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GTFVISGGTDGIGKAIAANRLKLGHEVVVIGRDTAKGQAFLDSAADIGAVDRAHFVVADLSLVSQTRRAI DEIGNCISEIDGLVLCARHFRTTRAVTAEGLEHTFALYYLSRFVLSHRLVGLLDAAEAPVILNVSGPGSG TDSIRWDDLGGEHDYEPQRILAQGGQLNDLLGVGFARRRVSPKTRYVLVHPGVVNTGFSGEYDAATADRI EQIRATAQPVEDAIVPILDIVDHPPAEPLTAVVEGRPIDVHGPAFDAALADRLYDQTTVLLGSLASAAMG VSPARLRQVLDAPVFGTVATIDPDGAPQQSVVWVGRDGDDVLFAVATGSRKERNLRRDPRVSILLSPPDE PYTYAVIHGKATLHTEGGHQLRDALAVKYTGKTYAEGNADAAARYGDVAMTVVRVTPERTVGRL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6848 | - | - | 100% (415) | putative oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3380 | - | 3e-11 | 35.06% (77) | pyridoxamine 5'-phosphate oxidase-related, FMN-binding |
| M. smegmatis MC2 155 | MSMEG_0876 | - | 6e-11 | 27.32% (194) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0069 | - | 1e-10 | 29.65% (199) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0151 | - | 6e-12 | 31.37% (204) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0068 | - | 1e-10 | 29.65% (199) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01508 | - | 3e-07 | 41.98% (81) | hypothetical protein MLBr_01508 |
| M. abscessus ATCC 19977 | MAB_0646c | - | 2e-12 | 28.35% (194) | short chain dehydrogenase |
| M. marinum M | MMAR_1680 | - | 4e-13 | 30.15% (199) | dehydrogenase/reductase |
| M. avium 104 | MAV_1610 | - | 3e-14 | 28.88% (277) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_4179 | - | 1e-10 | 31.68% (202) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1918 | - | 4e-13 | 30.15% (199) | dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_1061 | - | 2e-14 | 27.74% (292) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0151|M.gilvum_PYR-GCK --------------------------------------MTSKWTAADVPD
TH_4179|M.thermoresistible__bu --------------------------------------MTGKWTARDVPD
Mb0069|M.bovis_AF2122/97 ---------------------------------------MTKWTAADIPD
Rv0068|M.tuberculosis_H37Rv ---------------------------------------MTKWTAADIPD
MAB_0646c|M.abscessus_ATCC_199 -----------------------------------MSRSTTKWSTTDIPD
Mvan_1061|M.vanbaalenii_PYR-1 ------------------------------------MDHMTRKATVDARD
MMAR_1680|M.marinum_M ---MSVVDGIRSLLDTTLDRALDRTIVGGYTRVGYQLRHSGWSDDPSPAA
MUL_1918|M.ulcerans_Agy99 MISMSVVDGIRSLLDTTLDRALDRTIVGGYTRVGYQLRHSGWSGDPSPAA
MAV_1610|M.avium_104 --------------------------------------------------
MSMEG_6848|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01508|M.leprae_Br4923 --------------------------------------------------
Mflv_0151|M.gilvum_PYR-GCK QSGRVAVVTGANTGIGYETAEVLAGKGARVVIAVRDAGKGQKALDAITRK
TH_4179|M.thermoresistible__bu QTGRTAVITGANTGLGFETAKVLAEKGAHVVLAVRDPDKGRRAADRITAA
Mb0069|M.bovis_AF2122/97 QTGRTAVITGANTGLGFETAAALAAHGAHVVLAVRNLDKGKQAAARITEA
Rv0068|M.tuberculosis_H37Rv QTGRTAVITGANTGLGFETAAALAAHGAHVVLAVRNLDKGKQAAARITEA
MAB_0646c|M.abscessus_ATCC_199 QTGRIAIVTGANTGLGLETAKALAAHGAHVVLAVRNAEKGKAAAEAITAA
Mvan_1061|M.vanbaalenii_PYR-1 LHGKLAVITGGSDGIGFGLAGRLAAAGAEVILPVRNADKGRRAADAIRTT
MMAR_1680|M.marinum_M LRGRTAMVTGANRGLGKAIAAGLAELGATVVLTVRDRDSGQRARDEIAAA
MUL_1918|M.ulcerans_Agy99 LRGRTAMVTGANRGLGKAIAAGLAELGATVVLTVRDRDSGQRARDEIAAA
MAV_1610|M.avium_104 MTRRTIVITGASDGIGAAAARRLSRAGDRIVVVGRSQTKTAAVAAELGAD
MSMEG_6848|M.smegmatis_MC2_155 --MGTFVISGGTDGIGKAIAANRLKLGHEVVVIGRDTAKGQAFLDSAADI
MLBr_01508|M.leprae_Br4923 ----------------MRFGASLLRVRRRLYGMG-SQVFDDKLLAVISGN
. : .
Mflv_0151|M.gilvum_PYR-GCK HPGAAVSLQELDLSSLGSVRRATDALRSAHPRIDLLINNAGVMYPP-KQV
TH_4179|M.thermoresistible__bu APHADVTVRQLDLTSLDNIRRAADDLRAGYPRIDLLINNAGVMYPP-RQT
Mb0069|M.bovis_AF2122/97 TPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAGVMYTP-RQT
Rv0068|M.tuberculosis_H37Rv TPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAGVMYTP-RQT
MAB_0646c|M.abscessus_ATCC_199 HSNADVTLQSLDLSSLESVRRASDELKGRYDKIDLLINNAGVMWTE-KSS
Mvan_1061|M.vanbaalenii_PYR-1 TPDARISTRPMDLSSLQSVADLADELLREGRPIHLLINNAGVMNPPSRQT
MMAR_1680|M.marinum_M S-GADVRVEVCDVSSLSAVRAFATDLRTRVSRLDVLVHNAGLLPAA-RAE
MUL_1918|M.ulcerans_Agy99 S-GADVRVEVCDVSSLSVVRASATDLCTRVSRLDVLVHNAGLLPAA-RAE
MAV_1610|M.avium_104 H-------FVVDYADLSQVRALADKMRAQYPRIDVLLNNAGGVASR-IEL
MSMEG_6848|M.smegmatis_MC2_155 GAVDRAHFVVADLSLVSQTRRAIDEIGNCISEIDGLVLCARHFRTT-RAV
MLBr_01508|M.leprae_Br4923 SIGVLATIKRDGRPQLSNVQYHFDPRD---LAVRVSITEPGVKTRNLRRD
. . : : : .
Mflv_0151|M.gilvum_PYR-GCK TRDGFELQFGTNHLGHFAFTGLLLDNLLDVPGSRVVTVASLAHKNLADIH
TH_4179|M.thermoresistible__bu TRDGFELQFGTNHLGHFALTGQLLDNILPVDGSRVVTVASIAHRNMADIH
Mb0069|M.bovis_AF2122/97 TADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIH
Rv0068|M.tuberculosis_H37Rv TADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIH
MAB_0646c|M.abscessus_ATCC_199 TADGFELQFGTNHLGHYALTGLLLERLLPVEGSRVVTVSSIGHRIRADIH
Mvan_1061|M.vanbaalenii_PYR-1 TVDGFELQWGTNHLGHFALTARLLP-LLTAGAARVTTQSSIS-AARHAIN
MMAR_1680|M.marinum_M TVEGHEITLATHVLGPILLTELLVPMLAESDDPRVILMSSGGMYTQPLPI
MUL_1918|M.ulcerans_Agy99 TDEGHEITLATHVLGPILLTSLLVPMLAESDDPRVILMSSGGMYTQPLPI
MAV_1610|M.avium_104 TADGYERTYQVNYLAPFLLTTQLLDVLLESR-ATVVNTTSSSHKLILRAT
MSMEG_6848|M.smegmatis_MC2_155 TAEGLEHTFALYYLSRFVLSHRLVG-LLDAAEAPVILNVSGPGSGTDSIR
MLBr_01508|M.leprae_Br4923 PRASILVDVDDGWSYAVAEGTAELTPPAAAPDDDTVEALIVLYRNIVGEH
. . : .
Mflv_0151|M.gilvum_PYR-GCK FDDLQWERKYNRVAAYGQSKLANLMFTYELQRRLAARGAPTIAVAAHPGI
TH_4179|M.thermoresistible__bu FDDLQWERGYHRVAAYGQSKLANLMFAYELQRRLSAKNAPTISVAAHPGV
Mb0069|M.bovis_AF2122/97 FDDLQWERRYRRVAAYGQAKLANLLFTYELQRRLAP-GGTTIAVASHPGV
Rv0068|M.tuberculosis_H37Rv FDDLQWERRYRRVAAYGQAKLANLLFTYELQRRLAP-GGTTIAVASHPGV
MAB_0646c|M.abscessus_ATCC_199 FDDLQWERDYDRVAAYGQSKLANLLFTYELQRRLA--GTNTVALAAHPGG
Mvan_1061|M.vanbaalenii_PYR-1 WDDLNFEKSYAVGKAYSQSKIANLMFGLELDRRSRHAGWGITSNVAHPGV
MMAR_1680|M.marinum_M EDPEYRAGGYRGAVAYARTKRMQVAFTPLLARRWS--GERIRVYSMHPGW
MUL_1918|M.ulcerans_Agy99 EDPEYRAGGYRGAVAYARTKRMQVAFTPLLARRWS--GERIRVYSMHPGW
MAV_1610|M.avium_104 VDDLENTANRRPAVAYAYSKLAIVLFTKELHRRYH--ARGLSVAAVHPGN
MSMEG_6848|M.smegmatis_MC2_155 WDDLGGEHDYEPQRILAQGGQLNDLLGVGFARRRVS--PKTRYVLVHPGV
MLBr_01508|M.leprae_Br4923 LD----WDEYRQAMVTDRRVLLTLPILHVYG--------------LPPGI
* : **
Mflv_0151|M.gilvum_PYR-GCK SNTELMRHVPGT-----------SLPGVMKLAGL--VTNTPAVGALPTVR
TH_4179|M.thermoresistible__bu SNTELTRYIPGA-----------RLPGVSLLAGL--LTNSPAVGALATLR
Mb0069|M.bovis_AF2122/97 SNTELVRNMPRP-----------LVAVAAILAP---LMQDAELGALPTLR
Rv0068|M.tuberculosis_H37Rv SNTEVVRNMPRP-----------LVAVAAILAP---LMQDAELGALPTLR
MAB_0646c|M.abscessus_ATCC_199 SNTELARNSPLW-----------VRAVFDVVAPV--LVQGADMGALPTLR
Mvan_1061|M.vanbaalenii_PYR-1 TATNLLAAQPHMGRD----GDTLSVRLIRRLAGLGILTQTVDQGLLPALY
MMAR_1680|M.marinum_M ADTPGVAT---------------SLPGFRAVTGP--LLRTAEQGADTAVW
MUL_1918|M.ulcerans_Agy99 ADTPGVAT---------------SLPGFRAVIGP--LLRTAEQGADTAVW
MAV_1610|M.avium_104 VNSNIGIASGSR-----------FLVFMQRYTPAALFISSPDQGADPLVR
MSMEG_6848|M.smegmatis_MC2_155 VNTGFSGEYDAATADRIEQIRATAQPVEDAIVPILDIVDHPPAEPLTAVV
MLBr_01508|M.leprae_Br4923 R-------------------------------------------------
Mflv_0151|M.gilvum_PYR-GCK -AATDP------------------------GVTGGQYYGPSGFNEMVGHP
TH_4179|M.thermoresistible__bu -AATDP------------------------EVKGGQYYGPDGFQEIRGHP
Mb0069|M.bovis_AF2122/97 -AATDP------------------------AVRGGQYFGPDGFGEIRGYP
Rv0068|M.tuberculosis_H37Rv -AATDP------------------------AVRGGQYFGPDGFGEIRGYP
MAB_0646c|M.abscessus_ATCC_199 -AATDP------------------------AALGGQYYGPDGFMEQRGNP
Mvan_1061|M.vanbaalenii_PYR-1 -AATHP------------------------DAEGGKFYGPSGFQHLSGAP
MMAR_1680|M.marinum_M LAATRP------------------------APLSGTFWHDR-----RTRP
MUL_1918|M.ulcerans_Agy99 LAATRP------------------------APLSGTFWHDR-----RTRP
MAV_1610|M.avium_104 LASSPPDS----------------------EWTSGAYYAKR---------
MSMEG_6848|M.smegmatis_MC2_155 EGRPIDVHGPAFDAALADRLYDQTTVLLGSLASAAMGVSPARLRQVLDAP
MLBr_01508|M.leprae_Br4923 --------------------------------------------------
Mflv_0151|M.gilvum_PYR-GCK VLVTSNKKSHDVAVQQRLWTVSEELTGVKYGV------------------
TH_4179|M.thermoresistible__bu VLVGSSAKSRDEDIQRRLWTVSEELTGVTFPV------------------
Mb0069|M.bovis_AF2122/97 KVVASSAQSHDEQLQRRLWAVSEELTGVVYPVG-----------------
Rv0068|M.tuberculosis_H37Rv KVVASSAQSHDEQLQRRLWAVSEELTGVVYPVG-----------------
MAB_0646c|M.abscessus_ATCC_199 KVVASSEQSYNLDLQRRLWSVSEELTDVVFPVK-----------------
Mvan_1061|M.vanbaalenii_PYR-1 AEQQVYGPARDAADAARLWRVSEQLAGAQFALPRAGA-------------
MMAR_1680|M.marinum_M EHYLPWTRFSD-DDRQRLWRYCADAIGID---------------------
MUL_1918|M.ulcerans_Agy99 EHYLPWTRYSD-DDRQRLWRYCADAIGID---------------------
MAV_1610|M.avium_104 KIGKTTRLADDPRLAAELWERTAARLG-----------------------
MSMEG_6848|M.smegmatis_MC2_155 VFGTVATIDPDGAPQQSVVWVGRDGDDVLFAVATGSRKERNLRRDPRVSI
MLBr_01508|M.leprae_Br4923 --------------------------------------------------
Mflv_0151|M.gilvum_PYR-GCK --------------------------------------------------
TH_4179|M.thermoresistible__bu --------------------------------------------------
Mb0069|M.bovis_AF2122/97 --------------------------------------------------
Rv0068|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0646c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1061|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1680|M.marinum_M --------------------------------------------------
MUL_1918|M.ulcerans_Agy99 --------------------------------------------------
MAV_1610|M.avium_104 --------------------------------------------------
MSMEG_6848|M.smegmatis_MC2_155 LLSPPDEPYTYAVIHGKATLHTEGGHQLRDALAVKYTGKTYAEGNADAAA
MLBr_01508|M.leprae_Br4923 --------------------------------------------------
Mflv_0151|M.gilvum_PYR-GCK ---------------------
TH_4179|M.thermoresistible__bu ---------------------
Mb0069|M.bovis_AF2122/97 ---------------------
Rv0068|M.tuberculosis_H37Rv ---------------------
MAB_0646c|M.abscessus_ATCC_199 ---------------------
Mvan_1061|M.vanbaalenii_PYR-1 ---------------------
MMAR_1680|M.marinum_M ---------------------
MUL_1918|M.ulcerans_Agy99 ---------------------
MAV_1610|M.avium_104 ---------------------
MSMEG_6848|M.smegmatis_MC2_155 RYGDVAMTVVRVTPERTVGRL
MLBr_01508|M.leprae_Br4923 ---------------------