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RVEEEDGLVRARGLRYGTAARFTRAEPTPLWEGVLDATRSGPACPQRPSRVSWMTGPLLDGLVMDEDCLV LSVTAPADANGLPVMVWLHGGAYVSGSGESRKYDAAPLARHGDVVVVNVSYRLGTFGFLAPPGAPDGFNV GLTDQILALKWVRDNISAFGGDPGNVTVFGQSAGGDSVVKLMLAEEASGLFHRAIVQSAPLGLGDERADL AVAMRSALADALDGVDPLQATTQQLLDAQAAAASWAQPVEMLGAMMPFAPLLGHDPLPPADDVAGHLADA AARIELLVGYTRDDAAPFVTMHPEFSEMPDLTEFIFGAPAEALAAQWNDLGGRAASYRFEWSPDDAPLGA CHCLELPFLFGSPEAWADAAMLGNERRIDPTLADEMRTVWTQFAHHGVDALPARSLRFG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6303 | - | - | 100% (410) | para-nitrobenzyl esterase |
| M. smegmatis MC2 155 | MSMEG_1432 | - | 2e-49 | 36.49% (433) | acetylcholinesterase |
| M. smegmatis MC2 155 | MSMEG_0611 | - | 3e-46 | 36.41% (423) | para-nitrobenzyl esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 6e-37 | 31.56% (450) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_5051 | - | 5e-48 | 36.08% (449) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 6e-37 | 31.56% (450) | carboxylesterase LipT |
| M. leprae Br4923 | MLBr_00314 | - | 7e-05 | 26.98% (126) | putative esterase |
| M. abscessus ATCC 19977 | MAB_0301 | - | 3e-61 | 39.90% (396) | putative carboxylesterase |
| M. marinum M | MMAR_4363 | - | 5e-48 | 33.76% (471) | carboxylesterase |
| M. avium 104 | MAV_1226 | - | 1e-48 | 35.10% (473) | carboxylesterase superfamily protein |
| M. thermoresistible (build 8) | TH_3679 | - | 2e-53 | 35.76% (453) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 5e-36 | 32.44% (450) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_2609 | - | 4e-52 | 35.21% (443) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6303|M.smegmatis_MC2_155 ----------------------------MRVEEEDGLVR-----------
Mflv_5051|M.gilvum_PYR-GCK -----MLVALVVAVACGSQASPQPAPDPAVVQTSTGPVRG----TVADD-
Mb2071c|M.bovis_AF2122/97 -------------MALESATVGSMHERTVRARTATGIVEG----FTRDG-
Rv2045c|M.tuberculosis_H37Rv -------------MALESATVGSMHERTVRARTATGIVEG----FTRDG-
MUL_2261|M.ulcerans_Agy99 -----------------------MHERTVRARTATGVVEG----FTRDG-
Mvan_2609|M.vanbaalenii_PYR-1 -----------------------------MLSTPSGDLRG----EVEAG-
MMAR_4363|M.marinum_M ----------------MTSDIRRMASDGYVVETAYGPVRGAEDGIAAAGS
MAV_1226|M.avium_104 -----------------------MAVDDLVVETGYGPVR----GVPVDG-
TH_3679|M.thermoresistible__bu MPSTTPPDDRTPDDAPTRPAPAHSAVGSPVVDTVHGPVRG-----RDDG-
MAB_0301|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 ---------------------MAISAGAPVEIVESGPSIA----------
MSMEG_6303|M.smegmatis_MC2_155 ------ARGLRYGT----AARFTRAEPTPLWEGVLDATRSGPACPQRPSR
Mflv_5051|M.gilvum_PYR-GCK ---HRLFAGIPYAAPPVGALRWQGPRPAPKWDGVRDATAYGPRCMQD---
Mb2071c|M.bovis_AF2122/97 ---VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFANCAPQQR--
Rv2045c|M.tuberculosis_H37Rv ---VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFANCAPQQR--
MUL_2261|M.ulcerans_Agy99 ---VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFTHCSPQQR--
Mvan_2609|M.vanbaalenii_PYR-1 ---IGVWRGIPYAEQPTGQRRFLAPEPMAPWPGVREAREHGPLPPQSK--
MMAR_4363|M.marinum_M GVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFGPVCPQP---
MAV_1226|M.avium_104 ---VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVFGPACPQP---
TH_3679|M.thermoresistible__bu --VVKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRVGPACPQP---
MAB_0301|M.abscessus_ATCC_1997 -MDVVVHRDIRYAH----AARFCPPEPCAAGERGQVAG-IAPQNPSR---
MLBr_00314|M.leprae_Br4923 ----ARLASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPVTN--
.: *
MSMEG_6303|M.smegmatis_MC2_155 VSWMTGPLLDGLVMDEDCLVLSVTAPADANG----LPVMVWLHGGAYVSG
Mflv_5051|M.gilvum_PYR-GCK ---LDGDLELGRQTDEDCLNLNVWTPPVAGDRPEPKPVMVWIHGGSFVAG
Mb2071c|M.bovis_AF2122/97 -RYTVMGIGRYQTRSEDCLTLNVVTP-EEPATQ-PLPVMVFIHGGGYILG
Rv2045c|M.tuberculosis_H37Rv -RYTVMGIGRYQTRSEDCLTLNVVTP-EEPATQ-PLPVMVFIHGGGYILG
MUL_2261|M.ulcerans_Agy99 -RYTMLGLGKYQPMSEDCLTLNVVAP-EAPTHR-PLPVMVFIHGGGYILG
Mvan_2609|M.vanbaalenii_PYR-1 -SFVGGGRDDPKVRDEACLTLTVWSP-DTAAS---LPVMVWIPGGAFVYG
MMAR_4363|M.marinum_M -VLANMPIDLGAPQDEDCLRLNIWAPANTAPGA-AKPVMVWLHGGAYMLG
MAV_1226|M.avium_104 -VFPNMPLDLGAPQGEDCLRLNVWASADTQPGD-AKPVMVWLHGGAYVLG
TH_3679|M.thermoresistible__bu -ADPRIPLDLGAAIGEDCLNLNVWASSDTEPGD-RKPVLVWVHGGAYVIG
MAB_0301|M.abscessus_ATCC_1997 -LETVMGRPEVRPMSEDCLGLTITAPARPSPAG--HPVLVWLHGGAYVTG
MLBr_00314|M.leprae_Br4923 ------AARAEVNLSNTSAQLVRAAGVRPADGS--GRIVLYLHGGAFLGC
.: . * : ::::: **.::
MSMEG_6303|M.smegmatis_MC2_155 SGESRKYDAAPLARHGDVVVVNVSYRLG---TFGFLAPP--GAP--DGF-
Mflv_5051|M.gilvum_PYR-GCK S--SGVYDSRRLVARGDIIVVTVNYRLG---ALGFLAHPALGPP--GAVG
Mb2071c|M.bovis_AF2122/97 SSATPIYDGAALARRG-CVYVSVNYRLG---ALGCLDLSSLSTPQITLDS
Rv2045c|M.tuberculosis_H37Rv SSATPIYDGAALARRG-CVYVSVNYRLG---ALGCLDLSSLSTPQITLDS
MUL_2261|M.ulcerans_Agy99 SSATPIYDGAALARRG-CVYVSVNYRLG---ALGCLDLSSLSTPDIAIDG
Mvan_2609|M.vanbaalenii_PYR-1 AGQFQLYNGSRLAANGDVVVVNVTYRIG---VFGGLELSDLGD---GFDD
MMAR_4363|M.marinum_M SASQALYDGRRLASSGEVIVVTVNYRLG---ALGFLDLSSLSHAGRSFDS
MAV_1226|M.avium_104 SSSQTLYDGRRLVSHGDVVVVTVNYRLG---ALGFLDLSSLNSAGRSFDS
TH_3679|M.thermoresistible__bu AASQPLYHGRELVRRGDVVLVTLNYRLG---AFGFLELTALSSGRRRFDT
MAB_0301|M.abscessus_ATCC_1997 SGSWSCYDASRLVAETGIVVVAVSHRLG---VLGYMRAPGISQG------
MLBr_00314|M.leprae_Br4923 GANSHRRLVETLSKLADSPILVVNYRLLPKHSIG----------------
. * : :.:*: :*
MSMEG_6303|M.smegmatis_MC2_155 NVGLTDQILALKWVRDNISAFGGDPGNVTVFGQSAGGDSVVKLMLAEEAS
Mflv_5051|M.gilvum_PYR-GCK NYGLADQQAALRWVRDNIANFGGDPARVTVAGESAGAMSVCDHLVAPGSD
Mb2071c|M.bovis_AF2122/97 NVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPAAK
Rv2045c|M.tuberculosis_H37Rv NVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPAAK
MUL_2261|M.ulcerans_Agy99 NLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVPAAK
Mvan_2609|M.vanbaalenii_PYR-1 NLALRDQIAALRWVRDNISAFGGDPGRVTVFGESAGATSVLALMAAPSAQ
MMAR_4363|M.marinum_M NVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTPAAR
MAV_1226|M.avium_104 NVGLRDVLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLASPAAA
TH_3679|M.thermoresistible__bu NVGLRDVLFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTTLLGSPAAA
MAB_0301|M.abscessus_ATCC_1997 NLGLRDQIAALEWVRENIAEFGGDPQVVTVAGQSAGAHAVVAMLSIPATR
MLBr_00314|M.leprae_Br4923 -MALDDCHDGYQWLRR----LGYDPEQIVLAGDSAGGYLALALAQRLQDV
* * . *:: :* ** :.: *:***. .
MSMEG_6303|M.smegmatis_MC2_155 GLFHRAIVQSAPLGLGDER---ADLAVAMRSALADALDG--VDPLQATTQ
Mflv_5051|M.gilvum_PYR-GCK GLFDAAIVMS---GLCQSQ---ADLPTAEKRSLDYAAQAGCGGPVPAECL
Mb2071c|M.bovis_AF2122/97 GLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQASPA
Rv2045c|M.tuberculosis_H37Rv GLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQASPA
MUL_2261|M.ulcerans_Agy99 GLFARAISESPAAGMVRPREIAAEFATRFARLLGARKHDAASALMRATAA
Mvan_2609|M.vanbaalenii_PYR-1 RLFHRAIAQSPALPLVADREYRAANAHEFLRRLGVG-----AGEVKALPQ
MMAR_4363|M.marinum_M GLFSRAIAQSSPATSVYDRERAQRVAVHLLDKLGVAASDV-DKLTQLPTA
MAV_1226|M.avium_104 GLFAAAIAQSSPATSVYDRDRAARVAEAFLGKLGITASES-RRLIDMPMA
TH_3679|M.thermoresistible__bu GLFHRAIAQSSPATSCYGTERAIDVAEQFLGHLGLSPRDV-DRLPDVPVA
MAB_0301|M.abscessus_ATCC_1997 GLFRRVILHSAPLGLAYQAVADAERVGEVVLRHLAVPIG------QASVE
MLBr_00314|M.leprae_Br4923 GEEPAALVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAA
.:
MSMEG_6303|M.smegmatis_MC2_155 Q-LLDAQAAAASWAQPVEMLGAMMPFAPLLGHDPLPPADDVAGHLADAAA
Mflv_5051|M.gilvum_PYR-GCK R-GLDANALRT--PVWYYDIGDDRLSGPVTGSAVLPTAPPVA-FGDGKAA
Mb2071c|M.bovis_AF2122/97 Q-LVEAQHHLIR--QGMRKRLGAFPIGPVFGDDYLP-MDPVEAMRSGRVH
Rv2045c|M.tuberculosis_H37Rv Q-LVEAQHHLIR--QGMRKRLGAFPIGPVFGDDYLP-MDPVEAMRSGRVH
MUL_2261|M.ulcerans_Agy99 Q-LVQTQHRLID--QGMQKRLGAFPIGPTFGDDCLP-LDPVEAMRAGQSH
Mvan_2609|M.vanbaalenii_PYR-1 R-QLRRAAGILQ--LKSAANTPTLAYGLTYGTELLP-QHPVAAAREGRTS
MMAR_4363|M.marinum_M A-IVAASTEVFN--EVPVRNPGTLAFVPIVDGDVLT-DYPVKVAQEGRSH
MAV_1226|M.avium_104 A-ILAASQQVFD--EVPVRNPGTLAFVPIVDGDVLA-DYPVKVAQQGCSH
TH_3679|M.thermoresistible__bu A-IVEVSKHVFD--DVPARRPGTLAFAPIVDGDIVP-DYPVALARAGRTL
MAB_0301|M.abscessus_ATCC_1997 E-ILRAQGAAAS-ELAASGVPFAPPFLPIAGVDPWP--SEGAAEPWDGVG
MLBr_00314|M.leprae_Br4923 KNKVDDKPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVG
: .
MSMEG_6303|M.smegmatis_MC2_155 RIELLVGYTRDDAAPFVTMHPEFS-------EMPDLTEFIFGAP------
Mflv_5051|M.gilvum_PYR-GCK RVPVLMGTTRDEWTLFVALQHLRDGKDYAPQEYPRLLADTFGAD------
Mb2071c|M.bovis_AF2122/97 AVPLIVGTNAEEGRLFTRFLG-MLPTN--EPMVEELLSGMKPAD------
Rv2045c|M.tuberculosis_H37Rv AVPLIVGTNAEEGRLFTRFLG-MLPTN--EPMVEELLSGMKPAD------
MUL_2261|M.ulcerans_Agy99 KVPLIVGTNADEGRLFTRFLK-MLPTN--KAMIDELLADTEPAT------
Mvan_2609|M.vanbaalenii_PYR-1 GVPLIIGTNSHEASMFAWTKPPMLPTT--KASIDGYFQRVAPDA------
MMAR_4363|M.marinum_M PVPLLIGTNKHEAALFRLMRSPLMPIT--PRAITSMFTQIAAEQPDLQLP
MAV_1226|M.avium_104 PVPLIIGTNQHEAALFRLMRSALMPIT--PHAITSMFNQIAAEQPDLQLP
TH_3679|M.thermoresistible__bu PVPLVIGTNKDEASLFRWMKSPLLPIT--PDAIKKMFADIAAEQPGLRLP
MAB_0301|M.abscessus_ATCC_1997 DLDVMLGNTTDEFAAFLGRRTGPEFIDGFFDSATTRFADKLAVAG-----
MLBr_00314|M.leprae_Br4923 -VPAEIRVWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASK------
: : : *
MSMEG_6303|M.smegmatis_MC2_155 -AEALAAQW-----------------------------NDLGGRAASYRF
Mflv_5051|M.gilvum_PYR-GCK -APAVEAHYPLTAFSSVALAYAATVTDGVFACAGRRWAGDLAETAPVYFY
Mb2071c|M.bovis_AF2122/97 -RERITAAYPNYPAPSACIQLGG---DFAFSSAAWQIAEAHGANAPTYLY
Rv2045c|M.tuberculosis_H37Rv -RERITAAYPNYPAPSACIQLGG---DFAFSSAAWQIAEAHGANAPTYLY
MUL_2261|M.ulcerans_Agy99 -RERITAAYPNYPESAACIQLGG---DFAFNAAAWQIAEAQGVHAPTYLY
Mvan_2609|M.vanbaalenii_PYR-1 -KQRVLQAYPGYPRRSALVALGS---DAMFGGPTWAFADAYSALAPTRMY
MMAR_4363|M.marinum_M TEEEIGLAYSRLRRRARPLSIAT---DVGFRMPSVWLAEGHSRVAPVYLY
MAV_1226|M.avium_104 TEKQIGSAYSRFRRRARYLSIAT---DVGFRMPSVWLAEGHARVAPVYLY
TH_3679|M.thermoresistible__bu TETQISAAYRRQRGKRLGVGVAS---DIGFRMPSVWFAEGHTAVAPTYLY
MAB_0301|M.abscessus_ATCC_1997 --------------------------------------------ARVFRF
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MSMEG_6303|M.smegmatis_MC2_155 EWSPDDAP-----------LGACHCLELPFLFGS---------PEAWADA
Mflv_5051|M.gilvum_PYR-GCK EFNDRDAPAPDPLRTVPFPVGASHSLELRYLFDTGGA------PPPSPAQ
Mb2071c|M.bovis_AF2122/97 RYDYAPRTLR------WSGFGATHATELFAVFDIYRTRFGALLTAAADRR
Rv2045c|M.tuberculosis_H37Rv RYDYAPRTLR------WSGFGATHATELFAVFDIYRTRFGALLTAAADRR
MUL_2261|M.ulcerans_Agy99 RYDYAPRTLR------WSGFGATHATELFAVFDIYRTRFGALLTAAADRR
Mvan_2609|M.vanbaalenii_PYR-1 RFDHFGWSLR------MLGLGATHGSEIVHIHHSYESFVGRKLHPLG-RR
MMAR_4363|M.marinum_M RFDYSTPLLK------LLLVRAAHATELPYVWGNLGGPQDPTLRLGG-AK
MAV_1226|M.avium_104 RFDYSTPLLR------LLMVKAAHATELPYVWGTLGAPKDPTLKLGG-SK
TH_3679|M.thermoresistible__bu RFDWSTPTLR------LLRLGAAHATELPYVFGNLDTPKDPTFTLGG-RR
MAB_0301|M.abscessus_ATCC_1997 RVGELDPGAP---------LGACHCIDLPLLFGDEAAWRNAPMLSPPGAA
MLBr_00314|M.leprae_Br4923 --------------------ASRDRQSL----------------------
: . .:
MSMEG_6303|M.smegmatis_MC2_155 AMLGNERRIDPTLADEMRTV----------WTQFA--HHGVDALPARSLR
Mflv_5051|M.gilvum_PYR-GCK VRLG-EQMID-YWASFVKTG----------DPGFPGIDSGVMSLQPDGSR
Mb2071c|M.bovis_AF2122/97 AALRVSNEVQRRWRCFSQIG-----VPGDDWPAYTQDDRAV-LVFDRRCR
Rv2045c|M.tuberculosis_H37Rv AALRVSNEVQRRWRCFSQIG-----VPGDDWPAYTQDDRAV-LVFDRRCR
MUL_2261|M.ulcerans_Agy99 HALRVSDEVIRRWRSFSQTG-----TPGEDWPAYTHTRRAV-MVIDRKSR
Mvan_2609|M.vanbaalenii_PYR-1 IQPGVGRRMQRAWLDFARGSED---VDDEHWPLYETGERLTRLIASTRDV
MMAR_4363|M.marinum_M TAKAVSKRMRTRWINFATQDNPAGPAGEPDWPAYQDGDRAC-LVIDKSDR
MAV_1226|M.avium_104 TAKAVSKRVRTRWTNFAAHAKPAGPAGSPEWAPYQEQDRAC-LIIGKNDV
TH_3679|M.thermoresistible__bu TGRQVSQRIRTRWINFAVHGRPDGPPGEPRWHAYDRAERPC-LLIDRRDR
MAB_0301|M.abscessus_ATCC_1997 AAIQLGTSMRADWAAFARSG----VPESERWSVHRPGQAAFAQLP-----
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MSMEG_6303|M.smegmatis_MC2_155 FG-------------------
Mflv_5051|M.gilvum_PYR-GCK MIEDFDRVHQCVFWDGLG---
Mb2071c|M.bovis_AF2122/97 IEFDPHQHRRIAWDGFSLAN-
Rv2045c|M.tuberculosis_H37Rv IEFDPHQHRRIAWDGFSLAN-
MUL_2261|M.ulcerans_Agy99 VEIDPHRHRRLAWDGFSLAR-
Mvan_2609|M.vanbaalenii_PYR-1 MASDPDRDRRQAWAAVY----
MMAR_4363|M.marinum_M VARDIDAPIRAAWGREVVGFR
MAV_1226|M.avium_104 LAHDVDAKARAAWGSEMVSFR
TH_3679|M.thermoresistible__bu VVRDVDEPIRLTWGSEVLSFR
MAB_0301|M.abscessus_ATCC_1997 ---------------------
MLBr_00314|M.leprae_Br4923 ---------------------