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SAEVPSRRQRSTRVSAADVARAVGVSPATVSYVMNGRAGVSEQTRARILEVAEALGHISSARADRLRSHQ TRVIGLILTDIANPFYTEIAAGTIDAARARGYEVFLAHTQEDPQTLRSIVDTMIARQVDGVVITVLHPDD GEVIRSLRSARIPLVQLSRRIQRVDADFVGIDDRAAASEMMEHVVTHGYQDIVTVVGPRTSSASAAREEG FIRTAEAHGIRTVSSQRISTYLSERGGYEAVEQVLARKSLPRVIVCGSDVIALGAISALRERSLNVPDDV AVTGFDGLYPGPLVELTTINQPRREMAEQSIELLTRRIEGAGGSYQSVLRAHQLRIGTTCGCPRMRPHLA A*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6376 | - | - | 100% (352) | transcriptional regulator LacI family protein |
| M. smegmatis MC2 155 | MSMEG_6798 | rbsR | 3e-34 | 25.69% (327) | ribose operon repressor |
| M. smegmatis MC2 155 | MSMEG_2011 | - | 1e-32 | 29.90% (311) | transcriptional regulator, LacI family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 2e-20 | 27.98% (336) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 7e-22 | 28.20% (344) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 2e-20 | 27.98% (336) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | MLBr_00398 | - | 3e-08 | 25.35% (213) | putative D-ribose-binding protein |
| M. abscessus ATCC 19977 | MAB_2023c | - | 5e-11 | 23.05% (334) | LacI family transcriptional regulator |
| M. marinum M | MMAR_5070 | - | 5e-20 | 26.11% (337) | PurR family transcriptional regulator |
| M. avium 104 | MAV_0585 | - | 7e-21 | 27.43% (339) | transcriptional regulator, LacI family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 2e-20 | 26.11% (337) | PurR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2545 | - | 1e-31 | 32.43% (296) | periplasmic binding protein/LacI transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5070|M.marinum_M --MSPTPRRR-----ATLASLAAELKVSRSTISNAFNRPDQLSAELRERV
MUL_4146|M.ulcerans_Agy99 --MSPTPRRR-----ATLASLAAELKVSRSTISNAFNRPDQLSVELRERV
MAV_0585|M.avium_104 --MSPTPRRR-----ATLASLADELKVSRTTVSNAFNRPDQLSADLRERV
Mb3606c|M.bovis_AF2122/97 --MSPTPRRR-----ATLASLAAELKVSRTTVSNAFNRPDQLSADLRERV
Rv3575c|M.tuberculosis_H37Rv --MSPTPRRR-----ATLASLAAELKVSRTTVSNAFNRPDQLSADLRERV
Mflv_1457|M.gilvum_PYR-GCK MSRSPTPRRR-----ATLASLAAELKVSRTTVSNAYNRPDQLSAELRERV
Mvan_2545|M.vanbaalenii_PYR-1 ----MIPKQT-----VNMTDVARRSGVSIASVSRALRGESGVSAATRDRI
MSMEG_6376|M.smegmatis_MC2_155 -MSAEVPSRRQRSTRVSAADVARAVGVSPATVSYVMNGRAGVSEQTRARI
MAB_2023c|M.abscessus_ATCC_199 ------------------------MGLSKTTVADALGGSGRVSEATREKT
MLBr_00398|M.leprae_Br4923 ---------------------------------------MSTGTSVPLRV
. :
MMAR_5070|M.marinum_M LATAKRMGYPGPDPVARSLRT-RKAGAVGLVMAEPLTYFFSDPAARDFVT
MUL_4146|M.ulcerans_Agy99 LATAKRMGYPGPDPVARSLRT-RKAGAVGLVMAEPLTYFFSDPAARDFVT
MAV_0585|M.avium_104 LATAKRLGYPGPDPVARSLRT-RKAGAVGLVMAEPLTYFFSDPAARDFVT
Mb3606c|M.bovis_AF2122/97 LATAKRLGYAGPDPVARSLRT-RKAGAVGLVMAEPLTYFFSDPAARDFVA
Rv3575c|M.tuberculosis_H37Rv LATAKRLGYAGPDPVARSLRT-RKAGAVGLVMAEPLTYFFSDPAARDFVA
Mflv_1457|M.gilvum_PYR-GCK LSTAKRLGYPGPDPVARSLRT-RRAGAVGLVITEPLNYSFSDPAALDFVA
Mvan_2545|M.vanbaalenii_PYR-1 LSAARELAYVVS-PEASRLSG-GPTGRVGVIVPRVDAWFYST-----ILA
MSMEG_6376|M.smegmatis_MC2_155 LEVAEALGHISS-ARADRLRS-HQTRVIGLILTDIANPFYTE-----IAA
MAB_2023c|M.abscessus_ATCC_199 RLVAERMGYVSN-RAARLLRR-NETGALGLYIPGDVRNLSFY---MELAF
MLBr_00398|M.leprae_Br4923 ASIMLILGLLPAILPACGFSESHHKLTIGVSYPTANSPFWNA-----YTR
:. * : :*: .
MMAR_5070|M.marinum_M GVAQSCEELGQGLLLVAVGASRS-LEDGTAAVLNAGVDGFVVYSVR--DD
MUL_4146|M.ulcerans_Agy99 GVAQSCEELGQGLLLVAVGASRS-LEDGTAAVLNAGVDGFVVYSVR--DD
MAV_0585|M.avium_104 GVAQSCEALGQGLLLVAVGPSRS-LDEGTAAVLSAGVDGFVVYSVC--DD
Mb3606c|M.bovis_AF2122/97 GVAQSCEELGQGLQLVSVGSSRS-LADGTAAVLGAGVDGFVVYSVG--DD
Rv3575c|M.tuberculosis_H37Rv GVAQSCEELGQGLQLVSVGSSRS-LADGTAAVLGAGVDGFVVYSVG--DD
Mflv_1457|M.gilvum_PYR-GCK GLAESCEAVGQGLLLVAVGPNRS-VAEGSAAVLAAGVDGFVVYSAS--DD
Mvan_2545|M.vanbaalenii_PYR-1 GIADEFDTVGMDLILCTLPTSAARHRFFEALPLRRKVDAAVVVSLP--LS
MSMEG_6376|M.smegmatis_MC2_155 GTIDAARARGYEVFLAHTQEDPQTLRSIVDTMIARQVDGVVITVLHP-DD
MAB_2023c|M.abscessus_ATCC_199 GAADESAALGLDLTLIGRHLTGE------NRSRPPQVDGIIAVDPV--PG
MLBr_00398|M.leprae_Br4923 FIDEGSHQLGVYINAVSAEEDEQKQLSDVETLINQGIDGLIVTPQSTSIA
: * : :*. :
MMAR_5070|M.marinum_M DPYLQVVLQRRLPVVVVDQPK-----ELAG---VSRVGIDDRAAMRKIAD
MUL_4146|M.ulcerans_Agy99 DPYLQVVLQRRLPVVVVDQPK-----ELAG---VSRVGIDDRAAMRKIAD
MAV_0585|M.avium_104 DPYLQAVLQRRLPVVVVDQPK-----GLTG---VSRVGIDDRAAMRELAD
Mb3606c|M.bovis_AF2122/97 DPYLQVVLQRRLPVVVVDQPK-----DLSG---VSRVGIDDRAAMRELAG
Rv3575c|M.tuberculosis_H37Rv DPYLQVVLQRRLPVVVVDQPK-----DLSG---VSRVGIDDRAAMRELAG
Mflv_1457|M.gilvum_PYR-GCK DPYLPAVMERHLPVVVVDQPR-----DVPG---ASQVRIDDRAAMRSLAE
Mvan_2545|M.vanbaalenii_PYR-1 ARERTRLDQLAVPTVFVGGHR-----TEDH---RPWVGIDDERAAQQAVG
MSMEG_6376|M.smegmatis_MC2_155 GEVIRSLRSARIPLVQLSRRI-----QRVD---ADFVGIDDRAAASEMME
MAB_2023c|M.abscessus_ATCC_199 DAALESLLTSNVPIVTVGRIL-----DKDVSHHAAEIEIDHYRMVTLLLD
MLBr_00398|M.leprae_Br4923 PTLLRIATQANIPVVVVDRYPGYAPGQNKNADYVAFLGPNNEKAGSGIAE
:* * :. : :.
MMAR_5070|M.marinum_M YVLGLGHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGV
MUL_4146|M.ulcerans_Agy99 YVLSLGHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGV
MAV_0585|M.avium_104 YVLGLGHREIGLLTMRLGRDRRQG----LVDAERLRSPAFDVQRERITGV
Mb3606c|M.bovis_AF2122/97 YVLGLGHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGV
Rv3575c|M.tuberculosis_H37Rv YVLGLGHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGV
Mflv_1457|M.gilvum_PYR-GCK HVIDLGHREIGLLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERIHGV
Mvan_2545|M.vanbaalenii_PYR-1 HLLRIGHHDIAMIQAADDTD-----------------IPWATDQARIRGF
MSMEG_6376|M.smegmatis_MC2_155 HVVTHGYQDIVTVVG---------------------PRTSSASAAREEGF
MAB_2023c|M.abscessus_ATCC_199 AIRAAGGKRPALAALDQGAD-----------------SSYVFDVSR--GY
MLBr_00398|M.leprae_Br4923 ALMAGGGSKFLALGG---------------------MPGNSVAQGRKAGL
: * * *
MMAR_5070|M.marinum_M WEAMTAAGVDPESLTVVESYEHLPTSGGDAAKVALEANPR--ITALMCTA
MUL_4146|M.ulcerans_Agy99 WEAMTAAGVDPESLTVVESYEHLPTSGGDAAKVALEANPR--ITALMCTA
MAV_0585|M.avium_104 WEAMTAAGVDPDSLTVVESYEHLPESGGAAAKVALEANPR--ITALMCTA
Mb3606c|M.bovis_AF2122/97 WEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPR--LTALMCTA
Rv3575c|M.tuberculosis_H37Rv WEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPR--LTALMCTA
Mflv_1457|M.gilvum_PYR-GCK YDAMTAAGLDPASLTLVESYEHLPTSGGAGADIALEANPR--ITALMCTA
Mvan_2545|M.vanbaalenii_PYR-1 HQTMQEAGLADPTVVTVK---WSVDGGSHGMETLLSRSRP--PTAVFCHS
MSMEG_6376|M.smegmatis_MC2_155 IRTAEAHGIRTVSSQRISTY-LSERGGYEAVEQVLARKSL--PRVIVCGS
MAB_2023c|M.abscessus_ATCC_199 QEWCAKAGVVPLATRLSAT---PTDVELAQAIRGIVEHQG--IDALVVGA
MLBr_00398|M.leprae_Br4923 ESALTAVGHRLVQFQYAGD---SEDKGLAAAENMLQAHPAGDANAIWCFN
* : .:
MMAR_5070|M.marinum_M DILALSAMDYLRGHGIYVPGQMTVTGFDGVPEAISR---GLTTVSQ-PSL
MUL_4146|M.ulcerans_Agy99 DILALSAMDYLRGHGIYVPGQMTVTGFDGVPEAISR---GLTTVSQ-PSL
MAV_0585|M.avium_104 DILALSAMDYLRAHGVYVPGQLTVTGFDGVPDAISR---GLTTVSQ-SSL
Mb3606c|M.bovis_AF2122/97 DILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSR---GLTTVAQ-PSL
Rv3575c|M.tuberculosis_H37Rv DILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSR---GLTTVAQ-PSL
Mflv_1457|M.gilvum_PYR-GCK DVLALSAMDHLRAKGIYVPGQMTVTGFDGVPEARQR---GLTTVAQ-PGV
Mvan_2545|M.vanbaalenii_PYR-1 DEIALGALRTLRRSGISVPQQVSVIGVDDHPAAELS---DLTTVAQ-PVR
MSMEG_6376|M.smegmatis_MC2_155 DVIALGAISALRERSLNVPDDVAVTGFDGLYPGPLV---ELTTINQ-PRR
MAB_2023c|M.abscessus_ATCC_199 QGLAARSLPVLQSLGHEVGSNFHLGTLVGDPATELTNP-DIHAVDL-RPR
MLBr_00398|M.leprae_Br4923 DKLCQGAIKAVYN--ANREKEFIFGGMDLTPQAIAAIENGLYTVSLGAHW
: :. :: : :. . . : ::
MMAR_5070|M.marinum_M QKGRRAGELLQNPPRSG-----------LPVVELLDTELIRGRTAGPPA-
MUL_4146|M.ulcerans_Agy99 QKGRRAGELLQNPPRSG-----------LPVVELLDTELIRGRTAGPPA-
MAV_0585|M.avium_104 HKGRRAGELLLKPARSG-----------LPVVELLDTELIRGRTAGPPA-
Mb3606c|M.bovis_AF2122/97 HKGHRAGELLLKPPRSG-----------LPVIEVLDTELVRGRTAGPPA-
Rv3575c|M.tuberculosis_H37Rv HKGHRAGELLLKPPRSG-----------LPVIEVLDTELVRGRTAGPPA-
Mflv_1457|M.gilvum_PYR-GCK EKGRRAGELLHNPPRSG-----------LPVVEVLDTEVIRGRTSGPPA-
Mvan_2545|M.vanbaalenii_PYR-1 EQGRIAARVVLGGLGDGDASG------PPASVTTLPTRLVVRGSTAPPR-
MSMEG_6376|M.smegmatis_MC2_155 EMAEQSIELLTRRIEGAGG---------SYQSVLRAHQLRIGTTCGCPRM
MAB_2023c|M.abscessus_ATCC_199 EFGHQAVTFLHDIIAGRAS---------ANDRRTHQARLKIAGVSSPPAI
MLBr_00398|M.leprae_Br4923 LEGGFGLAILYRKIHGQDPAERMVKLDLLKVDKSNVAKFKARYIDNTPHY
. . .: . .. *
MMAR_5070|M.marinum_M ---------------
MUL_4146|M.ulcerans_Agy99 ---------------
MAV_0585|M.avium_104 ---------------
Mb3606c|M.bovis_AF2122/97 ---------------
Rv3575c|M.tuberculosis_H37Rv ---------------
Mflv_1457|M.gilvum_PYR-GCK ---------------
Mvan_2545|M.vanbaalenii_PYR-1 ---------------
MSMEG_6376|M.smegmatis_MC2_155 RPHLAA---------
MAB_2023c|M.abscessus_ATCC_199 RRAMSD---------
MLBr_00398|M.leprae_Br4923 NWKSTTPFDMTITLN