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VSSPRTAVPTSVGDIYALIRAKRGLTRSEVGALSGLSRTAVNARVSELTSRGLVVEDQHAPSTGGRPAAV LRFNAAAGIVLTAAVGGSRTRLGVCDLAGDALATADIDQEPGQGPASLMPDIVGRLDLLLSEADRRDARI FGVGLSLPGTVDPVRGTSIDTPVLSGWDGAPLFPYFRDLTPAPVVLGNDANVIALAEWREGAGRAFDDLL VIKASTGLGAGIILGGVLQVGSIRAAGEFGHNKTAAAAGRACRCGDVGCLETVAGGWALVRALREDGRTV ENLRDVVVLAHTGDALARRLIRDSGRHVGKVLAAAVNLLNPAALVVAGDVAGAYDIFVAGLRETLYGNAT ALATKNLDVLPAALGDRSGGIGSATMVLDEVLGPRAVDALVTTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1841 | - | - | 100% (394) | ROK family protein |
| M. gilvum PYR-GCK | Mflv_5102 | - | 4e-28 | 31.10% (299) | ROK family protein |
| M. gilvum PYR-GCK | Mflv_0087 | - | 3e-19 | 27.18% (390) | ROK family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0669 | - | 4e-24 | 29.37% (303) | sugar kinase |
| M. tuberculosis H37Rv | Rv0650 | - | 4e-24 | 29.37% (303) | sugar kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4059c | - | 5e-18 | 26.18% (382) | hypothetical protein MAB_4059c |
| M. marinum M | MMAR_0987 | - | 1e-27 | 32.24% (304) | carbohydrate kinase |
| M. avium 104 | MAV_4510 | - | 8e-29 | 33.33% (303) | sugar kinase |
| M. smegmatis MC2 155 | MSMEG_0316 | - | 1e-142 | 66.32% (386) | putative NagC regulator |
| M. thermoresistible (build 8) | TH_4374 | - | 1e-24 | 29.84% (305) | PUTATIVE glucokinase |
| M. ulcerans Agy99 | MUL_0739 | - | 8e-28 | 32.24% (304) | carbohydrate kinase |
| M. vanbaalenii PYR-1 | Mvan_4888 | - | 1e-169 | 77.78% (387) | ROK family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1841|M.gilvum_PYR-GCK --------------MSSPRTAVPTSVGDIYALIRAKRGLTRSEVGALSGL
Mvan_4888|M.vanbaalenii_PYR-1 --------------MALFRTSSASSVGDVFALIRHKRDLTRTEIGRLTGL
MSMEG_0316|M.smegmatis_MC2_155 -----------MEAMPPPATLVSPTPGEVFALIRDRRATTRGELGRLTGL
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
TH_4374|M.thermoresistible__bu --------------------------------------------------
MAB_4059c|M.abscessus_ATCC_199 MTAPVRRPVSRHQIHPPALYIGDSAASSVFRAARVRGPVARDAIAQVTGL
Mflv_1841|M.gilvum_PYR-GCK SRTAVNARVSELTSRGLVVEDQHAPST--GGRPAAVLRFNAAAGIVLTAA
Mvan_4888|M.vanbaalenii_PYR-1 SRTAVTARVSELTSRDLVVEREQAPST--GGRPAALLSFNADAGVVLTAA
MSMEG_0316|M.smegmatis_MC2_155 SRTAVTARVAALEAGGLVIERDQA-ST--GGRPAAQLMFNVDAGVVFSAA
Mb0669|M.bovis_AF2122/97 -------------------------------------------MLTLCLD
Rv0650|M.tuberculosis_H37Rv -------------------------------------------MLTLCLD
MMAR_0987|M.marinum_M -------------------------------------------MLTLCLD
MUL_0739|M.ulcerans_Agy99 -------------------------------------------MLTLCLD
MAV_4510|M.avium_104 -------------------------------------------MLTLGLD
TH_4374|M.thermoresistible__bu -------------------------------------------VLTLTLD
MAB_4059c|M.abscessus_ATCC_199 SIATVNRQVTALLDAGLLRERADLAVSGAIGRPRVPVELNHEPFLTLGIH
:.:
Mflv_1841|M.gilvum_PYR-GCK VGGSRTRLGVCDLAGDALATADIDQEPGQGPASLMPDIVGRLDLLLSEAD
Mvan_4888|M.vanbaalenii_PYR-1 VGGSRTRLAVCNLAGDVLTAADIDQEPGLGPQDLMPQVVKGLEVLLAESG
MSMEG_0316|M.smegmatis_MC2_155 IGRSRTQLAVCNLDGTILASTDIDQEPGIAPDDLLPDLVKRLDMLLDESA
Mb0669|M.bovis_AF2122/97 IGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAG
Rv0650|M.tuberculosis_H37Rv IGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAG
MMAR_0987|M.marinum_M IGGTKVAVGLADADGALVHTAQVPTPARCAAEQVWAAVAEAIAEALRVAD
MUL_0739|M.ulcerans_Agy99 IGGTKVAVGLADADGALVHTAQVPTPARCAAEQVWAAVAEAIAEALRVAD
MAV_4510|M.avium_104 IGGTKIAAALVDSSGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAAD
TH_4374|M.thermoresistible__bu IGGTKLAAGLVDGDGGLVHHTHAATPG-GDAEAVWTVLAGLIDDALTRAG
MAB_4059c|M.abscessus_ATCC_199 IGARATSIVATDLFGRTLDVVETPTPNGPQGAALASLAGSAQRYLARWHR
:* : * : . :
Mflv_1841|M.gilvum_PYR-GCK RRDARIFGVGLSLPGTVDPVRGTSIDTPVLSGWDGAPLFP-YFRDLTPAP
Mvan_4888|M.vanbaalenii_PYR-1 HSDA-VYGVGLSLPGTVDQERGSSIDTPVLSGWDGAPLIP-YFRQLTEAP
MSMEG_0316|M.smegmatis_MC2_155 RRDAHIFGVGLSLPGTVDQRTGASLDSPNMSGWDGVPLAP-YFTSLTDAP
Mb0669|M.bovis_AF2122/97 ---GAVGGVGIASAGPIDLHSG-RVSPINIGSWGGFPLRDRVAAAVPGVP
Rv0650|M.tuberculosis_H37Rv ---GAVGGVGIASAGPIDLHSG-RVSPINIGSWGGFPLRDRVAAAVPGVP
MMAR_0987|M.marinum_M ---ATVAAVGIASAGPVDLDSG-TVSPINIGSWRGFPLRDRVAAMVPDVP
MUL_0739|M.ulcerans_Agy99 ---ATVAAVGIASAGPVDLDSG-TVSPINIGSWRGFPLRDRVAAMVPDVP
MAV_4510|M.avium_104 ---APIAAVGIASAGPVDLPSG-SVSPINIAGWHRFPLRDKVAAAVPATP
TH_4374|M.thermoresistible__bu ---GRVRAVGVGSAGPIDLTAG-TVSPINLTAWSRFPLTERVSAALPGVP
MAB_4059c|M.abscessus_ATCC_199 ---RRPLWVGVATGGVVDGPAG-TVDHPRLG-WTEAPVGR-VFADTLGLP
**:. * :* * :. : * *: *
Mflv_1841|M.gilvum_PYR-GCK VVLGNDANVIALAEWREGAGRAFDDLLV---IKASTGLGAGIILGGVLQV
Mvan_4888|M.vanbaalenii_PYR-1 VVLGNDANVIALAEWRAGAGRGFDDLLV---VKASTGLGAGIIAGGAPQR
MSMEG_0316|M.smegmatis_MC2_155 VVIDNDANAIAVAERRGGYG-EYDDMLV---VKASTGLAAGIIMGGQLQR
Mb0669|M.bovis_AF2122/97 VRLGGDGVCMALGEHWLGAGRGARFLLG---LVVSTGVGGGLVLDGAPCL
Rv0650|M.tuberculosis_H37Rv VRLGGDGVCMALGEHWLGAGRGARFLLG---LVVSTGVGGGLVLDGAPCL
MMAR_0987|M.marinum_M VRLGGDGVCMALGEHWLGAGRGARFLLG---MVVSTGVGGGLVLGGVPYP
MUL_0739|M.ulcerans_Agy99 VRLGGDGVCMALGEHWLGAGRGARFLLG---MVVSTGVGGGLVLGGVPYP
MAV_4510|M.avium_104 VVLGGDGLCMALGEQWLGAGRGARFLLG---MVVSTGVGGGLVLDGAPYP
TH_4374|M.thermoresistible__bu VRLGGDGLCMAMGEQWRGAGRGARFVLG---IVVSTGVGGGLVLDGMPYQ
MAB_4059c|M.abscessus_ATCC_199 VSVASHVDAMAGAELLLGLRRFAARSLTSLYVYARETVGFALAIDGRVHS
* : .. :* .* * * : . :. .: .*
Mflv_1841|M.gilvum_PYR-GCK GSIRAAGEFGHNKTAAAAGRACRCGDVGCLETVAGGWALVRALREDGR--
Mvan_4888|M.vanbaalenii_PYR-1 GAIRAAGEFGHNKTPAAEGRPCRCGDTGCLETVAGGWALVRTLAQEGR--
MSMEG_0316|M.smegmatis_MC2_155 GAVQAAGEFGHSKTAAAAGVHCRCGDTGCLEAIAGGWALVRALQRDGR--
Mb0669|M.bovis_AF2122/97 GRTGNAGHVGHVVVDPD-GSPCPCGGRGCVETIASGPSLARWARANGWSA
Rv0650|M.tuberculosis_H37Rv GRTGNAGHVGHVVVDPD-GSPCPCGGRGCVETIASGPSLARWARANGWSA
MMAR_0987|M.marinum_M GRTGNAGHVGHVVVDQD-GLRCSCGGRGCVETIAAGPSMVRWARANGWSA
MUL_0739|M.ulcerans_Agy99 GRTGNAGHVGHVVVDQD-GLRCSCGGRGCVETIAAGPSMVRWARANGWSA
MAV_4510|M.avium_104 GRTGNAGHVGHVVVELD-GRPCTCGGHGCVETVASGPSMVRWARENGWSA
TH_4374|M.thermoresistible__bu GRTGNAGHVGHVVVDPR-GVACSCGGRGCVETMAAGPAMVRWARANGWNA
MAB_4059c|M.abscessus_ATCC_199 PSSGPGTIAALPVDSELLGGSGKLETTVSDEAVLAAARKLRIVPAGDG--
. . * . *:: .. * .
Mflv_1841|M.gilvum_PYR-GCK -TVENLRDVVVLAHTGDALARRLIRDSGRHVGKVLAAAVNLLNPAALVVA
Mvan_4888|M.vanbaalenii_PYR-1 -PVRNLRDLVELAHSGDALARRQIRDSGRYIGEVLAGAVNLLNPAALVVA
MSMEG_0316|M.smegmatis_MC2_155 -AVNHLRDVVALAHTGDPEARRMIRESGRHIGEVLAAAVNLLNPAVLVIA
Mb0669|M.bovis_AF2122/97 PPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAVCDLDLAVIG
Rv0650|M.tuberculosis_H37Rv PPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAVCDLDLAVIG
MMAR_0987|M.marinum_M RPEAGARELAAAAAAGDAVALAAFRRGTRGLAAMIASVGAVCDLDRVVIG
MUL_0739|M.ulcerans_Agy99 RPEAGARELAAAAAAGDAVALAAFRRGTRGLAAMIASVGAVCDLDRVVIG
MAV_4510|M.avium_104 APGAGARDLAAAAAS-DPLAQKAFHRSADALAAMIASVGAVCDLDVVVIG
TH_4374|M.thermoresistible__bu PPDADAEDLAAAAAAGVPVAVRAYRRGADALAAAISSVAAVCDLDLVVIG
MAB_4059c|M.abscessus_ATCC_199 ---VSVSAVYKAARGGNESARELLSERGRVLGQSVALLRDILNPDEVIVG
: * * :. :: : : ::.
Mflv_1841|M.gilvum_PYR-GCK GDVAGAYDIFVAGLRETLYGNATAL--------ATKNLDVLPAALGDRSG
Mvan_4888|M.vanbaalenii_PYR-1 GDAAGAYDIFVAGLRETLYGNATAL--------ATRVLEIRPAQLGDRGG
MSMEG_0316|M.smegmatis_MC2_155 GDMVGAYDLFVAGLRETLYGNATAL--------ATRTLQIVPSIHRERSS
Mb0669|M.bovis_AF2122/97 GGVAKSGRLLFEPLRAALADHARLD--------FLAGLRVVPAELGGAAG
Rv0650|M.tuberculosis_H37Rv GGVAKSGRLLFEPLRAALADHARLD--------FLAGLRVVPAELGGAAG
MMAR_0987|M.marinum_M GGVAKAGRLLFDPLRAALADYLGLD--------FLAGLRVVPAELGGQAG
MUL_0739|M.ulcerans_Agy99 GGVAKAGRLLFDPLRAALADYLGLD--------FLAGLRVVPAELGGQAG
MAV_4510|M.avium_104 GGVAQSGPLLFDPLRERLAHYAGLD--------FLSGLTVVPGELGGNAG
TH_4374|M.thermoresistible__bu GGVARSGPVLFDPLAEALTTYTGLS--------FLRGLRVVPARLGATAG
MAB_4059c|M.abscessus_ATCC_199 GQAFTEYPEVMNDVETAFLDRSTLSKRDIRVTAFGNRVQEAGAGVVSLGG
* .. : : : . ..
Mflv_1841|M.gilvum_PYR-GCK GIGSATMVLDEVLGPRAVDALVTTS
Mvan_4888|M.vanbaalenii_PYR-1 SIGSAMMVLDQVLGPRAVDALVAA-
MSMEG_0316|M.smegmatis_MC2_155 MVGCATNVLDRVLSPDAVDAAMYGD
Mb0669|M.bovis_AF2122/97 LVGAARLAAIA--------------
Rv0650|M.tuberculosis_H37Rv LVGAARLAAIA--------------
MMAR_0987|M.marinum_M LVGAARLAGLG--------------
MUL_0739|M.ulcerans_Agy99 LVGAARLAGLG--------------
MAV_4510|M.avium_104 LIGAARLATLARPAGS---------
TH_4374|M.thermoresistible__bu LIGAARLAISAC-------------
MAB_4059c|M.abscessus_ATCC_199 LFADPLGAMRRASARRGEASALA--
.. . .