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RSRPRALVTAPLRGSGLDKLRQLVDVVYDPWIGELEGGPLRIYSAEQLAERITSESVDIVVVEADSVSGA VLQLGLRAIFSTRGDPNNVDIAGATAAGIPVLNTPARNADAVAEMTVALLLASTRHLLTADADVRSGNIF HDGTIPYQRFRGWEIAGRTAGLVGLGAVGRATAWRLTGLGLRVIAHDPYCADARHGLAELLAESDIVSLH APVTDDTVGMIGAQQFASMRDGAVFLNTARAQLHDTDALVQALRAGKVAAAGLDHFVGEWLPTDHPLASM PNVVLTPHIGGATWNTEARQAQMVADGLQALLSGTRPTHILNPEVLAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1065 | serA2 | - | 100% (329) | D-3-phosphoglycerate dehydrogenase SerA2 |
| M. marinum M | MMAR_1715 | serA1 | 1e-40 | 36.67% (270) | D-3-phosphoglycerate dehydrogenase SerA1 |
| M. marinum M | MMAR_0531 | serA3 | 8e-37 | 39.08% (261) | D-3-phosphoglycerate dehydrogenase SerA3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0749c | serA2 | 1e-147 | 79.51% (327) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0334 | - | 2e-41 | 40.80% (250) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0728c | serA2 | 1e-146 | 79.20% (327) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 6e-41 | 37.78% (270) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 3e-41 | 37.78% (270) | D-3-phosphoglycerate dehydrogenase |
| M. avium 104 | MAV_4438 | - | 1e-154 | 82.98% (329) | 2-hydroxyacid dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2378 | serA | 2e-40 | 38.56% (236) | D-3-phosphoglycerate dehydrogenase |
| M. thermoresistible (build 8) | TH_2037 | serA | 7e-42 | 40.68% (236) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_0823 | serA2 | 0.0 | 99.09% (329) | D-3-phosphoglycerate dehydrogenase SerA2 |
| M. vanbaalenii PYR-1 | Mvan_0404 | - | 2e-40 | 39.20% (250) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3304c|M.abscessus_ATCC_199 ------MLIADKLAPSTVEALG---DGVEVRWVD--GPDRPALLAAVPEA
MSMEG_2378|M.smegmatis_MC2_155 -MSLPVVLIADKLAESTVAALG---DEVEVRWVD--GPDRAKLLAAVPEA
MLBr_01692|M.leprae_Br4923 -MDLPVVLIADKLAQSTVAALG---DQVEVRWVD--GPDRTKLLAAVPEA
TH_2037|M.thermoresistible__bu -VSLPVVLIADKLAESTVAALG---DQVEVRWVD--GPDREKLLAAVADA
Mflv_0334|M.gilvum_PYR-GCK -MRVLAHFLPG---PKVTEFLSPHTDWLDIRYCA--EDDDETFYRELPDA
Mvan_0404|M.vanbaalenii_PYR-1 -MRVLAHFVPGGPDSKVIEFLAPCRDWLDVRFCA--EDDDDTFYRELADA
MMAR_1065|M.marinum_M MRSRPRALVTAPLRGSGLDKLRQLVDVVYDPWIGELEGGPLRIYSAEQLA
MUL_0823|M.ulcerans_Agy99 MRSRPRALVTAPLRGSGLDKLRQLVDVVYDPWIGGLEGGPLRIYSAEQLA
MAV_4438|M.avium_104 MTSKPRALVTAPLRGPGLDKLRALAEVVYDPWI---EQRPLRIYSAEQLA
Mb0749c|M.bovis_AF2122/97 MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWI---DQRPLRIYSAEQLA
Rv0728c|M.tuberculosis_H37Rv MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWI---DQRPLRIYSAEQLA
::. * : : : : *
MAB_3304c|M.abscessus_ATCC_199 DALLVRSATTVDAEV-----LAAGTKLKIVARAGVGLDNVDVKAATARGV
MSMEG_2378|M.smegmatis_MC2_155 DALLVRSATTVDAEV-----IAAAPKLKIVARAGVGLDNVDVDAATARGV
MLBr_01692|M.leprae_Br4923 DALLVRSATTVDAEV-----LAAAPKLKIVARAGVGLDNVDVDAATARGV
TH_2037|M.thermoresistible__bu DALLVRSATTVDAEV-----LAAAPKLKIVARAGVGLDNVDVEAATARGV
Mflv_0334|M.gilvum_PYR-GCK EVIWH-VLRPISGDD-----LSKAPKLRLVHKLGAGVNTVDVDTATARGI
Mvan_0404|M.vanbaalenii_PYR-1 EVIWH-VLRPLSGED-----LARAPRLRLVHKLGAGVNTIDVDAATARGV
MMAR_1065|M.marinum_M ERITSESVDIVVVEADSVSGAVLQLGLRAIFSTRGDPNNVDIAGATAAGI
MUL_0823|M.ulcerans_Agy99 ERITSESVDIVVVEADSVSGAVLQLGLRAIFSTRGDPNNVDIAGATAAGI
MAV_4438|M.avium_104 ERIAAEEAEIVVVESDSVRGPVFELGVRAIAATRGDPNNVDIDGATAAGI
Mb0749c|M.bovis_AF2122/97 DRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGI
Rv0728c|M.tuberculosis_H37Rv DRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGI
: : : : :: : . ..:*: *** *:
MAB_3304c|M.abscessus_ATCC_199 LVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLKAHTWKRSSFNG---
MSMEG_2378|M.smegmatis_MC2_155 LVVNAPTSNIHSAAEHAIALLLATARQIPAADATLRERSWKRSSFSG---
MLBr_01692|M.leprae_Br4923 LVVNAPTSNIHSAAEHALALLLAASRQIAEADASLRAHIWKRSSFSG---
TH_2037|M.thermoresistible__bu LVVNAPTSNIHSAAEHAIALLLAAARQIPAADATLRQRTWKRSEFSG---
Mflv_0334|M.gilvum_PYR-GCK AVANMPGANAPSVAEGTLLLMLAALRRLPELDRATRTGNGWPSDPTLGES
Mvan_0404|M.vanbaalenii_PYR-1 AVANMPGANAESVAEGTLLLMLAALRRLPVLDRATREGRGWPSDPTLGET
MMAR_1065|M.marinum_M PVLNTPARNADAVAEMTVALLLASTRHLLTADADVRSGNIFHDGTIPYQR
MUL_0823|M.ulcerans_Agy99 PVLNTPARNADAVAEMTVALLLASTRHLLTADADVRSGNIFRDGTIPYQR
MAV_4438|M.avium_104 PVLNTPGRNADAVAEMTVALLLAATRHLLPADADVRGGNIFRDGSIPYQR
Mb0749c|M.bovis_AF2122/97 PVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQR
Rv0728c|M.tuberculosis_H37Rv PVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQR
* : * * :.** :: *:** *:: * : .
MAB_3304c|M.abscessus_ATCC_199 ---TEIFGKTVGVVGLGRIGQLFAQRLAAFGTHIVAYDPYVSAARAAQLG
MSMEG_2378|M.smegmatis_MC2_155 ---TEIFGKTVGVVGLGRIGQLVAQRLAAFGAHIVAYDPYVSQARAAQLG
MLBr_01692|M.leprae_Br4923 ---TEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLG
TH_2037|M.thermoresistible__bu ---VEIYDKTVGVVGLGRIGQLVAQRLAAFGTHLIAYDPYVSPARAAQLG
Mflv_0334|M.gilvum_PYR-GCK V--RDLGGCTVGLVGYGNIAKQVERILLAIGAEVVHTSTRDDGLPGWRT-
Mvan_0404|M.vanbaalenii_PYR-1 V--RDIGGCTVGLVGYGNIAKQVERILVAMGADVIHTSTRDDGSAGWRS-
MMAR_1065|M.marinum_M FRGWEIAGRTAGLVGLGAVGRATAWRLTGLGLRVIAHDPYCADAR-----
MUL_0823|M.ulcerans_Agy99 FRGWEIAGRTAGLVGLGAVGRATAWRLTGLGLWVIAHDPYCADAR-----
MAV_4438|M.avium_104 FRGGEIAGLTAGLVGLGAVGRATRWRLSGLGLRVIAHDPYHPEAR-----
Mb0749c|M.bovis_AF2122/97 FRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAG-----
Rv0728c|M.tuberculosis_H37Rv FRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAG-----
:: . *.*:** * :.: : .:* :: ..
MAB_3304c|M.abscessus_ATCC_199 IELLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARG
MSMEG_2378|M.smegmatis_MC2_155 IELLPLDDLLARADFISVHLPKTKETAGLLGKEALAKTKKGVIIVNAARG
MLBr_01692|M.leprae_Br4923 IELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARG
TH_2037|M.thermoresistible__bu IELVDLDELLGRADIISVHLPKTPETAGLIGADALAKVKPGVIIVNAARG
Mflv_0334|M.gilvum_PYR-GCK -----LPDLLSESDIVSLHLPLTGATEGLLGRKALAQMKTDAVLVNTSRG
Mvan_0404|M.vanbaalenii_PYR-1 -----LPDLLSACDIVSLHLPLTDATAGLLGRDALARMKSDAVLVNTSRG
MMAR_1065|M.marinum_M ---HGLAELLAESDIVSLHAPVTDDTVGMIGAQQFASMRDGAVFLNTARA
MUL_0823|M.ulcerans_Agy99 ---HGLAELLAESDIVSLHAPVTDDTVGMIGAQQFASMRDGAVFLNTARA
MAV_4438|M.avium_104 ---HGLDELLAESDVVSLHAPVTDETTGMIGAEQFAAMRDGVVFLNTARA
Mb0749c|M.bovis_AF2122/97 ---HSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARS
Rv0728c|M.tuberculosis_H37Rv ---HSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARS
: :**. .*.:*:* . * * *::. . :* : ..:::*::*.
MAB_3304c|M.abscessus_ATCC_199 GLIDEAALADAIRSGHVRGAGLDVFSTEPCT-DSPLFELDQVVVTPHLGA
MSMEG_2378|M.smegmatis_MC2_155 GLIDEQALADAITSGHVRGAGLDVYATEPCT-DSPLFDLPQVVVTPHLGA
MLBr_01692|M.leprae_Br4923 GLVDEVALADAVRSGHVRAAGLDVFATEPCT-DSPLFELSQVVVTPHLGA
TH_2037|M.thermoresistible__bu GLIDEQALADAIISGRVRAAGIDVFAKEPCT-DSPLFDLPQVVVTPHLGA
Mflv_0334|M.gilvum_PYR-GCK AIVDEAALVDALRAGTLAAAGLDVFAVEPVPSDNPLLGLPNVVLTPHVTW
Mvan_0404|M.vanbaalenii_PYR-1 PIVDEEALADALRTGKLAAAGLDVFAVEPVPADNPLLRLPNVVLTPHVTW
MMAR_1065|M.marinum_M QLHDTDALVQALRAGKVAAAGLDHFVGEWLPTDHPLASMPNVVLTPHIGG
MUL_0823|M.ulcerans_Agy99 QLHDTDALVQALRAGKVAAAGLDHFVGEWLPTDHPLASMPNVVLTPHIGG
MAV_4438|M.avium_104 QLHDTDALVEALRAGKVAAAGLDHFVGEWLPTDHPLVGMPNVVLTPHIGG
Mb0749c|M.bovis_AF2122/97 QLHDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGG
Rv0728c|M.tuberculosis_H37Rv QLRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGG
: * **.:*: * : .**:* : * . * ** : :**:***:
MAB_3304c|M.abscessus_ATCC_199 STSEAQDRAGTDVAASVQLALAGEFVPDAVNVGGGVVSEEVAPWLEVVRK
MSMEG_2378|M.smegmatis_MC2_155 STAEAQDRAGTDVAASVKLALAGEFVPDAVNVGGGVVGEEVAPWLELVRK
MLBr_01692|M.leprae_Br4923 STAEAQDRAGTDVAESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLVCK
TH_2037|M.thermoresistible__bu STVEAQDRAGTDVAASVKLALAGEFVPDAVNVGAGEVSEEVAPWVDLARK
Mflv_0334|M.gilvum_PYR-GCK YTADTMRRYLEFALDNCERLRDGRALAHVVNDPSG---------------
Mvan_0404|M.vanbaalenii_PYR-1 YTADTMRRYLEFAVDNCERLRDGRNLVNVVNDVAG---------------
MMAR_1065|M.marinum_M ATWNTEARQAQMVADGLQALLSGTRPTHILNPEVLAR-------------
MUL_0823|M.ulcerans_Agy99 ATWNTEARQAQMVADGLQALLSGTRPTHILNPEVLAR-------------
MAV_4438|M.avium_104 ATWNTEARQAQLVADDLEALLAGATPAHIVNPEVLAR-------------
Mb0749c|M.bovis_AF2122/97 ATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS-------------
Rv0728c|M.tuberculosis_H37Rv ATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS-------------
* :: * . . * . :*
MAB_3304c|M.abscessus_ATCC_199 LGVLIGAVSEQLPTSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQVT
MSMEG_2378|M.smegmatis_MC2_155 LGLLVGALADAPPVSLQVQVRGELASEDVEILKLSALRGLFSAVVDEQVT
MLBr_01692|M.leprae_Br4923 LGVLVAALSDELPASLSVHVRGELASEDVEILRLSALRGLFSTVIEDAVT
TH_2037|M.thermoresistible__bu LGLLVGTLSGEPTATLQVRVAGELASEDVEVLRLSALRGLFSTLTDQQVT
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3304c|M.abscessus_ATCC_199 FVNAPSIAEERGVSAEITTATESPNHRSVVDVRAVYADGSVINVAGTLSG
MSMEG_2378|M.smegmatis_MC2_155 FVNAPALAADRGVTAEISTATESPNHRSVVDVRAVHADGSSINVAGTLSG
MLBr_01692|M.leprae_Br4923 FVNAPALAAERGVSAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTLSG
TH_2037|M.thermoresistible__bu YVNAPTLAAERGMQAELEKVSESPNYRSVVDVRAVSTDGTVTNVAGTLSG
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3304c|M.abscessus_ATCC_199 PQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQ
MSMEG_2378|M.smegmatis_MC2_155 PQLVEKIVQINGRNFDLRAEGHNLIVNYSDKPGALGKIGTLLGGANVNIL
MLBr_01692|M.leprae_Br4923 PQLVQKIVQVNGRNFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVNIQ
TH_2037|M.thermoresistible__bu PQQVEKIVQINGRNFDLRAEGVNLVMHYVDRPGALGKIGTLLGAADVNIL
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3304c|M.abscessus_ATCC_199 AAQLSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
MSMEG_2378|M.smegmatis_MC2_155 AAQLSQDASGDHATVMLRVDTDVPDDVRAAIADAVGASTLEVVDLS
MLBr_01692|M.leprae_Br4923 AAQLSEDTEGPGATILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
TH_2037|M.thermoresistible__bu AAQLSQDISGDGATLMLRVNRDVPADVRDAIGAAVGASTLEVVDLS
Mflv_0334|M.gilvum_PYR-GCK ----------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 ----------------------------------------------
MMAR_1065|M.marinum_M ----------------------------------------------
MUL_0823|M.ulcerans_Agy99 ----------------------------------------------
MAV_4438|M.avium_104 ----------------------------------------------
Mb0749c|M.bovis_AF2122/97 ----------------------------------------------
Rv0728c|M.tuberculosis_H37Rv ----------------------------------------------