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MGQRRTDKMSLVAFMQAGSASVYAGSWRHPATEHGYLDAAYYAKVGRQLEEGCFDLMFFDDRLAMPGIYG GSVAEAVRYGARPVKLDLSVILGVLAQATSHIGLGATYSTTYYQPFHVARTFASLDHLSRGRAAWNVVTS VNDSEAQNFGVDAHLGHDERYDRADEFLDVVTGLWDTWDDDAIRHDRAGGMYADPDKVHELRHQGKYFSA RGPLTVPRTPQGRPVILQAGSSGRGRDFASRWAELIFTGDPGLAIAREHYADQKARIAEAGRNPSAVRIC PMVYAVVGESESHAKEREAMFLHDLVDPMASLTLLSELMNYDFAAHGLDDPVTDELIASVSGVRGLVQNI RNHIGGDTVTVRDLAGHRATLLQGPRFVGTGPQVADQMAEWFEAQACDGFVLAATHMPGAFEDVVRMVVP ELQRRGLFRSAYEASTLRGHLGLERPASTRLSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6641 | - | - | 100% (453) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_1162 | - | 3e-92 | 43.49% (430) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_4590 | ssuD | 6e-82 | 39.77% (440) | nitrilotriacetate monooxygenase component A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0137c | fgd2 | 1e-05 | 26.54% (211) | putative f420-dependant glucose-6-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 1e-83 | 39.59% (437) | hypothetical protein Mflv_0250 |
| M. tuberculosis H37Rv | Rv0132c | fgd2 | 1e-05 | 26.54% (211) | putative f420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3401 | - | 1e-73 | 37.65% (425) | putative monooxygenase |
| M. marinum M | MMAR_0703 | - | 1e-68 | 35.68% (412) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_0340 | - | 0.0 | 85.71% (448) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 3e-86 | 42.99% (428) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_0814 | - | 6e-09 | 24.54% (273) | flavin-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 8e-76 | 38.13% (438) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6641|M.smegmatis_MC2_155 --MGQRRTDKMSLVAFMQAGSASVYAGSWRHPATEHG---YLDAAYYAKV
MAV_0340|M.avium_104 -----MRTDKMALVAFMQAGSTSVYAGSWRHPANEHR---YLDAAYYAKI
TH_4079|M.thermoresistible__bu ------------LPETRLSG--------------------ITDIDHYLEL
Mvan_6020|M.vanbaalenii_PYR-1 ----------MMHLITWLMGNSYHAAGWRHQLAWERT---AMRLDVLIEI
MMAR_0703|M.marinum_M ---------MIRKPVHLAAHFPGVNNTTVWADPGAGS---QIEFESFVHL
Mflv_0250|M.gilvum_PYR-GCK ---MTDSAKRKAHLLGFVQHGVMNHASTMWAHPRDKVGYHWSRPEYWRDL
MAB_3401|M.abscessus_ATCC_1997 ---MTRVIRFNAFDMNCVAH----QSPGLWRHPDDQS-WRYKDLSYWTNL
Mb0137c|M.bovis_AF2122/97 MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
Rv0132c|M.tuberculosis_H37Rv MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
MUL_0814|M.ulcerans_Agy99 -------------------------------------------MRFSIAI
MSMEG_6641|M.smegmatis_MC2_155 GRQLEEGCFDLMFFDDRLAMPGIY-GGSVAEAVRYGARPVKLDLSVILGV
MAV_0340|M.avium_104 GRQLEEGCFDLMFFDDRLAMPGVY-GGSVGEAVRYGARPVKLDLGVILGV
TH_4079|M.thermoresistible__bu ARIAERGKLDAIFFADHPVLKGKT-EFRPFDA---------LDPVTLVTA
Mvan_6020|M.vanbaalenii_PYR-1 AKIAEEAKLDALFVADGNGVRNMD-KVGLFEANTPSARPTVYDPVTLMAA
MMAR_0703|M.marinum_M ARTAERGLFDFFFLAEGLRLREHRGRIHDLDVVGR------PDTFTLLAA
Mflv_0250|M.gilvum_PYR-GCK GRTMERGLFDAMFIADELAPYTTY-KGSSDPVVKFAGQCPVHEPASVVPI
MAB_3401|M.abscessus_ATCC_1997 ATLLERGRFDGLFIADVLGTYDIY-GASDEAAIRQAAQIPVADPLLLVSA
Mb0137c|M.bovis_AF2122/97 EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVG
Rv0132c|M.tuberculosis_H37Rv EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVG
MUL_0814|M.ulcerans_Agy99 PQLDTDG-FDAAGLRAYLARAEELGFEGGWGLEQIIGSSPLLAPLQLLAY
. :
MSMEG_6641|M.smegmatis_MC2_155 LAQATSHIGLGATYSTT-YYQPFHVARTFASLDHLSRGRAAWNVVTSVND
MAV_0340|M.avium_104 LAQATSRIGLGATYSTT-YYPPFHVARTFASLDHLSGGRAAWNVVTSVND
TH_4079|M.thermoresistible__bu LSTATTHIGLVATASTT-YTEPYGLARRFATLDHVSRGRAGWNIVTTANA
Mvan_6020|M.vanbaalenii_PYR-1 ISQHTKHIGLVGTASTT-YESPWVVARRFASLDHLSNGRASWNVVTGSNP
MMAR_0703|M.marinum_M LAGVTDRIGLTGTINTT-FNEPFEVARQFATLDHLSEGRAGWNIVTSSDA
Mflv_0250|M.gilvum_PYR-GCK VGAFTKHLGIGITLSTS-FVPPYMMARQLSTLDHLTGGRVGWNIVTSYSK
MAB_3401|M.abscessus_ATCC_1997 MALVTEHLGFGVTTGTG-FEHPYPFARRLSTLDHLTGGRVGWNVVTGYLP
Mb0137c|M.bovis_AF2122/97 NSTSSILFGTGVTCPIY-RYHPATVAQAFASLAILNPGRVFLGLGTG--K
Rv0132c|M.tuberculosis_H37Rv NSTSSILFGTGVTCPIY-RYHPATVAQAFASLAILNPGRVFLGLGTG--E
MUL_0814|M.ulcerans_Agy99 CAACTNRLRLGVAVLVTSLHDPLQLASSVTAVDRLSNGRLDLGVAAGGGS
. : : : * .* .::: :. ** .: :
MSMEG_6641|M.smegmatis_MC2_155 SEAQNFGVDAHLGHDERYDRADEFLDVVTGLWD-TWDDDAIRHDRAGGMY
MAV_0340|M.avium_104 SEAQNFGVDAHLGHDERYDRADEFMDVVTGLWD-TWEDDAVLHDRVSGRY
TH_4079|M.thermoresistible__bu AAAANFGRPAHPDPEHRYSRADEFLQVALRLWD-SWEDDAIVGDKQAPRF
Mvan_6020|M.vanbaalenii_PYR-1 GDSENFGLAHHPDRDSRYARAEEFVSACKALWN-SWDEDAFVERKDTGQY
MMAR_0703|M.marinum_M FTGANFRRGGYLDHADRYQRAEEFLTVARKFWD-SWAPGAVLADIENGDY
Mflv_0250|M.gilvum_PYR-GCK SEFQAMGKENLTPRDKRYEVVEEYMQLLYQLWD-SWDDDAIVYDRDNGVF
MAB_3401|M.abscessus_ATCC_1997 AAARNMGQTDQPAHDARYDHADEYLEVLYKLWEGSWEDDAVVRDAARGVF
Mb0137c|M.bovis_AF2122/97 RLNEQAATDTFGNYRERHDRLIEAIVLIRQLWS-----------------
Rv0132c|M.tuberculosis_H37Rv RLNEQAATDTFGNYRERHDRLIEAIVLIRQLWS-----------------
MUL_0814|M.ulcerans_Agy99 RKFAAFG----VDRATHVSYFTEGLQLMKAAWS-----------------
: * : *.
MSMEG_6641|M.smegmatis_MC2_155 ADPDKVHELRHQGKYFSARGPLTVPRTPQG-RPVILQAGSSGRGRDFASR
MAV_0340|M.avium_104 ADPAKVHELGHVGEFFSARGPLTVPRTPQG-RPVIIQAGSSGRGREFASR
TH_4079|M.thermoresistible__bu VDPDKIHAIDHRGEHFSVAGPLEVPRSPQG-HPVLFQAGSSEPGKQLAAK
Mvan_6020|M.vanbaalenii_PYR-1 LNARKVRVPDYKGRHLSVKGPLNVSRSPQG-RPVLFHAGQSEGGRRLAAR
MMAR_0703|M.marinum_M VDPERIRSVEHSGPQFEVRGFATLPAGPQG-HPVLLQAGDSEQGRAFGAR
Mflv_0250|M.gilvum_PYR-GCK ADPAKVREVNFQGEFFQSRGRHFVAPSPQK-RPVLWQAGSSAQGREFASR
MAB_3401|M.abscessus_ATCC_1997 TDPDKVHHIGHEGTHFTVPGVHLVEPSPQR-TPVIYQAGSSPRGVRFAAE
Mb0137c|M.bovis_AF2122/97 -----GERISFTGHYFR-TDELKLYDTPAM-PPPIFVAASGPQSATLAGR
Rv0132c|M.tuberculosis_H37Rv -----GERISFTGHYFR-TDELKLYDTPAM-PPPIFVAASGPQSATLAGR
MUL_0814|M.ulcerans_Agy99 ----DEPRVRFHGRFRDVDDLPIQPKRVQRPHPPIWFGGRAPKALARAVR
. * . * : .. . . . .
MSMEG_6641|M.smegmatis_MC2_155 WAELIFTG-DPGLAIAREHYADQKARIAEAGRNPSAVRICPMVYAVVGES
MAV_0340|M.avium_104 WAELIFTG-DPGIDVARSHYADQKDRIADAGRDPAAVRICPMAYAVVGES
TH_4079|M.thermoresistible__bu YAEAIFTA-QPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIGGT
Mvan_6020|M.vanbaalenii_PYR-1 HADCIFEA-AASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLGRT
MMAR_0703|M.marinum_M HADAMFTL-HSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIGDT
Mflv_0250|M.gilvum_PYR-GCK HAESVFGI-FPTPKSMRAYATDIRTRASDAGRDPESVKLIYGLQTIIDRD
MAB_3401|M.abscessus_ATCC_1997 NAEAVFTA-APTKELLRQTVTTIRRELELAGRDPYSAKIFNLTTVVTGEN
Mb0137c|M.bovis_AF2122/97 YGDGWIAQ-ARDINDAK-LLAAFAAGAQAAGRDPTTLGKRAELFAVVGDD
Rv0132c|M.tuberculosis_H37Rv YGDGWIAQ-ARDINDAK-LLAAFAAGAQAAGRDPTTLGKRAELFAVVGDD
MUL_0814|M.ulcerans_Agy99 HGDAFLGAGSSTTADFATAVTTLRHELAEQGRDPAGFTIGKRVYLMVDDD
.: : : * :* .
MSMEG_6641|M.smegmatis_MC2_155 ESHAKEREAMFLHDLVDPMASLTLLSELMNYDFAAHGLDDPVTDEL-IAS
MAV_0340|M.avium_104 EAHAKDREAMLLNDLVHPMASLTLLSELMNYDFAQHDLDDPVTDDI-LAS
TH_4079|M.thermoresistible__bu EEEARRIQRRLEDLTVP-DYGLEQLSRIVGYRVGRDDLDRRLQFGSDDPP
Mvan_6020|M.vanbaalenii_PYR-1 ESEAVELYSELNSLISP-DLGVDFLAKAVSEDLTGYPVDGPMPDLS--AP
MMAR_0703|M.marinum_M PDQAGEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDPIAD
Mflv_0250|M.gilvum_PYR-GCK KGRANDRYAEFVENVQI-ESALGILSGHTGFDFSTLGLDDNVVDAD---V
MAB_3401|M.abscessus_ATCC_1997 SEAAHAKHAELLGYGSA-EGALVFMSGWMGVDLARYGLDEPIGNVD---S
Mb0137c|M.bovis_AF2122/97 KAAAR-------------------AADLWRFTAGAVDQPNPVEIQR----
Rv0132c|M.tuberculosis_H37Rv KAAAR-------------------AADLWRFTAGAVDQPNPVEIQR----
MUL_0814|M.ulcerans_Agy99 PERARER-------------------------------------------
*
MSMEG_6641|M.smegmatis_MC2_155 VSGVRGLVQNIRNHIGGDTVTVR------DLAGHRATLLQGPRFVGTGPQ
MAV_0340|M.avium_104 VSGIRGLVQNLRAHIGGDAVTVR------DLANHRATLLQGPRFVGTGPQ
TH_4079|M.thermoresistible__bu AIHMQSRYALVRRLVSTENLTVR------ELLLRLSGGRGHRVFAGTPEQ
Mvan_6020|M.vanbaalenii_PYR-1 VVGGNSIRGQLDAIAKAEQLTVR------QMYERVVPTMGNTALIGTATQ
MMAR_0703|M.marinum_M AAISQGRVRHADPVAVARRYRERSQAENLSIRELVIAVTSRQQFVGTPSH
Mflv_0250|M.gilvum_PYR-GCK QGIRGLFDAILEAK-DGAPVTVR------EAAQIYGVSMGAPVAVGTPAD
MAB_3401|M.abscessus_ATCC_1997 NAILSAVAAFQAATADGREWKVR------DIAEWGEIGGMGPRIVGSGTE
Mb0137c|M.bovis_AF2122/97 AAESNPIEKVLANWAVGTDPGVH---------------------------
Rv0132c|M.tuberculosis_H37Rv AAESNPIEKVLANWAVGTDPGVH---------------------------
MUL_0814|M.ulcerans_Agy99 --VLAGLRSIYGKMGGLDAVAVA----------------------GTPDD
MSMEG_6641|M.smegmatis_MC2_155 VADQMAEWFEAQACDGFVLAATHMPGAFEDVVRMVVPELQRRGLFRSAYE
MAV_0340|M.avium_104 VADQMADWFQTGACDGFVLAATHLPGAFEDVVRMVVPELQRRGLFRTEYR
TH_4079|M.thermoresistible__bu VADTIEEWFTTGAADGFNLIPPALPSSLTAFVDHVVPELQRRGLFRTEYT
Mvan_6020|M.vanbaalenii_PYR-1 IADVMEEWYTTGACDGFVLGASISPFTLLLIRDELVPELQRRGLFRRHYT
MMAR_0703|M.marinum_M IADEIDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQERGAFRTAYT
Mflv_0250|M.gilvum_PYR-GCK VADQMEQYLDEGDCNGFMMLATDTPGCFNDMTELLVPELQKRGRFRTRYP
MAB_3401|M.abscessus_ATCC_1997 VADTLQEWVEETDVDGFNLAYAITPGTFEDFIEYVVPVLTERGAYQSSYT
Mb0137c|M.bovis_AF2122/97 -IGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR----------
Rv0132c|M.tuberculosis_H37Rv -IGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR----------
MUL_0814|M.ulcerans_Agy99 VTRGLAEVIAAGAQTLLLNPVGPDVGQNHEQTERLAAEVIPRLR------
: : : . :
MSMEG_6641|M.smegmatis_MC2_155 ASTLRGHLGLERPAS-----TRLSA-------------------------
MAV_0340|M.avium_104 SATLRGHLGLPRPAN-----ARVAHA------------------------
TH_4079|M.thermoresistible__bu GTTLRDHLGLPRPRNRFTTGRPVAAAS-----------------------
Mvan_6020|M.vanbaalenii_PYR-1 GSTLRENLGLPPVDN-----SPFAT-------------------------
MMAR_0703|M.marinum_M GQTLRDHLGLAGLPS-----------------------------------
Mflv_0250|M.gilvum_PYR-GCK GTTLRESLREY---------------------------------------
MAB_3401|M.abscessus_ATCC_1997 PGTLRHKLLGHGDRLPEEHRGAKYRIGGPLSTIIDRPSTVPSSSGSTAPA
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0814|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6641|M.smegmatis_MC2_155 -----
MAV_0340|M.avium_104 -----
TH_4079|M.thermoresistible__bu -----
Mvan_6020|M.vanbaalenii_PYR-1 -----
MMAR_0703|M.marinum_M -----
Mflv_0250|M.gilvum_PYR-GCK -----
MAB_3401|M.abscessus_ATCC_1997 PTPGR
Mb0137c|M.bovis_AF2122/97 -----
Rv0132c|M.tuberculosis_H37Rv -----
MUL_0814|M.ulcerans_Agy99 -----