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ATMRDVAQRAGVSAKTVSRVVNNDRYVSDDVRRRVEQAIEDLKYVPNMLAVSFRTGRDAAIGVAVPGVAD PFFAGIIGAVEREASARGVAVIVTSVGWEPSHEQRSIEAVLHRKVAGMIICPVGPDMSFLRPWQATTPLV FVDRMPGRLVADSVVQDDAGGGYEAVAHLISHGHRRIAFLGDDVVTAHLRLQGSREALADADMPHDERLV HLGDVDTDTVTAALRRFLAEPDPPTAVFSSNARCTVSVVSALQALRRNDIALVGFGDFPTAAALRPPITV IDQDGDEMGRFAAERLFARLDDPGRRLRRRTVLPVSLVTRSSCAMPGERARPGHGSAVPVRSSNVSAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1369 | - | - | 100% (349) | LacI-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6798 | rbsR | 4e-37 | 31.33% (332) | ribose operon repressor |
| M. smegmatis MC2 155 | MSMEG_0592 | - | 2e-36 | 33.53% (334) | putative rhamnose catabolism operon transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 2e-10 | 26.45% (363) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 8e-10 | 27.00% (337) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 2e-10 | 26.45% (363) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | MLBr_00398 | - | 7e-06 | 23.83% (277) | putative D-ribose-binding protein |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5070 | - | 2e-09 | 24.62% (333) | PurR family transcriptional regulator |
| M. avium 104 | MAV_5263 | - | 2e-12 | 25.55% (321) | transcriptional regulator, LacI family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 5e-10 | 24.92% (333) | PurR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0385 | - | 8e-22 | 28.28% (343) | periplasmic binding protein/LacI transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5070|M.marinum_M ---------MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQ--LSAEL
MUL_4146|M.ulcerans_Agy99 ---------MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQ--LSVEL
Mb3606c|M.bovis_AF2122/97 ---------MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQ--LSADL
Rv3575c|M.tuberculosis_H37Rv ---------MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQ--LSADL
Mflv_1457|M.gilvum_PYR-GCK -------MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPDQ--LSAEL
Mvan_0385|M.vanbaalenii_PYR-1 ---------MSTPRRRRPTMADVAERAGVSRTLVSFILDGKPG--ASDET
MSMEG_1369|M.smegmatis_MC2_155 ----------------MATMRDVAQRAGVSAKTVSRVVNNDRY--VSDDV
MAV_5263|M.avium_104 MTGPQGNGNSSSNKAARPTTADVARLAGVSTATVSYVLNNARGRRISPDT
MLBr_00398|M.leprae_Br4923 --------------------MSTGTSVPLRVASIMLILG-----------
. . : : .
MMAR_5070|M.marinum_M RERVLATAKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
MUL_4146|M.ulcerans_Agy99 RERVLATAKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Mb3606c|M.bovis_AF2122/97 RERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Rv3575c|M.tuberculosis_H37Rv RERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Mflv_1457|M.gilvum_PYR-GCK RERVLSTAKRLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALD
Mvan_0385|M.vanbaalenii_PYR-1 RRRVLAIADEIGYR-PDSAARLLAQGRSRTLGVMTDVRQLFQA------E
MSMEG_1369|M.smegmatis_MC2_155 RRRVEQAIEDLKYV-PNMLAVSFRTGRDAAIGVAVPGVADPFFAG-----
MAV_5263|M.avium_104 RDAVYRAAKLLGYR-PNLAARNLARGKSGVVLYVVPHVAVGEMP------
MLBr_00398|M.leprae_Br4923 --LLPAILPACGFS---------ESHHKLTIGVSYPTANSPFWN-----A
: : : .:
MMAR_5070|M.marinum_M FVTGVAQSCEELGQGLLLVAVGASRSLEDG-TAAVLNAGVDGFVVYSVRD
MUL_4146|M.ulcerans_Agy99 FVTGVAQSCEELGQGLLLVAVGASRSLEDG-TAAVLNAGVDGFVVYSVRD
Mb3606c|M.bovis_AF2122/97 FVAGVAQSCEELGQGLQLVSVGSSRSLADG-TAAVLGAGVDGFVVYSVGD
Rv3575c|M.tuberculosis_H37Rv FVAGVAQSCEELGQGLQLVSVGSSRSLADG-TAAVLGAGVDGFVVYSVGD
Mflv_1457|M.gilvum_PYR-GCK FVAGLAESCEAVGQGLLLVAVGPNRSVAEG-SAAVLAAGVDGFVVYSASD
Mvan_0385|M.vanbaalenii_PYR-1 LVTHIYPAAERLGYEVLLSANLPDRTEATV-VDSLLSHRCGALILLGPTG
MSMEG_1369|M.smegmatis_MC2_155 IIGAVEREASARGVAVIVTSVGWEPSHEQRSIEAVLHRKVAGMIICPVGP
MAV_5263|M.avium_104 -MQAGSRMTTALAREGLLQVQVFETDDDQHVVDAIANLDPVAVTSLFPLS
MLBr_00398|M.leprae_Br4923 YTRFIDEGSHQLGVYINAVSAEEDEQKQLSDVETLINQGIDGLIVTPQST
. . :: ..
MMAR_5070|M.marinum_M DDP---YLQVVLQRRLPVVVVDQPK-------ELAGVSRVGIDDRAAMRK
MUL_4146|M.ulcerans_Agy99 DDP---YLQVVLQRRLPVVVVDQPK-------ELAGVSRVGIDDRAAMRK
Mb3606c|M.bovis_AF2122/97 DDP---YLQVVLQRRLPVVVVDQPK-------DLSGVSRVGIDDRAAMRE
Rv3575c|M.tuberculosis_H37Rv DDP---YLQVVLQRRLPVVVVDQPK-------DLSGVSRVGIDDRAAMRE
Mflv_1457|M.gilvum_PYR-GCK DDP---YLPAVMERHLPVVVVDQPR-------DVPGASQVRIDDRAAMRS
Mvan_0385|M.vanbaalenii_PYR-1 DQS---FLEKLAQRAPVVVACRRLTGL----NQQTPLATVRTNDAKGIRQ
MSMEG_1369|M.smegmatis_MC2_155 DMS---FLRPWQATTPLVFVDRMPG--------RLVADSVVQDDAGGGYE
MAV_5263|M.avium_104 AAA---RRAVTEAGIPHIEIGTLPA--------------LNDPHLSVGEM
MLBr_00398|M.leprae_Br4923 SIAPTLLRIATQANIPVVVVDRYPGYAPGQNKNADYVAFLGPNNEKAGSG
. : : .
MMAR_5070|M.marinum_M IADYVLGLGHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERI
MUL_4146|M.ulcerans_Agy99 IADYVLSLGHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERI
Mb3606c|M.bovis_AF2122/97 LAGYVLGLGHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERI
Rv3575c|M.tuberculosis_H37Rv LAGYVLGLGHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERI
Mflv_1457|M.gilvum_PYR-GCK LAEHVIDLGHREIGLLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERI
Mvan_0385|M.vanbaalenii_PYR-1 AVDYLVGLGHRRIHHVDG--GRD--------------------PGSADRS
MSMEG_1369|M.smegmatis_MC2_155 AVAHLISHGHRRIAFLGD-----------------------DVVTAHLRL
MAV_5263|M.avium_104 RIAHLVERGHRRIAFAYTG------------------------IARWRPL
MLBr_00398|M.leprae_Br4923 IAEALMAGGGSKFLALGGMPGN---------------------SVAQGRK
:: * .:
MMAR_5070|M.marinum_M TGVWEAMTAAGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCT
MUL_4146|M.ulcerans_Agy99 TGVWEAMTAAGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCT
Mb3606c|M.bovis_AF2122/97 VGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCT
Rv3575c|M.tuberculosis_H37Rv VGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCT
Mflv_1457|M.gilvum_PYR-GCK HGVYDAMTAAGLDPASLTLVESYEHLPTSGGAGADIALEANPRITALMCT
Mvan_0385|M.vanbaalenii_PYR-1 RAYKAAMRAHGLAEEIEVIPG--AHNEDAGAAAARAMLAAPTLPTAVLAG
MSMEG_1369|M.smegmatis_MC2_155 QGSREALADADMPHD-ERLVHLGDVDTDTVTAALRRFLAEPDPPTAVFSS
MAV_5263|M.avium_104 GDYWFEGVSRAARLRGLPPVRADEVILDTAASVVSAWVRDG--VTAVCAQ
MLBr_00398|M.leprae_Br4923 AGLESALTAVGHRLVQFQYAGDSEDKGLAAAENMLQAHPAG-DANAIWCF
: .*: .
MMAR_5070|M.marinum_M ADILALSAMDYLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQ
MUL_4146|M.ulcerans_Agy99 ADILALSAMDYLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQ
Mb3606c|M.bovis_AF2122/97 ADILALSAMDYLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLH
Rv3575c|M.tuberculosis_H37Rv ADILALSAMDYLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLH
Mflv_1457|M.gilvum_PYR-GCK ADVLALSAMDHLRAKGIYVPGQMTVTGFDG--VPEARQRGLTTVAQPGVE
Mvan_0385|M.vanbaalenii_PYR-1 NDRCALGILDVFTRAGVDVPAQVSLMGYDDTRLSENPRIDLSTIHQDAAE
MSMEG_1369|M.smegmatis_MC2_155 NARCTVSVVSALQALRR---NDIALVGFGDFPTAAALRPPITVIDQDGDE
MAV_5263|M.avium_104 SDEIACLVLYGIHQAGLRCPGDLAVMGVDASPMGMVSTPPLTTVQFDPCA
MLBr_00398|M.leprae_Br4923 NDKLCQGAIKAVYNANREKEFIFGGMDLTPQAIAAIENGLYTVSLGAHWL
: . . . :.
MMAR_5070|M.marinum_M KGRRAGELLQNPPRS-GLP---VVELLDTELIRGRTAGPPA---------
MUL_4146|M.ulcerans_Agy99 KGRRAGELLQNPPRS-GLP---VVELLDTELIRGRTAGPPA---------
Mb3606c|M.bovis_AF2122/97 KGHRAGELLLKPPRS-GLP---VIEVLDTELVRGRTAGPPA---------
Rv3575c|M.tuberculosis_H37Rv KGHRAGELLLKPPRS-GLP---VIEVLDTELVRGRTAGPPA---------
Mflv_1457|M.gilvum_PYR-GCK KGRRAGELLHNPPRS-GLP---VVEVLDTEVIRGRTSGPPA---------
Mvan_0385|M.vanbaalenii_PYR-1 IARHAVQLAVQMLVE-GPPHAMDVVLEPTLVVRGTTAPPRGGPAARSGIA
MSMEG_1369|M.smegmatis_MC2_155 MGRFAAERLFARLDDPGRRLRRRTVLPVSLVTRSSCAMPGERARPGHGSA
MAV_5263|M.avium_104 VADAALAAVFERLGHAAPP-SPELTDIARLVVRSST--------------
MLBr_00398|M.leprae_Br4923 EGGFGLAILYRKIHG-QDPAERMVKLDLLKVDKSNVAKFKARYIDNTPHY
. . : :.
MMAR_5070|M.marinum_M ---------------
MUL_4146|M.ulcerans_Agy99 ---------------
Mb3606c|M.bovis_AF2122/97 ---------------
Rv3575c|M.tuberculosis_H37Rv ---------------
Mflv_1457|M.gilvum_PYR-GCK ---------------
Mvan_0385|M.vanbaalenii_PYR-1 DTIEG----------
MSMEG_1369|M.smegmatis_MC2_155 VPVRSSNVSAR----
MAV_5263|M.avium_104 ---------------
MLBr_00398|M.leprae_Br4923 NWKSTTPFDMTITLN