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TPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVVESDSVGGPVFE RGLRVVAATRGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDG TIPYQRFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLAEADIVSMHAAV TDDTIGMIGAQQFAAMRDGAVFLNTARSQLRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNV VLTPHIGGATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0728c | serA2 | - | 100% (326) | POSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA2 (PHOSPHOGLYCERATE DEHYDROGENASE) (PGDH) |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 1e-40 | 38.27% (277) | D-3-phosphoglycerate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0749c | serA2 | 0.0 | 99.69% (326) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0334 | - | 4e-42 | 41.60% (250) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. leprae Br4923 | MLBr_01692 | serA | 1e-40 | 38.33% (287) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 9e-41 | 36.13% (310) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_1065 | serA2 | 1e-146 | 79.20% (327) | D-3-phosphoglycerate dehydrogenase SerA2 |
| M. avium 104 | MAV_4438 | - | 1e-154 | 82.10% (324) | 2-hydroxyacid dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_0604 | - | 5e-42 | 41.43% (251) | glyoxylate reductase |
| M. thermoresistible (build 8) | TH_2037 | serA | 3e-42 | 38.13% (299) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_0823 | serA2 | 1e-145 | 79.20% (327) | D-3-phosphoglycerate dehydrogenase SerA2 |
| M. vanbaalenii PYR-1 | Mvan_0404 | - | 1e-41 | 40.80% (250) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0334|M.gilvum_PYR-GCK -------MRVLAHFLPG---PKVTEFLSPHTDWL---DIRYCAEDDDETF
Mvan_0404|M.vanbaalenii_PYR-1 -------MRVLAHFVPGGPDSKVIEFLAPCRDWL---DVRFCAEDDDDTF
MSMEG_0604|M.smegmatis_MC2_155 MAVNPGTVRVLAHFAPS---NTVLDFLAPHLDWL---DVRFCGEEDDETF
Rv0728c|M.tuberculosis_H37Rv -MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWI---DQRPLRIYSAEQL
Mb0749c|M.bovis_AF2122/97 -MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWI---DQRPLRIYSAEQL
MMAR_1065|M.marinum_M -MRSRPRALVTAPLRGSGLDKLRQLVDVVYDPWIGELEGGPLRIYSAEQL
MUL_0823|M.ulcerans_Agy99 -MRSRPRALVTAPLRGSGLDKLRQLVDVVYDPWIGGLEGGPLRIYSAEQL
MAV_4438|M.avium_104 -MTSKPRALVTAPLRGPGLDKLRALAEVVYDPWI---EQRPLRIYSAEQL
MLBr_01692|M.leprae_Br4923 --MDLPVVLIADKLAQSTVAALGDQVEVRWVDGP----------DRTKLL
MAB_3304c|M.abscessus_ATCC_199 -------MLIADKLAPSTVEALGDGVEVRWVDGP----------DRPALL
TH_2037|M.thermoresistible__bu --VSLPVVLIADKLAESTVAALGDQVEVRWVDGP----------DREKLL
: : :
Mflv_0334|M.gilvum_PYR-GCK YRELPDAEVIWHVLRPISGDDLSKAPKLRLVHKLGAGVNTVDVDTATARG
Mvan_0404|M.vanbaalenii_PYR-1 YRELADAEVIWHVLRPLSGEDLARAPRLRLVHKLGAGVNTIDVDAATARG
MSMEG_0604|M.smegmatis_MC2_155 YRELGDADVLWHVLRPITGDDLNRAPRLRLVHKLGAGVNTIDVETATQLG
Rv0728c|M.tuberculosis_H37Rv ADRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAG
Mb0749c|M.bovis_AF2122/97 ADRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAG
MMAR_1065|M.marinum_M AERITSESVDIVVVEADSVSGAVLQLGLRAIFSTRGDPNNVDIAGATAAG
MUL_0823|M.ulcerans_Agy99 AERITSESVDIVVVEADSVSGAVLQLGLRAIFSTRGDPNNVDIAGATAAG
MAV_4438|M.avium_104 AERIAAEEAEIVVVESDSVRGPVFELGVRAIAATRGDPNNVDIDGATAAG
MLBr_01692|M.leprae_Br4923 AAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARG
MAB_3304c|M.abscessus_ATCC_199 AAVPEADALLVRSATTVDAEVLAAGTKLKIVARAGVGLDNVDVKAATARG
TH_2037|M.thermoresistible__bu AAVADADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVEAATARG
. :: : . ..:*: ** *
Mflv_0334|M.gilvum_PYR-GCK IAVANMPGANAPSVAEGTLLLMLAALRRLPELDRATRTGNGWPSDPTLGE
Mvan_0404|M.vanbaalenii_PYR-1 VAVANMPGANAESVAEGTLLLMLAALRRLPVLDRATREGRGWPSDPTLGE
MSMEG_0604|M.smegmatis_MC2_155 ILVANMPGANAPSVAEGTVLLMLAALRRLPQLDRATRAGRGWPTDPTLGD
Rv0728c|M.tuberculosis_H37Rv IPVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQ
Mb0749c|M.bovis_AF2122/97 IPVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQ
MMAR_1065|M.marinum_M IPVLNTPARNADAVAEMTVALLLASTRHLLTADADVRSGNIFHDGTIPYQ
MUL_0823|M.ulcerans_Agy99 IPVLNTPARNADAVAEMTVALLLASTRHLLTADADVRSGNIFRDGTIPYQ
MAV_4438|M.avium_104 IPVLNTPGRNADAVAEMTVALLLAATRHLLPADADVRGGNIFRDGSIPYQ
MLBr_01692|M.leprae_Br4923 VLVVNAPTSNIHSAAEHALALLLAASRQIAEADASLRAHIWKRS------
MAB_3304c|M.abscessus_ATCC_199 VLVVNAPTSNIHSAAEHAVTLLLATARQIPAADASLKAHTWKRS------
TH_2037|M.thermoresistible__bu VLVVNAPTSNIHSAAEHAIALLLAAARQIPAADATLRQRTWKRS------
: * : * * :.** :: *:** *:: * :
Mflv_0334|M.gilvum_PYR-GCK SVR--DLGGCTVGLVGYGNIAKQVERILLAIGAE-VVHTSTRDDGLPG--
Mvan_0404|M.vanbaalenii_PYR-1 TVR--DIGGCTVGLVGYGNIAKQVERILVAMGAD-VIHTSTRDDGSAG--
MSMEG_0604|M.smegmatis_MC2_155 TVR--DIGGCTVGLVGYGNVAKRVERIVLAMGAEQVLHTSTRDTGHPR--
Rv0728c|M.tuberculosis_H37Rv RFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAG----
Mb0749c|M.bovis_AF2122/97 RFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAG----
MMAR_1065|M.marinum_M RFRGWEIAGRTAGLVGLGAVGRATAWRLTGLGLRVIAHDPYCADAR----
MUL_0823|M.ulcerans_Agy99 RFRGWEIAGRTAGLVGLGAVGRATAWRLTGLGLWVIAHDPYCADAR----
MAV_4438|M.avium_104 RFRGGEIAGLTAGLVGLGAVGRATRWRLSGLGLRVIAHDPYHPEAR----
MLBr_01692|M.leprae_Br4923 SFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQL
MAB_3304c|M.abscessus_ATCC_199 SFNGTEIFGKTVGVVGLGRIGQLFAQRLAAFGTHIVAYDPYVSAARAAQL
TH_2037|M.thermoresistible__bu EFSGVEIYDKTVGVVGLGRIGQLVAQRLAAFGTHLIAYDPYVSPARAAQL
. :: . *.*:** * :.: : .:* : : . .
Mflv_0334|M.gilvum_PYR-GCK ---WRTLPDLLSESDIVSLHLPLTGATEGLLGRKALAQMKTDAVLVNTSR
Mvan_0404|M.vanbaalenii_PYR-1 ---WRSLPDLLSACDIVSLHLPLTDATAGLLGRDALARMKSDAVLVNTSR
MSMEG_0604|M.smegmatis_MC2_155 ---WRNLPDLLAASDIVSLHLPLTDTSRGLLGPEAIAAMKPGAVLVNTAR
Rv0728c|M.tuberculosis_H37Rv ----HSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTAR
Mb0749c|M.bovis_AF2122/97 ----HSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTAR
MMAR_1065|M.marinum_M ----HGLAELLAESDIVSLHAPVTDDTVGMIGAQQFASMRDGAVFLNTAR
MUL_0823|M.ulcerans_Agy99 ----HGLAELLAESDIVSLHAPVTDDTVGMIGAQQFASMRDGAVFLNTAR
MAV_4438|M.avium_104 ----HGLDELLAESDVVSLHAPVTDETTGMIGAEQFAAMRDGVVFLNTAR
MLBr_01692|M.leprae_Br4923 GIELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAAR
MAB_3304c|M.abscessus_ATCC_199 GIELLTLDELLGRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAAR
TH_2037|M.thermoresistible__bu GIELVDLDELLGRADIISVHLPKTPETAGLIGADALAKVKPGVIIVNAAR
: :**. .*.:*:* . * : *::. . :* : ..:::*::*
Mflv_0334|M.gilvum_PYR-GCK GAIVDEAALVDALRAGTLAAAGLDVFAVEPVPSDNPLLGLPNVVLTPHVT
Mvan_0404|M.vanbaalenii_PYR-1 GPIVDEEALADALRTGKLAAAGLDVFAVEPVPADNPLLRLPNVVLTPHVT
MSMEG_0604|M.smegmatis_MC2_155 GPIVDEAALIEALRGGRLAAAGLDVFDTEPLPADHPLLGLDNVVLTPHVT
Rv0728c|M.tuberculosis_H37Rv SQLRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIG
Mb0749c|M.bovis_AF2122/97 SQLHDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIG
MMAR_1065|M.marinum_M AQLHDTDALVQALRAGKVAAAGLDHFVGEWLPTDHPLASMPNVVLTPHIG
MUL_0823|M.ulcerans_Agy99 AQLHDTDALVQALRAGKVAAAGLDHFVGEWLPTDHPLASMPNVVLTPHIG
MAV_4438|M.avium_104 AQLHDTDALVEALRAGKVAAAGLDHFVGEWLPTDHPLVGMPNVVLTPHIG
MLBr_01692|M.leprae_Br4923 GGLVDEVALADAVRSGHVRAAGLDVFATEPCT-DSPLFELSQVVVTPHLG
MAB_3304c|M.abscessus_ATCC_199 GGLIDEAALADAIRSGHVRGAGLDVFSTEPCT-DSPLFELDQVVVTPHLG
TH_2037|M.thermoresistible__bu GGLIDEQALADAIISGRVRAAGIDVFAKEPCT-DSPLFDLPQVVVTPHLG
. : * ** :*: * : .**:* * * . * ** : :**:***:
Mflv_0334|M.gilvum_PYR-GCK WYTADTMRRYLEFALDNCERLRDGRALAHVVNDPSG--------------
Mvan_0404|M.vanbaalenii_PYR-1 WYTADTMRRYLEFAVDNCERLRDGRNLVNVVNDVAG--------------
MSMEG_0604|M.smegmatis_MC2_155 WYTADTMRRYLSIGVENCRRIRDGEPLAHLVNEAR---------------
Rv0728c|M.tuberculosis_H37Rv GATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS------------
Mb0749c|M.bovis_AF2122/97 GATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS------------
MMAR_1065|M.marinum_M GATWNTEARQAQMVADGLQALLSGTRPTHILNPEVLAR------------
MUL_0823|M.ulcerans_Agy99 GATWNTEARQAQMVADGLQALLSGTRPTHILNPEVLAR------------
MAV_4438|M.avium_104 GATWNTEARQAQLVADDLEALLAGATPAHIVNPEVLAR------------
MLBr_01692|M.leprae_Br4923 ASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLVC
MAB_3304c|M.abscessus_ATCC_199 ASTSEAQDRAGTDVAASVQLALAGEFVPDAVNVGGGVVSEEVAPWLEVVR
TH_2037|M.thermoresistible__bu ASTVEAQDRAGTDVAASVKLALAGEFVPDAVNVGAGEVSEEVAPWVDLAR
* :: * . * . :*
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0604|M.smegmatis_MC2_155 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
MLBr_01692|M.leprae_Br4923 KLGVLVAALSDELPASLSVHVRGELASEDVEILRLSALRGLFSTVIEDAV
MAB_3304c|M.abscessus_ATCC_199 KLGVLIGAVSEQLPTSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQV
TH_2037|M.thermoresistible__bu KLGLLVGTLSGEPTATLQVRVAGELASEDVEVLRLSALRGLFSTLTDQQV
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0604|M.smegmatis_MC2_155 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
MLBr_01692|M.leprae_Br4923 TFVNAPALAAERGVSAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTLS
MAB_3304c|M.abscessus_ATCC_199 TFVNAPSIAEERGVSAEITTATESPNHRSVVDVRAVYADGSVINVAGTLS
TH_2037|M.thermoresistible__bu TYVNAPTLAAERGMQAELEKVSESPNYRSVVDVRAVSTDGTVTNVAGTLS
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0604|M.smegmatis_MC2_155 --------------------------------------------------
Rv0728c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0749c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1065|M.marinum_M --------------------------------------------------
MUL_0823|M.ulcerans_Agy99 --------------------------------------------------
MAV_4438|M.avium_104 --------------------------------------------------
MLBr_01692|M.leprae_Br4923 GPQLVQKIVQVNGRNFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVNI
MAB_3304c|M.abscessus_ATCC_199 GPQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNI
TH_2037|M.thermoresistible__bu GPQQVEKIVQINGRNFDLRAEGVNLVMHYVDRPGALGKIGTLLGAADVNI
Mflv_0334|M.gilvum_PYR-GCK -----------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 -----------------------------------------------
MSMEG_0604|M.smegmatis_MC2_155 -----------------------------------------------
Rv0728c|M.tuberculosis_H37Rv -----------------------------------------------
Mb0749c|M.bovis_AF2122/97 -----------------------------------------------
MMAR_1065|M.marinum_M -----------------------------------------------
MUL_0823|M.ulcerans_Agy99 -----------------------------------------------
MAV_4438|M.avium_104 -----------------------------------------------
MLBr_01692|M.leprae_Br4923 QAAQLSEDTEGPGATILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
MAB_3304c|M.abscessus_ATCC_199 QAAQLSQDASGAAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
TH_2037|M.thermoresistible__bu LAAQLSQDISGDGATLMLRVNRDVPADVRDAIGAAVGASTLEVVDLS