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EAEFDTVAEWTAKVAVDLGSDYYIPAGCRGSGSPAALDWLIEHTELAAGQRLLDCGAGVGGPAAYAAQAV PVYPVLVEPEAGACRAAQTLFGHPVLRAQAAALPLADNSFDAAWCLGVLCTTPAQTELLEELHRVVRPSG RIGLLAFVANREIPRDEFEGNHFPTPEHLTHLVDGAGLVIEEQLCTADLPAIPDGWNERVDAVEKALTER YGHTRAWQIAEEQSGKIGDLLADGGLTGELLILRQA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6663 | - | - | 100% (247) | C5-O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_2285 | - | 7e-08 | 36.52% (115) | methyltransferase type 11 |
| M. smegmatis MC2 155 | MSMEG_1005 | - | 7e-08 | 36.52% (115) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0229c | - | 2e-08 | 37.61% (109) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_3460 | - | 7e-87 | 60.48% (248) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0224c | - | 5e-08 | 36.70% (109) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_02584 | - | 3e-06 | 33.94% (109) | hypothetical protein MLBr_02584 |
| M. abscessus ATCC 19977 | MAB_4481 | - | 4e-06 | 39.00% (100) | hypothetical protein MAB_4481 |
| M. marinum M | MMAR_1627 | - | 7e-08 | 38.46% (117) | methyltransferase |
| M. avium 104 | MAV_4945 | - | 1e-08 | 36.97% (119) | SAM-dependent methyltransferase |
| M. thermoresistible (build 8) | TH_1968 | - | 7e-05 | 30.08% (123) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_1123 | - | 2e-07 | 39.05% (105) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1928 | - | 8e-09 | 35.88% (131) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4945|M.avium_104 ----------------MTDIFARRATLARSVRLLSQFRYERSEPARFYGA
MUL_1123|M.ulcerans_Agy99 --------------MAVTDRFARRATLSRSLRLLSEFRYEQPDPARFYGA
Mb0229c|M.bovis_AF2122/97 --------------MAVTDVFARRATLRRSLRLLADFRYEQRDPARFYRT
Rv0224c|M.tuberculosis_H37Rv --------------MAVTDVFARRATLRRSLRLLADFRYEQRDPARFYRT
MLBr_02584|M.leprae_Br4923 MDTRRRVWPVAIITPHVTDVFAQRATLTRSLQLLSEFRYEQPYPARFYRA
MAB_4481|M.abscessus_ATCC_1997 -------------MPDITDLFAQRATLRRSTSLLTAFRFEQSAPERFYGT
MSMEG_6663|M.smegmatis_MC2_155 ----------------------MEAEFDTVAEWTAKVAVDLG-SDYYIPA
Mflv_3460|M.gilvum_PYR-GCK ------------------MTEAMDAEFDTVAEWTAQVARDLG-PDYFVPA
MMAR_1627|M.marinum_M -------------MTTLAR---TEP-TDRGYESKHRALWALG-DYPAVAT
Mvan_1928|M.vanbaalenii_PYR-1 -------------MTTANAGVASDPDADRQLKAKHRALWASG-DYPAVAV
TH_1968|M.thermoresistible__bu -----------------------------LSFGAEAAAYERG--------
MAV_4945|M.avium_104 LAADTAAMVDDLWRAGHGESAAGRTLLDVGGGPGYFAAAFADAGVRYLGV
MUL_1123|M.ulcerans_Agy99 LAADTATLVSDLWLAARGESVAGRTLLDVGGGPGYFASAFAAAGVGYIGV
Mb0229c|M.bovis_AF2122/97 LAADTAAMIGDLWLATHSEPPVGRTLLDVGGGPGYFATAFSDAGVGYIGV
Rv0224c|M.tuberculosis_H37Rv LAADTAAMIGDLWLATHSEPPVGRTLLDVGGGPGYFATAFSDAGVGYIGV
MLBr_02584|M.leprae_Br4923 LAADTVAMVGDLWLSTHGAPPVGRILLDVGSGSGYFAAAFADAGVRYIGV
MAB_4481|M.abscessus_ATCC_1997 LAQDTVHLITDLWQQAEGVALRGRTVLDVGGGPGYFASAFADAGARYIGV
MSMEG_6663|M.smegmatis_MC2_155 GCRGSGSPAALDWLIEHTELAAGQRLLDCGAGVG---GPAAYAAQAVP-V
Mflv_3460|M.gilvum_PYR-GCK GCRGSGNPAALDWLVDRLELTPGESLLDSGAGVG---GPAGYAVSRVP-V
MMAR_1627|M.marinum_M DLVSPLGP----ILLEATRISAGDRVLDVAAGSGNVAIPAALAGADVI-A
Mvan_1928|M.vanbaalenii_PYR-1 DLIHSLGP----RLVEACRVGPGQRVLDVAAGSGNAAIPAAEAGATVI-A
TH_1968|M.thermoresistible__bu --RPSYPPEAIDWLLP----SDARDVLDLGAGTGKLTTRLVERGLNVTAV
. . :** ..* * .
MAV_4945|M.avium_104 EPDPGEMHAAGPVVAADTG---TFVRASGMALPFADDSVDICLSSNVAEH
MUL_1123|M.ulcerans_Agy99 EPDPNEMHAAGPAHAGGPG---SFVRASGMALPLADDSVDICLSSNVAEH
Mb0229c|M.bovis_AF2122/97 EPDPDEMHAAGPAFTGRPG---MFVRASGMALPLADDSVDICLSSNVAEH
Rv0224c|M.tuberculosis_H37Rv EPDPDEMHAAGPAFTGRPG---MFVRASGMALPFADDSVDICLSSNVAEH
MLBr_02584|M.leprae_Br4923 EPDPREMHAAGPALVPKAG---AFVRASGMALPFADDAVDICLSSNVAEH
MAB_4481|M.abscessus_ATCC_1997 EPDPREMHAAPQGHRGIQDPRTTYLRASGMALPLADNSVDICLSSNVAEH
MSMEG_6663|M.smegmatis_MC2_155 YPVLVEP-EAGACRAAQTLFGHPVLRAQAAALPLADNSFDAAWCLGVLCT
Mflv_3460|M.gilvum_PYR-GCK SPVLVEP-QIGACRAARSMFDYPAIQAVADALPFSDNAFDGAWCLGVLCT
MMAR_1627|M.marinum_M SDLCPNLLECGRGLAAARGASLRWVEANAQALPFDTDEFDAVVSCVGVMF
Mvan_1928|M.vanbaalenii_PYR-1 GDLTPELFEAGRETARRRGVEVQWMEADAEAMPFADNDFDVVMSCVGAMF
TH_1968|M.thermoresistible__bu DPIPEMLELLSKSLPDTPA-----LLGTAEEIPLPDNSVDAVLVAQAWHW
: . . :*: : .*
MAV_4945|M.avium_104 VPRPWQLGAEMLRVTRPGGLAVLSYTVWLG---------------PFGGH
MUL_1123|M.ulcerans_Agy99 VPRPWQLGAEMLRVTRPGGLAVLSYTVWLG---------------PFGGH
Mb0229c|M.bovis_AF2122/97 VPRPWQLGTEMLRVTKPGGLVVLSYTVWLG---------------PFGGH
Rv0224c|M.tuberculosis_H37Rv VPRPWQLGTEMLRVTKPGGLVVLSYTVWLG---------------PFGGH
MLBr_02584|M.leprae_Br4923 VPQPWQLGNEMLRVTKPGGLVVLSYTIWLG---------------PFGGH
MAB_4481|M.abscessus_ATCC_1997 VPQPWRLGEEMLRVTRPGGLAILSYTVWLG---------------PFGGH
MSMEG_6663|M.smegmatis_MC2_155 TPAQTELLEELHRVVRPSGRIGLLAFVAN-------------REIPRDE-
Mflv_3460|M.gilvum_PYR-GCK TDAQQQVLTELRRVVRAPGRIGLLVFVAT-------------TDLPDDQQ
MMAR_1627|M.marinum_M APYHQPCADELVRVCRPGGVIGLISWTPGGFIGEMFTTMKPYLAPPLPGA
Mvan_1928|M.vanbaalenii_PYR-1 APHHQATADELVRVTRPGGTIGLINWTPEGFIGNLFATMKPYAPPPPPGA
TH_1968|M.thermoresistible__bu FDVDRAVR-EVARVLRPGGRLGLVWNTRDE-------------RMGWVKE
*: ** :. * *
MAV_4945|M.avium_104 EMGLTHYLGGSRAAARYARKHGHPAKNNYGSSLFEVSVADGLAWAACTGA
MUL_1123|M.ulcerans_Agy99 EMGLSHYLGGARAAARYARRHGHPAKNNYGSSLFAVSAAEGLRWAEGTGT
Mb0229c|M.bovis_AF2122/97 EMGLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLRWAAGTGA
Rv0224c|M.tuberculosis_H37Rv EMGLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLRWAAGTGA
MLBr_02584|M.leprae_Br4923 EMGLTHYLGGARAATRYVRKHGHRAKNDYGSSLFPVSAADGLNWAASTGV
MAB_4481|M.abscessus_ATCC_1997 EMGLTHYFGGARAARWYTRKHGHPPKNNYGSSLFPVSVRDGLRWARDTGT
MSMEG_6663|M.smegmatis_MC2_155 FEGNHFPTPEHLTHLVDG--AGLVIEEQLCTADLPAIPDGWNERVDA--V
Mflv_3460|M.gilvum_PYR-GCK PDGNNFPTEKSLQQMLDT--AGLRVDARINTTDLPPIPQEWQDRVEA--V
MMAR_1627|M.marinum_M QPAPLWGTEGHVRELFADRVTDFAVRRGALLVDEFADGASFRDYFKANYG
Mvan_1928|M.vanbaalenii_PYR-1 SPAPLWGNAEHVRELFADRVTDLQMQRQTVVMDHCATPLEFREYWKANYG
TH_1968|M.thermoresistible__bu LGRIIGDEHDPLSKTVTLPEPFTDVQRHQVEWTNYLTPQALIDLVASRSY
MAV_4945|M.avium_104 ELAAFPRYHPRWAWWLTSVP--------------VLREFLVSNLVLVLQP
MUL_1123|M.ulcerans_Agy99 LIAAFPRYHPRSAWWMTSVP--------------MLREFLVSNLVLVLSP
Mb0229c|M.bovis_AF2122/97 ALAVFPRYHPRWAWWLTSVP--------------VLREFLVSNLVLVLTP
Rv0224c|M.tuberculosis_H37Rv ALAVFPRYHPRWAWWLTSVP--------------VLREFLVSNLVLVLTP
MLBr_02584|M.leprae_Br4923 AVAAFPRYHPRWAWWLTSVP--------------VLREFVVSNLVLVLRP
MAB_4481|M.abscessus_ATCC_1997 LTAAFPRYHPKWAWWITKIP--------------ALREVLVSNLVLVLRP
MSMEG_6663|M.smegmatis_MC2_155 EKALTERYGHTRAWQIAEEQSGKIG--------DLLADGGLTGELLILRQ
Mflv_3460|M.gilvum_PYR-GCK DDALERRFGGEEAWQIAERQSGRMG--------ELLGDGRVSGVVLSLRR
MMAR_1627|M.marinum_M PTIAAYRAIAAEPDRVAALDAELAALGDRY----LAGSSAMEWEYLLVTA
Mvan_1928|M.vanbaalenii_PYR-1 PTIATYRFNADDAERVAALDRDFLAFLEQWNQSGETGRTAYEAEYLLVTA
TH_1968|M.thermoresistible__bu CITSPAKVRARTLERVRELLATHP---------ALANNSGLALPYITVCI
: : : :
MAV_4945|M.avium_104 Q----
MUL_1123|M.ulcerans_Agy99 R----
Mb0229c|M.bovis_AF2122/97 -----
Rv0224c|M.tuberculosis_H37Rv -----
MLBr_02584|M.leprae_Br4923 R----
MAB_4481|M.abscessus_ATCC_1997 R----
MSMEG_6663|M.smegmatis_MC2_155 A----
Mflv_3460|M.gilvum_PYR-GCK AS---
MMAR_1627|M.marinum_M RKR--
Mvan_1928|M.vanbaalenii_PYR-1 TKR--
TH_1968|M.thermoresistible__bu RATLA