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TLLDVRGVTAGYGKLPVIHDVSIQVRGNETVALVGPNGAGKSTLLKSIFRLVEPMSGEISLLGEGLVNVP TAQMVRRGMAYVPQGGNTFPNLTVLENIRVALMPLGRSKVSAGIDLAFDRFPSLGKRRDSSASTLSGGER QMLAVAGALASDPKFLALDEPTTGLAPSIVGELIASIAGVTSDGVGVLWVVEENPAVILPHCDRVHIMQG GRISPEQEVAAVLEDEGLRKLFFGVEGSH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6876 | - | - | 100% (240) | branched chain amino acid transport ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_1217 | - | 1e-44 | 37.71% (236) | ABC-type transport system ATP-binding protein I |
| M. smegmatis MC2 155 | MSMEG_3251 | - | 7e-40 | 36.29% (237) | branched-chain amino acid ABC transporter ATP-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2419c | cysA1 | 5e-21 | 33.65% (211) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. gilvum PYR-GCK | Mflv_3570 | - | 2e-38 | 34.73% (239) | ABC transporter related |
| M. tuberculosis H37Rv | Rv2397c | cysA1 | 5e-21 | 33.65% (211) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. leprae Br4923 | MLBr_01122 | - | 4e-19 | 31.16% (215) | putative ABC transport protein, ATP-binding component |
| M. abscessus ATCC 19977 | MAB_2622c | - | 2e-33 | 33.90% (236) | branched chain amino acid ABC transporter |
| M. marinum M | MMAR_0034 | proV_1 | 5e-24 | 40.35% (171) | osmoprotectant (glycine |
| M. avium 104 | MAV_0058 | - | 2e-25 | 32.88% (219) | ABC transporter, ATP-binding protein |
| M. thermoresistible (build 8) | TH_3858 | - | 6e-40 | 36.71% (237) | PUTATIVE ABC transporter related |
| M. ulcerans Agy99 | MUL_0033 | proV_1 | 5e-23 | 39.77% (171) | osmoprotectant (glycine |
| M. vanbaalenii PYR-1 | Mvan_2845 | - | 4e-39 | 35.02% (237) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3570|M.gilvum_PYR-GCK -----MTNS------PDPRPVLLEVRDAVVHYG----RIKALHSVSLTVH
Mvan_2845|M.vanbaalenii_PYR-1 -----MSSPETVAGQPDPRPVLLEVRDVVVHYG----RIKALHSVSLTVH
TH_3858|M.thermoresistible__bu --------------------VMLEVRDVEVHYG----RIRALHGVSLRVH
MAB_2622c|M.abscessus_ATCC_199 -----------------MPPVQLKLNNVGVHYG----PIQAVNTLSFDVR
MSMEG_6876|M.smegmatis_MC2_155 -------------------MTLLDVRGVTAGYG----KLPVIHDVSIQVR
Mb2419c|M.bovis_AF2122/97 ------------------MTYAIVVADATKRYG----DFVALDHVDFVVP
Rv2397c|M.tuberculosis_H37Rv ------------------MTYAIVVADATKRYG----DFVALDHVDFVVP
MMAR_0034|M.marinum_M MPEAASADQPTTSDAPQSSGLRILLDGVTKRYGV--RSTPAVDNVTLEIG
MUL_0033|M.ulcerans_Agy99 MPEAASADQPTTSDAPQSSGLRILLDGVTKRYGV--RSTPAVDNVTLEIG
MAV_0058|M.avium_104 -----------MSNPASRASVSLACKDIHQTLN----GNAVLRGVDLDTP
MLBr_01122|M.leprae_Br4923 ------------------MSPLLEVTDLAVTFETNGEPVTAVRGISYRIN
: . .: :
Mflv_3570|M.gilvum_PYR-GCK EGELVTLLGSNGAGKTTMMRAISGLL---PLTSGSVWFEGKDISRVKAHK
Mvan_2845|M.vanbaalenii_PYR-1 EGELVTLLGSNGAGKTTMMRAISGLL---PLSSGSVWFDGKDISRVKAHK
TH_3858|M.thermoresistible__bu EGELVTLLGSNGAGKTTMMRAISGLR---PLTRGSVWFDGRDITRVSAHR
MAB_2622c|M.abscessus_ATCC_199 EGELVTLLGSNGAGKSTAMRAISGLV---PLSSGTIFFEGQDISKMKAHR
MSMEG_6876|M.smegmatis_MC2_155 GNETVALVGPNGAGKSTLLKSIFRLV---EPMSGEISLLGEGLVNVPTAQ
Mb2419c|M.bovis_AF2122/97 TGSLTALLGPSGSGKSTLLRTIAGLD---QPDTGTITINGRDVTRVPPQ-
Rv2397c|M.tuberculosis_H37Rv TGSLTALLGPSGSGKSTLLRTIAGLD---QPDTGTITINGRDVTRVPPQ-
MMAR_0034|M.marinum_M AGEIVMLVGPSGCGKTTTMKMINRLI---EPTSGRIFIGDDDVTRRNPDE
MUL_0033|M.ulcerans_Agy99 AGEIVMLVGPSGCGKTTTMKVINRLI---EPTSGRIFIGDDDVTRRNPDE
MAV_0058|M.avium_104 AGSTVAVIGPSGSGKSTLLRTLNRLY---EPDRGDILLDGRSVLHDDPDQ
MLBr_01122|M.leprae_Br4923 AGEVVAMVGESGSGKSAAAMAVVGLLPEYAQVRGSVRLHNTELVGLADKT
.. . ::* .*.**:: : * * : : . :
Mflv_3570|M.gilvum_PYR-GCK R---VTDGLIQAPEG--RGVFPGMTIIDNL--EMGCYGRKFATNAEHDEK
Mvan_2845|M.vanbaalenii_PYR-1 R---VADGLIQAPEG--RGVFPGMTIVENL--EMGCYGRKFPSKAEHDER
TH_3858|M.thermoresistible__bu R---VADGLIQVPEG--RGVFPGMTVLENL--DMGCYGRRFASRAEHRER
MAB_2622c|M.abscessus_ATCC_199 R---VRAGIVQAPEG--RGIFPGMTVAENL--EMGCYGRKFKSRAERRER
MSMEG_6876|M.smegmatis_MC2_155 M---VRRGMAYVPQG--GNTFPNLTVLENI--RVALMP---LGRSKVSAG
Mb2419c|M.bovis_AF2122/97 -----RRGIGFVFQH--YAAFKHLTVRDNV--AFGLKIRKRPKAEIKAKV
Rv2397c|M.tuberculosis_H37Rv -----RRGIGFVFQH--YAAFKHLTVRDNV--AFGLKIRKRPKAEIKAKV
MMAR_0034|M.marinum_M ----LRRHIGYVVQG--AGLFPHLTVGDNI--GIVPRLLKWDKNRVAARI
MUL_0033|M.ulcerans_Agy99 ----LRRHIGYVVQG--AGVFLHLTVGDNI--GIVPRLLKWDKNRVAARI
MAV_0058|M.avium_104 ----LRQRIGMVFQH--FNLFPHRTVLDNV--ALAPRKLRR-LPAEAARE
MLBr_01122|M.leprae_Br4923 MSRFRGKAIGTVFQDPMSALTPVYTVGDQITEAIKVHQPRVGKKAAHRRA
: . : *: ::: .
Mflv_3570|M.gilvum_PYR-GCK LDWVLETFPRLAERRSQ-VGGTLSGGEQQMLAIGRALMARPKVLLLDEPS
Mvan_2845|M.vanbaalenii_PYR-1 LDWVLETFPRLAERRNQ-VGGTLSGGEQQMLAIGRALMARPKVLLLDEPS
TH_3858|M.thermoresistible__bu LDWVLQTFPRLAERRDQ-VGGTLSGGEQQMLAIGRALMARPKVLLLDEPS
MAB_2622c|M.abscessus_ATCC_199 LDWINALFPRLAERRHQ-PGGTLSGGEQQMLSIGRALMARPKILLLDEPS
MSMEG_6876|M.smegmatis_MC2_155 IDLAFDRFPSLGKRRDS-SASTLSGGERQMLAVAGALASDPKFLALDEPT
Mb2419c|M.bovis_AF2122/97 DNLLQVVGLS--GFQSR-YPNQLSGGQRQRMALARALAVDPEVLLLDEPF
Rv2397c|M.tuberculosis_H37Rv DNLLQVVGLS--GFQSR-YPNQLSGGQRQRMALARALAVDPEVLLLDEPF
MMAR_0034|M.marinum_M DELLDLVNLDPAQYRDR-FPRELSGGQQQRVGVARALAADPPVLLMDEPF
MUL_0033|M.ulcerans_Agy99 DELLDLVNLDPAQYRDR-FPRELSGGQQQRVGVARALAADPPVLLMDEPF
MAV_0058|M.avium_104 LALTQLDRVGLKHKAGA-RPATLSGGQQQRVAIARALAMSPQVMFFDEAT
MLBr_01122|M.leprae_Br4923 VELLELVGITQPDRRARAFPHELSGGERQRVVIATAIANDPDLLICDEPT
****::* : :. *: * .: **.
Mflv_3570|M.gilvum_PYR-GCK MGLAPMVISQIFKIIAEINATGT-TVLLVEQNAQQALSRSDRAYILETG-
Mvan_2845|M.vanbaalenii_PYR-1 MGLAPMVISQIFRIIAEINAAGT-TVLLVEQNAQQALTRSDRAYILETG-
TH_3858|M.thermoresistible__bu MGLAPMVISQIFGIIADINAQGT-TVLLVEQNAQQALSRSDRAYILETG-
MAB_2622c|M.abscessus_ATCC_199 MGLAPLLITKIFNIIEEINAAGT-TVVLVEQNAQQALSRSDHAYILETG-
MSMEG_6876|M.smegmatis_MC2_155 TGLAPSIVGELIASIAGVTSDGVGVLWVVEENPAVILPHCDRVHIMQGG-
Mb2419c|M.bovis_AF2122/97 GALDAKVREELRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVLHKG-
Rv2397c|M.tuberculosis_H37Rv GALDAKVREELRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVLHKG-
MMAR_0034|M.marinum_M GAVDPITRQRLQDELLRLQEELHKTIVFVTHDFGEAVKLGDRIAILTTGS
MUL_0033|M.ulcerans_Agy99 GAVDPITRQRLQDELLRLQEELHKTIVFVTHDFGEAVKLGDRIAILTTGS
MAV_0058|M.avium_104 SALDPEMVKGILQLIADLGAEG-MTMVVVTHEMGFARSASDAVIFMDHG-
MLBr_01122|M.leprae_Br4923 TALDVTVQAQILEVLKTARDVTGAGVLIITHDLGVVTEFADQALVMYAG-
.: : : .: .: * .: *
Mflv_3570|M.gilvum_PYR-GCK EVTRTGNARELLADDS--IRAAYLGVA-----------------------
Mvan_2845|M.vanbaalenii_PYR-1 EVTRTGNARELLSDKS--IRAAYLGVA-----------------------
TH_3858|M.thermoresistible__bu EITRSGPARELLADDS--IRAAYLGVA-----------------------
MAB_2622c|M.abscessus_ATCC_199 SVVRSGAGRELLQDDS--IRSAYLGVV-----------------------
MSMEG_6876|M.smegmatis_MC2_155 RISPEQEVAAVLEDEG--LRKLFFGVEGSH--------------------
Mb2419c|M.bovis_AF2122/97 RIEQVGSPTDVYDAPANAFVMSFLGAVSTLNG-SLVRPHDIRVGRTPNMA
Rv2397c|M.tuberculosis_H37Rv RIEQVGSPTDVYDAPANAFVMSFLGAVSTLNG-SLVRPHDIRVGRTPNMA
MMAR_0034|M.marinum_M KVVQYDTPERILAEPANDFVRGFVGAGATLMQLSLTRVRDIDLH---EAV
MUL_0033|M.ulcerans_Agy99 KVVQYDTPERVLAEPANDFVRGFVGAGATLMQLSLTRVRDIDLH---EAV
MAV_0058|M.avium_104 KVVESGPPEQIFEAAETERLQRFLSQVL----------------------
MLBr_01122|M.leprae_Br4923 RVVESAQVSTLYRERQMPYTVGLLGSVPRLDATQGTRLVPIPGAPPSLAG
: : ..
Mflv_3570|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2845|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3858|M.thermoresistible__bu --------------------------------------------------
MAB_2622c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6876|M.smegmatis_MC2_155 --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 VAAADGTAGSTGVLRAVVDRVVVLGFEVR------VELTSAATGGAFTAQ
Rv2397c|M.tuberculosis_H37Rv VAAADGTAGSTGVLRAVVDRVVVLGFEVR------VELTSAATGGAFTAQ
MMAR_0034|M.marinum_M VAQAGGDPAEAVELAGSLDREHAIVLDRQNRPLRWLPLEELAKPQALAQV
MUL_0033|M.ulcerans_Agy99 VAQAGGDPAEAVELAGSLDRAHAIVLDRQNRPLRWLPLEELAKPQALAQV
MAV_0058|M.avium_104 --------------------------------------------------
MLBr_01122|M.leprae_Br4923 LQQECPFAPRCPLVVDECRLREPELVEVRAGHRTACIRTDQVSGRSAADI
Mflv_3570|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2845|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3858|M.thermoresistible__bu --------------------------------------------------
MAB_2622c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6876|M.smegmatis_MC2_155 --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 I-TRGDAEALALR-----EGDTVYVRATRVPPIAG------GVSGVDDAG
Rv2397c|M.tuberculosis_H37Rv I-TRGDAEALALR-----EGDTVYVRATRVPPIAG------GVSGVDDAG
MMAR_0034|M.marinum_M T-RDDDLECVNLASTLNDALDEMLTSSHGVVVVTGRRNTYQGVIRVETIM
MUL_0033|M.ulcerans_Agy99 T-RDDDLECVNLASTLNDALDEMLTSAHGVVVVTGRRNTYQGVIRVETIM
MAV_0058|M.avium_104 --------------------------------------------------
MLBr_01122|M.leprae_Br4923 YGINTDTRTSATSDSSVVVRVRDLVKTYRLTKGVGLRRAIGEIRAVNGVS
Mflv_3570|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2845|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3858|M.thermoresistible__bu --------------------------------------------------
MAB_2622c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6876|M.smegmatis_MC2_155 --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 VERVKVTST-----------------------------------------
Rv2397c|M.tuberculosis_H37Rv VERVKVTST-----------------------------------------
MMAR_0034|M.marinum_M EAIADIRGAANSEEPDT---------------------------------
MUL_0033|M.ulcerans_Agy99 EAIADIRGAANSEEPDT---------------------------------
MAV_0058|M.avium_104 --------------------------------------------------
MLBr_01122|M.leprae_Br4923 FELQQGRTLGIVGESGSGKSTTLHEILRLAVPQSGSIEVLGIDVATLNRA
Mflv_3570|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2845|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3858|M.thermoresistible__bu --------------------------------------------------
MAB_2622c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6876|M.smegmatis_MC2_155 --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 --------------------------------------------------
Rv2397c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0034|M.marinum_M --------------------------------------------------
MUL_0033|M.ulcerans_Agy99 --------------------------------------------------
MAV_0058|M.avium_104 --------------------------------------------------
MLBr_01122|M.leprae_Br4923 SRRSMRRNIQVVFQDPVASLDPRLPVFELIAEPLHANGFSKNYTQMRVAE
Mflv_3570|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2845|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3858|M.thermoresistible__bu --------------------------------------------------
MAB_2622c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6876|M.smegmatis_MC2_155 --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 --------------------------------------------------
Rv2397c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0034|M.marinum_M --------------------------------------------------
MUL_0033|M.ulcerans_Agy99 --------------------------------------------------
MAV_0058|M.avium_104 --------------------------------------------------
MLBr_01122|M.leprae_Br4923 LLDIVGLRRDDATRYPTEFSGGQKQRIGIARALALQPKILAFDEPVSALD
Mflv_3570|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2845|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3858|M.thermoresistible__bu --------------------------------------------------
MAB_2622c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6876|M.smegmatis_MC2_155 --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 --------------------------------------------------
Rv2397c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0034|M.marinum_M --------------------------------------------------
MUL_0033|M.ulcerans_Agy99 --------------------------------------------------
MAV_0058|M.avium_104 --------------------------------------------------
MLBr_01122|M.leprae_Br4923 VSIQAGIINLLLDLQDRLGLSYLFVSHDLSVIKHLAHQVAVMLAGTIVEQ
Mflv_3570|M.gilvum_PYR-GCK ----------------------------
Mvan_2845|M.vanbaalenii_PYR-1 ----------------------------
TH_3858|M.thermoresistible__bu ----------------------------
MAB_2622c|M.abscessus_ATCC_199 ----------------------------
MSMEG_6876|M.smegmatis_MC2_155 ----------------------------
Mb2419c|M.bovis_AF2122/97 ----------------------------
Rv2397c|M.tuberculosis_H37Rv ----------------------------
MMAR_0034|M.marinum_M ----------------------------
MUL_0033|M.ulcerans_Agy99 ----------------------------
MAV_0058|M.avium_104 ----------------------------
MLBr_01122|M.leprae_Br4923 GDSHDVFRNPQHDYTRRLLGAIPRPEVG