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MSEVTAELVATGAGTVRGLLAADHRVFYGIPYAAPPQGRARFTAPEPYEPWPGVRDATTPGPTAPQAQRD GFGRLDMSPFFGPGWVRDPDYLTVNVWTPRTERAPGHPVMVFVHGGGFVSGSTRSPLYDGSAFARDGVVL VTVTYRLGITGFLDIAGAPRNRGLLDVLGALRWVRDNIAAFGGDPGNVTLFGQSAGATLTAGVLAEPQAQ QLIRRVIIQSGNPYGAFTGEQAARVTHAAADALGVDPVLEDFEGISDERLIGAAGGLGGLDLRTADGFDP LVGLSPFSLVCDEQPAVGAHPDVGVLIGTTLEEGNLYLVPQGQFGTSTREDVHALAARVHADPVALVQEY RERHPDADWDRLRSAILGDALFRAGSERFALSRNAYRYEFGWRSTAVDGLLGAAHAVELPFVFDRLDAEV LRGPDALLGPGDVPQALADEMHGAWVRFATTGDPGWAPGEVRRFTEIEVRDSKRADRVPHGNLGVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0611 | - | - | 100% (486) | para-nitrobenzyl esterase |
| M. smegmatis MC2 155 | MSMEG_1432 | - | 8e-58 | 39.03% (474) | acetylcholinesterase |
| M. smegmatis MC2 155 | MSMEG_3667 | - | 3e-53 | 34.74% (475) | para-nitrobenzyl esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 1e-51 | 34.62% (468) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_3419 | - | 4e-56 | 35.28% (513) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 1e-51 | 34.62% (468) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3453c | - | 2e-51 | 33.82% (476) | carboxylesterase LipT |
| M. marinum M | MMAR_4363 | - | 4e-54 | 34.43% (485) | carboxylesterase |
| M. avium 104 | MAV_1226 | - | 4e-53 | 34.08% (490) | carboxylesterase superfamily protein |
| M. thermoresistible (build 8) | TH_3679 | - | 4e-54 | 34.89% (493) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 8e-46 | 32.34% (501) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_1303 | - | 2e-54 | 37.80% (500) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3419|M.gilvum_PYR-GCK --------------------------MTAEATPRSSAPVVDTSTGPVRG-
TH_3679|M.thermoresistible__bu ---------MPSTTPPDDRTPDDAPTRPAPAHSAVGSPVVDTVHGPVRG-
MMAR_4363|M.marinum_M -------------------------MTSDIRRMASDGYVVETAYGPVRGA
MAV_1226|M.avium_104 --------------------------------MAVDDLVVETGYGPVR--
Mb2071c|M.bovis_AF2122/97 ----------------------MALESATVGSMHERTVRARTATGIVEG-
Rv2045c|M.tuberculosis_H37Rv ----------------------MALESATVGSMHERTVRARTATGIVEG-
MUL_2261|M.ulcerans_Agy99 --------------------------------MHERTVRARTATGVVEG-
MAB_3453c|M.abscessus_ATCC_199 ----------------------------MASGSKTPTVRVTTPNGIVEG-
MSMEG_0611|M.smegmatis_MC2_155 -------------------------------MSEVTAELVATGAGTVRG-
Mvan_1303|M.vanbaalenii_PYR-1 MPIPRLGVLAVLMVLVAACGRGDAGDRGHEARSPVDPAVVQTAAGAVRG-
. * * *.
Mflv_3419|M.gilvum_PYR-GCK ----LDDG---IIKSWKGVPYAAAPVGELRWRAPEPPPAWTEPRDATRVG
TH_3679|M.thermoresistible__bu ----RDDG---VVKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRVG
MMAR_4363|M.marinum_M EDGIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFG
MAV_1226|M.avium_104 --GVPVDG----VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVFG
Mb2071c|M.bovis_AF2122/97 ---FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFA
Rv2045c|M.tuberculosis_H37Rv ---FTRDG----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFA
MUL_2261|M.ulcerans_Agy99 ---FTRDG----VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFT
MAB_3453c|M.abscessus_ATCC_199 ---FVRGG----VRRFRSIPYARPPIGLLRLRAPQPALPWEGVRDCTEFG
MSMEG_0611|M.smegmatis_MC2_155 ---LLAAD----HRVFYGIPYAAPPQGRARFTAPEPYEPWPGVRDATTPG
Mvan_1303|M.vanbaalenii_PYR-1 ---TVEPD----HRLFAGIPYAAPPIGPLRWRDPEPAPRWDGVRDATAFG
. : : .: *. .* * * *.* * ..
Mflv_3419|M.gilvum_PYR-GCK PVCPQP-TDPKIPLDLG------APQGEDFLSLNVWAPSGTQPGDRKPVM
TH_3679|M.thermoresistible__bu PACPQP-ADPRIPLDLG------AAIGEDCLNLNVWASSDTEPGDRKPVL
MMAR_4363|M.marinum_M PVCPQP-VLANMPIDLG------APQDEDCLRLNIWAPANTAPGAAKPVM
MAV_1226|M.avium_104 PACPQP-VFPNMPLDLG------APQGEDCLRLNVWASADTQPGDAKPVM
Mb2071c|M.bovis_AF2122/97 NCAPQQRRYTVMGIGRY------QTRSEDCLTLNVVTPEEPAT-QPLPVM
Rv2045c|M.tuberculosis_H37Rv NCAPQQRRYTVMGIGRY------QTRSEDCLTLNVVTPEEPAT-QPLPVM
MUL_2261|M.ulcerans_Agy99 HCSPQQRRYTMLGLGKY------QPMSEDCLTLNVVAPEAPTH-RPLPVM
MAB_3453c|M.abscessus_ATCC_199 AAAPQRRRYRVLGPGRV------QRASEDCLTVNVVTPDRPSN-EPLPVM
MSMEG_0611|M.smegmatis_MC2_155 PTAPQAQRDGFGRLDMSPFFGPGWVRDPDYLTVNVWTP-RTERAPGHPVM
Mvan_1303|M.vanbaalenii_PYR-1 ---SRCLQDLAGDLELG------RQTDEDCLNLNVWTP-AAEPGRPRAVM
.: . * * :*: :. . .*:
Mflv_3419|M.gilvum_PYR-GCK VWVHGGAYVLGSASQPLYHGRAMAGAGDVIVVTVNYRLGALGFLELSTLD
TH_3679|M.thermoresistible__bu VWVHGGAYVIGAASQPLYHGRELVRRGDVVLVTLNYRLGAFGFLELTALS
MMAR_4363|M.marinum_M VWLHGGAYMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLS
MAV_1226|M.avium_104 VWLHGGAYVLGSSSQTLYDGRRLVSHGDVVVVTVNYRLGALGFLDLSSLN
Mb2071c|M.bovis_AF2122/97 VFIHGGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLS
Rv2045c|M.tuberculosis_H37Rv VFIHGGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLS
MUL_2261|M.ulcerans_Agy99 VFIHGGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLS
MAB_3453c|M.abscessus_ATCC_199 FFIYGGGYLLGSSATPLYDGAALARRG-CVYVSVNYRVGALGALDLSSLS
MSMEG_0611|M.smegmatis_MC2_155 VFVHGGGFVSGSTRSPLYDG-SAFARDGVVLVTVTYRLGITGFLDIA---
Mvan_1303|M.vanbaalenii_PYR-1 VWIHGGSFVAGSGG--IYDARRLAARGDIVVVTLNYRLGAPGFLAHPSL-
.:::**.:: *: :*.. . : *::.**:* * * .
Mflv_3419|M.gilvum_PYR-GCK DSGR-FASNLGLRDVLAALGWVRDNIAAFGGDPGRVTVFGESAGGGIVTS
TH_3679|M.thermoresistible__bu SGRRRFDTNVGLRDVLFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTT
MMAR_4363|M.marinum_M HAGRSFDSNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTT
MAV_1226|M.avium_104 SAGRSFDSNVGLRDVLAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTT
Mb2071c|M.bovis_AF2122/97 TPQITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITAT
Rv2045c|M.tuberculosis_H37Rv TPQITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITAT
MUL_2261|M.ulcerans_Agy99 TPDIAIDGNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITAT
MAB_3453c|M.abscessus_ATCC_199 DRDHTIDGNLFLRDVVLALQWVHDNIGTFGGDPGNVTIFGESAGAHCVET
MSMEG_0611|M.smegmatis_MC2_155 ----GAPRNRGLLDVLGALRWVRDNIAAFGGDPGNVTLFGQSAGATLTAG
Mvan_1303|M.vanbaalenii_PYR-1 -GPPGEVGNYGLADQQAALRWVRDNIAAFGGDPGKVTVAGESAGAMSVCD
* * * ** *:::** ***** .:*: *:***. .
Mflv_3419|M.gilvum_PYR-GCK LLGSPAAAGLFHAAIAQSSPATSMYDVGRARRVATRFLEVIGVDRADMS-
TH_3679|M.thermoresistible__bu LLGSPAAAGLFHRAIAQSSPATSCYGTERAIDVAEQFLGHLGLSPRDVD-
MMAR_4363|M.marinum_M LLVTPAARGLFSRAIAQSSPATSVYDRERAQRVAVHLLDKLGVAASDVD-
MAV_1226|M.avium_104 LLASPAAAGLFAAAIAQSSPATSVYDRDRAARVAEAFLGKLGITASESR-
Mb2071c|M.bovis_AF2122/97 LLAVPAAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAAN
Rv2045c|M.tuberculosis_H37Rv LLAVPAAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAAN
MUL_2261|M.ulcerans_Agy99 LLAVPAAKGLFARAISESPAAGMVRPREIAAEFATRFARLLGARKHDAAS
MAB_3453c|M.abscessus_ATCC_199 LMATPAAAGLFHRAICQSTASGMAVPADSAAMYAQKFAQILGATTQSAAE
MSMEG_0611|M.smegmatis_MC2_155 VLAEPQAQQLIRRVIIQSGNPYGAFTGEQAARVTHAAADALGVDPVLEDF
Mvan_1303|M.vanbaalenii_PYR-1 HLVAPASQGLFDAAIIMSGPCQAQAPLPVAEQRSIEYAAALGCADKATAA
: * : *: .* * * : :*
Mflv_3419|M.gilvum_PYR-GCK ALTTAPISALVEASRTVFNEVPVRTPG-TLAFAPTIDGDLLPDYPVNLAR
TH_3679|M.thermoresistible__bu RLPDVPVAAIVEVSKHVFDDVPARRPG-TLAFAPIVDGDIVPDYPVALAR
MMAR_4363|M.marinum_M KLTQLPTAAIVAASTEVFNEVPVRNPG-TLAFVPIVDGDVLTDYPVKVAQ
MAV_1226|M.avium_104 RLIDMPMAAILAASQQVFDEVPVRNPG-TLAFVPIVDGDVLADYPVKVAQ
Mb2071c|M.bovis_AF2122/97 ALMQASPAQLVEAQHHLIRQGMRKRLG-AFPIGPVFGDDYLPMDPVEAMR
Rv2045c|M.tuberculosis_H37Rv ALMQASPAQLVEAQHHLIRQGMRKRLG-AFPIGPVFGDDYLPMDPVEAMR
MUL_2261|M.ulcerans_Agy99 ALMRATAAQLVQTQHRLIDQGMQKRLG-AFPIGPTFGDDCLPLDPVEAMR
MAB_3453c|M.abscessus_ATCC_199 TVLRSSPAELGAALNMLIADIVTNMPGGSFAIGPCIDGHYLPRHPIEAME
MSMEG_0611|M.smegmatis_MC2_155 EGISDERLIGAAGGLGGLDLRTADGFD------PLVGLSPFSLVCDEQPA
Mvan_1303|M.vanbaalenii_PYR-1 ECLRALPGNKLRTPVWFYEIGDDRLSG------PATGSAELPADPVTAFG
. * . ..
Mflv_3419|M.gilvum_PYR-GCK NGKTHPVPLLIGTNKNEAALFRYMKSPLMPVAPESVRAMFAEISAEQPTL
TH_3679|M.thermoresistible__bu AGRTLPVPLVIGTNKDEASLFRWMKSPLLPITPDAIKKMFADIAAEQPGL
MMAR_4363|M.marinum_M EGRSHPVPLLIGTNKHEAALFRLMRSPLMPITPRAITSMFTQIAAEQPDL
MAV_1226|M.avium_104 QGCSHPVPLIIGTNQHEAALFRLMRSALMPITPHAITSMFNQIAAEQPDL
Mb2071c|M.bovis_AF2122/97 SGRVHAVPLIVGTNAEEGRLFTRFLG-MLPTNEPMVEELLSGMKPA----
Rv2045c|M.tuberculosis_H37Rv SGRVHAVPLIVGTNAEEGRLFTRFLG-MLPTNEPMVEELLSGMKPA----
MUL_2261|M.ulcerans_Agy99 AGQSHKVPLIVGTNADEGRLFTRFLK-MLPTNKAMIDELLADTEPA----
MAB_3453c|M.abscessus_ATCC_199 HGEAHRVPLIVGHNADEAKLFTRVLK-MMPLSESALEGMLARGGPG----
MSMEG_0611|M.smegmatis_MC2_155 VGAHPDVGVLIGTTLEEGNLYLVPQG--QFG--TSTREDVHALAARVHAD
Mvan_1303|M.vanbaalenii_PYR-1 AGRAARVPVLIGTTRDEWTLFVALQH--LRDGRDYTPEEYPRLLADTFGA
* * :::* . .* *: .
Mflv_3419|M.gilvum_PYR-GCK QLPSEDHLRGIYRG-RGKNHALGLTSDLGFRMPSIWFADGHRAVAPVYLY
TH_3679|M.thermoresistible__bu RLPTETQISAAYRRQRGKRLGVGVASDIGFRMPSVWFAEGHTAVAPTYLY
MMAR_4363|M.marinum_M QLPTEEEIGLAYSRLRRRARPLSIATDVGFRMPSVWLAEGHSRVAPVYLY
MAV_1226|M.avium_104 QLPTEKQIGSAYSRFRRRARYLSIATDVGFRMPSVWLAEGHARVAPVYLY
Mb2071c|M.bovis_AF2122/97 ---DRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLY
Rv2045c|M.tuberculosis_H37Rv ---DRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLY
MUL_2261|M.ulcerans_Agy99 ---TRERITAAYPNYPESAACIQLGGDFAFNAAAWQIAEAQGVHAPTYLY
MAB_3453c|M.abscessus_ATCC_199 ---HRDRIVAAYPGYPERSARVKLAGDMNFSTAAWQMAEAHHRYAPVYFY
MSMEG_0611|M.smegmatis_MC2_155 PVALVQEYRERHPDADWDRLRSAILGDALFRAGSERFA--LSRNAYRYEF
Mvan_1303|M.vanbaalenii_PYR-1 DARAVAGRYPLSAFPDVALAYAATVTDGILACPAERWARQLSRDASVYFY
* : : * * * :
Mflv_3419|M.gilvum_PYR-GCK RFDFATPLLRVARLHAAHATELPFVWGNLGSGRKDPTFALGGR-KSGTAV
TH_3679|M.thermoresistible__bu RFDWSTPTLRLLRLGAAHATELPYVFGNLDTP-KDPTFTLGGR-RTGRQV
MMAR_4363|M.marinum_M RFDYSTPLLKLLLVRAAHATELPYVWGNLGGP-QDPTLRLGGA-KTAKAV
MAV_1226|M.avium_104 RFDYSTPLLRLLMVKAAHATELPYVWGTLGAP-KDPTLKLGGS-KTAKAV
Mb2071c|M.bovis_AF2122/97 RYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADR-RAALRV
Rv2045c|M.tuberculosis_H37Rv RYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADR-RAALRV
MUL_2261|M.ulcerans_Agy99 RYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADR-RHALRV
MAB_3453c|M.abscessus_ATCC_199 RYDYAPGALRIAGMGATHATELLAVFDSYRGAMGTVMAGALGR-RDAVRV
MSMEG_0611|M.smegmatis_MC2_155 GWRSTA---VDGLLGAAHAVELPFVFDRLDAEVLRGPDALLGPGDVPQAL
Mvan_1303|M.vanbaalenii_PYR-1 EFNDRN---APAPDPLRTLPFPVGASHSLELRYLFDVGGAPPPDPAQVRL
: . :
Mflv_3419|M.gilvum_PYR-GCK SQRMQSRWTNFAANGDPS-APGAPTWRPYD-ASRATLVIDKHDSVVDDLD
TH_3679|M.thermoresistible__bu SQRIRTRWINFAVHGRPDGPPGEPRWHAYDRAERPCLLIDRRDRVVRDVD
MMAR_4363|M.marinum_M SKRMRTRWINFATQDNPAGPAGEPDWPAYQDGDRACLVIDKSDRVARDID
MAV_1226|M.avium_104 SKRVRTRWTNFAAHAKPAGPAGSPEWAPYQEQDRACLIIGKNDVLAHDVD
Mb2071c|M.bovis_AF2122/97 SNEVQRRWRCFSQIGVPG-----DDWPAYTQDDRAVLVFDRRCRIEFDPH
Rv2045c|M.tuberculosis_H37Rv SNEVQRRWRCFSQIGVPG-----DDWPAYTQDDRAVLVFDRRCRIEFDPH
MUL_2261|M.ulcerans_Agy99 SDEVIRRWRSFSQTGTPG-----EDWPAYTHTRRAVMVIDRKSRVEIDPH
MAB_3453c|M.abscessus_ATCC_199 SNDVQRRWLAFARSGVPG-----DGWPTYGPPDRAVMVFDHATRVELDPE
MSMEG_0611|M.smegmatis_MC2_155 ADEMHGAWVRFATTGDPG-------WA--PGEVRRFTEIEVRDSKRADRV
Mvan_1303|M.vanbaalenii_PYR-1 GEQMVDHWAAFVRAGDPG-------WPGVDAGVMSLQPDGSRMVETFGEV
.. : * * * * .
Mflv_3419|M.gilvum_PYR-GCK AHVRRAWGDDVLSFL
TH_3679|M.thermoresistible__bu EPIRLTWGSEVLSFR
MMAR_4363|M.marinum_M APIRAAWGREVVGFR
MAV_1226|M.avium_104 AKARAAWGSEMVSFR
Mb2071c|M.bovis_AF2122/97 QHRRIAWDGFSLAN-
Rv2045c|M.tuberculosis_H37Rv QHRRIAWDGFSLAN-
MUL_2261|M.ulcerans_Agy99 RHRRLAWDGFSLAR-
MAB_3453c|M.abscessus_ATCC_199 AARRAAWEGFSLTL-
MSMEG_0611|M.smegmatis_MC2_155 PHGNLGVR-------
Mvan_1303|M.vanbaalenii_PYR-1 HQCSFWAGLQ-----