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VDVVVHRDIRYAHAARFCPPEPCAAGERGQVAGIAPQNPSRLETVMGRPEVRPMSEDCLGLTITAPARPS PAGHPVLVWLHGGAYVTGSGSWSCYDASRLVAETGIVVVAVSHRLGVLGYMRAPGISQGNLGLRDQIAAL EWVRENIAEFGGDPQVVTVAGQSAGAHAVVAMLSIPATRGLFRRVILHSAPLGLAYQAVADAERVGEVVL RHLAVPIGQASVEEILRAQGAAASELAASGVPFAPPFLPIAGVDPWPSEGAAEPWDGVGDLDVMLGNTTD EFAAFLGRRTGPEFIDGFFDSATTRFADKLAVAGARVFRFRVGELDPGAPLGACHCIDLPLLFGDEAAWR NAPMLSPPGAAAAIQLGTSMRADWAAFARSGVPESERWSVHRPGQAAFAQLP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0301 | - | - | 100% (402) | putative carboxylesterase |
| M. abscessus ATCC 19977 | MAB_3803c | - | 6e-42 | 33.50% (409) | carboxylesterase |
| M. abscessus ATCC 19977 | MAB_3453c | - | 3e-34 | 30.24% (420) | carboxylesterase LipT |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 1e-34 | 36.04% (308) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_5051 | - | 3e-36 | 32.99% (394) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 1e-34 | 36.04% (308) | carboxylesterase LipT |
| M. leprae Br4923 | MLBr_00314 | - | 7e-05 | 31.01% (129) | putative esterase |
| M. marinum M | MMAR_4363 | - | 2e-39 | 31.35% (453) | carboxylesterase |
| M. avium 104 | MAV_1226 | - | 8e-38 | 32.49% (397) | carboxylesterase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6303 | - | 4e-61 | 39.90% (396) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_2744 | - | 3e-39 | 33.56% (450) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 2e-35 | 40.10% (192) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_3172 | - | 3e-37 | 30.44% (450) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5051|M.gilvum_PYR-GCK ---------MLVALVVAVACGSQASPQPAPDPAVVQTSTGPVRG------
MSMEG_6303|M.smegmatis_MC2_155 --------------------------------MRVEEEDGLVR-------
Mb2071c|M.bovis_AF2122/97 -----MALESATVG------------SMHERTVRARTATGIVEG------
Rv2045c|M.tuberculosis_H37Rv -----MALESATVG------------SMHERTVRARTATGIVEG------
MUL_2261|M.ulcerans_Agy99 ---------------------------MHERTVRARTATGVVEG------
TH_2744|M.thermoresistible__bu VVLVSMRIPSLKVMGSASHNYHAGVTAVVERSPIADTPLGRLRGSYENVP
MMAR_4363|M.marinum_M -------MTSDIRR-------------MASDGYVVETAYGPVRGAED---
MAV_1226|M.avium_104 ---------------------------MAVDDLVVETGYGPVR-------
Mvan_3172|M.vanbaalenii_PYR-1 -----MTADATTRS-------------SAGGRPVVETTNGPVR-------
MAB_0301|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 -------------------------MAISAGAPVEIVESGPSIA------
Mflv_5051|M.gilvum_PYR-GCK TVADDH-----RLFAGIPYAAPPVGALRWQGPRPAPKWDGVRDATAYGPR
MSMEG_6303|M.smegmatis_MC2_155 -------------ARGLRYGT----AARFTRAEPTPLWEGVLDATRSGPA
Mb2071c|M.bovis_AF2122/97 -FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFANC
Rv2045c|M.tuberculosis_H37Rv -FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFANC
MUL_2261|M.ulcerans_Agy99 -FTRDG----VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFTHC
TH_2744|M.thermoresistible__bu AQAAEG----VAVWRGVPYARQPVGDLRFRAPEPPRPWSGVRDAVEPAPI
MMAR_4363|M.marinum_M GIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFGPV
MAV_1226|M.avium_104 GVPVDG----VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVFGPA
Mvan_3172|M.vanbaalenii_PYR-1 GVDDGS----VKSWKAVRYAAAPVGELRWRAPEPPQAWSEPVDAGRVGPV
MAB_0301|M.abscessus_ATCC_1997 ------------MDVVVHRDIRYAHAARFCPPEPCAAGERGQVAG-IAPQ
MLBr_00314|M.leprae_Br4923 -----------ARLASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVL
: *
Mflv_5051|M.gilvum_PYR-GCK CMQD------LDGDLELGRQTDEDCLNLNVWTPPVAGDRPEPKPVMVWIH
MSMEG_6303|M.smegmatis_MC2_155 CPQRPSRVSWMTGPLLDGLVMDEDCLVLSVTAPADANG----LPVMVWLH
Mb2071c|M.bovis_AF2122/97 APQQR---RYTVMGIGRYQTRSEDCLTLNVVTPEEP-ATQP-LPVMVFIH
Rv2045c|M.tuberculosis_H37Rv APQQR---RYTVMGIGRYQTRSEDCLTLNVVTPEEP-ATQP-LPVMVFIH
MUL_2261|M.ulcerans_Agy99 SPQQR---RYTMLGLGKYQPMSEDCLTLNVVAPEAP-THRP-LPVMVFIH
TH_2744|M.thermoresistible__bu PPQGR---SFVGGGKDDPRIRDEACLTLTVWSPD---PGGS-LPVMVWIP
MMAR_4363|M.marinum_M CPQP----VLANMPIDLGAPQDEDCLRLNIWAPANTAPGAA-KPVMVWLH
MAV_1226|M.avium_104 CPQP----VFPNMPLDLGAPQGEDCLRLNVWASADTQPGDA-KPVMVWLH
Mvan_3172|M.vanbaalenii_PYR-1 CPQP----TDPRIPIDLGAPQGEDFLTLNIWAPSGTQPGDA-KPVMVWIH
MAB_0301|M.abscessus_ATCC_1997 NPSR----LETVMGRPEVRPMSEDCLGLTITAPARPSPAGH--PVLVWLH
MLBr_00314|M.leprae_Br4923 LPVTN--------AARAEVNLSNTSAQLVRAAGVRPADGSG--RIVLYLH
.: * : :::::
Mflv_5051|M.gilvum_PYR-GCK GGSFVAGS--SGVYDSRRLVARGDIIVVTVNYRLGALGFLAHPALGPPGA
MSMEG_6303|M.smegmatis_MC2_155 GGAYVSGSGESRKYDAAPLARHGDVVVVNVSYRLGTFGFLAPP--GAPDG
Mb2071c|M.bovis_AF2122/97 GGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQI
Rv2045c|M.tuberculosis_H37Rv GGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQI
MUL_2261|M.ulcerans_Agy99 GGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDI
TH_2744|M.thermoresistible__bu GGAFVYGAGHLQLYNGSRLAANGNVVVVNVTYRLGVFGGFELSGLG---A
MMAR_4363|M.marinum_M GGAYMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGR
MAV_1226|M.avium_104 GGAYVLGSSSQTLYDGRRLVSHGDVVVVTVNYRLGALGFLDLSSLNSAGR
Mvan_3172|M.vanbaalenii_PYR-1 GGAYILGSASQPLYHGGTLASGGDAVVVTVNYRLGALGFLELSTLGADPE
MAB_0301|M.abscessus_ATCC_1997 GGAYVTGSGSWSCYDASRLVAETGIVVVAVSHRLGVLGYMRAPGISQ---
MLBr_00314|M.leprae_Br4923 GGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIG---------
**.:: . * : *.:** :
Mflv_5051|M.gilvum_PYR-GCK VG--NYGLADQQAALRWVRDNIANFGGDPARVTVAGESAGAMSVCDHLVA
MSMEG_6303|M.smegmatis_MC2_155 F---NVGLTDQILALKWVRDNISAFGGDPGNVTVFGQSAGGDSVVKLMLA
Mb2071c|M.bovis_AF2122/97 TLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAV
Rv2045c|M.tuberculosis_H37Rv TLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAV
MUL_2261|M.ulcerans_Agy99 AIDGNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAV
TH_2744|M.thermoresistible__bu GFDDNLALRDQVAALRWVRDNIAAFGGDPGRVTVFGESAGATSVLALLAS
MMAR_4363|M.marinum_M SFDSNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVT
MAV_1226|M.avium_104 SFDSNVGLRDVLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLAS
Mvan_3172|M.vanbaalenii_PYR-1 RFATNLGLRDVLAALEWVRDNIAAFGGDPGRVTVFGESAGGGIVASLLAS
MAB_0301|M.abscessus_ATCC_1997 ---GNLGLRDQIAALEWVRENIAEFGGDPQVVTVAGQSAGAHAVVAMLSI
MLBr_00314|M.leprae_Br4923 -----MALDDCHDGYQWLRR----LGYDPEQIVLAGDSAGGYLALALAQR
* * . .*:: :* ** :.: *:***. .
Mflv_5051|M.gilvum_PYR-GCK PGSDGLFDAAIVMS---GLCQSQ---ADLPTAEKRSLDYAAQAGCGGPVP
MSMEG_6303|M.smegmatis_MC2_155 EEASGLFHRAIVQSAPLGLGDER---ADLAVAMRSALADALDG--VDPLQ
Mb2071c|M.bovis_AF2122/97 PAAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQ
Rv2045c|M.tuberculosis_H37Rv PAAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQ
MUL_2261|M.ulcerans_Agy99 PAAKGLFARAISESPAAGMVRPREIAAEFATRFARLLGARKHDAASALMR
TH_2744|M.thermoresistible__bu PAARGLFHRAIAQSPALPLIADADLRAGRAARFVERLGVGVDD-----IR
MMAR_4363|M.marinum_M PAARGLFSRAIAQSSPATSVYDRERAQRVAVHLLDKLGVAASDV-DKLTQ
MAV_1226|M.avium_104 PAAAGLFAAAIAQSSPATSVYDRDRAARVAEAFLGKLGITASES-RRLID
Mvan_3172|M.vanbaalenii_PYR-1 PAAAGLFSAAIAQSAPVTSTYELGRAQRVAERFLDVLGARPDDL-HRLSE
MAB_0301|M.abscessus_ATCC_1997 PATRGLFRRVILHSAPLGLAYQAVADAERVGEVVLRHLAVPIG------Q
MLBr_00314|M.leprae_Br4923 LQDVGEEPAALVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVA
* .:
Mflv_5051|M.gilvum_PYR-GCK AECLR-GLDANALRT--PVWYYDIGDDRLSGPVTGSAVLPTAPPVA-FGD
MSMEG_6303|M.smegmatis_MC2_155 ATTQQ-LLDAQAAAASWAQPVEMLGAMMPFAPLLGHDPLPPADDVAGHLA
Mb2071c|M.bovis_AF2122/97 ASPAQ-LVEAQHHLIR--QGMRKRLGAFPIGPVFGDDYLP-MDPVEAMRS
Rv2045c|M.tuberculosis_H37Rv ASPAQ-LVEAQHHLIR--QGMRKRLGAFPIGPVFGDDYLP-MDPVEAMRS
MUL_2261|M.ulcerans_Agy99 ATAAQ-LVQTQHRLID--QGMQKRLGAFPIGPTFGDDCLP-LDPVEAMRA
TH_2744|M.thermoresistible__bu ELPQR-ALRRAAGLVQ--LDSIADSPALAYGLTHGVDLLP-RHPIAAARA
MMAR_4363|M.marinum_M LPTAA-IVAASTEVFN--EVPVRNPGTLAFVPIVDGDVLT-DYPVKVAQE
MAV_1226|M.avium_104 MPMAA-ILAASQQVFD--EVPVRNPGTLAFVPIVDGDVLA-DYPVKVAQQ
Mvan_3172|M.vanbaalenii_PYR-1 APIDV-LVEASRTVFD--EVPVRTPGTLAFAPTVDGDLLP-DYPVNLARQ
MAB_0301|M.abscessus_ATCC_1997 ASVEE-ILRAQGAAAS-ELAASGVPFAPPFLPIAGVDPWP--SEGAAEPW
MLBr_00314|M.leprae_Br4923 SSAAKNKVDDKPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKL
: .
Mflv_5051|M.gilvum_PYR-GCK GKAARVPVLMGTTRDEWTLFVALQHLRDGKDYAPQEYPRLLADTFGAD--
MSMEG_6303|M.smegmatis_MC2_155 DAAARIELLVGYTRDDAAPFVTMHPEFS-------EMPDLTEFIFGAP--
Mb2071c|M.bovis_AF2122/97 GRVHAVPLIVGTNAEEGRLFTR-FLGMLP--TNEPMVEELLSGMKPAD--
Rv2045c|M.tuberculosis_H37Rv GRVHAVPLIVGTNAEEGRLFTR-FLGMLP--TNEPMVEELLSGMKPAD--
MUL_2261|M.ulcerans_Agy99 GQSHKVPLIVGTNADEGRLFTR-FLKMLP--TNKAMIDELLADTEPAT--
TH_2744|M.thermoresistible__bu GTVHPVPLIIGTNSDEASMFAWGRPPMLP--TTPDRVEHYFRRHAPHA--
MMAR_4363|M.marinum_M GRSHPVPLLIGTNKHEAALFRLMRSPLMP--ITPRAITSMFTQIAAEQPD
MAV_1226|M.avium_104 GCSHPVPLIIGTNQHEAALFRLMRSALMP--ITPHAITSMFNQIAAEQPD
Mvan_3172|M.vanbaalenii_PYR-1 GRTHPVPLIIGTNKNEAALFRYMKSPLMP--IAPASIKAMFAEIAAEQPG
MAB_0301|M.abscessus_ATCC_1997 DGVGDLDVMLGNTTDEFAAFLGRRTGPEFIDGFFDSATTRFADKLAVAG-
MLBr_00314|M.leprae_Br4923 AAVG-VPAEIRVWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASK--
: : : *
Mflv_5051|M.gilvum_PYR-GCK -----APAVEAHYPLTAFSSVALAYAATVTDGVFACAGRRWAGDLAETAP
MSMEG_6303|M.smegmatis_MC2_155 -----AEALAAQW-----------------------------NDLGGRAA
Mb2071c|M.bovis_AF2122/97 -----RERITAAYPNYPAPSACIQLGG---DFAFSSAAWQIAEAHGANAP
Rv2045c|M.tuberculosis_H37Rv -----RERITAAYPNYPAPSACIQLGG---DFAFSSAAWQIAEAHGANAP
MUL_2261|M.ulcerans_Agy99 -----RERITAAYPNYPESAACIQLGG---DFAFNAAAWQIAEAQGVHAP
TH_2744|M.thermoresistible__bu -----RDTVLAAYPGYPRRRAAVAVGA---DVMFAAPTWAFADAYSAHAP
MMAR_4363|M.marinum_M LQLPTEEEIGLAYSRLRRRARPLSIAT---DVGFRMPSVWLAEGHSRVAP
MAV_1226|M.avium_104 LQLPTEKQIGSAYSRFRRRARYLSIAT---DVGFRMPSVWLAEGHARVAP
Mvan_3172|M.vanbaalenii_PYR-1 LQLPSEDILKGTY-RGRGKTKGLGLTS---DLGFRMPSLWFADGHRAVAP
MAB_0301|M.abscessus_ATCC_1997 ------------------------------------------------AR
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_5051|M.gilvum_PYR-GCK VYFYEFNDRDAPAPDPLRTVPFPVGASHSLELRYLFDTGGAPPPSPAQVR
MSMEG_6303|M.smegmatis_MC2_155 SYRFEWSPDDAP-----------LGACHCLELPFLFGS---PEAWADAAM
Mb2071c|M.bovis_AF2122/97 TYLYRYDYAPRTLR------WSGFGATHATELFAVFDIYRTRFGALLTAA
Rv2045c|M.tuberculosis_H37Rv TYLYRYDYAPRTLR------WSGFGATHATELFAVFDIYRTRFGALLTAA
MUL_2261|M.ulcerans_Agy99 TYLYRYDYAPRTLR------WSGFGATHATELFAVFDIYRTRFGALLTAA
TH_2744|M.thermoresistible__bu TYLYRFEHAPPALR------ALGLGATHGSEIVHIQHTYASYPGRRLHPL
MMAR_4363|M.marinum_M VYLYRFDYSTPLLK------LLLVRAAHATELPYVWGNLGG-PQDPTLRL
MAV_1226|M.avium_104 VYLYRFDYSTPLLR------LLMVKAAHATELPYVWGTLGA-PKDPTLKL
Mvan_3172|M.vanbaalenii_PYR-1 VYLYRFDFHTPLLR------LVRLHAAHATELPFVWGNLVAGRRDPTFAL
MAB_0301|M.abscessus_ATCC_1997 VFRFRVGELDPGAP---------LGACHCIDLPLLFGDEAAWRNAPMLSP
MLBr_00314|M.leprae_Br4923 ------------------------ASRDRQSL------------------
: . .:
Mflv_5051|M.gilvum_PYR-GCK LG-------EQMID-YWASFVK----------TGDPGFPGIDSGVMSLQP
MSMEG_6303|M.smegmatis_MC2_155 LGN------ERRIDPTLADEMR----------TVWTQFA--HHGVDALPA
Mb2071c|M.bovis_AF2122/97 ADRRAALRVSNEVQRRWRCFSQIGVPG-----DDWPAYTQDDR-AVLVFD
Rv2045c|M.tuberculosis_H37Rv ADRRAALRVSNEVQRRWRCFSQIGVPG-----DDWPAYTQDDR-AVLVFD
MUL_2261|M.ulcerans_Agy99 ADRRHALRVSDEVIRRWRSFSQTGTPG-----EDWPAYTHTRR-AVMVID
TH_2744|M.thermoresistible__bu GARRTPA-VGRRMQRAWLAFATDDHPG-----SDWPRYDTGRRRTRLIRT
MMAR_4363|M.marinum_M GGAKTAKAVSKRMRTRWINFATQDNPAGPAGEPDWPAYQDGDR-ACLVID
MAV_1226|M.avium_104 GGSKTAKAVSKRVRTRWTNFAAHAKPAGPAGSPEWAPYQEQDR-ACLIIG
Mvan_3172|M.vanbaalenii_PYR-1 GGRKSGAAVSERMRARWVSFAAHGAPTGPAGEPVWRPYGADDR-ATLVID
MAB_0301|M.abscessus_ATCC_1997 PGAAAAIQLGTSMRADWAAFARSGVPE----SERWSVHRPGQAAFAQLP-
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mflv_5051|M.gilvum_PYR-GCK DGSRMIEDFDRVHQCVFWDGLG---
MSMEG_6303|M.smegmatis_MC2_155 RSLRFG-------------------
Mb2071c|M.bovis_AF2122/97 RRCRIEFDPHQHRRIAWDGFSLAN-
Rv2045c|M.tuberculosis_H37Rv RRCRIEFDPHQHRRIAWDGFSLAN-
MUL_2261|M.ulcerans_Agy99 RKSRVEIDPHRHRRLAWDGFSLAR-
TH_2744|M.thermoresistible__bu GEDLVADDPDVVRRTAWQGVY----
MMAR_4363|M.marinum_M KSDRVARDIDAPIRAAWGREVVGFR
MAV_1226|M.avium_104 KNDVLAHDVDAKARAAWGSEMVSFR
Mvan_3172|M.vanbaalenii_PYR-1 KQDTVVDDLDADVRRAWGDDVLSFL
MAB_0301|M.abscessus_ATCC_1997 -------------------------
MLBr_00314|M.leprae_Br4923 -------------------------