For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VACDTVKAEIEGNGALVRATQGNRTPRVGTSTDDVRRRNLSSVLTMVHRRRAVSRAELTRHTGLSRSTTK DLVEELVARGLVDESPAPSASQVGRPSPIVRPGDRVLAVAVTPEVDAVTVGLVSMGGTVREVIRRPTARV PTPADTVTIAADAICDIQRTLRDGQTVTAVGVAVPGLVHGRESAVQLAPNLDWHDVEIGQMLSAATELPV FAGNDANAGAVAEHRFGNHHNAEHLIYVNGGPSGIGAGFVVAGGLLEGVAGYAGELGHTFVGGGEQCHCG SVGCLETEVTQAPLTSLLSELDGAATRHPSSTERDVLARQSRALAIALGNAVNMLNPGLIVLGGFLRVFP TFAAPMLRDELARRCMAAPRALVRVVPATLGADTLVIGAAELAFAPVLADPGRY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5295 | - | - | 100% (404) | ROK family protein |
| M. vanbaalenii PYR-1 | Mvan_4888 | - | 2e-26 | 28.72% (376) | ROK family protein |
| M. vanbaalenii PYR-1 | Mvan_1251 | - | 1e-16 | 28.62% (290) | ROK family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0669 | - | 1e-15 | 28.91% (294) | sugar kinase |
| M. gilvum PYR-GCK | Mflv_1841 | - | 2e-26 | 28.42% (380) | ROK family protein |
| M. tuberculosis H37Rv | Rv0650 | - | 1e-15 | 28.91% (294) | sugar kinase |
| M. leprae Br4923 | MLBr_01023 | ppgK | 3e-05 | 23.67% (245) | polyphosphate glucokinase |
| M. abscessus ATCC 19977 | MAB_4059c | - | 2e-11 | 25.39% (323) | hypothetical protein MAB_4059c |
| M. marinum M | MMAR_0987 | - | 7e-17 | 29.29% (297) | carbohydrate kinase |
| M. avium 104 | MAV_4510 | - | 2e-17 | 28.42% (292) | sugar kinase |
| M. smegmatis MC2 155 | MSMEG_6022 | - | 1e-174 | 79.90% (388) | xylose repressor, ROK-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_0877 | - | 4e-14 | 24.27% (379) | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_0739 | - | 5e-17 | 29.29% (297) | carbohydrate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5295|M.vanbaalenii_PYR-1 --------MACDTVKAEIEGNGALVRATQGN--RTPRVGTSTDDVRRRNL
MSMEG_6022|M.smegmatis_MC2_155 -----------------------MANGTQQN--RAARVGTSNDDVRRRNL
MAB_4059c|M.abscessus_ATCC_199 ----------------------MTAP-VRRP-VSRHQIHPPALYIGDSAA
TH_0877|M.thermoresistible__bu VARTANTVSTPRTASSLLRPAGVTASRTRRPLVSRQRVVAPSLRVADAAA
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
Mflv_1841|M.gilvum_PYR-GCK --------------------------------------MSSPRTAVPTSV
MLBr_01023|M.leprae_Br4923 -----------------------------------------MIRLRSAAA
Mvan_5295|M.vanbaalenii_PYR-1 SSVLTMVHRRRAVSRAELTRHTGLSRSTTKDLVEELVARGLVDESPAPSA
MSMEG_6022|M.smegmatis_MC2_155 SSVLTLVHRRRSLSRADLTRHTGLSRSTTKDLVEELVALGLVDESPAPSV
MAB_4059c|M.abscessus_ATCC_199 SSVFRAARVRGPVARDAIAQVTGLSIATVNRQVTALLDAGLLRERADLAV
TH_0877|M.thermoresistible__bu ASVFEAARLRGPIARDAIAKATGLSIATVNRQVIALLEAGLLRERPDLAV
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
Mflv_1841|M.gilvum_PYR-GCK GDIYALIRAKRGLTRSEVGALSGLSRTAVNARVSELTSRGLVVEDQH--A
MLBr_01023|M.leprae_Br4923 RDRCQVLSLAYRITVAGRCQTVSPHHRQAKVSEQPSLAKEIAITSTDATA
Mvan_5295|M.vanbaalenii_PYR-1 S-QVGRP-SPIVRPGDRVLAVAVTPEVDAVTVGLVSM-GGTVREVIRRP-
MSMEG_6022|M.smegmatis_MC2_155 S-QVGRP-SPIVRPSDRVLAVAVTPEVDAVTVGLVSL-GGAVLDVVRHP-
MAB_4059c|M.abscessus_ATCC_199 SGAIGRPRVPVELNHEPFLTLGIHIGARATSIVATDL-FGRTLDVVETP-
TH_0877|M.thermoresistible__bu SGAIGRPRVPVEVDHDPYLTLGIHIGARTTSIAATDL-FGRTLDVVETP-
Mb0669|M.bovis_AF2122/97 -----------------MLTLCLDIGGTKIAAGLADP-AGTLVHTAQRP-
Rv0650|M.tuberculosis_H37Rv -----------------MLTLCLDIGGTKIAAGLADP-AGTLVHTAQRP-
MMAR_0987|M.marinum_M -----------------MLTLCLDIGGTKVAVGLADA-DGALVHTAQVP-
MUL_0739|M.ulcerans_Agy99 -----------------MLTLCLDIGGTKVAVGLADA-DGALVHTAQVP-
MAV_4510|M.avium_104 -----------------MLTLGLDIGGTKIAAALVDS-SGTLVHTAVRP-
Mflv_1841|M.gilvum_PYR-GCK PSTGGRPAAVLRFNAAAGIVLTAAVGGSRTRLGVCDL-AGDALATADIDQ
MLBr_01023|M.leprae_Br4923 DTPRTSPPSDTAGTTSRHRGFGIDIGGSSIKGGIVDLDIGQLIGDRIKLL
. . *
Mvan_5295|M.vanbaalenii_PYR-1 TARVPTPADTVTIAADAICDIQRTLRDGQTVTAVGVAVPGLVHGRESAVQ
MSMEG_6022|M.smegmatis_MC2_155 TAGIPTPSDTVAIAAEAIGDIRRNLRDEQALTAVGMAVPGLVHGRASFVQ
MAB_4059c|M.abscessus_ATCC_199 TPNGPQGAALASLAGSAQRYLARWHR--RRPLWVGVATGGVVDGPAGTVD
TH_0877|M.thermoresistible__bu TPRGAQPGAVASLAESARRYLSRWHR--RRPLWVGVAAGGVFDVTTGHLD
Mb0669|M.bovis_AF2122/97 TPAYGGAEQVWAAVAEMIADALGVAG--GAVGGVGIASAGPIDLHSGRVS
Rv0650|M.tuberculosis_H37Rv TPAYGGAEQVWAAVAEMIADALGVAG--GAVGGVGIASAGPIDLHSGRVS
MMAR_0987|M.marinum_M TPARCAAEQVWAAVAEAIAEALRVAD--ATVAAVGIASAGPVDLDSGTVS
MUL_0739|M.ulcerans_Agy99 TPARCAAEQVWAAVAEAIAEALRVAD--ATVAAVGIASAGPVDLDSGTVS
MAV_4510|M.avium_104 TPNPAPADDVWDVVHALIAEVVRAAD--APIAAVGIASAGPVDLPSGSVS
Mflv_1841|M.gilvum_PYR-GCK EPGQGPASLMPDIVGRLDLLLSEADRRDARIFGVGLSLPGTVDPVRGTSI
MLBr_01023|M.leprae_Br4923 TPQPATPLAVAKTIAEVVNAFGWTAP-------LGVTYPGVVTQGVVRTA
. :*:: * .
Mvan_5295|M.vanbaalenii_PYR-1 LAPNLDWHDVEIG-QMLSAATELPVFAGNDANAGAVAEHRFGNHH---NA
MSMEG_6022|M.smegmatis_MC2_155 LAPNLDWHDVEIG-EMLSAATGLPVYAGNDANVGAIAEHLFGSHH---DV
MAB_4059c|M.abscessus_ATCC_199 HP-RLGWTEAPVG-RVFADTLGLPVSVASHVDAMAGAELLLGLRRFAARS
TH_0877|M.thermoresistible__bu HP-LLGWTDAPVG-PVLAETLGLPVSVAPHLDAMAAAELLLGRSR--RRG
Mb0669|M.bovis_AF2122/97 PINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGR----G
Rv0650|M.tuberculosis_H37Rv PINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGR----G
MMAR_0987|M.marinum_M PINIGSWRGFPLRDRVAAMVPDVPVRLGGDGVCMALGEHWLGAGR----G
MUL_0739|M.ulcerans_Agy99 PINIGSWRGFPLRDRVAAMVPDVPVRLGGDGVCMALGEHWLGAGR----G
MAV_4510|M.avium_104 PINIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWLGAGR----G
Mflv_1841|M.gilvum_PYR-GCK DTPVLSGWDGAPLFPYFRDLTPAPVVLGNDANVIALAEWREGAGR----A
MLBr_01023|M.leprae_Br4923 ANVDDSWIGTNARDIISAELNSQEVTILNDADAAGLAEGRYGAGK---NN
. * . . .* * :
Mvan_5295|M.vanbaalenii_PYR-1 EHLIYVNGGPSGIGAGFVVAGGLLEGVAG----YAGELGH-TFVGG-GEQ
MSMEG_6022|M.smegmatis_MC2_155 EDLIYVNGGPSGIGAGFVVAGDLLQGVAG----YAGELGH-TFVGG-QRL
MAB_4059c|M.abscessus_ATCC_199 LTSLYVYARET-VGFALAIDGRVHSPSSGPGTIAALPVDS-ELLGGSGKL
TH_0877|M.thermoresistible__bu TTSLFMYARET-VGYALSIAGRVHSPAAGPGTIAALPVNS-DLLGGTGQL
Mb0669|M.bovis_AF2122/97 ARFLLGLVVSTGVGGGLVLDGAPCLGRTG----NAGHVGH-VVVDPDGSP
Rv0650|M.tuberculosis_H37Rv ARFLLGLVVSTGVGGGLVLDGAPCLGRTG----NAGHVGH-VVVDPDGSP
MMAR_0987|M.marinum_M ARFLLGMVVSTGVGGGLVLGGVPYPGRTG----NAGHVGH-VVVDQDGLR
MUL_0739|M.ulcerans_Agy99 ARFLLGMVVSTGVGGGLVLGGVPYPGRTG----NAGHVGH-VVVDQDGLR
MAV_4510|M.avium_104 ARFLLGMVVSTGVGGGLVLDGAPYPGRTG----NAGHVGH-VVVELDGRP
Mflv_1841|M.gilvum_PYR-GCK FDDLLVIKASTGLGAGIILGGVLQVGSIR----AAGEFGHNKTAAAAGRA
MLBr_01023|M.leprae_Br4923 SGLIVLLTFGTGIGSAVIHNGKLIP---------NTEFGH---LEVDGKE
: : :* .. * ..
Mvan_5295|M.vanbaalenii_PYR-1 CHCGSVGCLETEVTQAPLTSLLSELDGAAT-------RHPS-----STER
MSMEG_6022|M.smegmatis_MC2_155 CHCGSTGCLETEVTQAPLAALLDDLDGAAG-------DATSD----CAGR
MAB_4059c|M.abscessus_ATCC_199 ETTVSDEAVLAAARKLRIVP-AGDGVSVSA-------VYKAARGGNESAR
TH_0877|M.thermoresistible__bu ETTVSDQAVVTAARRLNVIPPEGPASTIAA-------VLRAAQRGDSTAR
Mb0669|M.bovis_AF2122/97 CPCGGRGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVAL
Rv0650|M.tuberculosis_H37Rv CPCGGRGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVAL
MMAR_0987|M.marinum_M CSCGGRGCVETIAAGPSMVRWARANGWSARPEAGARELAAAAAAGDAVAL
MUL_0739|M.ulcerans_Agy99 CSCGGRGCVETIAAGPSMVRWARANGWSARPEAGARELAAAAAAGDAVAL
MAV_4510|M.avium_104 CTCGGHGCVETVASGPSMVRWARENGWSAAPGAGARDLAAAAAS-DPLAQ
Mflv_1841|M.gilvum_PYR-GCK CRCGDVGCLETVAGGWALVRALREDGRTVEN---LRDVVVLAHTGDALAR
MLBr_01023|M.leprae_Br4923 AEQRAASSVKDKYKWS----------------------------------
.:
Mvan_5295|M.vanbaalenii_PYR-1 DVLARQSRALAIALGNAVNMLNPGLIVLGGFLRVFPTFAAPMLRDELARR
MSMEG_6022|M.smegmatis_MC2_155 DELHRQARALAIALGTAINMLNPGLVVLGGFLRVFPAFAAAVLREELARR
MAB_4059c|M.abscessus_ATCC_199 ELLSERGRVLGQSVALLRDILNPDEVIVGGQAFTEYPEVMNDVETAFLDR
TH_0877|M.thermoresistible__bu ELLDERARVLGESLALLRDMLNPDEVVVGGQAFTDYPAGMETLTAAFTTR
Mb0669|M.bovis_AF2122/97 RAFRRGAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADH
Rv0650|M.tuberculosis_H37Rv RAFRRGAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADH
MMAR_0987|M.marinum_M AAFRRGTRGLAAMIASVGAVCDLDRVVIGGGVAKAGRLLFDPLRAALADY
MUL_0739|M.ulcerans_Agy99 AAFRRGTRGLAAMIASVGAVCDLDRVVIGGGVAKAGRLLFDPLRAALADY
MAV_4510|M.avium_104 KAFHRSADALAAMIASVGAVCDLDVVVIGGGVAQSGPLLFDPLRERLAHY
Mflv_1841|M.gilvum_PYR-GCK RLIRDSGRHVGKVLAAAVNLLNPAALVVAGDVAGAYDIFVAGLRETLYGN
MLBr_01023|M.leprae_Br4923 --YRTWAKQVTRVLVAIENAMCPDLFIAGGGISRKADRWIPLLENRTP--
: : : .* :
Mvan_5295|M.vanbaalenii_PYR-1 CMAAPRALVRVVPATLGADTLVIGAAELAFAPVLADPGRY----------
MSMEG_6022|M.smegmatis_MC2_155 TMAAPCSLVRIVPATLGPDTLMIGAAELAFAPVLADPGGVEAG-------
MAB_4059c|M.abscessus_ATCC_199 STLSKRDIR---VTAFGNRVQEAGAGVVSLGGLFADPLGAMRRAS-ARRG
TH_0877|M.thermoresistible__bu SVLPPLEIR---TTAFGNRVQEAGAGVVSLGSLYADPIGAMRRALDAPRT
Mb0669|M.bovis_AF2122/97 ARLDFLAGLRVVPAELGGAAGLVGAARLAAIA------------------
Rv0650|M.tuberculosis_H37Rv ARLDFLAGLRVVPAELGGAAGLVGAARLAAIA------------------
MMAR_0987|M.marinum_M LGLDFLAGLRVVPAELGGQAGLVGAARLAGLG------------------
MUL_0739|M.ulcerans_Agy99 LGLDFLAGLRVVPAELGGQAGLVGAARLAGLG------------------
MAV_4510|M.avium_104 AGLDFLSGLTVVPGELGGNAGLIGAARLATLARPAGS-------------
Mflv_1841|M.gilvum_PYR-GCK ATALATKNLDVLPAALGDRSGGIGSATMVLDEVLGPRAVDALVTTS----
MLBr_01023|M.leprae_Br4923 ----------MVAAALQNTAGIVGAAMASTADVTH---------------
: *:.
Mvan_5295|M.vanbaalenii_PYR-1 ------------
MSMEG_6022|M.smegmatis_MC2_155 ------------
MAB_4059c|M.abscessus_ATCC_199 EASALA------
TH_0877|M.thermoresistible__bu SARVLTGQHATG
Mb0669|M.bovis_AF2122/97 ------------
Rv0650|M.tuberculosis_H37Rv ------------
MMAR_0987|M.marinum_M ------------
MUL_0739|M.ulcerans_Agy99 ------------
MAV_4510|M.avium_104 ------------
Mflv_1841|M.gilvum_PYR-GCK ------------
MLBr_01023|M.leprae_Br4923 ------------