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RNAPVSEENPQRAPVGVFVGLATLDVIHRIAKPPAVNEKITSTAQFVAAGGPAANAAVTFAALGGEATLV TALGDDPVADLIRADLTAYGVSVIDAAAGSARPVPVSSVAVVESTGDRSVISSDAVTSDAAPPDAIAELV ARADVVLVDGHHPLMARAAAQHANQRGTTVVVDAGRWKPVMADLVPHVSDMVCSGDFRTPGADTSNATAA GLVESGVRTVVITHGGDPVTWWSGGESGEVPVPPVTVVDTLGAGDAFHGAYAYYSTRSDSGVAERIDRSS RVAALRCSVVGPRAWLSKLPDQIRKRER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6801 | - | - | 100% (309) | kinase, pfkB family protein |
| M. smegmatis MC2 155 | MSMEG_4585 | rbsK | 1e-19 | 32.53% (249) | ribokinase |
| M. smegmatis MC2 155 | MSMEG_0504 | - | 7e-14 | 29.60% (277) | carbohydrate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2462 | rbsK | 9e-18 | 29.11% (292) | ribokinase RBSK |
| M. gilvum PYR-GCK | Mflv_2643 | - | 5e-18 | 31.56% (282) | ribokinase |
| M. tuberculosis H37Rv | Rv2436 | rbsK | 9e-18 | 29.11% (292) | ribokinase RBSK |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1617c | - | 9e-14 | 26.15% (283) | ribokinase RbsK |
| M. marinum M | MMAR_4574 | pfkB | 4e-06 | 22.83% (254) | fructokinase, PfkB |
| M. avium 104 | MAV_0347 | - | 7e-15 | 30.83% (253) | kinase, PfkB family protein |
| M. thermoresistible (build 8) | TH_1517 | rbsK | 3e-09 | 29.80% (151) | RIBOKINASE RBSK |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 8e-06 | 22.44% (254) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_3935 | - | 2e-17 | 29.96% (247) | ribokinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2643|M.gilvum_PYR-GCK ------------MATRLCVVGSVNADLTFTVDALPRPGETVLADALACAP
Mvan_3935|M.vanbaalenii_PYR-1 ------------MATRLSVVGSANVDLTFSVTALPRPGETVLASALSSTP
TH_1517|M.thermoresistible__bu ------------VAARVCVVGSVNLDLTFNVDALPERGETVLAHSMSSAP
Mb2462|M.bovis_AF2122/97 -MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTP
Rv2436|M.tuberculosis_H37Rv -MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTP
MAB_1617c|M.abscessus_ATCC_199 ------------------------MDLTLRVEELPAPGATVLATSAMPAP
MMAR_4574|M.marinum_M -------------MARGLVIGEALIDIVDGPDP-------------AEYV
MUL_4435|M.ulcerans_Agy99 -------------MARGLVIGEALIDIVDGPDP-------------AEYV
MSMEG_6801|M.smegmatis_MC2_155 MRNAPVSEENPQRAPVGVFVGLATLDVIHRIAKPPAVNEKITSTAQFVAA
MAV_0347|M.avium_104 ----------------MVVIGQIGRDLVLRTDRPPTAGESATVLRREELL
*:
Mflv_2643|M.gilvum_PYR-GCK GGKGGNQAVAAARAGADVQLVAALGTDASAEQLRDHLRANSVGLDAVVAV
Mvan_3935|M.vanbaalenii_PYR-1 GGKGGNQAVAAARAGAQVQLVAALGTDAAAEQLKAHLKANAVGLDGVTAV
TH_1517|M.thermoresistible__bu GGKGGNQAVAAARAGADVELIAALGDDAAGERLRSHLRDNGVGLDGVTTV
Mb2462|M.bovis_AF2122/97 GGKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTV
Rv2436|M.tuberculosis_H37Rv GGKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTV
MAB_1617c|M.abscessus_ATCC_199 GGKGANQAVAAARAGASVQFIGAVGSDGAAPMLRSHLADNNVGLDGLVEV
MMAR_4574|M.marinum_M GGSPLNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQT
MUL_4435|M.ulcerans_Agy99 GGSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQT
MSMEG_6801|M.smegmatis_MC2_155 GGPAANAAVTFAALGGEATLVTALGDDPVADLIRADLTAYGVSVIDAAAG
MAV_0347|M.avium_104 GGKGANQAVGLAQLGVPVTLIGVVGDDQAGTSILQQAQRDGIDVSKVARR
** * ** * * . : .* * . : : :
Mflv_2643|M.gilvum_PYR-GCK PG--PSGTAAILVDAGAENCIVVAPGANAHLSLAS--------PVVRSAI
Mvan_3935|M.vanbaalenii_PYR-1 PG--PSGSAAILVDAAGENCIVVAPGANGHLSLSS--------PAVREVV
TH_1517|M.thermoresistible__bu AG--PSGSAVIVVDSDAENTIVVAPGANAALTIDAEGDGADDSASAGAII
Mb2462|M.bovis_AF2122/97 PG--PSGTAIIVVDASAENTVLVAPGANAHLTPVP------------SAV
Rv2436|M.tuberculosis_H37Rv PG--PSGTAIIVVDASAENTVLVAPGANAHLTPVP------------SAV
MAB_1617c|M.abscessus_ATCC_199 DG--PSGMATITVEDSGENCIVVAPGANTTFTLDEK--------VHKDII
MMAR_4574|M.marinum_M ADRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPP-----LLVHTGSIA
MUL_4435|M.ulcerans_Agy99 ADRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPP-----LLVHTGSIA
MSMEG_6801|M.smegmatis_MC2_155 SARPVPVSSVAVVESTGDRSVISSDAVTSDAAPPD---------AIAELV
MAV_0347|M.avium_104 GT---TALLVDVVAAPPERMLLEDVPDSSLVRVADLD-------RSSSLF
. .
Mflv_2643|M.gilvum_PYR-GCK ADADVVLLSLEIPIDTAVAAARAGRYAGATVMLN---ASPTPREVG---T
Mvan_3935|M.vanbaalenii_PYR-1 ADSDVVLLSLEIPIDTAVTAARIGRSAGATVVLN---ASPASAQAS---A
TH_1517|M.thermoresistible__bu AASDVVLMQLEIPAATAVAAAXXXRXAGVG--------------------
Mb2462|M.bovis_AF2122/97 ANCDVLLTQLEIPVATALAAARAAQSADAVVMVN---ASPAGQDRSSLQD
Rv2436|M.tuberculosis_H37Rv ANCDVLLTQLEIPVATALAAARAAQSADAVVMVN---ASPAGQDRSSLQD
MAB_1617c|M.abscessus_ATCC_199 CSHDVLLCQLEIPVRVALTAARWAAEAGKQFVLN---ASPVPERSPDLAE
MMAR_4574|M.marinum_M AAREPGCLAVAALLDAYRAAATVSFDPNVRPSLS---ADPDLTRER-IQR
MUL_4435|M.ulcerans_Agy99 AAREPGCLAVAALLDAYRAAATVSFDPNVRPSLR---ADPDLTRER-IQR
MSMEG_6801|M.smegmatis_MC2_155 ARADVVLVDGHHPLMARAAAQHANQRGTTVVVDAGRWKPVMADLVPHVSD
MAV_0347|M.avium_104 DTADTVSIQLQQPAATALEAAQRARQRGLRVVADG-VPAPQVRADLLATL
: . *
Mflv_2643|M.gilvum_PYR-GCK LAAHVDVVVVN-------------ETEADAWRDGDRILVPHLVVTHGARG
Mvan_3935|M.vanbaalenii_PYR-1 LADLADVVVVN-------------ETESDGWLDGDRPRVPHLVITRGARG
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mb2462|M.bovis_AF2122/97 LAAIADVVIAN-------------EHEANDWPSPP----THFVITLGVRG
Rv2436|M.tuberculosis_H37Rv LAAIADVVIAN-------------EHEANDWPSPP----THFVITLGVRG
MAB_1617c|M.abscessus_ATCC_199 LAFRASVVVVN-------------ETEARSWLYPSR----HLVTTLGDEG
MMAR_4574|M.marinum_M LVERSDIIKASAEDLHWIDPTQPPEQTARAWLACGP---AIVALTLGDQG
MUL_4435|M.ulcerans_Agy99 LVERSDIIKASAEDLHWIDPTQPPEQTARAWLACGP---AIVALTFGDQS
MSMEG_6801|M.smegmatis_MC2_155 MVCSGDFRTPG------------ADTSNATAAGLVESGVRTVVITHGGDP
MAV_0347|M.avium_104 DVLRADATEASIIAGTEITTVEQAFELADHLLSGGP---ELVALAVPDVG
Mflv_2643|M.gilvum_PYR-GCK ATCVGQC-HLEVPAPAVEAVDTTGAGDVFAG-VLAANWEQG------VEF
Mvan_3935|M.vanbaalenii_PYR-1 ATYVGET-RLEFPAPAVEAVDTTGAGDVFAG-VLAANWPRG------ADY
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mb2462|M.bovis_AF2122/97 ARYVGADGVFEVPAPTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERLR
Rv2436|M.tuberculosis_H37Rv ARYVGADGVFEVPAPTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERLR
MAB_1617c|M.abscessus_ATCC_199 SRYRSPQGQITVPSYPVRPLDTTGAGDVFAG-VLAAWWPQG------AET
MMAR_4574|M.marinum_M AVAFCAAGPASVPAQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLGADRRT
MUL_4435|M.ulcerans_Agy99 AVAFCAAGPASMPAQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLDADRRT
MSMEG_6801|M.smegmatis_MC2_155 VTWWSGGESGEVPVPPVTVVDTLGAGDAFHG-AYAYYSTRS------DSG
MAV_0347|M.avium_104 DLLTWRGGSELFEFADVEVVDPTGAGDAFVAGLVAALREGA------APR
Mflv_2643|M.gilvum_PYR-GCK AMARACAAGALATLVPGAGDCAPSREAVEDVLDAL-------
Mvan_3935|M.vanbaalenii_PYR-1 ALARACAAGALSTLVHGAGDCAPYSEAVEDVLEAS-------
TH_1517|M.thermoresistible__bu ------------------------------------------
Mb2462|M.bovis_AF2122/97 ALRRACAAGVLATLVSGAGDCAPAAAAIDAALRANRHNGS--
Rv2436|M.tuberculosis_H37Rv ALRRACAAGALATLVSGVGDCAPAAAAIDAALRANRHNGS--
MAB_1617c|M.abscessus_ATCC_199 ALRRANVAGALATLRAGAGNCAPTGARIELSLKGS-------
MMAR_4574|M.marinum_M ELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR
MUL_4435|M.ulcerans_Agy99 ELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR
MSMEG_6801|M.smegmatis_MC2_155 VAERIDRSSRVAALRCSVVGPRAWLSKLPDQIRKRER-----
MAV_0347|M.avium_104 EAGRRAAAAAGATVQRLGGRPDLTGLRA--------------