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MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPGGKGANQAVAAARAGAQVQFS GAFGDDPAAAQLRAHLRANAVGLDRTVTVPGPSGTAIIVVDASAENTVLVAPGANAHLTPVPSAVANCDV LLTQLEIPVATALAAARAAQSADAVVMVNASPAGQDRSSLQDLAAIADVVIANEHEANDWPSPPTHFVIT LGVRGARYVGADGVFEVPAPTVTPVDTAGAGDVFAGVLAANWPRNPGSPAERLRALRRACAAGALATLVS GVGDCAPAAAAIDAALRANRHNGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2436 | rbsK | - | 100% (304) | RIBOKINASE RBSK |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2462 | rbsK | 1e-170 | 99.34% (304) | ribokinase RBSK |
| M. gilvum PYR-GCK | Mflv_2643 | - | 5e-85 | 60.34% (295) | ribokinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1617c | - | 3e-69 | 53.57% (280) | ribokinase RbsK |
| M. marinum M | MMAR_4574 | pfkB | 2e-10 | 29.26% (270) | fructokinase, PfkB |
| M. avium 104 | MAV_1743 | - | 1e-107 | 70.36% (280) | kinase, pfkB family protein |
| M. smegmatis MC2 155 | MSMEG_4585 | rbsK | 2e-84 | 59.72% (288) | ribokinase |
| M. thermoresistible (build 8) | TH_1517 | rbsK | 2e-46 | 60.12% (163) | RIBOKINASE RBSK |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 6e-09 | 28.15% (270) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_3935 | - | 2e-86 | 59.93% (297) | ribokinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2436|M.tuberculosis_H37Rv MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
Mb2462|M.bovis_AF2122/97 MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
MAV_1743|M.avium_104 ---------------------MNLDLSLAVDALPRPGETVLASSLRQAPG
MSMEG_4585|M.smegmatis_MC2_155 ----------MGAARVCVVGSINADLTFTVANLPRPGQTVLASSLASAPG
TH_1517|M.thermoresistible__bu -----------VAARVCVVGSVNLDLTFNVDALPERGETVLAHSMSSAPG
Mflv_2643|M.gilvum_PYR-GCK -----------MATRLCVVGSVNADLTFTVDALPRPGETVLADALACAPG
Mvan_3935|M.vanbaalenii_PYR-1 -----------MATRLSVVGSANVDLTFSVTALPRPGETVLASALSSTPG
MAB_1617c|M.abscessus_ATCC_199 -----------------------MDLTLRVEELPAPGATVLATSAMPAPG
MMAR_4574|M.marinum_M ----------------MARGLVIGEALIDIVDGPDP---------AEYVG
MUL_4435|M.ulcerans_Agy99 ----------------MARGLVIGEALIDIVDGPDP---------AEYVG
: : : * *
Rv2436|M.tuberculosis_H37Rv GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVP
Mb2462|M.bovis_AF2122/97 GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVP
MAV_1743|M.avium_104 GKGGNQAVAAARAGARVQFVGAVGDDAAAGQLRAHLQANGVGLDGAVEIP
MSMEG_4585|M.smegmatis_MC2_155 GKGGNQAVAAARAGAATSLVAAVGDDAAAESLRAHLRANGVDEDAVVSLA
TH_1517|M.thermoresistible__bu GKGGNQAVAAARAGADVELIAALGDDAAGERLRSHLRDNGVGLDGVTTVA
Mflv_2643|M.gilvum_PYR-GCK GKGGNQAVAAARAGADVQLVAALGTDASAEQLRDHLRANSVGLDAVVAVP
Mvan_3935|M.vanbaalenii_PYR-1 GKGGNQAVAAARAGAQVQLVAALGTDAAAEQLKAHLKANAVGLDGVTAVP
MAB_1617c|M.abscessus_ATCC_199 GKGANQAVAAARAGASVQFIGAVGSDGAAPMLRSHLADNNVGLDGLVEVD
MMAR_4574|M.marinum_M GSPLNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTA
MUL_4435|M.ulcerans_Agy99 GSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTA
*. * **. ** * ..: .* * . : :: . *
Rv2436|M.tuberculosis_H37Rv GPSGTAIIVVDASA--------ENTVLVAPGANAHLTP------------
Mb2462|M.bovis_AF2122/97 GPSGTAIIVVDASA--------ENTVLVAPGANAHLTP------------
MAV_1743|M.avium_104 GPSGTAIVVVDANA--------ENTIVVAPGANGRFTLNDE--------R
MSMEG_4585|M.smegmatis_MC2_155 GPSGSAAIVVDAAG--------ENHIVVAPGANALLDVDAP--------A
TH_1517|M.thermoresistible__bu GPSGSAVIVVDSDA--------ENTIVVAPGANAALTIDAEGDGADDSAS
Mflv_2643|M.gilvum_PYR-GCK GPSGTAAILVDAGA--------ENCIVVAPGANAHLSLASP--------V
Mvan_3935|M.vanbaalenii_PYR-1 GPSGSAAILVDAAG--------ENCIVVAPGANGHLSLSSP--------A
MAB_1617c|M.abscessus_ATCC_199 GPSGMATITVEDSG--------ENCIVVAPGANTTFTLDEK--------V
MMAR_4574|M.marinum_M DRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPPLLVHTGSIAAAREPG
MUL_4435|M.ulcerans_Agy99 DRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPPLLVHTGSIAAAREPG
. : * : . * : :* . :
Rv2436|M.tuberculosis_H37Rv VPSAVANCDVLLTQLEIPVATALAAARAAQ-SADAVVMVNASPAGQDRSS
Mb2462|M.bovis_AF2122/97 VPSAVANCDVLLTQLEIPVATALAAARAAQ-SADAVVMVNASPAGQDRSS
MAV_1743|M.avium_104 ARAVLAGCDVMLTQLEIPVATAVAAARHAR-SGGAVVVVNASPAGRDPDS
MSMEG_4585|M.smegmatis_MC2_155 ARAAIGSADVVLLQLEISPTTAIAAAQQAR-DAGALVMLNASPVGTAAHH
TH_1517|M.thermoresistible__bu AGAIIAASDVVLMQLEIPAATAVAAAXXXR-XAG---------VG-----
Mflv_2643|M.gilvum_PYR-GCK VRSAIADADVVLLSLEIPIDTAVAAARAGR-YAGATVMLN---ASPTPRE
Mvan_3935|M.vanbaalenii_PYR-1 VREVVADSDVVLLSLEIPIDTAVTAARIGR-SAGATVVLN---ASPASAQ
MAB_1617c|M.abscessus_ATCC_199 HKDIICSHDVLLCQLEIPVRVALTAARWAA-EAGKQFVLNASPVPERSPD
MMAR_4574|M.marinum_M CLAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRERIQRLVERSDIIKA
MUL_4435|M.ulcerans_Agy99 CLAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRERIQRLVERSDIIKA
*. :. : .:
Rv2436|M.tuberculosis_H37Rv LQDLAAIADVVIANEHEANDWPSP----PTHFVITLGVRGARYVGADGVF
Mb2462|M.bovis_AF2122/97 LQDLAAIADVVIANEHEANDWPSP----PTHFVITLGVRGARYVGADGVF
MAV_1743|M.avium_104 LSELAAAADVVITNEEEASEWPWR----PRHLVVTLGSHGARYVGADGEY
MSMEG_4585|M.smegmatis_MC2_155 LLALSHLTDVVVVNETEAAEWHWP----VRHLVITRGARGASYVSDDERF
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mflv_2643|M.gilvum_PYR-GCK VGTLAAHVDVVVVNETEADAWRDGDRILVPHLVVTHGARGATCVG-QCHL
Mvan_3935|M.vanbaalenii_PYR-1 ASALADLADVVVVNETESDGWLDGDRPRVPHLVITRGARGATYVG-ETRL
MAB_1617c|M.abscessus_ATCC_199 LAELAFRASVVVVNETEARSWLYP----SRHLVTTLGDEGSRYRSPQGQI
MMAR_4574|M.marinum_M SAEDLHWIDPTQPPEQTARAWLACG---PAIVALTLGDQGAVAFCAAGPA
MUL_4435|M.ulcerans_Agy99 SAEDLHWIDPTQPPEQTARAWLACG---PAIVALTFGDQSAVAFCAAGPA
Rv2436|M.tuberculosis_H37Rv EVPAPTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERLRALRRACAAGA
Mb2462|M.bovis_AF2122/97 EVPAPTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERLRALRRACAAGV
MAV_1743|M.avium_104 SVPSPDVDAVDTTGAGDVFAG-VLAANWPLEPGSPDQRRLALRRACAAGA
MSMEG_4585|M.smegmatis_MC2_155 DVPALRVRAVDTTGAGDVFAG-VLAAGWPAG------HEHALQRACAAGA
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mflv_2643|M.gilvum_PYR-GCK EVPAPAVEAVDTTGAGDVFAG-VLAANWEQG------VEFAMARACAAGA
Mvan_3935|M.vanbaalenii_PYR-1 EFPAPAVEAVDTTGAGDVFAG-VLAANWPRG------ADYALARACAAGA
MAB_1617c|M.abscessus_ATCC_199 TVPSYPVRPLDTTGAGDVFAG-VLAAWWPQG------AETALRRANVAGA
MMAR_4574|M.marinum_M SVPAQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLGADRRTELRKIGVSAL
MUL_4435|M.ulcerans_Agy99 SMPAQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLDADRRTELRKIGVSAL
Rv2436|M.tuberculosis_H37Rv LATLVSGVGDCAPAAAAIDAALRANRHNGS--
Mb2462|M.bovis_AF2122/97 LATLVSGAGDCAPAAAAIDAALRANRHNGS--
MAV_1743|M.avium_104 LATLVPGAGDCAPRAEEIERALRGKS------
MSMEG_4585|M.smegmatis_MC2_155 LATLVRGAGDCAPSAADIDAVLTP--------
TH_1517|M.thermoresistible__bu --------------------------------
Mflv_2643|M.gilvum_PYR-GCK LATLVPGAGDCAPSREAVEDVLDAL-------
Mvan_3935|M.vanbaalenii_PYR-1 LSTLVHGAGDCAPYSEAVEDVLEAS-------
MAB_1617c|M.abscessus_ATCC_199 LATLRAGAGNCAPTGARIELSLKGS-------
MMAR_4574|M.marinum_M TSALEVAALTSALTVARAGADLPYRADLRQSR
MUL_4435|M.ulcerans_Agy99 TSALEVAALTSALTVARAGADLPYRADLRQSR