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LANGTQQNRAARVGTSNDDVRRRNLSSVLTLVHRRRSLSRADLTRHTGLSRSTTKDLVEELVALGLVDES PAPSVSQVGRPSPIVRPSDRVLAVAVTPEVDAVTVGLVSLGGAVLDVVRHPTAGIPTPSDTVAIAAEAIG DIRRNLRDEQALTAVGMAVPGLVHGRASFVQLAPNLDWHDVEIGEMLSAATGLPVYAGNDANVGAIAEHL FGSHHDVEDLIYVNGGPSGIGAGFVVAGDLLQGVAGYAGELGHTFVGGQRLCHCGSTGCLETEVTQAPLA ALLDDLDGAAGDATSDCAGRDELHRQARALAIALGTAINMLNPGLVVLGGFLRVFPAFAAAVLREELARR TMAAPCSLVRIVPATLGPDTLMIGAAELAFAPVLADPGGVEAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6022 | - | - | 100% (393) | xylose repressor, ROK-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0316 | - | 2e-27 | 29.32% (382) | putative NagC regulator |
| M. smegmatis MC2 155 | MSMEG_1363 | - | 5e-20 | 30.54% (298) | glucokinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0669 | - | 1e-15 | 28.14% (295) | sugar kinase |
| M. gilvum PYR-GCK | Mflv_1841 | - | 4e-29 | 29.08% (392) | ROK family protein |
| M. tuberculosis H37Rv | Rv0650 | - | 1e-15 | 28.14% (295) | sugar kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4059c | - | 6e-14 | 27.23% (382) | hypothetical protein MAB_4059c |
| M. marinum M | MMAR_0987 | - | 4e-16 | 27.84% (291) | carbohydrate kinase |
| M. avium 104 | MAV_4510 | - | 1e-17 | 29.61% (304) | sugar kinase |
| M. thermoresistible (build 8) | TH_0877 | - | 2e-16 | 26.51% (381) | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_0739 | - | 2e-16 | 27.84% (291) | carbohydrate kinase |
| M. vanbaalenii PYR-1 | Mvan_5295 | - | 1e-174 | 79.90% (388) | ROK family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6022|M.smegmatis_MC2_155 -------------------------MANGTQQNRAARVGTSNDDVRRRNL
Mvan_5295|M.vanbaalenii_PYR-1 ----------MACDTVKAEIEGNGALVRATQGNRTPRVGTSTDDVRRRNL
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
MAB_4059c|M.abscessus_ATCC_199 ----------------------MTAP-VRRP-VSRHQIHPPALYIGDSAA
TH_0877|M.thermoresistible__bu VARTANTVSTPRTASSLLRPAGVTASRTRRPLVSRQRVVAPSLRVADAAA
Mflv_1841|M.gilvum_PYR-GCK --------------------------------------MSSPRTAVPTSV
MSMEG_6022|M.smegmatis_MC2_155 SSVLTLVHRRRSLSRADLTRHTGLSRSTTKDLVEELVALGLVDESPAPSV
Mvan_5295|M.vanbaalenii_PYR-1 SSVLTMVHRRRAVSRAELTRHTGLSRSTTKDLVEELVARGLVDESPAPSA
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
MAB_4059c|M.abscessus_ATCC_199 SSVFRAARVRGPVARDAIAQVTGLSIATVNRQVTALLDAGLLRERADLAV
TH_0877|M.thermoresistible__bu ASVFEAARLRGPIARDAIAKATGLSIATVNRQVIALLEAGLLRERPDLAV
Mflv_1841|M.gilvum_PYR-GCK GDIYALIRAKRGLTRSEVGALSGLSRTAVNARVSELTSRGLVVEDQH--A
MSMEG_6022|M.smegmatis_MC2_155 S-QVGRP-SPIVRPSDRVLAVAVTPEVDAVTVGLVSLGGAVLDVVRHP-T
Mvan_5295|M.vanbaalenii_PYR-1 S-QVGRP-SPIVRPGDRVLAVAVTPEVDAVTVGLVSMGGTVREVIRRP-T
Mb0669|M.bovis_AF2122/97 -----------------MLTLCLDIGGTKIAAGLADPAGTLVHTAQRP-T
Rv0650|M.tuberculosis_H37Rv -----------------MLTLCLDIGGTKIAAGLADPAGTLVHTAQRP-T
MMAR_0987|M.marinum_M -----------------MLTLCLDIGGTKVAVGLADADGALVHTAQVP-T
MUL_0739|M.ulcerans_Agy99 -----------------MLTLCLDIGGTKVAVGLADADGALVHTAQVP-T
MAV_4510|M.avium_104 -----------------MLTLGLDIGGTKIAAALVDSSGTLVHTAVRP-T
MAB_4059c|M.abscessus_ATCC_199 SGAIGRPRVPVELNHEPFLTLGIHIGARATSIVATDLFGRTLDVVETP-T
TH_0877|M.thermoresistible__bu SGAIGRPRVPVEVDHDPYLTLGIHIGARTTSIAATDLFGRTLDVVETP-T
Mflv_1841|M.gilvum_PYR-GCK PSTGGRPAAVLRFNAAAGIVLTAAVGGSRTRLGVCDLAGDALATADIDQE
:.: . * .
MSMEG_6022|M.smegmatis_MC2_155 AGIPTPSDTVAIAAEAIGDIRRNLRDEQALTAVGMAVPGLVHGRASF-VQ
Mvan_5295|M.vanbaalenii_PYR-1 ARVPTPADTVTIAADAICDIQRTLRDGQTVTAVGVAVPGLVHGRESA-VQ
Mb0669|M.bovis_AF2122/97 PAYGGAEQVWAAVAEMIADALG--VAGGAVGGVGIASAGPIDLHSGR-VS
Rv0650|M.tuberculosis_H37Rv PAYGGAEQVWAAVAEMIADALG--VAGGAVGGVGIASAGPIDLHSGR-VS
MMAR_0987|M.marinum_M PARCAAEQVWAAVAEAIAEALR--VADATVAAVGIASAGPVDLDSGT-VS
MUL_0739|M.ulcerans_Agy99 PARCAAEQVWAAVAEAIAEALR--VADATVAAVGIASAGPVDLDSGT-VS
MAV_4510|M.avium_104 PNPAPADDVWDVVHALIAEVVR--AADAPIAAVGIASAGPVDLPSGS-VS
MAB_4059c|M.abscessus_ATCC_199 PNGPQGAALASLAGSAQRYLAR--WHRRRPLWVGVATGGVVDGPAGT-VD
TH_0877|M.thermoresistible__bu PRGAQPGAVASLAESARRYLSR--WHRRRPLWVGVAAGGVFDVTTGH-LD
Mflv_1841|M.gilvum_PYR-GCK PGQGPASLMPDIVGRLDLLLSEADRRDARIFGVGLSLPGTVDPVRGTSID
. . **:: * .. . :.
MSMEG_6022|M.smegmatis_MC2_155 LAPNLDWHDVEIGEMLSAAT-GLPVYAGNDANVGAIAEHLFGSHHDVEDL
Mvan_5295|M.vanbaalenii_PYR-1 LAPNLDWHDVEIGQMLSAAT-ELPVFAGNDANAGAVAEHRFGNHHNAEHL
Mb0669|M.bovis_AF2122/97 PINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGRGARFL
Rv0650|M.tuberculosis_H37Rv PINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGRGARFL
MMAR_0987|M.marinum_M PINIGSWRGFPLRDRVAAMVPDVPVRLGGDGVCMALGEHWLGAGRGARFL
MUL_0739|M.ulcerans_Agy99 PINIGSWRGFPLRDRVAAMVPDVPVRLGGDGVCMALGEHWLGAGRGARFL
MAV_4510|M.avium_104 PINIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWLGAGRGARFL
MAB_4059c|M.abscessus_ATCC_199 HP-RLGWTEAPVG-RVFADTLGLPVSVASHVDAMAGAELLLGLRRFAARS
TH_0877|M.thermoresistible__bu HP-LLGWTDAPVG-PVLAETLGLPVSVAPHLDAMAAAELLLGRSR--RRG
Mflv_1841|M.gilvum_PYR-GCK TPVLSGWDGAPLFPYFRDLT-PAPVVLGNDANVIALAEWREGAGRAFDDL
.* : . . ** . . * .* * :
MSMEG_6022|M.smegmatis_MC2_155 IYVNGGPSGIGAGFVVAGDLLQGVAGYAGELGH-TFVG-GQRLCHCGSTG
Mvan_5295|M.vanbaalenii_PYR-1 IYVNGGPSGIGAGFVVAGGLLEGVAGYAGELGH-TFVG-GGEQCHCGSVG
Mb0669|M.bovis_AF2122/97 LGLVVS-TGVGGGLVLDGAPCLGRTGNAGHVGH-VVVDPDGSPCPCGGRG
Rv0650|M.tuberculosis_H37Rv LGLVVS-TGVGGGLVLDGAPCLGRTGNAGHVGH-VVVDPDGSPCPCGGRG
MMAR_0987|M.marinum_M LGMVVS-TGVGGGLVLGGVPYPGRTGNAGHVGH-VVVDQDGLRCSCGGRG
MUL_0739|M.ulcerans_Agy99 LGMVVS-TGVGGGLVLGGVPYPGRTGNAGHVGH-VVVDQDGLRCSCGGRG
MAV_4510|M.avium_104 LGMVVS-TGVGGGLVLDGAPYPGRTGNAGHVGH-VVVELDGRPCTCGGHG
MAB_4059c|M.abscessus_ATCC_199 LTSLYVYARETVGFALA---IDGRVHSPSSGPG-TIAALPVDSELLGGSG
TH_0877|M.thermoresistible__bu TTSLFMYARETVGYALS---IAGRVHSPAAGPG-TIAALPVNSDLLGGTG
Mflv_1841|M.gilvum_PYR-GCK LVIKAS-TGLGAGIILGGVLQVGSIRAAGEFGHNKTAAAAGRACRCGDVG
: * : * .. . *. *
MSMEG_6022|M.smegmatis_MC2_155 CLETEVTQAPLAALLD-------------DLDGAAGDATSDCAGRDELHR
Mvan_5295|M.vanbaalenii_PYR-1 CLETEVTQAPLTSLLS-------------ELDGAATRHPS-STERDVLAR
Mb0669|M.bovis_AF2122/97 CVETIASGPSLARWARANGWSA--PPGAGAKELAEAAGAGDPVALRAFRR
Rv0650|M.tuberculosis_H37Rv CVETIASGPSLARWARANGWSA--PPGAGAKELAEAAGAGDPVALRAFRR
MMAR_0987|M.marinum_M CVETIAAGPSMVRWARANGWSA--RPEAGARELAAAAAAGDAVALAAFRR
MUL_0739|M.ulcerans_Agy99 CVETIAAGPSMVRWARANGWSA--RPEAGARELAAAAAAGDAVALAAFRR
MAV_4510|M.avium_104 CVETVASGPSMVRWARENGWSA--APGAGARDLAAAAAS-DPLAQKAFHR
MAB_4059c|M.abscessus_ATCC_199 KLETTVSDEAVLAAARKLRIVP-AGDGVSVSAVYKAARGGNESARELLSE
TH_0877|M.thermoresistible__bu QLETTVSDQAVVTAARRLNVIPPEGPASTIAAVLRAAQRGDSTARELLDE
Mflv_1841|M.gilvum_PYR-GCK CLETVAGGWALVRALREDGRTV-----ENLRDVVVLAHTGDALARRLIRD
:** . .: :
MSMEG_6022|M.smegmatis_MC2_155 QARALAIALGTAINMLNPGLVVLGGFLRVFPAFAAAVLREELARRTMAAP
Mvan_5295|M.vanbaalenii_PYR-1 QSRALAIALGNAVNMLNPGLIVLGGFLRVFPTFAAPMLRDELARRCMAAP
Mb0669|M.bovis_AF2122/97 GAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDF
Rv0650|M.tuberculosis_H37Rv GAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDF
MMAR_0987|M.marinum_M GTRGLAAMIASVGAVCDLDRVVIGGGVAKAGRLLFDPLRAALADYLGLDF
MUL_0739|M.ulcerans_Agy99 GTRGLAAMIASVGAVCDLDRVVIGGGVAKAGRLLFDPLRAALADYLGLDF
MAV_4510|M.avium_104 SADALAAMIASVGAVCDLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLDF
MAB_4059c|M.abscessus_ATCC_199 RGRVLGQSVALLRDILNPDEVIVGGQAFTEYPEVMNDVETAFLDRSTLSK
TH_0877|M.thermoresistible__bu RARVLGESLALLRDMLNPDEVVVGGQAFTDYPAGMETLTAAFTTRSVLPP
Mflv_1841|M.gilvum_PYR-GCK SGRHVGKVLAAAVNLLNPAALVVAGDVAGAYDIFVAGLRETLYGNATALA
:. :. : : ::.* : :
MSMEG_6022|M.smegmatis_MC2_155 CSLVRIVPATLGPDTLMIGAAELAFAPVLADPGGVEAG------------
Mvan_5295|M.vanbaalenii_PYR-1 RALVRVVPATLGADTLVIGAAELAFAPVLADPGRY---------------
Mb0669|M.bovis_AF2122/97 LAGLRVVPAELGGAAGLVGAARLAAIA-----------------------
Rv0650|M.tuberculosis_H37Rv LAGLRVVPAELGGAAGLVGAARLAAIA-----------------------
MMAR_0987|M.marinum_M LAGLRVVPAELGGQAGLVGAARLAGLG-----------------------
MUL_0739|M.ulcerans_Agy99 LAGLRVVPAELGGQAGLVGAARLAGLG-----------------------
MAV_4510|M.avium_104 LSGLTVVPGELGGNAGLIGAARLATLARPAGS------------------
MAB_4059c|M.abscessus_ATCC_199 RD---IRVTAFGNRVQEAGAGVVSLGGLFADPLGAMRRAS-ARRGEASAL
TH_0877|M.thermoresistible__bu LE---IRTTAFGNRVQEAGAGVVSLGSLYADPIGAMRRALDAPRTSARVL
Mflv_1841|M.gilvum_PYR-GCK TKNLDVLPAALGDRSGGIGSATMVLDEVLGPRAVDALVTTS---------
: :* *:. :
MSMEG_6022|M.smegmatis_MC2_155 -------
Mvan_5295|M.vanbaalenii_PYR-1 -------
Mb0669|M.bovis_AF2122/97 -------
Rv0650|M.tuberculosis_H37Rv -------
MMAR_0987|M.marinum_M -------
MUL_0739|M.ulcerans_Agy99 -------
MAV_4510|M.avium_104 -------
MAB_4059c|M.abscessus_ATCC_199 A------
TH_0877|M.thermoresistible__bu TGQHATG
Mflv_1841|M.gilvum_PYR-GCK -------