan_2128|M.vanbaalenii_PYR-1       RIGQLVAQRLAAFGAHITAYDPYVSHARAAQLGIELLTLDELLGRADFIS
MAB_3304c|M.abscessus_ATCC_199      RIGQLFAQRLAAFGTHIVAYDPYVSAARAAQLGIELLTLDELLGRADFIS
MSMEG_2378|M.smegmatis_MC2_155      RIGQLVAQRLAAFGAHIVAYDPYVSQARAAQLGIELLPLDDLLARADFIS
Mb3020c|M.bovis_AF2122/97           RIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFIS
Rv2996c|M.tuberculosis_H37Rv        RIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFIS
MLBr_01692|M.leprae_Br4923          RIGQLVAARIAAFGAHVIAYDPYVAPARAAQLGIELMSFDDLLARADFIS
MMAR_1715|M.marinum_M               RIGQLVAQRVEAFGAHVVAYDPYVSPARAAQLGIELLPLDDLLARADFIS
MUL_1952|M.ulcerans_Agy99           RIGQLVAQRVEAFGAHVVAYDPYVSPARAAQLGIELLPLDDLLARADFIS
MAV_3847|M.avium_104                RIGQLVAQRLSAFGTHLIAYDPYVSPARAAQLGIELLSLDELLARADFIS
TH_2037|M.thermoresistible__bu      RIGQLVAQRLAAFGTHLIAYDPYVSPARAAQLGIELVDLDELLGRADIIS
                                    *****.* *: ***::: ******: **********: :*:**.***:**

Mflv_4234|M.gilvum_PYR-GCK          VHLPKTKETAGLIGTEALAKTKPGVIIVNAARGGLIDEQALADAITSGHV
Mvan_2128|M.vanbaalenii_PYR-1       VHLPKTKETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAINSGHV
MAB_3304c|M.abscessus_ATCC_199      VHLPKTPETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAIRSGHV
MSMEG_2378|M.smegmatis_MC2_155      VHLPKTKETAGLLGKEALAKTKKGVIIVNAARGGLIDEQALADAITSGHV
Mb3020c|M.bovis_AF2122/97           VHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHV
Rv2996c|M.tuberculosis_H37Rv        VHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHV
MLBr_01692|M.leprae_Br4923          VHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADAVRSGHV
MMAR_1715|M.marinum_M               VHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAEAITSGHV
MUL_1952|M.ulcerans_Agy99           VHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAEAITSGYV
MAV_3847|M.avium_104                VHLPKTPETAGLIDKDALAKTKPGVIIVNAARGGLVDEAALADAVRSGHV
TH_2037|M.thermoresistible__bu      VHLPKTPETAGLIGADALAKVKPGVIIVNAARGGLIDEQALADAIISGRV
                                    ****** *****:. :****.* ************:** ***:*: .* *

Mflv_4234|M.gilvum_PYR-GCK          RGAGLDVFSTEPCTDSPLFELPQVVVTPHLGASTVEAQDRAGTDVAASVK
Mvan_2128|M.vanbaalenii_PYR-1       RGAGLDVFSTEPCTDSPLFELPQVVVTPHLGASTVEAQDRAGTDVAASVK
MAB_3304c|M.abscessus_ATCC_199      RGAGLDVFSTEPCTDSPLFELDQVVVTPHLGASTSEAQDRAGTDVAASVQ
MSMEG_2378|M.smegmatis_MC2_155      RGAGLDVYATEPCTDSPLFDLPQVVVTPHLGASTAEAQDRAGTDVAASVK
Mb3020c|M.bovis_AF2122/97           RAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVR
Rv2996c|M.tuberculosis_H37Rv        RAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVR
MLBr_01692|M.leprae_Br4923          RAAGLDVFATEPCTDSPLFELSQVVVTPHLGASTAEAQDRAGTDVAESVR
MMAR_1715|M.marinum_M               RGAGLDVFATEPCTDSPLFELPQVVVTPHLGASTAEAQDRAGTDVAASVK
MUL_1952|M.ulcerans_Agy99           RGAGLDVFATEPCTDSPLFELPQVVVTPHLGASTAEAQDRAGTDVAASVK
MAV_3847|M.avium_104                RAAGLDVFSKEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDVAASVK
TH_2037|M.thermoresistible__bu      RAAGIDVFAKEPCTDSPLFDLPQVVVTPHLGASTVEAQDRAGTDVAASVK
                                    *.**:**::.*********:* ************ *********** **:

Mflv_4234|M.gilvum_PYR-GCK          LALAGEFVPDAVNVGGGAVGEEVAPWLDLVRKLGLLVGALSAELPTNLCV
Mvan_2128|M.vanbaalenii_PYR-1       LALAGEFVPDAVNVGGGAVGEEVAPWLDLVRKLGLLVGVLSSEPPVSLQV
MAB_3304c|M.abscessus_ATCC_199      LALAGEFVPDAVNVGGGVVSEEVAPWLEVVRKLGVLIGAVSEQLPTSLSV
MSMEG_2378|M.smegmatis_MC2_155      LALAGEFVPDAVNVGGGVVGEEVAPWLELVRKLGLLVGALADAPPVSLQV
Mb3020c|M.bovis_AF2122/97           LALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSV
Rv2996c|M.tuberculosis_H37Rv        LALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSV
MLBr_01692|M.leprae_Br4923          LALAGEFVPDAVNVDGGVVNEEVAPWLDLVCKLGVLVAALSDELPASLSV
MMAR_1715|M.marinum_M               LALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSDEPPVSLSV
MUL_1952|M.ulcerans_Agy99           LALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSDEPPVSLSV
MAV_3847|M.avium_104                LALAGEFVPDAVNVAGGTVNEEVAPWLDLVRKLGLLAATLSDGPPVSLSV
TH_2037|M.thermoresistible__bu      LALAGEFVPDAVNVGAGEVSEEVAPWVDLARKLGLLVGTLSGEPTATLQV
                                    *************: .* *.******:::. ***:* ..::   ...* *

Mflv_4234|M.gilvum_PYR-GCK          QVRGELASEEVEVLRLSALRGLFSAVIEDQVTFVNAPALATERGVEASID
Mvan_2128|M.vanbaalenii_PYR-1       QVQGELASEEVEVLKLSALRGLFSAVIEHPVTFVNAPALASERGVEASIT
MAB_3304c|M.abscessus_ATCC_199      DVRGELASEDVAVLKLSALRGLFSSVIEDQVTFVNAPSIAEERGVSAEIT
MSMEG_2378|M.smegmatis_MC2_155      QVRGELASEDVEILKLSALRGLFSAVVDEQVTFVNAPALAADRGVTAEIS
Mb3020c|M.bovis_AF2122/97           QVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEIC
Rv2996c|M.tuberculosis_H37Rv        QVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEIC
MLBr_01692|M.leprae_Br4923          HVRGELASEDVEILRLSALRGLFSTVIEDAVTFVNAPALAAERGVSAEIT
MMAR_1715|M.marinum_M               QARGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAERGVSVEIS
MUL_1952|M.ulcerans_Agy99           QAGGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAERGVSVEIS
MAV_3847|M.avium_104                QVRGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAEERGVTAEIS
TH_2037|M.thermoresistible__bu      RVAGELASEDVEVLRLSALRGLFSTLTDQQVTYVNAPTLAAERGMQAELE
                                     . ****:*:* :*:*********:: :  **:****::* :**: ..: 

Mflv_4234|M.gilvum_PYR-GCK          TESESPNHRSVVDVRAVAADGSTVNVSGTLTGPQLVEKIVQINGRNLDLR
Mvan_2128|M.vanbaalenii_PYR-1       TATESANHRSVVDVRAVAADGSTVNVAGTLTGPQLVEKIVQINGRNLELR
MAB_3304c|M.abscessus_ATCC_199      TATESPNHRSVVDVRAVYADGSVINVAGTLSGPQLVQKIVQINGRNFDLR
MSMEG_2378|M.smegmatis_MC2_155      TATESPNHRSVVDVRAVHADGSSINVAGTLSGPQLVEKIVQINGRNFDLR
Mb3020c|M.bovis_AF2122/97           KASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLR
Rv2996c|M.tuberculosis_H37Rv        KASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLR
MLBr_01692|M.leprae_Br4923          TGSESPNHRSVVDVRAVASDGSVVNIAGTLSGPQLVQKIVQVNGRNFDLR
MMAR_1715|M.marinum_M               KASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQINGRHFDLR
MUL_1952|M.ulcerans_Agy99           KASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQINGRHFDLR
MAV_3847|M.avium_104                TASESPNHRSVVDVRAVSHDGTVVNVAGTLSGPQLVEKIVQINGRNFDLR
TH_2037|M.thermoresistible__bu      KVSESPNYRSVVDVRAVSTDGTVTNVAGTLSGPQQVEKIVQINGRNFDLR
                                    . :**.*:*******.*  **:  .::*** *.*  .****:***:::**

Mflv_4234|M.gilvum_PYR-GCK          AEGVNVIINYHDQPGALGKIGTLLGGANVNILAAQLSQDADGEGATIMLR
Mvan_2128|M.vanbaalenii_PYR-1       AEGVNLIINYDDQPGALGKIGTLLGGAAVNILAAQLSQDADGIGATVMLR
MAB_3304c|M.abscessus_ATCC_199      AEGVNLVINYADVPGALGKIGTVLGGAEVNIQAAQLSQDASGAAATIILR
MSMEG_2378|M.smegmatis_MC2_155      AEGHNLIVNYSDKPGALGKIGTLLGGANVNILAAQLSQDASGDHATVMLR
Mb3020c|M.bovis_AF2122/97           AQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLR
Rv2996c|M.tuberculosis_H37Rv        AQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLR
MLBr_01692|M.leprae_Br4923          AQGMNLVIRYVDQPGALGKIGTLLGAAGVNIQAAQLSEDTEGPGATILLR
MMAR_1715|M.marinum_M               AEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPGATVLLR
MUL_1952|M.ulcerans_Agy99           AEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPGATVLLR
MAV_3847|M.avium_104                ARGINLVINYVDQPGALGKIGTLLGSAGVNIQAAQLSEDAEGPGATILLR
TH_2037|M.thermoresistible__bu      AEGVNLVMHYVDRPGALGKIGTLLGAADVNILAAQLSQDISGDGATLMLR
                                    *.* *:::.* * *********:** * *** *****:* .*  **::**

Mflv_4234|M.gilvum_PYR-GCK          VDREVPADVLAGIGRDVNALTLEVVDLT
Mvan_2128|M.vanbaalenii_PYR-1       LDREVPGEVLAAIGRDVNAVTLEVVDLT
MAB_3304c|M.abscessus_ATCC_199      IDRTAPDAVLDEIRAAVGATTLELVDLS
MSMEG_2378|M.smegmatis_MC2_155      VDTDVPDDVRAAIADAVGASTLEVVDLS
Mb3020c|M.bovis_AF2122/97           LDQDVPDDVRTAIAAAVDAYKLEVVDLS
Rv2996c|M.tuberculosis_H37Rv        LDQDVPDDVRTAIAAAVDAYKLEVVDLS
MLBr_01692|M.leprae_Br4923          LDQDVPGDVRSAIVAAVSANKLEVVNLS
MMAR_1715|M.marinum_M               LDQDVPEDVRSAIAAAVGANRLEVVDLS
MUL_1952|M.ulcerans_Agy99           LDQDVPEDVRSAIAAAVGANRLEVVDLS
MAV_3847|M.avium_104                LDQDVPADVRSAIGAAVGANKLEVVDLS
TH_2037|M.thermoresistible__bu      VNRDVPADVRDAIGAAVGASTLEVVDLS
                                    ::  .*  *   *   *.*  **:*:*: