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TTANAGVASDPDADRQLKAKHRALWASGDYPAVAVDLIHSLGPRLVEACRVGPGQRVLDVAAGSGNAAIP AAEAGATVIAGDLTPELFEAGRETARRRGVEVQWMEADAEAMPFADNDFDVVMSCVGAMFAPHHQATADE LVRVTRPGGTIGLINWTPEGFIGNLFATMKPYAPPPPPGASPAPLWGNAEHVRELFADRVTDLQMQRQTV VMDHCATPLEFREYWKANYGPTIATYRFNADDAERVAALDRDFLAFLEQWNQSGETGRTAYEAEYLLVTA TKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1928 | - | - | 100% (284) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_2287 | - | e-120 | 73.40% (282) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_1774 | - | 2e-17 | 30.86% (269) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 7e-70 | 49.26% (270) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_4060 | - | 1e-121 | 75.18% (274) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1405c | - | 7e-70 | 49.26% (270) | putative methyltransferase |
| M. leprae Br4923 | MLBr_00551 | - | 2e-63 | 44.24% (269) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_3930c | - | 1e-12 | 35.14% (111) | ubiquinone/menaquinone biosynthesis methlytransferase UbiE |
| M. marinum M | MMAR_1627 | - | 2e-91 | 60.29% (277) | methyltransferase |
| M. avium 104 | MAV_3373 | - | 6e-66 | 46.13% (271) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_2285 | - | 1e-91 | 59.26% (270) | methyltransferase type 11 |
| M. thermoresistible (build 8) | TH_2937 | - | 3e-18 | 31.09% (267) | PUTATIVE Methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_3409 | - | 2e-91 | 60.29% (277) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1440c|M.bovis_AF2122/97 MTIDTPAR-----EDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAAA
Rv1405c|M.tuberculosis_H37Rv MTIDTPAR-----EDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAAA
MLBr_00551|M.leprae_Br4923 MNLYTPIH-----EDQSLAAIHRAMWALGDYALMAEEVMAPLGPILVTAT
MAV_3373|M.avium_104 MTLDTTT------ADASVAARHRTVWALGDYALMAEEVMAPLGPTLVEAA
Mvan_1928|M.vanbaalenii_PYR-1 MTTANAGVASDPDADRQLKAKHRALWASGDYPAVAVDLIHSLGPRLVEAC
Mflv_4060|M.gilvum_PYR-GCK MATVDN------EDDRALKAKHRALWASGDYPAVAAELIPSLGPELVRAC
MMAR_1627|M.marinum_M MTTLAR----TEPTDRGYESKHRALWALGDYPAVATDLVSPLGPILLEAT
MUL_3409|M.ulcerans_Agy99 MTTLAR----TEPTDRGYESKHRALWALGDYPAVATDLVSPLGPILLEAT
MSMEG_2285|M.smegmatis_MC2_155 MGVVT--------VDRELEAKHRALWALGNYGAIAAHIVAPLGPVLVEAC
TH_2937|M.thermoresistible__bu ---------------------VTTNWAAGRYEAVGERIAPIADEVLDAAA
MAB_3930c|M.abscessus_ATCC_199 MNRATLEK-----DPHEVASMFDAVARRYDITNTVLSFGRDRFWRRATRE
: .
Mb1440c|M.bovis_AF2122/97 GIG--PGVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQ
Rv1405c|M.tuberculosis_H37Rv GIG--PGVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQ
MLBr_00551|M.leprae_Br4923 GIR--PGMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRSQARATE
MAV_3373|M.avium_104 GIG--PGVRVLDVAAGSGNITLPAAAAGASVVSTDLTPELLQRSRDRAAG
Mvan_1928|M.vanbaalenii_PYR-1 RVG--PGQRVLDVAAGSGNAAIPAAEAGATVIAGDLTPELFEAGRETARR
Mflv_4060|M.gilvum_PYR-GCK GVR--SGDRVLDVAAGSGNASIPAAAAGAVVTASDLTPELFDAGRRIAAE
MMAR_1627|M.marinum_M RIS--AGDRVLDVAAGSGNVAIPAALAGADVIASDLCPNLLECGRGLAAA
MUL_3409|M.ulcerans_Agy99 RIS--AGDRVLDVAAGSGNVAIPAALAGADVIASDLCPNLLECGRGLAAA
MSMEG_2285|M.smegmatis_MC2_155 GIG--PGDRVLDIAAGTGNASIPAALAGAQVTASDLCPQLVDEGAHESAE
TH_2937|M.thermoresistible__bu RRTPLRGATLVDLACGTGSAALSATARGAAVTGVDITSELIALAAGKPG-
MAB_3930c|M.abscessus_ATCC_199 ALRLKPGDKVLDIAAGTAVSTAELTQSGAWCVAADFSVGMLKAG------
* ::*:*.*:. : : ** . *: :. .
Mb1440c|M.bovis_AF2122/97 QGLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRP
Rv1405c|M.tuberculosis_H37Rv QGLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRP
MLBr_00551|M.leprae_Br4923 LGLTLEYREADAQALPFGDGEFDVVMSAIGVMFAPDHRRAASELVRVCRP
MAV_3373|M.avium_104 MGLTIDYREANAQALPFGDGEFDAVVSAIGVQFAPDHQRAADELVRVCRP
Mvan_1928|M.vanbaalenii_PYR-1 RGVEVQWMEADAEAMPFADNDFDVVMSCVGAMFAPHHQATADELVRVTRP
Mflv_4060|M.gilvum_PYR-GCK RGVAVEWVEADAEALPFPDDSFDVVMSCVGAMFAPHHQATADEIVRVTRP
MMAR_1627|M.marinum_M RGASLRWVEANAQALPFDTDEFDAVVSCVGVMFAPYHQPCADELVRVCRP
MUL_3409|M.ulcerans_Agy99 RGASLRWVEANAQALPFDTDEFDAVVSCVGVMFAPYHQPCADGLVRVCRP
MSMEG_2285|M.smegmatis_MC2_155 RGVDITWKEANAEALPFSDGEFDVVMSCIGVMFAPHHDQSARELLRVTRS
TH_2937|M.thermoresistible__bu -GSTVTWVTADAADTGLKTASFDVAVSNMGIIFVPPDRQVA-ELARLLKP
MAB_3930c|M.abscessus_ATCC_199 ARRDVPKVAGDATRLPFADHSFDAVTISFGLRNVVDHVEGLREMARVTKP
: .:* : .**.. .* . . : *: :.
Mb1440c|M.bovis_AF2122/97 GGTIGVISWTCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLG
Rv1405c|M.tuberculosis_H37Rv GGTIGVISWTCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLG
MLBr_00551|M.leprae_Br4923 NGTIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREAYIRGLLD
MAV_3373|M.avium_104 GGRIGLISWTPEGFFGRMLATIRPYRPSLSHPVPPAALWGRPGYVRALLG
Mvan_1928|M.vanbaalenii_PYR-1 GGTIGLINWTPEGFIGNLFATMKPYAPPPPPGASPAPLWGNAEHVRELFA
Mflv_4060|M.gilvum_PYR-GCK GGTLGLISWTPEGFIGHLFATMKPYAPPPPPGASPPPMWGSENHVEALFG
MMAR_1627|M.marinum_M GGVIGLISWTPGGFIGEMFTTMKPYLAPPLPGAQPAPLWGTEGHVRELFA
MUL_3409|M.ulcerans_Agy99 GGVIGLISWTPGGFIGEMFTTMKPYLAPPLPGAQPAPLWGTEGHVRELFA
MSMEG_2285|M.smegmatis_MC2_155 GGRIGLISWTPEGFIGQLFATMKPFVPAPPPGVSPPPLWGNADHVRTLLG
TH_2937|M.thermoresistible__bu GGVLSFSAWIRTDEN-PFSDPVAEVLGPPPAGFSPD-QWGDAETLTERLT
MAB_3930c|M.abscessus_ATCC_199 GGRLAVCEFS-TPVNRPFRTLYMEYLMKTLPEVARAVSSNPDAYV--YLA
.* :.. : : . : :
Mb1440c|M.bovis_AF2122/97 DGVTGLKTARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAA
Rv1405c|M.tuberculosis_H37Rv DGVTGLKTARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAA
MLBr_00551|M.leprae_Br4923 DTVTNVKTERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAA
MAV_3373|M.avium_104 ERIGEITTARGMLPVNRFGSAEDVHAYFKQHYGPTIEAYANIGHNRVLAA
Mvan_1928|M.vanbaalenii_PYR-1 DRVTDLQMQRQTVVMDHCATPLEFREYWKANYGPTIATYRFNADDAERVA
Mflv_4060|M.gilvum_PYR-GCK DRVRDLTMRRQTVRFDHCASPLDFREYWKRNYGPTLAAYRFNEDRPERLA
MMAR_1627|M.marinum_M DRVTDFAVRRGALLVDEFADGASFRDYFKANYGPTIAAYRAIAAEPDRVA
MUL_3409|M.ulcerans_Agy99 DRVTDFAVRRGTLLVDEFADGASFRDYFKANYGPTIAAYRAIAAEPDRVA
MSMEG_2285|M.smegmatis_MC2_155 DGIEDFETQRRSLTVDMFADGAAFRDFFKANYGPTIAAYRAVGDDAERTA
TH_2937|M.thermoresistible__bu PHFDAIDLIRG-LHPWEFDSPATALHFLRTESPVHVEIFRRAG--PARRE
MAB_3930c|M.abscessus_ATCC_199 ESIRAWPDQEALAHQIASAGWSNVR--WRNLTGGIVALHIATL-------
. . : : .
Mb1440c|M.bovis_AF2122/97 ELDRQLVELAAQYLSD-----GVMEWEYLLLTAEKR--
Rv1405c|M.tuberculosis_H37Rv ELDRQLVELAAQYLSD-----GVMEWEYLLLTAEKR--
MLBr_00551|M.leprae_Br4923 ELDAQLTELAQKYLTN-----STMGWEYLLLTAQKH--
MAV_3373|M.avium_104 ELDAQLVELAAQHLSD-----GTMGWEYLLVTAEKRSG
Mvan_1928|M.vanbaalenii_PYR-1 ALDRDFLAFLEQWNQSGETGRTAYEAEYLLVTATKR--
Mflv_4060|M.gilvum_PYR-GCK ELDAAFLDFLTTWNQADGTDGTAYDAEYLLVTATKR--
MMAR_1627|M.marinum_M ALDAELAALGDRYLAG----SSAMEWEYLLVTARKR--
MUL_3409|M.ulcerans_Agy99 ALDAELAALGDRYLAG----SSAMEWEYLLVTARKR--
MSMEG_2285|M.smegmatis_MC2_155 ALDEAIALLGDRYLD-----SGAMQWEYLVVTAHKR--
TH_2937|M.thermoresistible__bu RLAAAFRSALRPHAGPAG--TVGFTAPYVIVTARRRG-
MAB_3930c|M.abscessus_ATCC_199 --------------------------------------