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MTETLKTMTYEVTGRVARITFNRPETGNAIIADTPLELAALVERADLDPSVHVILVSGRGEGFCAGFDLG AYAEGSSTAGTDRRGTVLDGKTQAINHRADQPWDPMIDYQMMSRFVRGFSSLMRCDKPTVVKIHGYCVAG GTDIALHADQVIAAADAKIGYPPTRVWGVPAAGMWAHRLGDQRAKRLLLTGDCLTGAQAAEWGLAVEAPD PADLDERTERLVERIAAVPVNQLIMVKLAMNSALYNQGVATSAMISTVFDGIARHTPEGHAFVAQAREHG FREAVRGRDEPFGDYGRTTSGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1270 | - | - | 100% (302) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_0780 | - | 2e-49 | 37.04% (297) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_5190 | - | 5e-23 | 30.65% (248) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0692 | echA4 | 1e-151 | 86.42% (302) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4357 | - | 6e-22 | 29.41% (289) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv0673 | echA4 | 1e-151 | 86.42% (302) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 4e-15 | 24.11% (282) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3859c | - | 1e-136 | 77.44% (297) | enoyl-CoA hydratase |
| M. marinum M | MMAR_1002 | echA4 | 1e-151 | 85.43% (302) | enoyl-CoA hydratase, EchA4 |
| M. avium 104 | MAV_4499 | - | 1e-150 | 85.76% (302) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1388 | - | 1e-151 | 86.09% (302) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_1117 | - | 2e-24 | 31.74% (293) | enoyl-CoA hydratase/isomerase family protein |
| M. ulcerans Agy99 | MUL_0754 | echA4 | 1e-148 | 84.44% (302) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4357|M.gilvum_PYR-GCK -----MTTTDDDRVLFDVDRDTRIATITLNNPKQRNSYDAAMRNLLARHL
TH_1117|M.thermoresistible__bu -----MPTT-DDRVLFDVDRDKRIATITLNNPAQRNSYDAAMRDALERCL
Mb0692|M.bovis_AF2122/97 MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLELSALV
Rv0673|M.tuberculosis_H37Rv MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLELSALV
MMAR_1002|M.marinum_M MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
MUL_0754|M.ulcerans_Agy99 MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
MAV_4499|M.avium_104 MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
MSMEG_1388|M.smegmatis_MC2_155 MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
Mvan_1270|M.vanbaalenii_PYR-1 MT--------ETLKTMTYEVTGRVARITFNRPETGNAIIADTPLELAALV
MAB_3859c|M.abscessus_ATCC_199 --------MVDTLKTMTYEVTDRVARITFNRPEQGNAIIADTPLELAALV
MLBr_02402|M.leprae_Br4923 ----------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAA
: : *:. **:*.* *: : :
Mflv_4357|M.gilvum_PYR-GCK DEVAEDDDITVVLLRGAEGVFSTGADMNN---------AYGWYGPEDPAG
TH_1117|M.thermoresistible__bu DQVAEDDDLTVVLLRGADGVFSTGADMNN---------AYAWYGEENSPQ
Mb0692|M.bovis_AF2122/97 ERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVLDG
Rv0673|M.tuberculosis_H37Rv ERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVLDG
MMAR_1002|M.marinum_M ERADLDPAVHVILVSGRGEGFCAGFDLSAYAEGSSSSGAEGGYRGTVLDG
MUL_0754|M.ulcerans_Agy99 ERADLDPAVQVILVSGRGEGFCAGFDLSAYAEGSSSSGAEGGYRGTVLDG
MAV_4499|M.avium_104 ERADLDPNVHVILVSGRGAGFCAGFDLSAYADRTGSAGGTGAYAGTVLDG
MSMEG_1388|M.smegmatis_MC2_155 ERADLDPDVHVILVSGRGEGFCAGFDLSAYAEGSSSAGGGSPYEGTVLSG
Mvan_1270|M.vanbaalenii_PYR-1 ERADLDPSVHVILVSGRGEGFCAGFDLGAYAEGSSTAGTDR--RGTVLDG
MAB_3859c|M.abscessus_ATCC_199 ERADLDPQVHVILVSGRGDGFCGGFDLSAYAEANDE--GSVRYSGTALDG
MLBr_02402|M.leprae_Br4923 KELDIDPDVGAILITGSPKVFAAGADIKE---------------------
.. * : .:*: * *. * *:
Mflv_4357|M.gilvum_PYR-GCK AGKPRKSRPSQRRRLTVDRKSFGFYHN----LMGFPKVTVGEISGYALGG
TH_1117|M.thermoresistible__bu ARR----RPSQRRRLTVDRRTFGFYHN----FMGFPKVTVGEISGYALGG
Mb0692|M.bovis_AF2122/97 KTQAVNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGYCVAG
Rv0673|M.tuberculosis_H37Rv KTQAVNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGYCVAG
MMAR_1002|M.marinum_M KAQAVNHLPNQPWDPMIDYQMMSRFVRGFSSLMHADKPTVVKIHGYCVAG
MUL_0754|M.ulcerans_Agy99 KAQAVNHLPNQPWDPMIDYQMMSRFVRGFSSLTHADKPTVVKIHGYCVAG
MAV_4499|M.avium_104 KTQAVNHLPDQPWDPMIDYQMMSRFVRGFSSLMHADKPTVVKIHGYCVAG
MSMEG_1388|M.smegmatis_MC2_155 KTQALNHLPDEPWDPMVDYQMMSRFVRGFASLMHCDKPTVVKIHGYCVAG
Mvan_1270|M.vanbaalenii_PYR-1 KTQAINHRADQPWDPMIDYQMMSRFVRGFSSLMRCDKPTVVKIHGYCVAG
MAB_3859c|M.abscessus_ATCC_199 QVQLRNHLPNINWDPMLDYQMMSRFTRGFSSLLHANKPTVVKVHGYCVAG
MLBr_02402|M.leprae_Br4923 -------MASLTFTDAFDADFFSAWGK----LAAVRTPMIAAVAGYALGG
.. .* :. : . : . : : **.:.*
Mflv_4357|M.gilvum_PYR-GCK GFEMALMTDISVIARDTRIGMPATRFLGPA-LGSLHLFFHRLGPVQARRL
TH_1117|M.thermoresistible__bu GFELALMCDIAVIGRDAKIGMPATRFLGPA-LGSLHMFFHRLGPVLARRL
Mb0692|M.bovis_AF2122/97 GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAHRLGDQRAKRL
Rv0673|M.tuberculosis_H37Rv GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAHRLGDQRAKRL
MMAR_1002|M.marinum_M GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAHRLGDQRAKRL
MUL_0754|M.ulcerans_Agy99 GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAHRLGDQRAKRL
MAV_4499|M.avium_104 GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAHRLGDQRAKRL
MSMEG_1388|M.smegmatis_MC2_155 GTDIALHADQVIAAADAKIGYPPMRVWG---VPAAGLWAHRLGDQRAKRL
Mvan_1270|M.vanbaalenii_PYR-1 GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGMWAHRLGDQRAKRL
MAB_3859c|M.abscessus_ATCC_199 GTDIALHADQLIVAADAKIGYPPTRVWG---VPATGLWAHKLGDQRAKRL
MLBr_02402|M.leprae_Br4923 GCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDL
* ::*: * : . :::* * :. : . : :* * *
Mflv_4357|M.gilvum_PYR-GCK LLTGDIIRAADVEHLGVFTETCDADAVTARARYWAEKAAKMPADGVVIAK
TH_1117|M.thermoresistible__bu LLTGDIIEAGSVEHLGVFTETCDPAMVGPRARYWAEKAAKMPADGVVIAK
Mb0692|M.bovis_AF2122/97 LFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVNQLIMVK
Rv0673|M.tuberculosis_H37Rv LFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVNQLIMVK
MMAR_1002|M.marinum_M LFTGDCITGAQAAEWGLAVEAPDPKDLDERTERLVERIAALPVNQLIMIK
MUL_0754|M.ulcerans_Agy99 LFTGDCITGAQAAEWGLAVEAPDPKDLDERTERLVERIAALPVNQLIMIK
MAV_4499|M.avium_104 LFTGDCITGAQAAEWGLAVEAPDPADLDERTERLVQRIAAVPVNQLIMVK
MSMEG_1388|M.smegmatis_MC2_155 LFTGDCITGAQAAEWGLAVEAPDPADLDARTERLVERIAAMPVNQLIMAK
Mvan_1270|M.vanbaalenii_PYR-1 LLTGDCLTGAQAAEWGLAVEAPDPADLDERTERLVERIAAVPVNQLIMVK
MAB_3859c|M.abscessus_ATCC_199 LLTGDCLSGRQAYDWGLAVEAPEPDELDERTERLVERIAAMPLNQLMMIK
MLBr_02402|M.leprae_Br4923 ILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQMSRSATRMAK
::** : . .. *: .. . : .:. . : :. . : *
Mflv_4357|M.gilvum_PYR-GCK EAFRLVEQSQAYQGEEVASYLFHAYGTNLQFADGEFNFVKTRAQHGTKEA
TH_1117|M.thermoresistible__bu EAFRLVEQSQAYQGEEVASYLFHAFGTNLQFAPGEFNFVKTRAEHGTKEA
Mb0692|M.bovis_AF2122/97 LALNSALLQQGVATSRMVSTVFDGAAR---HTPEGHAFVADAVEHGFRDA
Rv0673|M.tuberculosis_H37Rv LALNSALLQQGVATSRMVSTVFDGAAR---HTPEGHAFVADAVEHGFRDA
MMAR_1002|M.marinum_M LALNSALLQQGVVNSRMLSTVFDGVAR---HTPEGHAFVADAVEHGFRDA
MUL_0754|M.ulcerans_Agy99 LALNSALLQQGGVNSRMLSTVFDGVAR---HTPEGHAFVADAVEHGFRDA
MAV_4499|M.avium_104 LALNSALLQQGVATSRMVSTVFDGVAR---HTPEGHAFVADAVKHGFREA
MSMEG_1388|M.smegmatis_MC2_155 LACNTALLNQGVATSQMVSTVFDGIAR---HTPEGHAFVATAREHGFREA
Mvan_1270|M.vanbaalenii_PYR-1 LAMNSALYNQGVATSAMISTVFDGIAR---HTPEGHAFVAQAREHGFREA
MAB_3859c|M.abscessus_ATCC_199 LACNSVLINQGIANSAMIGTVFDGISR---HTPEAHAFTADAIANGYRQA
MLBr_02402|M.leprae_Br4923 EAVNRSFESTLAEGLLHERRLFH------------STFVTDDQSEGMAAF
* . . :*. *. .*
Mflv_4357|M.gilvum_PYR-GCK FRLRDEHFHVPEP-----
TH_1117|M.thermoresistible__bu FRLRDEHFHVPEPEPR--
Mb0692|M.bovis_AF2122/97 VRRRDEPFGDYGRQASRV
Rv0673|M.tuberculosis_H37Rv VRRRDEPFGDYGRQASRV
MMAR_1002|M.marinum_M VKHRDEPFGDYGRRASSV
MUL_0754|M.ulcerans_Agy99 VNHRDEPFGDYGRRASSV
MAV_4499|M.avium_104 VRHRDEPFGDHGRQASQV
MSMEG_1388|M.smegmatis_MC2_155 VRRRDEPMGDHGRRASDV
Mvan_1270|M.vanbaalenii_PYR-1 VRGRDEPFGDYGRTTSGV
MAB_3859c|M.abscessus_ATCC_199 VRHRDEPFGDYGRKPTEL
MLBr_02402|M.leprae_Br4923 IEKRAPQFTHR-------
.. * :