For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ATRLCVVGSVNADLTFTVDALPRPGETVLADALACAPGGKGGNQAVAAARAGADVQLVAALGTDASAEQL RDHLRANSVGLDAVVAVPGPSGTAAILVDAGAENCIVVAPGANAHLSLASPVVRSAIADADVVLLSLEIP IDTAVAAARAGRYAGATVMLNASPTPREVGTLAAHVDVVVVNETEADAWRDGDRILVPHLVVTHGARGAT CVGQCHLEVPAPAVEAVDTTGAGDVFAGVLAANWEQGVEFAMARACAAGALATLVPGAGDCAPSREAVED VLDAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2643 | - | - | 100% (286) | ribokinase |
| M. gilvum PYR-GCK | Mflv_1827 | - | 1e-07 | 26.81% (235) | ribokinase-like domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2947 | - | 3e-06 | 26.12% (268) | adenosine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2462 | rbsK | 3e-85 | 60.34% (295) | ribokinase RBSK |
| M. tuberculosis H37Rv | Rv2436 | rbsK | 4e-85 | 60.34% (295) | ribokinase RBSK |
| M. leprae Br4923 | MLBr_00873 | - | 2e-06 | 24.72% (271) | putative carbohydrate kinase |
| M. abscessus ATCC 19977 | MAB_1617c | - | 3e-67 | 53.51% (271) | ribokinase RbsK |
| M. marinum M | MMAR_4574 | pfkB | 6e-10 | 28.02% (232) | fructokinase, PfkB |
| M. avium 104 | MAV_1743 | - | 1e-83 | 61.48% (283) | kinase, pfkB family protein |
| M. smegmatis MC2 155 | MSMEG_4585 | rbsK | 7e-91 | 65.52% (290) | ribokinase |
| M. thermoresistible (build 8) | TH_1517 | rbsK | 5e-50 | 64.02% (164) | RIBOKINASE RBSK |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 9e-09 | 27.47% (233) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_3935 | - | 1e-121 | 77.54% (285) | ribokinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2462|M.bovis_AF2122/97 MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
Rv2436|M.tuberculosis_H37Rv MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
MAV_1743|M.avium_104 ---------------------MNLDLSLAVDALPRPGETVLASSLRQAPG
Mflv_2643|M.gilvum_PYR-GCK -----------MATRLCVVGSVNADLTFTVDALPRPGETVLADALACAPG
Mvan_3935|M.vanbaalenii_PYR-1 -----------MATRLSVVGSANVDLTFSVTALPRPGETVLASALSSTPG
MSMEG_4585|M.smegmatis_MC2_155 ----------MGAARVCVVGSINADLTFTVANLPRPGQTVLASSLASAPG
TH_1517|M.thermoresistible__bu -----------VAARVCVVGSVNLDLTFNVDALPERGETVLAHSMSSAPG
MAB_1617c|M.abscessus_ATCC_199 -----------------------MDLTLRVEELPAPGATVLATSAMPAPG
MMAR_4574|M.marinum_M ----------------MARGLVIGEALIDIVDGPDP---------AEYVG
MUL_4435|M.ulcerans_Agy99 ----------------MARGLVIGEALIDIVDGPDP---------AEYVG
MLBr_00873|M.leprae_Br4923 ---MTIAVTGSIATDHLMRFPGRFSEQLLVDNLHKVSLSFLVDDLVIHRG
. : : *
Mb2462|M.bovis_AF2122/97 GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVP
Rv2436|M.tuberculosis_H37Rv GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVP
MAV_1743|M.avium_104 GKGGNQAVAAARAGARVQFVGAVGDDAAAGQLRAHLQANGVGLDGAVEIP
Mflv_2643|M.gilvum_PYR-GCK GKGGNQAVAAARAGADVQLVAALGTDASAEQLRDHLRANSVGLDAVVAVP
Mvan_3935|M.vanbaalenii_PYR-1 GKGGNQAVAAARAGAQVQLVAALGTDAAAEQLKAHLKANAVGLDGVTAVP
MSMEG_4585|M.smegmatis_MC2_155 GKGGNQAVAAARAGAATSLVAAVGDDAAAESLRAHLRANGVDEDAVVSLA
TH_1517|M.thermoresistible__bu GKGGNQAVAAARAGADVELIAALGDDAAGERLRSHLRDNGVGLDGVTTVA
MAB_1617c|M.abscessus_ATCC_199 GKGANQAVAAARAGASVQFIGAVGSDGAAPMLRSHLADNNVGLDGLVEVD
MMAR_4574|M.marinum_M GSPLNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTA
MUL_4435|M.ulcerans_Agy99 GSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTA
MLBr_00873|M.leprae_Br4923 GVAGNMAYAIGVLGGDVALIGAVGDDFAD--YRDWLQNHGVNCDSVLISK
* * * . . * . : .* * : *
Mb2462|M.bovis_AF2122/97 G--PSGTAIIVVDASAENTVLVAPGANAHLTP------------VPSAVA
Rv2436|M.tuberculosis_H37Rv G--PSGTAIIVVDASAENTVLVAPGANAHLTP------------VPSAVA
MAV_1743|M.avium_104 G--PSGTAIVVVDANAENTIVVAPGANGRFTLNDE--------RARAVLA
Mflv_2643|M.gilvum_PYR-GCK G--PSGTAAILVDAGAENCIVVAPGANAHLSLASP--------VVRSAIA
Mvan_3935|M.vanbaalenii_PYR-1 G--PSGSAAILVDAAGENCIVVAPGANGHLSLSSP--------AVREVVA
MSMEG_4585|M.smegmatis_MC2_155 G--PSGSAAIVVDAAGENHIVVAPGANALLDVDAP--------AARAAIG
TH_1517|M.thermoresistible__bu G--PSGSAVIVVDSDAENTIVVAPGANAALTIDAEGDGADDSASAGAIIA
MAB_1617c|M.abscessus_ATCC_199 G--PSGMATITVEDSGENCIVVAPGANTTFTLDEK--------VHKDIIC
MMAR_4574|M.marinum_M DRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPP-----LLVHTGSIAA
MUL_4435|M.ulcerans_Agy99 DRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPP-----LLVHTGSIAA
MLBr_00873|M.leprae_Br4923 T---AHTARFVCTTDLDMAQIGSFYTGAMSEARNIK-----LVDAIATIG
: * .
Mb2462|M.bovis_AF2122/97 NCDVLLTQLEIPVATALAAARAAQSADAVVMVNASPAGQDRSS--LQDLA
Rv2436|M.tuberculosis_H37Rv NCDVLLTQLEIPVATALAAARAAQSADAVVMVNASPAGQDRSS--LQDLA
MAV_1743|M.avium_104 GCDVMLTQLEIPVATAVAAARHARSGGAVVVVNASPAGRDPDS--LSELA
Mflv_2643|M.gilvum_PYR-GCK DADVVLLSLEIPIDTAVAAARAGRYAGATVMLNASPTPREVG-----TLA
Mvan_3935|M.vanbaalenii_PYR-1 DSDVVLLSLEIPIDTAVTAARIGRSAGATVVLNASPASAQAS-----ALA
MSMEG_4585|M.smegmatis_MC2_155 SADVVLLQLEISPTTAIAAAQQARDAGALVMLNASPVGTAAHH--LLALS
TH_1517|M.thermoresistible__bu ASDVVLMQLEIPAATAVAAAXXXRXAG---------VG------------
MAB_1617c|M.abscessus_ATCC_199 SHDVLLCQLEIPVRVALTAARWAAEAGKQFVLNASPVPERSPD--LAELA
MMAR_4574|M.marinum_M AREPGCLAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRER---IQRLV
MUL_4435|M.ulcerans_Agy99 AREPGCLAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRER---IQRLV
MLBr_00873|M.leprae_Br4923 TPELVIIGANDP-AAMLGYTQECRKLGLAFAADPSQQLARLSGEEIRNLI
: . : .
Mb2462|M.bovis_AF2122/97 AIADVVIAN-------------EHEANDWPSP----PTHFVIT-LGVRGA
Rv2436|M.tuberculosis_H37Rv AIADVVIAN-------------EHEANDWPSP----PTHFVIT-LGVRGA
MAV_1743|M.avium_104 AAADVVITN-------------EEEASEWPWR----PRHLVVT-LGSHGA
Mflv_2643|M.gilvum_PYR-GCK AHVDVVVVN-------------ETEADAWRDGDRILVPHLVVT-HGARGA
Mvan_3935|M.vanbaalenii_PYR-1 DLADVVVVN-------------ETESDGWLDGDRPRVPHLVIT-RGARGA
MSMEG_4585|M.smegmatis_MC2_155 HLTDVVVVN-------------ETEAAEWHWP----VRHLVIT-RGARGA
TH_1517|M.thermoresistible__bu --------------------------------------------------
MAB_1617c|M.abscessus_ATCC_199 FRASVVVVN-------------ETEARSWLYP----SRHLVTT-LGDEGS
MMAR_4574|M.marinum_M ERSDIIKASAEDLHWIDPTQPPEQTARAWLACG---PAIVALT-LGDQGA
MUL_4435|M.ulcerans_Agy99 ERSDIIKASAEDLHWIDPTQPPEQTARAWLACG---PAIVALT-FGDQSA
MLBr_00873|M.leprae_Br4923 DGATYLFTN-------DYEWDLLLSKTGWSEADVMAQIQLRVTTLGAKGV
Mb2462|M.bovis_AF2122/97 RYVGADGVFEVP--APTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERL
Rv2436|M.tuberculosis_H37Rv RYVGADGVFEVP--APTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERL
MAV_1743|M.avium_104 RYVGADGEYSVP--SPDVDAVDTTGAGDVFAG-VLAANWPLEPGSPDQRR
Mflv_2643|M.gilvum_PYR-GCK TCVG-QCHLEVP--APAVEAVDTTGAGDVFAG-VLAANWEQG------VE
Mvan_3935|M.vanbaalenii_PYR-1 TYVG-ETRLEFP--APAVEAVDTTGAGDVFAG-VLAANWPRG------AD
MSMEG_4585|M.smegmatis_MC2_155 SYVSDDERFDVP--ALRVRAVDTTGAGDVFAG-VLAAGWPAG------HE
TH_1517|M.thermoresistible__bu --------------------------------------------------
MAB_1617c|M.abscessus_ATCC_199 RYRSPQGQITVP--SYPVRPLDTTGAGDVFAG-VLAAWWPQG------AE
MMAR_4574|M.marinum_M VAFCAAGPASVP--AQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLGADRR
MUL_4435|M.ulcerans_Agy99 VAFCAAGPASMP--AQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLDADRR
MLBr_00873|M.leprae_Br4923 DLVEPDGTRVHVSVVPEAGQVDPTGVGDAFRAGFLTGRSAGLSLERSAQL
Mb2462|M.bovis_AF2122/97 RALRRACAAGVLATLVSGAGDCAPAAAAIDAALRANRHNGS----
Rv2436|M.tuberculosis_H37Rv RALRRACAAGALATLVSGVGDCAPAAAAIDAALRANRHNGS----
MAV_1743|M.avium_104 LALRRACAAGALATLVPGAGDCAPRAEEIERALRGKS--------
Mflv_2643|M.gilvum_PYR-GCK FAMARACAAGALATLVPGAGDCAPSREAVEDVLDAL---------
Mvan_3935|M.vanbaalenii_PYR-1 YALARACAAGALSTLVHGAGDCAPYSEAVEDVLEAS---------
MSMEG_4585|M.smegmatis_MC2_155 HALQRACAAGALATLVRGAGDCAPSAADIDAVLTP----------
TH_1517|M.thermoresistible__bu ---------------------------------------------
MAB_1617c|M.abscessus_ATCC_199 TALRRANVAGALATLRAGAGNCAPTGARIELSLKGS---------
MMAR_4574|M.marinum_M TELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR--
MUL_4435|M.ulcerans_Agy99 TELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR--
MLBr_00873|M.leprae_Br4923 GSLVAVLVLESTGTQQWGWDRDVAVARLAGAYGEEAAAEITVVLS