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AGERGRGRVTLRDVALAANVSTTTVSDSLNGSGSLPEKTRQRVRKIALELGYRPSVAARSLRNGRTGILV IAMLPSDVDAESLWHVDYFMRVMAGAAIEANQRGFFLAVAPAAMQLDVAHDGLIAVDPAEGDPLVESARQ RGTPASTVGRTASDAASWVDNDWAGVVGDVLDHLERGGARRPMLIAPDSAASYIGSVEREFVSRCRRHGY APRSARIAGAFNPAAARAAVRDILDGPDRPDALFVGLDQLALAAELAATDLGLRVPEDLMLVNLGDGAAV ALAPVPISVVELHAEEMGRAAVRMLVDQIEQNAEPRHEVVPAHLVVRASSRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6736 | - | - | 100% (333) | LacI-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2011 | - | 1e-21 | 29.88% (338) | transcriptional regulator, LacI family protein |
| M. smegmatis MC2 155 | MSMEG_2989 | - | 2e-21 | 31.27% (339) | LacI family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 1e-08 | 26.18% (359) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 3e-09 | 25.53% (333) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 1e-08 | 26.18% (359) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2023c | - | 4e-28 | 32.46% (305) | LacI family transcriptional regulator |
| M. marinum M | MMAR_5070 | - | 4e-09 | 24.39% (328) | PurR family transcriptional regulator |
| M. avium 104 | MAV_5263 | - | 4e-11 | 27.61% (355) | transcriptional regulator, LacI family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 4e-09 | 24.39% (328) | PurR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0385 | - | 3e-19 | 28.82% (340) | periplasmic binding protein/LacI transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5070|M.marinum_M ---------MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQ--LSAEL
MUL_4146|M.ulcerans_Agy99 ---------MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQ--LSVEL
Mb3606c|M.bovis_AF2122/97 ---------MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQ--LSADL
Rv3575c|M.tuberculosis_H37Rv ---------MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQ--LSADL
Mflv_1457|M.gilvum_PYR-GCK -------MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPDQ--LSAEL
Mvan_0385|M.vanbaalenii_PYR-1 ---------MSTPRRRRPTMADVAERAGVSRTLVSFILDGKPG--ASDET
MSMEG_6736|M.smegmatis_MC2_155 --------MAGERGRGRVTLRDVALAANVSTTTVSDSLNGSGS--LPEKT
MAB_2023c|M.abscessus_ATCC_199 --------------------------MGLSKTTVADALGGSGR--VSEAT
MAV_5263|M.avium_104 MTGPQGNGNSSSNKAARPTTADVARLAGVSTATVSYVLNNARGRRISPDT
:* : :: . .
MMAR_5070|M.marinum_M RERVLATAKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
MUL_4146|M.ulcerans_Agy99 RERVLATAKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Mb3606c|M.bovis_AF2122/97 RERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Rv3575c|M.tuberculosis_H37Rv RERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARD
Mflv_1457|M.gilvum_PYR-GCK RERVLSTAKRLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALD
Mvan_0385|M.vanbaalenii_PYR-1 RRRVLAIADEIGYR-PDSAARLLAQGRSRTLGVMTDVRQLFQA------E
MSMEG_6736|M.smegmatis_MC2_155 RQRVRKIALELGYR-PSVAARSLRNGRTGILVIAMLPSDVDAESLWHVDY
MAB_2023c|M.abscessus_ATCC_199 REKTRLVAERMGYV-SNRAARLLRRNETGALGLYIPG---DVRNLSFYME
MAV_5263|M.avium_104 RDAVYRAAKLLGYR-PNLAARNLARGKSGVVLYVVPHVAVGEMPMQAGSR
* . * :** .. .** * .: :
MMAR_5070|M.marinum_M FVTGVAQSCEELGQGLLLVAVGASRSLEDGTAAVLNAGVDGFVVYSVRDD
MUL_4146|M.ulcerans_Agy99 FVTGVAQSCEELGQGLLLVAVGASRSLEDGTAAVLNAGVDGFVVYSVRDD
Mb3606c|M.bovis_AF2122/97 FVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDD
Rv3575c|M.tuberculosis_H37Rv FVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDD
Mflv_1457|M.gilvum_PYR-GCK FVAGLAESCEAVGQGLLLVAVGPNRSVAEGSAAVLAAGVDGFVVYSASDD
Mvan_0385|M.vanbaalenii_PYR-1 LVTHIYPAAERLGYEVLLSANLPDRTEATVVDSLLSHRCGALILLGPTGD
MSMEG_6736|M.smegmatis_MC2_155 FMRVMAGAAIEANQRGFFLAVAP-------AAMQLDVAHDGLIAVDPAEG
MAB_2023c|M.abscessus_ATCC_199 LAFGAADESAALGLDLTLIGRHLTG-----ENRSRPPQVDGIIAVDPVPG
MAV_5263|M.avium_104 MTTALAR---EGLLQVQVFETDDDQHVVDAIANLDPVAVTSLFPLSAAAR
: . .:. .
MMAR_5070|M.marinum_M DPYLQVVLQRRLPVVVVDQPK---ELAGVSRVGIDDRAAMRKIADYVLGL
MUL_4146|M.ulcerans_Agy99 DPYLQVVLQRRLPVVVVDQPK---ELAGVSRVGIDDRAAMRKIADYVLSL
Mb3606c|M.bovis_AF2122/97 DPYLQVVLQRRLPVVVVDQPK---DLSGVSRVGIDDRAAMRELAGYVLGL
Rv3575c|M.tuberculosis_H37Rv DPYLQVVLQRRLPVVVVDQPK---DLSGVSRVGIDDRAAMRELAGYVLGL
Mflv_1457|M.gilvum_PYR-GCK DPYLPAVMERHLPVVVVDQPR---DVPGASQVRIDDRAAMRSLAEHVIDL
Mvan_0385|M.vanbaalenii_PYR-1 QSFLEKLAQRAPVVVACRRLTGLNQQTPLATVRTNDAKGIRQAVDYLVGL
MSMEG_6736|M.smegmatis_MC2_155 DPLVESARQRGTPASTVGRTAS----DAASWVDNDWAGVVGDVLDHLERG
MAB_2023c|M.abscessus_ATCC_199 DAALESLLTSNVPIVTVGRILDKDVSHHAAEIEIDHYRMVTLLLDAIRAA
MAV_5263|M.avium_104 ----RAVTEAGIPHIEIGTLP---------ALNDPHLSVGEMRIAHLVER
: :
MMAR_5070|M.marinum_M GHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMT
MUL_4146|M.ulcerans_Agy99 GHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMT
Mb3606c|M.bovis_AF2122/97 GHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMT
Rv3575c|M.tuberculosis_H37Rv GHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMT
Mflv_1457|M.gilvum_PYR-GCK GHREIGLLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERIHGVYDAMT
Mvan_0385|M.vanbaalenii_PYR-1 GHRRIHHVDG--GRD--------------------PGSADRSRAYKAAMR
MSMEG_6736|M.smegmatis_MC2_155 GARRPMLIAPDSAAS-------------------YIGSVER--EFVSRCR
MAB_2023c|M.abscessus_ATCC_199 GGKRPALAALDQGADS-------------------SYVFDVSRGYQEWCA
MAV_5263|M.avium_104 GHRRIAFAYTGIARWR-------------------PLGDYWFEGVSRAAR
* :. .
MMAR_5070|M.marinum_M AAGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSA
MUL_4146|M.ulcerans_Agy99 AAGVDPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSA
Mb3606c|M.bovis_AF2122/97 AAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSA
Rv3575c|M.tuberculosis_H37Rv AAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSA
Mflv_1457|M.gilvum_PYR-GCK AAGLDPASLTLVESYEHLPTSGGAGADIALEANPRITALMCTADVLALSA
Mvan_0385|M.vanbaalenii_PYR-1 AHGLAEEIEVIPG--AHNEDAGAAAARAMLAAPTLPTAVLAGNDRCALGI
MSMEG_6736|M.smegmatis_MC2_155 RHGYAPRSARIAG--AFNPAAARAAVRDILDGPDRPDALFVGLDQLALAA
MAB_2023c|M.abscessus_ATCC_199 KAGVVPLATRLSA--TPTDVELAQAIRGIVEHQG-IDALVVGAQGLAARS
MAV_5263|M.avium_104 LRGLPPVR-------ADEVILDTAASVVSAWVRDGVTAVCAQSDEIACLV
* . *: : *
MMAR_5070|M.marinum_M MDYLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGEL
MUL_4146|M.ulcerans_Agy99 MDYLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGEL
Mb3606c|M.bovis_AF2122/97 MDYLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGEL
Rv3575c|M.tuberculosis_H37Rv MDYLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGEL
Mflv_1457|M.gilvum_PYR-GCK MDHLRAKGIYVPGQMTVTGFDG--VPEARQRGLTTVAQPGVEKGRRAGEL
Mvan_0385|M.vanbaalenii_PYR-1 LDVFTRAGVDVPAQVSLMGYDDTRLSENPRIDLSTIHQDAAEIARHAVQL
MSMEG_6736|M.smegmatis_MC2_155 ELAATDLGLRVPEDLMLVNLGDGAAVALAPVPISVVELHAEEMGRAAVRM
MAB_2023c|M.abscessus_ATCC_199 LPVLQSLGHEVGSNFHLGTLVGDPATELTNPDIHAVDLRPREFGHQAVTF
MAV_5263|M.avium_104 LYGIHQAGLRCPGDLAVMGVDASPMGMVSTPPLTTVQFDPCAVADAALAA
* :. : : .: . *
MMAR_5070|M.marinum_M LQNPPRSGLP---VVELLDTELIRGRTAGPPA--------------
MUL_4146|M.ulcerans_Agy99 LQNPPRSGLP---VVELLDTELIRGRTAGPPA--------------
Mb3606c|M.bovis_AF2122/97 LLKPPRSGLP---VIEVLDTELVRGRTAGPPA--------------
Rv3575c|M.tuberculosis_H37Rv LLKPPRSGLP---VIEVLDTELVRGRTAGPPA--------------
Mflv_1457|M.gilvum_PYR-GCK LHNPPRSGLP---VVEVLDTEVIRGRTSGPPA--------------
Mvan_0385|M.vanbaalenii_PYR-1 AVQMLVEGPPHAMDVVLEPTLVVRGTTAPPRGGPAARSGIADTIEG
MSMEG_6736|M.smegmatis_MC2_155 LVDQIEQNAEPR-HEVVPAHLVVRASSRG-----------------
MAB_2023c|M.abscessus_ATCC_199 LHDIIAGRASANDRRTHQARLKIAGVSSPPAIRRAMSD--------
MAV_5263|M.avium_104 VFERLGHAAPPSPELTDIARLVVRSST-------------------
. : . :