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TEAMDAEFDTVAEWTAQVARDLGPDYFVPAGCRGSGNPAALDWLVDRLELTPGESLLDSGAGVGGPAGYA VSRVPVSPVLVEPQIGACRAARSMFDYPAIQAVADALPFSDNAFDGAWCLGVLCTTDAQQQVLTELRRVV RAPGRIGLLVFVATTDLPDDQQPDGNNFPTEKSLQQMLDTAGLRVDARINTTDLPPIPQEWQDRVEAVDD ALERRFGGEEAWQIAERQSGRMGELLGDGRVSGVVLSLRRAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3460 | - | - | 100% (253) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 5e-05 | 35.40% (113) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv1405c | - | 5e-05 | 35.40% (113) | putative methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3689 | - | 1e-06 | 32.77% (119) | putative methyltransferase |
| M. marinum M | MMAR_4497 | - | 3e-05 | 28.97% (107) | methyltransferase |
| M. avium 104 | MAV_3373 | - | 4e-06 | 34.51% (113) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_6663 | - | 8e-87 | 60.48% (248) | C5-O-methyltransferase |
| M. thermoresistible (build 8) | TH_1968 | - | 8e-06 | 30.08% (123) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_4668 | - | 2e-05 | 28.97% (107) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1928 | - | 2e-06 | 34.51% (113) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4497|M.marinum_M MSATPDPREVTRGLLTEPCDLRRGFLDVLGESTSSPVPTVAQRAMNSRFV
MUL_4668|M.ulcerans_Agy99 MSATPDPREVTRGLLTEPGDLRHGFLDVLGESTSSPVPTVAQRAMNSRFV
Mb1440c|M.bovis_AF2122/97 --------------------------------MT-----IDTPAREDQTL
Rv1405c|M.tuberculosis_H37Rv --------------------------------MT-----IDTPAREDQTL
MAV_3373|M.avium_104 --------------------------------MT-----LDTTT-ADASV
Mvan_1928|M.vanbaalenii_PYR-1 --------------------------------MTTANAGVASDPDADRQL
Mflv_3460|M.gilvum_PYR-GCK ---------------------------------MTEAMDAEFDTVAEWTA
MSMEG_6663|M.smegmatis_MC2_155 -------------------------------------MEAEFDTVAEWTA
MAB_3689|M.abscessus_ATCC_1997 --------------------------------------------MPDAQA
TH_1968|M.thermoresistible__bu --------------------------------------------------
MMAR_4497|M.marinum_M ATVYERLWRPAAFYLASGVTTRAEQHRAAAALHLSTAHRLLDVACGPGNF
MUL_4668|M.ulcerans_Agy99 ATVYERLWRPAAFYLASGVTTRAEQHRAAAALHLSTAHRLLDVACGPGNF
Mb1440c|M.bovis_AF2122/97 AATHRAMWALGDYALMAEEVMAPLGPILVAAAGIGPGVRVLDVAAGSGNI
Rv1405c|M.tuberculosis_H37Rv AATHRAMWALGDYALMAEEVMAPLGPILVAAAGIGPGVRVLDVAAGSGNI
MAV_3373|M.avium_104 AARHRTVWALGDYALMAEEVMAPLGPTLVEAAGIGPGVRVLDVAAGSGNI
Mvan_1928|M.vanbaalenii_PYR-1 KAKHRALWASGDYPAVAVDLIHSLGPRLVEACRVGPGQRVLDVAAGSGNA
Mflv_3460|M.gilvum_PYR-GCK QVARDLGPDYFVPAGCRGSGNPAALDWLVDRLELTPGESLLDSGAGVGGP
MSMEG_6663|M.smegmatis_MC2_155 KVAVDLGSDYYIPAGCRGSGSPAALDWLIEHTELAAGQRLLDCGAGVGGP
MAB_3689|M.abscessus_ATCC_1997 EPSLSFGSQAAAYERGRPSYPPEAIDWLLP----PGAHDVLDLGAGTGKL
TH_1968|M.thermoresistible__bu ---LSFGAEAAAYERGRPSYPPEAIDWLLP----SDARDVLDLGAGTGKL
. :** ..* *
MMAR_4497|M.marinum_M TAPLVKQLPAGSLAVGLDISEPMLTRAVLDNSGPQTCYVRGDARMLPFDD
MUL_4668|M.ulcerans_Agy99 TAPLVKQLPAGSLAVGLDISEPMLTRAVLDNSGPQTCYVRGDARMLPFDD
Mb1440c|M.bovis_AF2122/97 SLPAAKTG-ATVISTDLTPELLQRSQARAAQQGLTLQYQEANAQALPFAD
Rv1405c|M.tuberculosis_H37Rv SLPAAKTG-ATVISTDLTPELLQRSQARAAQQGLTLQYQEANAQALPFAD
MAV_3373|M.avium_104 TLPAAAAG-ASVVSTDLTPELLQRSRDRAAGMGLTIDYREANAQALPFGD
Mvan_1928|M.vanbaalenii_PYR-1 AIPAAEAG-ATVIAGDLTPELFEAGRETARRRGVEVQWMEADAEAMPFAD
Mflv_3460|M.gilvum_PYR-GCK AGYAVSRVPVSPVLVEPQIGACR-----AARSMFDYPAIQAVADALPFSD
MSMEG_6663|M.smegmatis_MC2_155 AAYAAQAVPVYPVLVEPEAGACR-----AAQTLFGHPVLRAQAAALPLAD
MAB_3689|M.abscessus_ATCC_1997 TTRLVERG-LNVVAVDPLAEMLEV----LSNSLPDTPALLGTAEEIPLPD
TH_1968|M.thermoresistible__bu TTRLVERG-LNVTAVDPIPEMLEL----LSKSLPDTPALLGTAEEIPLPD
: . . * :*: *
MMAR_4497|M.marinum_M ETFDAVCCFGALYLMPEPFRIAREMVRVLGPGGRIAILTTYSG-----QR
MUL_4668|M.ulcerans_Agy99 ETFDAVCCFGALYLMPEPFRIAREMVRVLGPGGRIAILTTYSG-----QR
Mb1440c|M.bovis_AF2122/97 DEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISWTCEGFFGRML
Rv1405c|M.tuberculosis_H37Rv DEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISWTCEGFFGRML
MAV_3373|M.avium_104 GEFDAVVSAIGVQFAPDHQRAADELVRVCRPGGRIGLISWTPEGFFGRML
Mvan_1928|M.vanbaalenii_PYR-1 NDFDVVMSCVGAMFAPHHQATADELVRVTRPGGTIGLINWTPEGFIGNLF
Mflv_3460|M.gilvum_PYR-GCK NAFDGAWCLGVLCTTDAQQQVLTELRRVVRAPGRIGLLVFVAT-------
MSMEG_6663|M.smegmatis_MC2_155 NSFDAAWCLGVLCTTPAQTELLEELHRVVRPSGRIGLLAFVAN-------
MAB_3689|M.abscessus_ATCC_1997 NSVDAVLVAQAWHWVDPE-RAIPEVARVLRPGGRLGLVWNVRDERLGWVS
TH_1968|M.thermoresistible__bu NSVDAVLVAQAWHWFDVD-RAVREVARVLRPGGRLGLVWNTRDERMGWVK
.* . *: ** . * :.::
MMAR_4497|M.marinum_M APIR-HALDAAAGAIGLTMFDQDSFVDLFSSAGLVDIDQQT---------
MUL_4668|M.ulcerans_Agy99 APIR-HALDAAAGAIGLTMFDQDSFVDLFSSAGLVDIDQQT---------
Mb1440c|M.bovis_AF2122/97 ATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFD
Rv1405c|M.tuberculosis_H37Rv ATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFD
MAV_3373|M.avium_104 ATIRPYRPSLSHPVPPAALWGRPGYVRALLGERIGEITTARGMLPVNRFG
Mvan_1928|M.vanbaalenii_PYR-1 ATMKPYAPPPPPGASPAPLWGNAEHVRELFADRVTDLQMQRQTVVMDHCA
Mflv_3460|M.gilvum_PYR-GCK ---TDLPDDQQPDGNNFPTEKSLQQMLDTAGLRVDARINTTDLPPIPQE-
MSMEG_6663|M.smegmatis_MC2_155 ---REIPRDE-FEGNHFPTPEHLTHLVDGAGLVIEEQLCTADLPAIPDG-
MAB_3689|M.abscessus_ATCC_1997 DLGHIIGHENAADSADVGALPAPFTGQERHQVEWTNYLTPQALLDMVAS-
TH_1968|M.thermoresistible__bu ELGRIIGDEHDPLSKTV-TLPEPFTDVQRHQVEWTNYLTPQALIDLVAS-
MMAR_4497|M.marinum_M ---------------------------------------------QRG--
MUL_4668|M.ulcerans_Agy99 ---------------------------------------------QRG--
Mb1440c|M.bovis_AF2122/97 TAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDG--
Rv1405c|M.tuberculosis_H37Rv TAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDG--
MAV_3373|M.avium_104 SAEDVHAYFKQHYGPTIEAYANIGHNRVLAAELDAQLVELAAQHLSDG--
Mvan_1928|M.vanbaalenii_PYR-1 TPLEFREYWKANYGPTIATYRFNADDAERVAALDRDFLAFLEQWNQSGET
Mflv_3460|M.gilvum_PYR-GCK ---------WQDRVEAVDDALERRFGGEEAWQIAERQSGRMGELLGDG--
MSMEG_6663|M.smegmatis_MC2_155 ---------WNERVDAVEKALTERYGHTRAWQIAEEQSGKIGDLLADG--
MAB_3689|M.abscessus_ATCC_1997 ---------RSYCITAPEAARKKTLQQVRELLATHPALAQSAGLALPY--
TH_1968|M.thermoresistible__bu ---------RSYCITSPAKVRARTLERVRELLATHPALANNSGLALPY--
MMAR_4497|M.marinum_M ------LQFVVAAKPK---
MUL_4668|M.ulcerans_Agy99 ------LQFVVAAKPK---
Mb1440c|M.bovis_AF2122/97 ---VMEWEYLLLTAEKR--
Rv1405c|M.tuberculosis_H37Rv ---VMEWEYLLLTAEKR--
MAV_3373|M.avium_104 ---TMGWEYLLVTAEKRSG
Mvan_1928|M.vanbaalenii_PYR-1 GRTAYEAEYLLVTATKR--
Mflv_3460|M.gilvum_PYR-GCK -----RVSGVVLSLRRAS-
MSMEG_6663|M.smegmatis_MC2_155 -----GLTGELLILRQA--
MAB_3689|M.abscessus_ATCC_1997 -----VTVSIRATLNR---
TH_1968|M.thermoresistible__bu -----ITVCIRATLA----