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MTLTLALDIGGTKIAAGLVDDDGALVHQAQLPTPDGDGELIWNVVDELVTGALRVADGAVDGVGIAAAGP IDLPGGTISPINIVEWQRFPIVDRVAAATGLPVRLGGDGLCMALGEHWRGAGRGAQFLLGMVVSTGVGGG LVLDGAPYDGRTGNAGHAGHVIVELEDGDLCTCGGHGCVETVASGPNMTRWARRQGWQAPADADAKELAD AANAGDAVALAAYRRGARAVAAMIASVGAVCDLDLVVIGGGVAKSGALLFDPIREALKNYAGLDFLRTLQ VVPAELGGDAGLIGAAALARA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1363 | - | - | 100% (301) | glucokinase |
| M. smegmatis MC2 155 | MSMEG_6022 | - | 4e-20 | 30.54% (298) | xylose repressor, ROK-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0316 | - | 2e-19 | 25.52% (290) | putative NagC regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0669 | - | 1e-117 | 71.91% (299) | sugar kinase |
| M. gilvum PYR-GCK | Mflv_5102 | - | 1e-122 | 71.38% (297) | ROK family protein |
| M. tuberculosis H37Rv | Rv0650 | - | 1e-117 | 71.91% (299) | sugar kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4059c | - | 1e-07 | 25.30% (253) | hypothetical protein MAB_4059c |
| M. marinum M | MMAR_0987 | - | 1e-117 | 70.57% (299) | carbohydrate kinase |
| M. avium 104 | MAV_4510 | - | 1e-113 | 69.57% (299) | sugar kinase |
| M. thermoresistible (build 8) | TH_4374 | - | 1e-114 | 67.79% (298) | PUTATIVE glucokinase |
| M. ulcerans Agy99 | MUL_0739 | - | 1e-117 | 70.57% (299) | carbohydrate kinase |
| M. vanbaalenii PYR-1 | Mvan_1251 | - | 1e-123 | 73.65% (296) | ROK family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5102|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1251|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1363|M.smegmatis_MC2_155 --------------------------------------------------
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
TH_4374|M.thermoresistible__bu --------------------------------------------------
MAB_4059c|M.abscessus_ATCC_199 MTAPVRRPVSRHQIHPPALYIGDSAASSVFRAARVRGPVARDAIAQVTGL
Mflv_5102|M.gilvum_PYR-GCK -------------------------------------MALSMSDLTLTLD
Mvan_1251|M.vanbaalenii_PYR-1 -----------------------------------------MNDLVLALD
MSMEG_1363|M.smegmatis_MC2_155 ------------------------------------------MTLTLALD
Mb0669|M.bovis_AF2122/97 -------------------------------------------MLTLCLD
Rv0650|M.tuberculosis_H37Rv -------------------------------------------MLTLCLD
MMAR_0987|M.marinum_M -------------------------------------------MLTLCLD
MUL_0739|M.ulcerans_Agy99 -------------------------------------------MLTLCLD
MAV_4510|M.avium_104 -------------------------------------------MLTLGLD
TH_4374|M.thermoresistible__bu -------------------------------------------VLTLTLD
MAB_4059c|M.abscessus_ATCC_199 SIATVNRQVTALLDAGLLRERADLAVSGAIGRPRVPVELNHEPFLTLGIH
*.* :.
Mflv_5102|M.gilvum_PYR-GCK IGGTKLAAGLVDADGNLVRRAQTPTPD-GDAETIWDAVASLLAETRSAAD
Mvan_1251|M.vanbaalenii_PYR-1 IGGTKIAAGLVDADGTLVHRAQQPTPD-GDAETVWDTAAALLAETRDAAP
MSMEG_1363|M.smegmatis_MC2_155 IGGTKIAAGLVDDDGALVHQAQLPTPD-GDGELIWNVVDELVTGALRVAD
Mb0669|M.bovis_AF2122/97 IGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAG
Rv0650|M.tuberculosis_H37Rv IGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAG
MMAR_0987|M.marinum_M IGGTKVAVGLADADGALVHTAQVPTPARCAAEQVWAAVAEAIAEALRVAD
MUL_0739|M.ulcerans_Agy99 IGGTKVAVGLADADGALVHTAQVPTPARCAAEQVWAAVAEAIAEALRVAD
MAV_4510|M.avium_104 IGGTKIAAALVDSSGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAAD
TH_4374|M.thermoresistible__bu IGGTKLAAGLVDGDGGLVHHTHAATPG-GDAEAVWTVLAGLIDDALTRAG
MAB_4059c|M.abscessus_ATCC_199 IGARATSIVATDLFGRTLDVVETPTPNGPQGAALASLAGSAQRYLARWHR
**. : .* * : . .** . :
Mflv_5102|M.gilvum_PYR-GCK STIGAVGIASAGPVDVPAGTVSPINIAEWHRFPIVERVEAAT-GLPVYLG
Mvan_1251|M.vanbaalenii_PYR-1 GPVSAVGIGSAGPIDVPGGTVSPINIAEWSHFPIVRRVADLT-GLPVRLG
MSMEG_1363|M.smegmatis_MC2_155 GAVDGVGIAAAGPIDLPGGTISPINIVEWQRFPIVDRVAAAT-GLPVRLG
Mb0669|M.bovis_AF2122/97 GAVGGVGIASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVPGVPVRLG
Rv0650|M.tuberculosis_H37Rv GAVGGVGIASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVPGVPVRLG
MMAR_0987|M.marinum_M ATVAAVGIASAGPVDLDSGTVSPINIGSWRGFPLRDRVAAMVPDVPVRLG
MUL_0739|M.ulcerans_Agy99 ATVAAVGIASAGPVDLDSGTVSPINIGSWRGFPLRDRVAAMVPDVPVRLG
MAV_4510|M.avium_104 APIAAVGIASAGPVDLPSGSVSPINIAGWHRFPLRDKVAAAVPATPVVLG
TH_4374|M.thermoresistible__bu GRVRAVGVGSAGPIDLTAGTVSPINLTAWSRFPLTERVSAALPGVPVRLG
MAB_4059c|M.abscessus_ATCC_199 RRPLWVGVATGGVVDGPAGTVDHPRLG-WTEAPVG-RVFADTLGLPVSVA
**:.:.* :* .* :. .: * *: :* ** :.
Mflv_5102|M.gilvum_PYR-GCK GDGLCMAMGEWWRGAGRNRRFMLG---MVVSTGIGGGLVLDGAPFHGRTG
Mvan_1251|M.vanbaalenii_PYR-1 GDGLCMALGEWWRGAGRGAGFLLG---MVVSTGIGGGLVLDGAPYHGRSG
MSMEG_1363|M.smegmatis_MC2_155 GDGLCMALGEHWRGAGRGAQFLLG---MVVSTGVGGGLVLDGAPYDGRTG
Mb0669|M.bovis_AF2122/97 GDGVCMALGEHWLGAGRGARFLLG---LVVSTGVGGGLVLDGAPCLGRTG
Rv0650|M.tuberculosis_H37Rv GDGVCMALGEHWLGAGRGARFLLG---LVVSTGVGGGLVLDGAPCLGRTG
MMAR_0987|M.marinum_M GDGVCMALGEHWLGAGRGARFLLG---MVVSTGVGGGLVLGGVPYPGRTG
MUL_0739|M.ulcerans_Agy99 GDGVCMALGEHWLGAGRGARFLLG---MVVSTGVGGGLVLGGVPYPGRTG
MAV_4510|M.avium_104 GDGLCMALGEQWLGAGRGARFLLG---MVVSTGVGGGLVLDGAPYPGRTG
TH_4374|M.thermoresistible__bu GDGLCMAMGEQWRGAGRGARFVLG---IVVSTGVGGGLVLDGMPYQGRTG
MAB_4059c|M.abscessus_ATCC_199 SHVDAMAGAELLLGLRRFAARSLTSLYVYARETVGFALAIDGRVHSPSSG
.. .** .* * * * : . :* .*.:.* :*
Mflv_5102|M.gilvum_PYR-GCK NAGHVGHVVVEP-DGDACTCGGRGCVETVASGPHLARWARAH-GWEG---
Mvan_1251|M.vanbaalenii_PYR-1 NAGHVGHVVVEP-GGAPCTCGGRGCVETVASGPHLARWAHDN-GWAAAPD
MSMEG_1363|M.smegmatis_MC2_155 NAGHAGHVIVELEDGDLCTCGGHGCVETVASGPNMTRWARRQ-GWQAPAD
Mb0669|M.bovis_AF2122/97 NAGHVGHVVVDP-DGSPCPCGGRGCVETIASGPSLARWARAN-GWSAPPG
Rv0650|M.tuberculosis_H37Rv NAGHVGHVVVDP-DGSPCPCGGRGCVETIASGPSLARWARAN-GWSAPPG
MMAR_0987|M.marinum_M NAGHVGHVVVDQ-DGLRCSCGGRGCVETIAAGPSMVRWARAN-GWSARPE
MUL_0739|M.ulcerans_Agy99 NAGHVGHVVVDQ-DGLRCSCGGRGCVETIAAGPSMVRWARAN-GWSARPE
MAV_4510|M.avium_104 NAGHVGHVVVEL-DGRPCTCGGHGCVETVASGPSMVRWAREN-GWSAAPG
TH_4374|M.thermoresistible__bu NAGHVGHVVVDP-RGVACSCGGRGCVETMAAGPAMVRWARAN-GWNAPPD
MAB_4059c|M.abscessus_ATCC_199 -PGTIAALPVDS-----ELLGGSGKLETTVSDEAVLAAARKLRIVPAGDG
.* . : *: ** * :** .:. : *: .
Mflv_5102|M.gilvum_PYR-GCK ADARELAEAAGRGEDVALRAFARGADAVARTIASVAAVCDLDLVVVGGGV
Mvan_1251|M.vanbaalenii_PYR-1 ADAKDLAEAAGRGDPVALRAFARGADAVARTIASVAAVCDLDLVVVGGGV
MSMEG_1363|M.smegmatis_MC2_155 ADAKELADAANAGDAVALAAYRRGARAVAAMIASVGAVCDLDLVVIGGGV
Mb0669|M.bovis_AF2122/97 AGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAVCDLDLAVIGGGV
Rv0650|M.tuberculosis_H37Rv AGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAVCDLDLAVIGGGV
MMAR_0987|M.marinum_M AGARELAAAAAAGDAVALAAFRRGTRGLAAMIASVGAVCDLDRVVIGGGV
MUL_0739|M.ulcerans_Agy99 AGARELAAAAAAGDAVALAAFRRGTRGLAAMIASVGAVCDLDRVVIGGGV
MAV_4510|M.avium_104 AGARDLAAAAAS-DPLAQKAFHRSADALAAMIASVGAVCDLDVVVIGGGV
TH_4374|M.thermoresistible__bu ADAEDLAAAAAAGVPVAVRAYRRGADALAAAISSVAAVCDLDLVVIGGGV
MAB_4059c|M.abscessus_ATCC_199 VSVSAVYKAARGGNESARELLSERGRVLGQSVALLRDILNPDEVIVGGQA
... : ** * . :. :: : : : * .::** .
Mflv_5102|M.gilvum_PYR-GCK AKAGSLLFDPLHQALRTYAGLD--------FLTDLRVVPAELGGDAGLVG
Mvan_1251|M.vanbaalenii_PYR-1 AKAGALLFDPLRQALTMYAGLE--------FLRGLRVVPAELGGDAGLVG
MSMEG_1363|M.smegmatis_MC2_155 AKSGALLFDPIREALKNYAGLD--------FLRTLQVVPAELGGDAGLIG
Mb0669|M.bovis_AF2122/97 AKSGRLLFEPLRAALADHARLD--------FLAGLRVVPAELGGAAGLVG
Rv0650|M.tuberculosis_H37Rv AKSGRLLFEPLRAALADHARLD--------FLAGLRVVPAELGGAAGLVG
MMAR_0987|M.marinum_M AKAGRLLFDPLRAALADYLGLD--------FLAGLRVVPAELGGQAGLVG
MUL_0739|M.ulcerans_Agy99 AKAGRLLFDPLRAALADYLGLD--------FLAGLRVVPAELGGQAGLVG
MAV_4510|M.avium_104 AQSGPLLFDPLRERLAHYAGLD--------FLSGLTVVPGELGGNAGLIG
TH_4374|M.thermoresistible__bu ARSGPVLFDPLAEALTTYTGLS--------FLRGLRVVPARLGATAGLIG
MAB_4059c|M.abscessus_ATCC_199 FTEYPEVMNDVETAFLDRSTLSKRDIRVTAFGNRVQEAGAGVVSLGGLFA
::: : : *. * : . . : . .**..
Mflv_5102|M.gilvum_PYR-GCK AAALAAHHGRFG--------
Mvan_1251|M.vanbaalenii_PYR-1 AAALVHDSVRFG--------
MSMEG_1363|M.smegmatis_MC2_155 AAALARA-------------
Mb0669|M.bovis_AF2122/97 AARLAAIA------------
Rv0650|M.tuberculosis_H37Rv AARLAAIA------------
MMAR_0987|M.marinum_M AARLAGLG------------
MUL_0739|M.ulcerans_Agy99 AARLAGLG------------
MAV_4510|M.avium_104 AARLATLARPAGS-------
TH_4374|M.thermoresistible__bu AARLAISAC-----------
MAB_4059c|M.abscessus_ATCC_199 DPLGAMRRASARRGEASALA
. .