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AVTDVFARRATLRRSLRLLADFRYEQRDPARFYRTLAADTAAMIGDLWLATHSEPPVGRTLLDVGGGPGY FATAFSDAGVGYIGVEPDPDEMHAAGPAFTGRPGMFVRASGMALPFADDSVDICLSSNVAEHVPRPWQLG TEMLRVTKPGGLVVLSYTVWLGPFGGHEMGLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLR WAAGTGAALAVFPRYHPRWAWWLTSVPVLREFLVSNLVLVLTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0224c | - | - | 100% (254) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. tuberculosis H37Rv | Rv1405c | - | 5e-08 | 29.46% (129) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0839 | - | 5e-06 | 31.58% (133) | hypothetical protein Rv0839 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0229c | - | 1e-149 | 99.61% (254) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_0427 | - | 1e-108 | 74.41% (254) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_02584 | - | 1e-125 | 82.94% (252) | hypothetical protein MLBr_02584 |
| M. abscessus ATCC 19977 | MAB_4481 | - | 1e-103 | 69.80% (255) | hypothetical protein MAB_4481 |
| M. marinum M | MMAR_0473 | - | 1e-128 | 84.65% (254) | methyltransferase |
| M. avium 104 | MAV_4945 | - | 1e-123 | 82.54% (252) | SAM-dependent methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 2e-09 | 36.54% (104) | methyltransferase |
| M. thermoresistible (build 8) | TH_2028 | - | 1e-110 | 74.71% (257) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_1123 | - | 1e-126 | 83.86% (254) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0241 | - | 1e-107 | 73.62% (254) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0224c|M.tuberculosis_H37Rv ----------------------MAVTDVFARRATLRRSLRLLADFRYEQR
Mb0229c|M.bovis_AF2122/97 ----------------------MAVTDVFARRATLRRSLRLLADFRYEQR
MLBr_02584|M.leprae_Br4923 --------MDTRRRVWPVAIITPHVTDVFAQRATLTRSLQLLSEFRYEQP
MMAR_0473|M.marinum_M ----------------------MAVTDRFARRATLSRSLRLLSEFRYEQP
MUL_1123|M.ulcerans_Agy99 ----------------------MAVTDRFARRATLSRSLRLLSEFRYEQP
MAV_4945|M.avium_104 ------------------------MTDIFARRATLARSVRLLSQFRYERS
Mflv_0427|M.gilvum_PYR-GCK --------MAA--------------TDLLAGRATLSRSLRLLSAFRFEQT
Mvan_0241|M.vanbaalenii_PYR-1 --------MPA--------------TDRFSDRATLARSVRLLTAFRFEQS
TH_2028|M.thermoresistible__bu --------MDAPR-----AAARRDVTELFARRATLRRSVRLLSEFRFEQS
MAB_4481|M.abscessus_ATCC_1997 ---------------------MPDITDLFAQRATLRRSTSLLTAFRFEQS
MSMEG_0098|M.smegmatis_MC2_155 MDTALRRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAPKNTGLIQKAWASP
: :. : . * :
Rv0224c|M.tuberculosis_H37Rv DPARFYRTLAADTAAMIGDLWLATHSE-PPVGRTLLDVGGGPGYFATAFS
Mb0229c|M.bovis_AF2122/97 DPARFYRTLAADTAAMIGDLWLATHSE-PPVGRTLLDVGGGPGYFATAFS
MLBr_02584|M.leprae_Br4923 YPARFYRALAADTVAMVGDLWLSTHGA-PPVGRILLDVGSGSGYFAAAFA
MMAR_0473|M.marinum_M DPARFYGALAADTATLVSDLWLAARGE-SVAGRTLLDVGGGPGYFASAFA
MUL_1123|M.ulcerans_Agy99 DPARFYGALAADTATLVSDLWLAARGE-SVAGRTLLDVGGGPGYFASAFA
MAV_4945|M.avium_104 EPARFYGALAADTAAMVDDLWRAGHGE-SAAGRTLLDVGGGPGYFAAAFA
Mflv_0427|M.gilvum_PYR-GCK DPDRFYGALASDTVAMVDDLWRATTGT-STRNLTVLDVGGGPGYFASAFT
Mvan_0241|M.vanbaalenii_PYR-1 APDRFYGALADDTVAMVGDLWESATGE-SQAGLTLLDVGGGPGYFASAFT
TH_2028|M.thermoresistible__bu DPARFYGALADDTAALVADLWRAATGS-DPAGRTVLDVGGGPGYFAAAFA
MAB_4481|M.abscessus_ATCC_1997 APERFYGTLAQDTVHLITDLWQQAEGV-ALRGRTVLDVGGGPGYFASAFA
MSMEG_0098|M.smegmatis_MC2_155 LGSKLYDRAQLLNRRLVASTRPPVEWLRIPPGGTVLDIGCGPGNITAQLA
::* . :: . . :**:* *.* ::: ::
Rv0224c|M.tuberculosis_H37Rv DAG---VGYIGVEPDPDEMHAAGPAFTGR----PGMFVRASGMALPFADD
Mb0229c|M.bovis_AF2122/97 DAG---VGYIGVEPDPDEMHAAGPAFTGR----PGMFVRASGMALPLADD
MLBr_02584|M.leprae_Br4923 DAG---VRYIGVEPDPREMHAAGPALVPK----AGAFVRASGMALPFADD
MMAR_0473|M.marinum_M AAG---VGYIGVEPDPNEMHAAGPAHAGG----PGSFVRASGMALPFADD
MUL_1123|M.ulcerans_Agy99 AAG---VGYIGVEPDPNEMHAAGPAHAGG----PGSFVRASGMALPLADD
MAV_4945|M.avium_104 DAG---VRYLGVEPDPGEMHAAGPVVAAD----TGTFVRASGMALPFADD
Mflv_0427|M.gilvum_PYR-GCK DAG---LHYVGVEPDPGEMHAAAPRTHSR----AGSFVRASGTALPFADG
Mvan_0241|M.vanbaalenii_PYR-1 AAG---VNYIGVEPDPREMHAAAALTHER----AGTFVRASGTALPFADD
TH_2028|M.thermoresistible__bu RAG---MRYIGVEPDPREIHAGPAVECPEDDPAAGTFVRASGMALPFADA
MAB_4481|M.abscessus_ATCC_1997 DAG---ARYIGVEPDPREMHAAPQGHRGIQDP-RTTYLRASGMALPLADN
MSMEG_0098|M.smegmatis_MC2_155 RAAGLDGLALGVDISEPMLARAVAAEAGR----QVGFVRADAQQLPFRDE
*. :**: . : . ::**.. **: *
Rv0224c|M.tuberculosis_H37Rv SVDICLSSNVAEHVPRPWQLGTEMLRVTKPGGLVVLSYTVWLGPFGGHEM
Mb0229c|M.bovis_AF2122/97 SVDICLSSNVAEHVPRPWQLGTEMLRVTKPGGLVVLSYTVWLGPFGGHEM
MLBr_02584|M.leprae_Br4923 AVDICLSSNVAEHVPQPWQLGNEMLRVTKPGGLVVLSYTIWLGPFGGHEM
MMAR_0473|M.marinum_M SVDICLSSNVAEHVPRPWQLGAEMLRVTRPGGLAVLSYTVWLGPFGGHEM
MUL_1123|M.ulcerans_Agy99 SVDICLSSNVAEHVPRPWQLGAEMLRVTRPGGLAVLSYTVWLGPFGGHEM
MAV_4945|M.avium_104 SVDICLSSNVAEHVPRPWQLGAEMLRVTRPGGLAVLSYTVWLGPFGGHEM
Mflv_0427|M.gilvum_PYR-GCK SVDICLSSNVAEHVAQPWRLGEEMLRVTRPGGLAVLSYTVWLGPFGGHEM
Mvan_0241|M.vanbaalenii_PYR-1 SVDVCLSSNVAEHVAQPWRLGDEMLRVTRPGGLAVLSYTVWLGPFGGHEM
TH_2028|M.thermoresistible__bu SVDICLSSNVAEHVPQPWLLGREMLRVTRPGGLAVLSYTVWLGPFGGHET
MAB_4481|M.abscessus_ATCC_1997 SVDICLSSNVAEHVPQPWRLGEEMLRVTRPGGLAILSYTVWLGPFGGHEM
MSMEG_0098|M.smegmatis_MC2_155 VFDAATSLAVFQLIPDPVAAVSEIVRVLKPGGRVAI-----MVPTAGAVK
.* . * * : :. * *::** :*** . : : * .*
Rv0224c|M.tuberculosis_H37Rv GLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLRWAAGTGAAL
Mb0229c|M.bovis_AF2122/97 GLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLRWAAGTGAAL
MLBr_02584|M.leprae_Br4923 GLTHYLGGARAATRYVRKHGHRAKNDYGSSLFPVSAADGLNWAASTGVAV
MMAR_0473|M.marinum_M GLSHYLGGARAAARYARRHGHPAKNNYGSSLFAVSAAEGLRWAEGTGTLI
MUL_1123|M.ulcerans_Agy99 GLSHYLGGARAAARYARRHGHPAKNNYGSSLFAVSAAEGLRWAEGTGTLI
MAV_4945|M.avium_104 GLTHYLGGSRAAARYARKHGHPAKNNYGSSLFEVSVADGLAWAACTGAEL
Mflv_0427|M.gilvum_PYR-GCK GLSHYLGGYRAAERYTRRHGHRPKNDYGSSLFAVSAADGLRWARSTGALA
Mvan_0241|M.vanbaalenii_PYR-1 GLTHYLGGRRAAEMYTRRHGHRPKNDYGSSLFAVHARDGLRWAQGTGALL
TH_2028|M.thermoresistible__bu GLWHYLGGRRAADRYARRHGHRPKNDYGSSLFAVSAADGLRWAAATGALL
MAB_4481|M.abscessus_ATCC_1997 GLTHYFGGARAARWYTRKHGHPPKNNYGSSLFPVSVRDGLRWARDTGTLT
MSMEG_0098|M.smegmatis_MC2_155 PVTFLARG--GARIFGDDELGDIFENVGLVGVRVKTHGFIQWVRGTKL--
: . * .* : . :: * . * . : *. *
Rv0224c|M.tuberculosis_H37Rv AVFPRYHPRWAWWLTSVPVLREFLVSNLVLVLTP-----
Mb0229c|M.bovis_AF2122/97 AVFPRYHPRWAWWLTSVPVLREFLVSNLVLVLTP-----
MLBr_02584|M.leprae_Br4923 AAFPRYHPRWAWWLTSVPVLREFVVSNLVLVLRPR----
MMAR_0473|M.marinum_M AAFPRYHPRWAWWMTSVPMLREFLVSNLVLVLSPR----
MUL_1123|M.ulcerans_Agy99 AAFPRYHPRSAWWMTSVPMLREFLVSNLVLVLSPR----
MAV_4945|M.avium_104 AAFPRYHPRWAWWLTSVPVLREFLVSNLVLVLQPQ----
Mflv_0427|M.gilvum_PYR-GCK AAFPRYHPRWAWGLTRVPGVREFLVSNLVLVLRPT----
Mvan_0241|M.vanbaalenii_PYR-1 AAFPRYHPRWAWGLTKVPGLREFLVSNLVLVLRPC----
TH_2028|M.thermoresistible__bu AAFPRYHPKWGWWLTRAPVVREFLVSNLVLVLSPPEIVN
MAB_4481|M.abscessus_ATCC_1997 AAFPRYHPKWAWWITKIPALREVLVSNLVLVLRPR----
MSMEG_0098|M.smegmatis_MC2_155 ---------------------------------------