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TTMDDVARLAGVSTSTVSHVLNGTRKVNAETRLRVEEAIEQTGYRRNVVARALAAGRTNTVGLSISALTN PYFGSLVHAVERALSDAGYVLIVGDSHDEAESEKRVVDSLLGRKVDGMIVAPAAGSERASLPEIARAGTP LVLIDRGADIESDQVGPENESSAKALTDHLLDIGHTRVGVVRGLAGISSTTERFDGYVAALSDRGIDLDA SLIVDGESNTEAAERGVYALMSSADRPTALVSMNNAMTIGTLKAIRRLGLSIPGDVAFVCYDDFEWSDLF EPKLTAAAQDVETIGATAVELLLRRIQGDDGAAQHIRVPTTFHHRNSCGCA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6798 | rbsR | - | 100% (332) | ribose operon repressor |
| M. smegmatis MC2 155 | MSMEG_0592 | - | 4e-38 | 33.33% (312) | putative rhamnose catabolism operon transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1369 | - | 4e-37 | 31.33% (332) | LacI-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 5e-15 | 24.70% (332) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 1e-15 | 24.55% (334) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 5e-15 | 24.70% (332) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | MLBr_00398 | - | 3e-11 | 22.30% (278) | putative D-ribose-binding protein |
| M. abscessus ATCC 19977 | MAB_2023c | - | 2e-05 | 26.67% (165) | LacI family transcriptional regulator |
| M. marinum M | MMAR_5070 | - | 1e-12 | 23.33% (330) | PurR family transcriptional regulator |
| M. avium 104 | MAV_0585 | - | 8e-14 | 23.87% (331) | transcriptional regulator, LacI family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 2e-12 | 22.73% (330) | PurR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0385 | - | 2e-26 | 27.47% (324) | periplasmic binding protein/LacI transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3606c|M.bovis_AF2122/97 --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAK
Rv3575c|M.tuberculosis_H37Rv --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAK
MMAR_5070|M.marinum_M --MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQLSAELRERVLATAK
MUL_4146|M.ulcerans_Agy99 --MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQLSVELRERVLATAK
MAV_0585|M.avium_104 --MSPTPRRRATLASLADELKVSRTTVSNAFNRPDQLSADLRERVLATAK
Mflv_1457|M.gilvum_PYR-GCK MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPDQLSAELRERVLSTAK
Mvan_0385|M.vanbaalenii_PYR-1 --MSTPRRRRPTMADVAERAGVSRTLVSFILDGKPGASDETRRRVLAIAD
MSMEG_6798|M.smegmatis_MC2_155 ---------MTTMDDVARLAGVSTSTVSHVLNGTRKVNAETRLRVEEAIE
MAB_2023c|M.abscessus_ATCC_199 -------------------MGLSKTTVADALGGSGRVSEATREKTRLVAE
MLBr_00398|M.leprae_Br4923 -------------MSTGTSVPLRVASIMLILG-----------LLPAILP
: : : .
Mb3606c|M.bovis_AF2122/97 RLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSC
Rv3575c|M.tuberculosis_H37Rv RLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSC
MMAR_5070|M.marinum_M RMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
MUL_4146|M.ulcerans_Agy99 RMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
MAV_0585|M.avium_104 RLGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
Mflv_1457|M.gilvum_PYR-GCK RLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALDFVAGLAESC
Mvan_0385|M.vanbaalenii_PYR-1 EIGYR-PDSAARLLAQGRSRTLGVMTDVRQLFQA------ELVTHIYPAA
MSMEG_6798|M.smegmatis_MC2_155 QTGYR-RNVVARALAAGRTNTVGLSISALTNPYFG-----SLVHAVERAL
MAB_2023c|M.abscessus_ATCC_199 RMGYV-SNRAARLLRRNETGALGLYIPGDVRNLS---FYMELAFGAADES
MLBr_00398|M.leprae_Br4923 ACGFS---------ESHHKLTIGVSYPTANSPFWN-----AYTRFIDEGS
*: . ::*: .
Mb3606c|M.bovis_AF2122/97 EELGQGLQLVSVGSSR-SLADGTAAVLGAGVDGFVVYSVGD-DDPYLQVV
Rv3575c|M.tuberculosis_H37Rv EELGQGLQLVSVGSSR-SLADGTAAVLGAGVDGFVVYSVGD-DDPYLQVV
MMAR_5070|M.marinum_M EELGQGLLLVAVGASR-SLEDGTAAVLNAGVDGFVVYSVRD-DDPYLQVV
MUL_4146|M.ulcerans_Agy99 EELGQGLLLVAVGASR-SLEDGTAAVLNAGVDGFVVYSVRD-DDPYLQVV
MAV_0585|M.avium_104 EALGQGLLLVAVGPSR-SLDEGTAAVLSAGVDGFVVYSVCD-DDPYLQAV
Mflv_1457|M.gilvum_PYR-GCK EAVGQGLLLVAVGPNR-SVAEGSAAVLAAGVDGFVVYSASD-DDPYLPAV
Mvan_0385|M.vanbaalenii_PYR-1 ERLGYEVLLSANLPDR-TEATVVDSLLSHRCGALILLGPTG-DQSFLEKL
MSMEG_6798|M.smegmatis_MC2_155 SDAGYVLIVGDSHDEAESEKRVVDSLLGRKVDGMIVAPAAGSERASLPEI
MAB_2023c|M.abscessus_ATCC_199 AALGLDLTLIGRHLTG------ENRSRPPQVDGIIAVDPVP-GDAALESL
MLBr_00398|M.leprae_Br4923 HQLGVYINAVSAEEDEQKQLSDVETLINQGIDGLIVTPQSTSIAPTLLRI
* : ..:: . * :
Mb3606c|M.bovis_AF2122/97 LQRR-LPVVVVDQPKDLSGVS--------RVGIDDRAAMRELAGYVLGLG
Rv3575c|M.tuberculosis_H37Rv LQRR-LPVVVVDQPKDLSGVS--------RVGIDDRAAMRELAGYVLGLG
MMAR_5070|M.marinum_M LQRR-LPVVVVDQPKELAGVS--------RVGIDDRAAMRKIADYVLGLG
MUL_4146|M.ulcerans_Agy99 LQRR-LPVVVVDQPKELAGVS--------RVGIDDRAAMRKIADYVLSLG
MAV_0585|M.avium_104 LQRR-LPVVVVDQPKGLTGVS--------RVGIDDRAAMRELADYVLGLG
Mflv_1457|M.gilvum_PYR-GCK MERH-LPVVVVDQPRDVPGAS--------QVRIDDRAAMRSLAEHVIDLG
Mvan_0385|M.vanbaalenii_PYR-1 AQRA-PVVVACRRLTGLNQQTP-----LATVRTNDAKGIRQAVDYLVGLG
MSMEG_6798|M.smegmatis_MC2_155 ARAG-TPLVLIDRGADIESDQ---------VGPENESSAKALTDHLLDIG
MAB_2023c|M.abscessus_ATCC_199 LTSN-VPIVTVGRILDKDVSHH-----AAEIEIDHYRMVTLLLDAIRAAG
MLBr_00398|M.leprae_Br4923 ATQANIPVVVVDRYPGYAPGQNKNADYVAFLGPNNEKAGSGIAEALMAGG
:* : : :. : *
Mb3606c|M.bovis_AF2122/97 HRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMTA
Rv3575c|M.tuberculosis_H37Rv HRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMTA
MMAR_5070|M.marinum_M HRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMTA
MUL_4146|M.ulcerans_Agy99 HRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMTA
MAV_0585|M.avium_104 HREIGLLTMRLGRDRRQG----LVDAERLRSPAFDVQRERITGVWEAMTA
Mflv_1457|M.gilvum_PYR-GCK HREIGLLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERIHGVYDAMTA
Mvan_0385|M.vanbaalenii_PYR-1 HRRIHHVDG--GRD--------------------PGSADRSRAYKAAMRA
MSMEG_6798|M.smegmatis_MC2_155 HTRVGVVRGLAGIS---------------------STTERFDGYVAALSD
MAB_2023c|M.abscessus_ATCC_199 GKRPALAALDQGADS-------------------SYVFDVSRGYQEWCAK
MLBr_00398|M.leprae_Br4923 GSKFLALGGMPGNS---------------------VAQGRKAGLESALTA
. * . .
Mb3606c|M.bovis_AF2122/97 AGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAM
Rv3575c|M.tuberculosis_H37Rv AGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAM
MMAR_5070|M.marinum_M AGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSAM
MUL_4146|M.ulcerans_Agy99 AGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSAM
MAV_0585|M.avium_104 AGVDPDSLTVVESYEHLPESGGAAAKVALEANPRITALMCTADILALSAM
Mflv_1457|M.gilvum_PYR-GCK AGLDPASLTLVESYEHLPTSGGAGADIALEANPRITALMCTADVLALSAM
Mvan_0385|M.vanbaalenii_PYR-1 HGLAEEIEVIPG--AHNEDAGAAAARAMLAAPTLPTAVLAGNDRCALGIL
MSMEG_6798|M.smegmatis_MC2_155 RGIDLDASLIVDG-ESNTEAAERGVYALMSSADRPTALVSMNNAMTIGTL
MAB_2023c|M.abscessus_ATCC_199 AGVVPLATRLSATPTDVELAQAIRGIVEHQG---IDALVVGAQGLAARSL
MLBr_00398|M.leprae_Br4923 VGHRLVQFQYAGDSEDKGLAAAENMLQAHPAG-DANAIWCFNDKLCQGAI
* : . *: : :
Mb3606c|M.bovis_AF2122/97 DYLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGELL
Rv3575c|M.tuberculosis_H37Rv DYLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGELL
MMAR_5070|M.marinum_M DYLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGELL
MUL_4146|M.ulcerans_Agy99 DYLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGELL
MAV_0585|M.avium_104 DYLRAHGVYVPGQLTVTGFDG--VPDAISRGLTTVSQSSLHKGRRAGELL
Mflv_1457|M.gilvum_PYR-GCK DHLRAKGIYVPGQMTVTGFDG--VPEARQRGLTTVAQPGVEKGRRAGELL
Mvan_0385|M.vanbaalenii_PYR-1 DVFTRAGVDVPAQVSLMGYDDTRLSENPRIDLSTIHQDAAEIARHAVQLA
MSMEG_6798|M.smegmatis_MC2_155 KAIRRLGLSIPGDVAFVCYDDFEWSDLFEPKLTAAAQDVETIGATAVELL
MAB_2023c|M.abscessus_ATCC_199 PVLQSLGHEVGSNFHLGTLVGDPATELTNPDIHAVDLRPREFGHQAVTFL
MLBr_00398|M.leprae_Br4923 KAVYNANREKEFIFGGMDLTPQAIAAIENGLYTVSLGAHWLEGGFGLAIL
. . . . . . . :
Mb3606c|M.bovis_AF2122/97 LKPPRSGLP---VIEVLDTELVRGRTAGPPA-------------------
Rv3575c|M.tuberculosis_H37Rv LKPPRSGLP---VIEVLDTELVRGRTAGPPA-------------------
MMAR_5070|M.marinum_M QNPPRSGLP---VVELLDTELIRGRTAGPPA-------------------
MUL_4146|M.ulcerans_Agy99 QNPPRSGLP---VVELLDTELIRGRTAGPPA-------------------
MAV_0585|M.avium_104 LKPARSGLP---VVELLDTELIRGRTAGPPA-------------------
Mflv_1457|M.gilvum_PYR-GCK HNPPRSGLP---VVEVLDTEVIRGRTSGPPA-------------------
Mvan_0385|M.vanbaalenii_PYR-1 VQMLVEGPPHAMDVVLEPTLVVRGTTAPPRGGPAARSGIADTIEG-----
MSMEG_6798|M.smegmatis_MC2_155 LRRIQGDDGAAQHIRVPTTFHHRNSCGCA---------------------
MAB_2023c|M.abscessus_ATCC_199 HDIIAGRASANDRRTHQARLKIAGVSSPPAIRRAMSD-------------
MLBr_00398|M.leprae_Br4923 YRKIHGQDPAERMVKLDLLKVDKSNVAKFKARYIDNTPHYNWKSTTPFDM
. .
Mb3606c|M.bovis_AF2122/97 -----
Rv3575c|M.tuberculosis_H37Rv -----
MMAR_5070|M.marinum_M -----
MUL_4146|M.ulcerans_Agy99 -----
MAV_0585|M.avium_104 -----
Mflv_1457|M.gilvum_PYR-GCK -----
Mvan_0385|M.vanbaalenii_PYR-1 -----
MSMEG_6798|M.smegmatis_MC2_155 -----
MAB_2023c|M.abscessus_ATCC_199 -----
MLBr_00398|M.leprae_Br4923 TITLN