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MATRLSVVGSANVDLTFSVTALPRPGETVLASALSSTPGGKGGNQAVAAARAGAQVQLVAALGTDAAAEQ LKAHLKANAVGLDGVTAVPGPSGSAAILVDAAGENCIVVAPGANGHLSLSSPAVREVVADSDVVLLSLEI PIDTAVTAARIGRSAGATVVLNASPASAQASALADLADVVVVNETESDGWLDGDRPRVPHLVITRGARGA TYVGETRLEFPAPAVEAVDTTGAGDVFAGVLAANWPRGADYALARACAAGALSTLVHGAGDCAPYSEAVE DVLEAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3935 | - | - | 100% (286) | ribokinase |
| M. vanbaalenii PYR-1 | Mvan_4916 | - | 1e-08 | 25.58% (301) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1394 | - | 6e-06 | 26.07% (280) | ribokinase-like domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2462 | rbsK | 1e-86 | 59.93% (297) | ribokinase RBSK |
| M. gilvum PYR-GCK | Mflv_2643 | - | 1e-121 | 77.54% (285) | ribokinase |
| M. tuberculosis H37Rv | Rv2436 | rbsK | 1e-86 | 59.93% (297) | ribokinase RBSK |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1617c | - | 2e-70 | 52.88% (278) | ribokinase RbsK |
| M. marinum M | MMAR_4574 | pfkB | 2e-09 | 26.39% (269) | fructokinase, PfkB |
| M. avium 104 | MAV_1743 | - | 2e-85 | 60.99% (282) | kinase, pfkB family protein |
| M. smegmatis MC2 155 | MSMEG_4585 | rbsK | 2e-91 | 63.99% (286) | ribokinase |
| M. thermoresistible (build 8) | TH_1517 | rbsK | 1e-48 | 61.59% (164) | RIBOKINASE RBSK |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 7e-09 | 26.02% (269) | fructokinase, PfkB |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2462|M.bovis_AF2122/97 MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
Rv2436|M.tuberculosis_H37Rv MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
MAV_1743|M.avium_104 ---------------------MNLDLSLAVDALPRPGETVLASSLRQAPG
Mvan_3935|M.vanbaalenii_PYR-1 -----------MATRLSVVGSANVDLTFSVTALPRPGETVLASALSSTPG
Mflv_2643|M.gilvum_PYR-GCK -----------MATRLCVVGSVNADLTFTVDALPRPGETVLADALACAPG
MSMEG_4585|M.smegmatis_MC2_155 ----------MGAARVCVVGSINADLTFTVANLPRPGQTVLASSLASAPG
TH_1517|M.thermoresistible__bu -----------VAARVCVVGSVNLDLTFNVDALPERGETVLAHSMSSAPG
MAB_1617c|M.abscessus_ATCC_199 -----------------------MDLTLRVEELPAPGATVLATSAMPAPG
MMAR_4574|M.marinum_M ----------------MARGLVIGEALIDIVDGPDP---------AEYVG
MUL_4435|M.ulcerans_Agy99 ----------------MARGLVIGEALIDIVDGPDP---------AEYVG
: : : * *
Mb2462|M.bovis_AF2122/97 GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVP
Rv2436|M.tuberculosis_H37Rv GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVP
MAV_1743|M.avium_104 GKGGNQAVAAARAGARVQFVGAVGDDAAAGQLRAHLQANGVGLDGAVEIP
Mvan_3935|M.vanbaalenii_PYR-1 GKGGNQAVAAARAGAQVQLVAALGTDAAAEQLKAHLKANAVGLDGVTAVP
Mflv_2643|M.gilvum_PYR-GCK GKGGNQAVAAARAGADVQLVAALGTDASAEQLRDHLRANSVGLDAVVAVP
MSMEG_4585|M.smegmatis_MC2_155 GKGGNQAVAAARAGAATSLVAAVGDDAAAESLRAHLRANGVDEDAVVSLA
TH_1517|M.thermoresistible__bu GKGGNQAVAAARAGADVELIAALGDDAAGERLRSHLRDNGVGLDGVTTVA
MAB_1617c|M.abscessus_ATCC_199 GKGANQAVAAARAGASVQFIGAVGSDGAAPMLRSHLADNNVGLDGLVEVD
MMAR_4574|M.marinum_M GSPLNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTA
MUL_4435|M.ulcerans_Agy99 GSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTA
*. * **. ** * ..: .* * . : :: . *
Mb2462|M.bovis_AF2122/97 G--PSGTAIIVVDASAENTVLVAPGANAHLTP------------VPSAVA
Rv2436|M.tuberculosis_H37Rv G--PSGTAIIVVDASAENTVLVAPGANAHLTP------------VPSAVA
MAV_1743|M.avium_104 G--PSGTAIVVVDANAENTIVVAPGANGRFTLNDE--------RARAVLA
Mvan_3935|M.vanbaalenii_PYR-1 G--PSGSAAILVDAAGENCIVVAPGANGHLSLSSP--------AVREVVA
Mflv_2643|M.gilvum_PYR-GCK G--PSGTAAILVDAGAENCIVVAPGANAHLSLASP--------VVRSAIA
MSMEG_4585|M.smegmatis_MC2_155 G--PSGSAAIVVDAAGENHIVVAPGANALLDVDAP--------AARAAIG
TH_1517|M.thermoresistible__bu G--PSGSAVIVVDSDAENTIVVAPGANAALTIDAEGDGADDSASAGAIIA
MAB_1617c|M.abscessus_ATCC_199 G--PSGMATITVEDSGENCIVVAPGANTTFTLDEK--------VHKDIIC
MMAR_4574|M.marinum_M DRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPP-----LLVHTGSIAA
MUL_4435|M.ulcerans_Agy99 DRTPTATARIGPDGSATYAFDLEWQIPDTPPVAPP-----LLVHTGSIAA
. *:. * : : . . :
Mb2462|M.bovis_AF2122/97 NCDVLLTQLEIPVATALAAARAAQSADAVVMVNASPAGQDRSSLQDLAAI
Rv2436|M.tuberculosis_H37Rv NCDVLLTQLEIPVATALAAARAAQSADAVVMVNASPAGQDRSSLQDLAAI
MAV_1743|M.avium_104 GCDVMLTQLEIPVATAVAAARHARSGGAVVVVNASPAGRDPDSLSELAAA
Mvan_3935|M.vanbaalenii_PYR-1 DSDVVLLSLEIPIDTAVTAARIGRSAGATVVLNASPASAQAS---ALADL
Mflv_2643|M.gilvum_PYR-GCK DADVVLLSLEIPIDTAVAAARAGRYAGATVMLNASPTPREVG---TLAAH
MSMEG_4585|M.smegmatis_MC2_155 SADVVLLQLEISPTTAIAAAQQARDAGALVMLNASPVGTAAHHLLALSHL
TH_1517|M.thermoresistible__bu ASDVVLMQLEIPAATAVAAAXXXRXAG---------VG------------
MAB_1617c|M.abscessus_ATCC_199 SHDVLLCQLEIPVRVALTAARWAAEAGKQFVLNASPVPERSPDLAELAFR
MMAR_4574|M.marinum_M AREPGCLAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRER-IQRLVER
MUL_4435|M.ulcerans_Agy99 AREPGCLAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRER-IQRLVER
: : . :** .
Mb2462|M.bovis_AF2122/97 ADVVIAN-------------EHEANDWPSP----PTHFVITLGVRGARYV
Rv2436|M.tuberculosis_H37Rv ADVVIAN-------------EHEANDWPSP----PTHFVITLGVRGARYV
MAV_1743|M.avium_104 ADVVITN-------------EEEASEWPWR----PRHLVVTLGSHGARYV
Mvan_3935|M.vanbaalenii_PYR-1 ADVVVVN-------------ETESDGWLDGDRPRVPHLVITRGARGATYV
Mflv_2643|M.gilvum_PYR-GCK VDVVVVN-------------ETEADAWRDGDRILVPHLVVTHGARGATCV
MSMEG_4585|M.smegmatis_MC2_155 TDVVVVN-------------ETEAAEWHWP----VRHLVITRGARGASYV
TH_1517|M.thermoresistible__bu --------------------------------------------------
MAB_1617c|M.abscessus_ATCC_199 ASVVVVN-------------ETEARSWLYP----SRHLVTTLGDEGSRYR
MMAR_4574|M.marinum_M SDIIKASAEDLHWIDPTQPPEQTARAWLACG---PAIVALTLGDQGAVAF
MUL_4435|M.ulcerans_Agy99 SDIIKASAEDLHWIDPTQPPEQTARAWLACG---PAIVALTFGDQSAVAF
Mb2462|M.bovis_AF2122/97 GADGVFEVPAPTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERLRALRR
Rv2436|M.tuberculosis_H37Rv GADGVFEVPAPTVTPVDTAGAGDVFAG-VLAANWPRNPGSPAERLRALRR
MAV_1743|M.avium_104 GADGEYSVPSPDVDAVDTTGAGDVFAG-VLAANWPLEPGSPDQRRLALRR
Mvan_3935|M.vanbaalenii_PYR-1 G-ETRLEFPAPAVEAVDTTGAGDVFAG-VLAANWPRG------ADYALAR
Mflv_2643|M.gilvum_PYR-GCK G-QCHLEVPAPAVEAVDTTGAGDVFAG-VLAANWEQG------VEFAMAR
MSMEG_4585|M.smegmatis_MC2_155 SDDERFDVPALRVRAVDTTGAGDVFAG-VLAAGWPAG------HEHALQR
TH_1517|M.thermoresistible__bu --------------------------------------------------
MAB_1617c|M.abscessus_ATCC_199 SPQGQITVPSYPVRPLDTTGAGDVFAG-VLAAWWPQG------AETALRR
MMAR_4574|M.marinum_M CAAGPASVPAQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLGADRRTELRK
MUL_4435|M.ulcerans_Agy99 CAAGPASMPAQPVRVVDTVGAGDAFMAGLLDTLWEQG-LLDADRRTELRK
Mb2462|M.bovis_AF2122/97 ACAAGVLATLVSGAGDCAPAAAAIDAALRANRHNGS--
Rv2436|M.tuberculosis_H37Rv ACAAGALATLVSGVGDCAPAAAAIDAALRANRHNGS--
MAV_1743|M.avium_104 ACAAGALATLVPGAGDCAPRAEEIERALRGKS------
Mvan_3935|M.vanbaalenii_PYR-1 ACAAGALSTLVHGAGDCAPYSEAVEDVLEAS-------
Mflv_2643|M.gilvum_PYR-GCK ACAAGALATLVPGAGDCAPSREAVEDVLDAL-------
MSMEG_4585|M.smegmatis_MC2_155 ACAAGALATLVRGAGDCAPSAADIDAVLTP--------
TH_1517|M.thermoresistible__bu --------------------------------------
MAB_1617c|M.abscessus_ATCC_199 ANVAGALATLRAGAGNCAPTGARIELSLKGS-------
MMAR_4574|M.marinum_M IGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR
MUL_4435|M.ulcerans_Agy99 IGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR