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QLTFDADVEAFRDEFISFLDRNLPDQAAGMERPRSCSHVPEWARRWQRLLFDNGWLIPGNPPEFGGRNAS LLQQYVHLQELARRRLYRSFNPQGVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPGAGSDLAS LKTRAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTDPDAPKHKGISALLIPTDTPGVVRRPFASV CDHDDVDFNEVFFTDAAVPAENLVGELNGGWRVATGSLGHERTMLWLGYANLLGELATDFTPAGVLQRDR YATLVMDTQAMRLLGSATLASAARGQEDVPAQSVLKLLGSEALQRACEDALDSAGGDGLVHPSITAPIAA LNLDNHYGSWFDRYARSFAGTIAGGTSEIQRNIIAERILGLPRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4751 | - | - | 100% (395) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4718 | - | e-172 | 73.67% (395) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3980 | - | 6e-58 | 40.91% (352) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3590c | fadE30 | 1e-51 | 37.84% (399) | acyl-CoA dehydrogenase FADE30 |
| M. gilvum PYR-GCK | Mflv_2492 | - | 1e-156 | 68.02% (394) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3560c | fadE30 | 1e-51 | 37.84% (399) | acyl-CoA dehydrogenase FADE30 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 7e-21 | 27.14% (350) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 6e-51 | 36.64% (393) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_0898 | - | 0.0 | 82.23% (394) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4805 | - | 1e-167 | 71.14% (395) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4023 | - | 1e-169 | 71.83% (394) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_0322 | - | 0.0 | 99.17% (360) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4162 | - | 1e-156 | 67.77% (394) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3590c|M.bovis_AF2122/97 --------------MQDV--EEFRAQVRGWLADNLAGEFAALKGLGGPGR
Rv3560c|M.tuberculosis_H37Rv --------------MQDV--EEFRAQVRGWLADNLAGEFAALKGLGGPGR
MAB_0597|M.abscessus_ATCC_1997 MVESQVSPAPAGEPMSEMSDDQVRTEIREWLAENLVGEFAELKGLGGPGS
MMAR_4751|M.marinum_M -----------MQLTFDADVEAFRDEFISFLDRNLPDQAAGME---RPRS
MUL_0322|M.ulcerans_Agy99 -----------MQLTFDADVEAFRDEFISFLDRNLPDQAAGME---RPRS
MAV_0898|M.avium_104 -----------MQLTFDADVEAFRAEFVAFLDAHLPAEAEALE---RPRS
MSMEG_4805|M.smegmatis_MC2_155 -----------MQLTFDSDVEKFRAEFVAFLDANLPSEAATLE---RPRS
TH_4023|M.thermoresistible__bu -----------MQLTFDADVEEFRAEFIAFLEANLPDEAQTLE---RPRS
Mflv_2492|M.gilvum_PYR-GCK -----------MQLAFDSDVEEFRAEFSAFLDEHTPSAAETLE---RPRS
Mvan_4162|M.vanbaalenii_PYR-1 -----------MQLTFEPDVEEFRAEFSAFLDEHTPSAAETLE---RPRS
MLBr_00737|M.leprae_Br4923 ----------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAAD
: : .: : .
Mb3590c|M.bovis_AF2122/97 EHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARAD
Rv3560c|M.tuberculosis_H37Rv EHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARAD
MAB_0597|M.abscessus_ATCC_1997 EHEAFEERLAWNRHLAAAGWTCLGWPVEHGGRGATVSQRVIFYEEYARAE
MMAR_4751|M.marinum_M CSHVPEWARRWQRLLFDNGWLIPGNPPEFGGRNASLLQQYVHLQELARRR
MUL_0322|M.ulcerans_Agy99 CSHVPEWARRWQRLLFDNGWLIPGNPPEFGGRNASLLQQYVHLQELARRR
MAV_0898|M.avium_104 SSHVPEWARRWQRLLFDSGWLLPGNPPEFGGRNATLLQQYVYFEELGRRR
MSMEG_4805|M.smegmatis_MC2_155 VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNANVVQQFVHLDELCRRR
TH_4023|M.thermoresistible__bu VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNATVLQQYVHLEELCKRR
Mflv_2492|M.gilvum_PYR-GCK VSHMPQWARDWQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRR
Mvan_4162|M.vanbaalenii_PYR-1 VSHMPQWAREWQRLLFDNGWLLPAQPPEFGGRNASVLQTFVHAEELCRRR
MLBr_00737|M.leprae_Br4923 VDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
. . * * * *.**:. :* :
Mb3590c|M.bovis_AF2122/97 APDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPGAG
Rv3560c|M.tuberculosis_H37Rv APDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPGAG
MAB_0597|M.abscessus_ATCC_1997 APHKVNHLGEELLGPTLIAYGTPEQQQRFLPAIRDVTELWCQGYSEPGAG
MMAR_4751|M.marinum_M LYRSFNPQGVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPGAG
MUL_0322|M.ulcerans_Agy99 LYRSFNPQGVGIIAESLLSFGTPEQKRRWAVPILRAEMTASLGMSEPGAG
MAV_0898|M.avium_104 IYQSFNPQGVGIIAASLLSFGTPEQKQRWAVPILRAEMTASLGMSEPGAG
MSMEG_4805|M.smegmatis_MC2_155 IYHSFNPQGVNIIAASLLTFGTEEQKHRWAVPVLRGEKTASLGMSEPSAG
TH_4023|M.thermoresistible__bu IYHSFNPQGVNIIAASLLSFGSDEQKHRWAVPVLKAEMTASLGMSEPSAG
Mflv_2492|M.gilvum_PYR-GCK IYHSFNPQGVNIIAASLLTFGTDEQKHRWAVPVLRGERTASLGMSEPSAG
Mvan_4162|M.vanbaalenii_PYR-1 IYHSFNPQGVNIIAASLLTFGTDEQKHQWAVPVLRGERTASLGMSEPSAG
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAG
.. : *: *: : ::: : . . ** **
Mb3590c|M.bovis_AF2122/97 SDLASVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVLARTEKGSQ
Rv3560c|M.tuberculosis_H37Rv SDLASVATTAELD----GDQWVINGQKVWTSLAHLSQWCFVLARTEKGSQ
MAB_0597|M.abscessus_ATCC_1997 SDLANVSTSAVLD----GGDWVINGQKVWTSLALQSQWCFVVARTEPGSS
MMAR_4751|M.marinum_M SDLASLKTRAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTDPDAP
MUL_0322|M.ulcerans_Agy99 SDLASLKTRAVRYRDGEGDRFVVNGQKVWTSGAHDADVLLTFVRTYPDAP
MAV_0898|M.avium_104 SDLASLKTRAVL----DGDHFVVNGQKVWTSGAHDADVLLTFVRTDPNAP
MSMEG_4805|M.smegmatis_MC2_155 SDLASLRTRAVR----DGDEFVVNGQKVWTSGAHDADWLLTFVRTDPDAP
TH_4023|M.thermoresistible__bu SDLASLRTRAEFVSGDDGDHFVVNGQKVWTSGAHDADFLLTFVRTDPDAP
Mflv_2492|M.gilvum_PYR-GCK SDLASLRTKAVRD----GDEFVVNGQKVWTSGAHDADFLLTFVRTDPDAP
Mvan_4162|M.vanbaalenii_PYR-1 SDLASLRTKAVLVSESGGSYFVVNGQKVWTSGAHDADFLLTFVRTDPDAP
MLBr_00737|M.leprae_Br4923 SDAASMRTRAKAD----GDDWILNGFKCWITNGGKSTWYTVMAVTDPD-K
** *.: * * *. :::** * * : . : ... * .
Mb3590c|M.bovis_AF2122/97 RHAGLSYLLVPLDQPGVQIRPIVQITG--TAEFNEVFFDDARTDADLVVG
Rv3560c|M.tuberculosis_H37Rv RHAGLSYLLVPLDQPGVQIRPIVQITG--TAEFNEVFFDDARTDADLVVG
MAB_0597|M.abscessus_ATCC_1997 RHKGLSYLLVPLDQPGVEIRPIIQLTG--TSEFNEVFFDNARTSADLVVG
MMAR_4751|M.marinum_M KHKGISALLIPTDTPGVVRRPFASVCDHDDVDFNEVFFTDAAVPAENLVG
MUL_0322|M.ulcerans_Agy99 KHKGISALLIPTDTPGVVRRPFASVCDHDDVDFNEVFFTDAAAPAENLVG
MAV_0898|M.avium_104 KHKGISVLLIPTDTPGVVRRPFASMCDIDEIDFNEVFFTDARVPAENLVG
MSMEG_4805|M.smegmatis_MC2_155 KHKGISVLIVPTDTPGVVCRPFADMTGQENLDFNEVFFTDARVPAENLVG
TH_4023|M.thermoresistible__bu KHKGISVLIIPTDLPGVVCRPFADICGPENKDFNEVFFTDVRVPAENLVG
Mflv_2492|M.gilvum_PYR-GCK KHKGISVLLIPTDLDGVVCRPFADMTGIENLDFNEVFFTDVRVPAENLVG
Mvan_4162|M.vanbaalenii_PYR-1 KHKGISVLLIPTDLEGVVCRPFADMTGIDNLDFNEVFFTDVRVPVENLVG
MLBr_00737|M.leprae_Br4923 GANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIG
*:* ::: * *. * . . .*::* . : ::*
Mb3590c|M.bovis_AF2122/97 APGDGWRVAMATLTFER-GVSTLGQQIVYARELSNLVELARRTAAADDPL
Rv3560c|M.tuberculosis_H37Rv APGDGWRVAMATLTFER-GVSTLGQQIVYARELSNLVELARRTAAADDPL
MAB_0597|M.abscessus_ATCC_1997 EPGDGWRVAMGTLTFER-GVSTLGNQITYARELSRLAELAKSNGAADDPA
MMAR_4751|M.marinum_M ELNGGWRVATGSLGHER-TMLWLGYANLLGELATDFTPAGVLQRDRYATL
MUL_0322|M.ulcerans_Agy99 ELNGGWRVATGSLGHER-TMLWLGYANLLGELATDFTPAGVLQRDHYATL
MAV_0898|M.avium_104 ELNEGWRVATGSLGHER-VMLWMGYVDLLHELSADFRPADALQRDRYATL
MSMEG_4805|M.smegmatis_MC2_155 PLNQGWKVANGSLGHER-TMMWLGFADRIDNMLADFNPRTELERDQYATT
TH_4023|M.thermoresistible__bu PLNGGWKVANGSLGHER-TMMWLGFADRIDNIIADFTPRTPLERDQYATA
Mflv_2492|M.gilvum_PYR-GCK PLNGGWGVANGSLGHER-TMMWLGFADRIANCIADFVPRTPLERDALASS
Mvan_4162|M.vanbaalenii_PYR-1 PLNGGWGVANGSLGHER-TMMWLGFADRIANCIADFKPKNPLERDALATS
MLBr_00737|M.leprae_Br4923 EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESIS
. *: .* .:* . * : . : :
Mb3590c|M.bovis_AF2122/97 IRERLTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWANWHRNLGE
Rv3560c|M.tuberculosis_H37Rv IRERLTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWANWHRNLGE
MAB_0597|M.abscessus_ATCC_1997 IRERLAQAYVGMRTMRAYALATMD---EERPGQDNVSKLLWANWHRDLGE
MMAR_4751|M.marinum_M VMDTQAMRLLGSATLASAARGQED------VPAQSVLKLLGSEALQRACE
MUL_0322|M.ulcerans_Agy99 VMDTQAMRLLGSATLASAARGQED------VPAQSVLKLLGSEALQRACE
MAV_0898|M.avium_104 VMDAHALRLLGSAALAAAARGEED------VPAQSVLKLLGSEALQRASE
MSMEG_4805|M.smegmatis_MC2_155 IMDYQALRALGSAALARAARGEQD------TASVSVLKLLGSEAERNAFE
TH_4023|M.thermoresistible__bu IMDYQALRLIGSVGLAKAARGEMD------TASVSVAKLLGSEAELRAAE
Mflv_2492|M.gilvum_PYR-GCK IMDYEALRLLGSVGIAKAARGEVD------VASVSIPKLLGAEAEQRIEG
Mvan_4162|M.vanbaalenii_PYR-1 IMDYQALRLLGSVGIAKAARGEVD------VASVSIPKLLGAEAEQRIEG
MLBr_00737|M.leprae_Br4923 TFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASD
: . * :: :
Mb3590c|M.bovis_AF2122/97 LAMDVIGKPGMTMP-----------DGEFDEWQRLYLFTRADTIYGGSNE
Rv3560c|M.tuberculosis_H37Rv LAMDVIGKPGMTMP-----------DGEFDEWQRLYLFTRADTIYGGSNE
MAB_0597|M.abscessus_ATCC_1997 LAMEIIGTSTLLTN-----------AGEMDEWQRLFLFSRADTIYGGSNE
MMAR_4751|M.marinum_M DALDSAGGDGLVHPSITAPIAALNLDNHYGSWFDRYARSFAGTIAGGTSE
MUL_0322|M.ulcerans_Agy99 DALDSAGGDGLVHPSITAPIAALNLDNHYGS-------------------
MAV_0898|M.avium_104 DALEAAGSAGLVRRAVTAQVAPLNLDSHYRSWFDRYARTFAATIAGGTSE
MSMEG_4805|M.smegmatis_MC2_155 NALAAAGPEGLIHPSTSGPYAHMNLDHYFASWFERYARSFGGTIAGGTSE
TH_4023|M.thermoresistible__bu MALTAAGSDGLIHPSTTGPYAHMNLDHYFASWFERFARSFSGTIAGGTSE
Mflv_2492|M.gilvum_PYR-GCK LALEAAGLDGLVHPATSGPYEHMNLDHYFASWFERYCRSFGGTIAGGTSE
Mvan_4162|M.vanbaalenii_PYR-1 LALEAAGPDGLVHPATSGPYEHMNLDHYFASWFERYCRSFGGTIAGGTSE
MLBr_00737|M.leprae_Br4923 IAMEVTTDAVQLFGG-----AGYTSDFPVERFMR---DAKITQIYEGTNQ
*:
Mb3590c|M.bovis_AF2122/97 IQRNIIAERVLGLPREAKG
Rv3560c|M.tuberculosis_H37Rv IQRNIIAERVLGLPREAKG
MAB_0597|M.abscessus_ATCC_1997 IQRNIISERVLGLPREAR-
MMAR_4751|M.marinum_M IQRNIIAERILGLPRG---
MUL_0322|M.ulcerans_Agy99 -------------------
MAV_0898|M.avium_104 IQRNIIAERVLGLPRN---
MSMEG_4805|M.smegmatis_MC2_155 IQRNIIATQVLGLPRG---
TH_4023|M.thermoresistible__bu IQRNIIAQQVLGLPRR---
Mflv_2492|M.gilvum_PYR-GCK IQRNIIAQQVLGLPRR---
Mvan_4162|M.vanbaalenii_PYR-1 IQRNIIAQQVLGLPRR---
MLBr_00737|M.leprae_Br4923 IQRVVMSRALLR-------