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VVSMREVAAAASVSVGTVSNVLNAPDKVAPATVARVQAAIDKLGFVRNDAARQLKAGRSRSVGLVVLDIG NPFFTDIARAAERRAGEHNLTVLLGTSDDDATRERAYVDAFDEQRVYGLLVSPVGEDLNRLVALRERGTP VVLVDRDGGGTPFDSVAVDDVAGGCLAVQHLCATGRRKIAFVGGPGTLRQIRDRRRGAADAVGRTPGATL EIIDTDAPSVLAGRAVGEQLRRRARQDRPDAVFCANDLLAIGVLQALSLTGDLRVPDDMALVGYDDIDFA RSAVVPLTSVRQPTGEIGTTAVDLLIGAAEDATGRNPEHVVFQPELVVRDSTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0592 | - | - | 100% (333) | putative rhamnose catabolism operon transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6798 | rbsR | 4e-38 | 33.33% (312) | ribose operon repressor |
| M. smegmatis MC2 155 | MSMEG_1369 | - | 2e-36 | 33.53% (334) | LacI-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 1e-18 | 28.66% (335) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 1e-17 | 29.17% (336) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 1e-18 | 28.66% (335) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | MLBr_00398 | - | 6e-07 | 22.86% (210) | putative D-ribose-binding protein |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5070 | - | 2e-16 | 27.25% (334) | PurR family transcriptional regulator |
| M. avium 104 | MAV_0585 | - | 3e-17 | 28.40% (338) | transcriptional regulator, LacI family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 1e-16 | 27.25% (334) | PurR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0385 | - | 2e-24 | 33.43% (350) | periplasmic binding protein/LacI transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3606c|M.bovis_AF2122/97 --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAK
Rv3575c|M.tuberculosis_H37Rv --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAK
MMAR_5070|M.marinum_M --MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQLSAELRERVLATAK
MUL_4146|M.ulcerans_Agy99 --MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQLSVELRERVLATAK
MAV_0585|M.avium_104 --MSPTPRRRATLASLADELKVSRTTVSNAFNRPDQLSADLRERVLATAK
Mflv_1457|M.gilvum_PYR-GCK MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPDQLSAELRERVLSTAK
Mvan_0385|M.vanbaalenii_PYR-1 --MSTPRRRRPTMADVAERAGVSRTLVSFILDGKPGASDETRRRVLAIAD
MSMEG_0592|M.smegmatis_MC2_155 ---------MVSMREVAAAASVSVGTVSNVLNAPDKVAPATVARVQAAID
MLBr_00398|M.leprae_Br4923 -------------MSTGTSVPLRVASIMLILG-----------LLPAILP
. . : : . : :
Mb3606c|M.bovis_AF2122/97 RLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSC
Rv3575c|M.tuberculosis_H37Rv RLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSC
MMAR_5070|M.marinum_M RMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
MUL_4146|M.ulcerans_Agy99 RMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
MAV_0585|M.avium_104 RLGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
Mflv_1457|M.gilvum_PYR-GCK RLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALDFVAGLAESC
Mvan_0385|M.vanbaalenii_PYR-1 EIGYR-PDSAARLLAQGRSRTLGVMTDVRQLFQA------ELVTHIYPAA
MSMEG_0592|M.smegmatis_MC2_155 KLGFVRNDAAR-QLKAGRSRSVGLVVLDIGNPFFT-----DIARAAERRA
MLBr_00398|M.leprae_Br4923 ACGFS---------ESHHKLTIGVSYPTANSPFWN-----AYTRFIDEGS
*: : ::*: . .
Mb3606c|M.bovis_AF2122/97 EELGQGLQLVSVGSSRS-LADGTAAVLGAGVDGFVVYSVGDDDP--YLQV
Rv3575c|M.tuberculosis_H37Rv EELGQGLQLVSVGSSRS-LADGTAAVLGAGVDGFVVYSVGDDDP--YLQV
MMAR_5070|M.marinum_M EELGQGLLLVAVGASRS-LEDGTAAVLNAGVDGFVVYSVRDDDP--YLQV
MUL_4146|M.ulcerans_Agy99 EELGQGLLLVAVGASRS-LEDGTAAVLNAGVDGFVVYSVRDDDP--YLQV
MAV_0585|M.avium_104 EALGQGLLLVAVGPSRS-LDEGTAAVLSAGVDGFVVYSVCDDDP--YLQA
Mflv_1457|M.gilvum_PYR-GCK EAVGQGLLLVAVGPNRS-VAEGSAAVLAAGVDGFVVYSASDDDP--YLPA
Mvan_0385|M.vanbaalenii_PYR-1 ERLGYEVLLSANLPDRT-EATVVDSLLSHRCGALILLGPTGDQS--FLEK
MSMEG_0592|M.smegmatis_MC2_155 GEHNLTVLLGTSDDDATRERAYVDAFDEQRVYGLLVSPVGEDLN--RLVA
MLBr_00398|M.leprae_Br4923 HQLGVYINAVSAEEDEQKQLSDVETLINQGIDGLIVTPQSTSIAPTLLRI
. : : . :. .::: . *
Mb3606c|M.bovis_AF2122/97 VLQRRLPVVVVDQPK--------DLSGVSRVGIDDRAAMRELAGYVLGLG
Rv3575c|M.tuberculosis_H37Rv VLQRRLPVVVVDQPK--------DLSGVSRVGIDDRAAMRELAGYVLGLG
MMAR_5070|M.marinum_M VLQRRLPVVVVDQPK--------ELAGVSRVGIDDRAAMRKIADYVLGLG
MUL_4146|M.ulcerans_Agy99 VLQRRLPVVVVDQPK--------ELAGVSRVGIDDRAAMRKIADYVLSLG
MAV_0585|M.avium_104 VLQRRLPVVVVDQPK--------GLTGVSRVGIDDRAAMRELADYVLGLG
Mflv_1457|M.gilvum_PYR-GCK VMERHLPVVVVDQPR--------DVPGASQVRIDDRAAMRSLAEHVIDLG
Mvan_0385|M.vanbaalenii_PYR-1 LAQRAPVVVACRRLTGLN-----QQTPLATVRTNDAKGIRQAVDYLVGLG
MSMEG_0592|M.smegmatis_MC2_155 LRERGTPVVLVDRDG--------GGTPFDSVAVDDVAGGCLAVQHLCATG
MLBr_00398|M.leprae_Br4923 ATQANIPVVVVDRYPGYAPGQNKNADYVAFLGPNNEKAGSGIAEALMAGG
: ** : : :: . . : *
Mb3606c|M.bovis_AF2122/97 HRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMTA
Rv3575c|M.tuberculosis_H37Rv HRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMTA
MMAR_5070|M.marinum_M HRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMTA
MUL_4146|M.ulcerans_Agy99 HRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMTA
MAV_0585|M.avium_104 HREIGLLTMRLGRDRRQG----LVDAERLRSPAFDVQRERITGVWEAMTA
Mflv_1457|M.gilvum_PYR-GCK HREIGLLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERIHGVYDAMTA
Mvan_0385|M.vanbaalenii_PYR-1 HRRIHHVDG--GRD--------------------PGSADRSRAYKAAMRA
MSMEG_0592|M.smegmatis_MC2_155 RRKIAFVGG---------------------PGTLRQIRDRRRGAADAVGR
MLBr_00398|M.leprae_Br4923 GSKFLALGG---------------------MPGNSVAQGRKAGLESALTA
.: : * . *:
Mb3606c|M.bovis_AF2122/97 AGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAM
Rv3575c|M.tuberculosis_H37Rv AGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAM
MMAR_5070|M.marinum_M AGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSAM
MUL_4146|M.ulcerans_Agy99 AGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSAM
MAV_0585|M.avium_104 AGVDPDSLTVVESYEHLPESGGAAAKVALEANPRITALMCTADILALSAM
Mflv_1457|M.gilvum_PYR-GCK AGLDPASLTLVESYEHLPTSGGAGADIALEANPRITALMCTADVLALSAM
Mvan_0385|M.vanbaalenii_PYR-1 HGLAEEIEVIPG--AHNEDAGAAAARAMLAAPTLPTAVLAGNDRCALGIL
MSMEG_0592|M.smegmatis_MC2_155 TPGATLEIIDTDAPSVLAGRAVGEQLRRRARQDRPDAVFCANDLLAIGVL
MLBr_00398|M.leprae_Br4923 VGHRLVQFQYAGDSEDKGLAAAENMLQAHPAG-DANAIWCFNDKLCQGAI
. *: . * . . :
Mb3606c|M.bovis_AF2122/97 DYLRAHG-IYVPGQMTVTGFDG--VPEALSR-GLTTVAQPSLHKGHRAGE
Rv3575c|M.tuberculosis_H37Rv DYLRAHG-IYVPGQMTVTGFDG--VPEALSR-GLTTVAQPSLHKGHRAGE
MMAR_5070|M.marinum_M DYLRGHG-IYVPGQMTVTGFDG--VPEAISR-GLTTVSQPSLQKGRRAGE
MUL_4146|M.ulcerans_Agy99 DYLRGHG-IYVPGQMTVTGFDG--VPEAISR-GLTTVSQPSLQKGRRAGE
MAV_0585|M.avium_104 DYLRAHG-VYVPGQLTVTGFDG--VPDAISR-GLTTVSQSSLHKGRRAGE
Mflv_1457|M.gilvum_PYR-GCK DHLRAKG-IYVPGQMTVTGFDG--VPEARQR-GLTTVAQPGVEKGRRAGE
Mvan_0385|M.vanbaalenii_PYR-1 DVFTRAG-VDVPAQVSLMGYDDTRLSENPRI-DLSTIHQDAAEIARHAVQ
MSMEG_0592|M.smegmatis_MC2_155 QALSLTGDLRVPDDMALVGYDDIDFARSAVV-PLTSVRQPTGEIGTTAVD
MLBr_00398|M.leprae_Br4923 KAVYNAN---REKEFIFGGMDLTPQAIAAIENGLYTVSLGAHWLEGGFGL
. . . :. . * * . * ::
Mb3606c|M.bovis_AF2122/97 LLLKPPRSGLP----VIEVLDTELVRGRTAGPPA----------------
Rv3575c|M.tuberculosis_H37Rv LLLKPPRSGLP----VIEVLDTELVRGRTAGPPA----------------
MMAR_5070|M.marinum_M LLQNPPRSGLP----VVELLDTELIRGRTAGPPA----------------
MUL_4146|M.ulcerans_Agy99 LLQNPPRSGLP----VVELLDTELIRGRTAGPPA----------------
MAV_0585|M.avium_104 LLLKPARSGLP----VVELLDTELIRGRTAGPPA----------------
Mflv_1457|M.gilvum_PYR-GCK LLHNPPRSGLP----VVEVLDTEVIRGRTSGPPA----------------
Mvan_0385|M.vanbaalenii_PYR-1 LAVQMLVEGPPH-AMDVVLEPTLVVRGTTAPPRGGPAARSGIADTIEG--
MSMEG_0592|M.smegmatis_MC2_155 LLIGAAEDATGRNPEHVVFQPELVVRDSTS--------------------
MLBr_00398|M.leprae_Br4923 AILYRKIHGQDPAERMVKLDLLKVDKSNVAKFKARYIDNTPHYNWKSTTP
. : . : :. .:
Mb3606c|M.bovis_AF2122/97 --------
Rv3575c|M.tuberculosis_H37Rv --------
MMAR_5070|M.marinum_M --------
MUL_4146|M.ulcerans_Agy99 --------
MAV_0585|M.avium_104 --------
Mflv_1457|M.gilvum_PYR-GCK --------
Mvan_0385|M.vanbaalenii_PYR-1 --------
MSMEG_0592|M.smegmatis_MC2_155 --------
MLBr_00398|M.leprae_Br4923 FDMTITLN