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VREKGFQVLRELLPDLPLDGFQRDGSFGDELLEIGLDNVFGRLWSREGLSRRDRSLVTMGILIALRATDE FASHVKIARNNGLTEQEIAEVIYHSSGYAGFPNANTAMKVAKGVLEGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6150 | - | - | 100% (118) | 4-carboxymuconolactone decarboxylase |
| M. smegmatis MC2 155 | MSMEG_2604 | pcaC | 2e-16 | 40.18% (112) | 4-carboxymuconolactone decarboxylase |
| M. smegmatis MC2 155 | MSMEG_5856 | pcaC | 1e-09 | 31.07% (103) | hypothetical protein MSMEG_5856 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0794 | - | 6e-09 | 29.91% (107) | 4-carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_0527 | - | 2e-13 | 40.79% (76) | 4-carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv0771 | - | 6e-09 | 29.91% (107) | 4-carboxymuconolactone decarboxylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1221 | - | 2e-09 | 31.97% (122) | 4-carboxymuconolactone decarboxylase |
| M. marinum M | MMAR_4925 | - | 3e-10 | 33.01% (103) | 4-carboxymuconolactone decarboxylase |
| M. avium 104 | MAV_3552 | pcaC | 4e-11 | 45.07% (71) | hypothetical protein MAV_3552 |
| M. thermoresistible (build 8) | TH_0621 | - | 6e-47 | 78.63% (117) | 4-carboxymuconolactone decarboxylase |
| M. ulcerans Agy99 | MUL_0480 | - | 2e-10 | 33.01% (103) | 4-carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_0563 | - | 2e-13 | 40.79% (76) | 4-carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6150|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK MSNPPLTAIHLGGPDDGPLLLLGPSLGTTTATLWTGVAQRLVDHVRVVGW
Mvan_0563|M.vanbaalenii_PYR-1 MSNPPLTAIHLGGPDDGPLLLLGPSLGTTTATLWTGVAQRLVDHVRVVGW
MAV_3552|M.avium_104 --------------------------------------------------
MSMEG_6150|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK DLPGHGRGRRAHPFTIADLAAAVLVIADDLNVETFHYAGDSVGGCVGLQL
Mvan_0563|M.vanbaalenii_PYR-1 DLPGHGRGRRAHPFTIADLAAAVLVIADDLNVETFHYAGDSVGGCVGLQL
MAV_3552|M.avium_104 --------------------------------------------------
MSMEG_6150|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK LLDAPQRVSSATLLCTGAAIGTPDGWLARAATVRAGGVDTMLTGAAERWF
Mvan_0563|M.vanbaalenii_PYR-1 LLDAPQRVSSATLLCTGAAIGTPDGWLARAATVRAGGVDTMLAGAAERWF
MAV_3552|M.avium_104 -----------------------------MSRSDSAARHQRGVRTFAEVM
MSMEG_6150|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK APGFVDREPGTASALLDALSHTDAESYAQVCEALAVFDVTDRLSEIVTPV
Mvan_0563|M.vanbaalenii_PYR-1 APGFVDREPGTASALLDALSHTDAESYAQVCEALAVFDVTNQLSEIVTPV
MAV_3552|M.avium_104 TFDPPDDASPCASGLIDFVFGEVWSRPGLSRRDRRFVTLACVAAADAQAP
MSMEG_6150|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1221|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK LAVAGSADSPTPPESLRRIASDVKDGDVVVLEGVGHLAPAEAPERVAGLI
Mvan_0563|M.vanbaalenii_PYR-1 LAVAGSVDVPTPPESLRRIASDVKDGDLVVLEGVGHLAPAEAPQRVAGLI
MAV_3552|M.avium_104 LEQHVYAALNSGDLSITEMREAVLHFAVYAGWPKASRFNIVVDQQWARIA
MSMEG_6150|M.smegmatis_MC2_155 --------MREKGFQVLRELLPDLPLDG--FQRDG-------SFGDELLE
TH_0621|M.thermoresistible__bu --------MREQGLQVFRELLPGVLPDGDVDFRDG-------SFGDELLE
MMAR_4925|M.marinum_M -------------MDELRRKGLDKMNEVYGWEMPN-------IEGDAYFD
MUL_0480|M.ulcerans_Agy99 -------------MDELRRKGLDKMNEVYGWEMPN-------IEGDAYFD
Mb0794|M.bovis_AF2122/97 ------------MMDELRRTGLDKMNEVYAWDMPD-------MPG-EFFA
Rv0771|M.tuberculosis_H37Rv ------------MMDELRRTGLDKMNEVYAWDMPD-------MPG-EFFA
MAB_1221|M.abscessus_ATCC_1997 ---MVCHTRKGQVMDELRRQGLDKMKEVYGWDMPD-------IPG-DYFK
Mflv_0527|M.gilvum_PYR-GCK AEIVGVPQPPSKTLEDVHRAGMAVRREVLGHAHVDRAVAGTTDLTADFQH
Mvan_0563|M.vanbaalenii_PYR-1 AEIVGVPQPPSKTLEDVHRAGMAVRREVLGEAHVDRAVAGTTDLTADFQH
MAV_3552|M.avium_104 AERGEPTPDPEPLLPLVTAADPEQRLRGGERSFKDINCLPFAPPRDNPYS
: . .
MSMEG_6150|M.smegmatis_MC2_155 IG--LDNVFGRLWSREGLSRRDRSLVTMGILIALRATDEFASHVKIARNN
TH_0621|M.thermoresistible__bu IG--IDNVFGRLWTRDGLSRRDRSLVTLGILIALRATDELRFHVQIARNN
MMAR_4925|M.marinum_M LT--VDHLFGTIWTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAALLN
MUL_0480|M.ulcerans_Agy99 LT--VDHLFGTIWTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAAPLN
Mb0794|M.bovis_AF2122/97 LT--VDHLFGRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHN
Rv0771|M.tuberculosis_H37Rv LT--VDHLFGRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHN
MAB_1221|M.abscessus_ATCC_1997 YT--IDHLFGTIWTRPELSMRDRRLLLLGAVSALGLDEILEIQTSAALKN
Mflv_0527|M.gilvum_PYR-GCK MI--TQYAWGSIWTRPGLDFRSRSMITLTALVARGHHEELAMHLRAARRN
Mvan_0563|M.vanbaalenii_PYR-1 MI--TQYAWGTIWTRPGLDLRSRSMITLTALVARGHHEELAMHLRAARRN
MAV_3552|M.avium_104 GAGILNFVFGEMWLRPGLGMKERRLITVACVAFQDAEIPIMSHVYAALKS
: :* :* * *. :.* : : : : . .
MSMEG_6150|M.smegmatis_MC2_155 G-LTEQEIAEVIYHSSGYAGFPNANTAMKVAKGVLEGP------------
TH_0621|M.thermoresistible__bu G-LTEDEIAEVIYHATGYAGFPNASTAMKVAKEVLAEEHSRAADADKQSR
MMAR_4925|M.marinum_M GELTEAELKEMAVFLTHYLGFPLGSGLNGAVDTVVARRKKAAAKGAGEDK
MUL_0480|M.ulcerans_Agy99 GELTEAELKEMAVFLTHYLGFPLGSGLNGAVDTVVARRKKAAAKGAGEDK
Mb0794|M.bovis_AF2122/97 DELTIDELRELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLPDT
Rv0771|M.tuberculosis_H37Rv DELTIDELRELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLPDT
MAB_1221|M.abscessus_ATCC_1997 GELTEAELREVAIFITHYVGWPLGQRVNKHVEMAVAKQNEARR------T
Mflv_0527|M.gilvum_PYR-GCK G-LSNDEIKELLLQTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS----
Mvan_0563|M.vanbaalenii_PYR-1 G-LSNDEIKELLMQTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS----
MAV_3552|M.avium_104 GDVSFREMDEVALQFAAYYGCAKADHLNQALAEQKQRVIAENHSDATPVG
. :: *: *: : * * . ..
MSMEG_6150|M.smegmatis_MC2_155 -----------------
TH_0621|M.thermoresistible__bu LGESNP-----------
MMAR_4925|M.marinum_M KGNVDDALKMHSGGKPD
MUL_0480|M.ulcerans_Agy99 KGNVDDALKMHSGSKPD
Mb0794|M.bovis_AF2122/97 KANVAEVLAKESGKSS-
Rv0771|M.tuberculosis_H37Rv KANVAEVLAKESGKSS-
MAB_1221|M.abscessus_ATCC_1997 KESSDD-----------
Mflv_0527|M.gilvum_PYR-GCK -----------------
Mvan_0563|M.vanbaalenii_PYR-1 -----------------
MAV_3552|M.avium_104 -----------------