For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MEAMPPPATLVSPTPGEVFALIRDRRATTRGELGRLTGLSRTAVTARVAALEAGGLVIERDQASTGGRPA AQLMFNVDAGVVFSAAIGRSRTQLAVCNLDGTILASTDIDQEPGIAPDDLLPDLVKRLDMLLDESARRDA HIFGVGLSLPGTVDQRTGASLDSPNMSGWDGVPLAPYFTSLTDAPVVIDNDANAIAVAERRGGYGEYDDM LVVKASTGLAAGIIMGGQLQRGAVQAAGEFGHSKTAAAAGVHCRCGDTGCLEAIAGGWALVRALQRDGRA VNHLRDVVALAHTGDPEARRMIRESGRHIGEVLAAAVNLLNPAVLVIAGDMVGAYDLFVAGLRETLYGNA TALATRTLQIVPSIHRERSSMVGCATNVLDRVLSPDAVDAAMYGD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0316 | - | - | 100% (395) | putative NagC regulator |
| M. smegmatis MC2 155 | MSMEG_6022 | - | 2e-27 | 29.32% (382) | xylose repressor, ROK-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1363 | - | 3e-19 | 25.52% (290) | glucokinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0669 | - | 9e-16 | 26.19% (252) | sugar kinase |
| M. gilvum PYR-GCK | Mflv_1841 | - | 1e-142 | 66.32% (386) | ROK family protein |
| M. tuberculosis H37Rv | Rv0650 | - | 9e-16 | 26.19% (252) | sugar kinase |
| M. leprae Br4923 | MLBr_01023 | ppgK | 9e-05 | 32.69% (104) | polyphosphate glucokinase |
| M. abscessus ATCC 19977 | MAB_4059c | - | 1e-14 | 24.54% (383) | hypothetical protein MAB_4059c |
| M. marinum M | MMAR_0987 | - | 1e-18 | 25.85% (294) | carbohydrate kinase |
| M. avium 104 | MAV_4510 | - | 7e-20 | 29.25% (294) | sugar kinase |
| M. thermoresistible (build 8) | TH_0877 | - | 2e-17 | 29.30% (372) | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_0739 | - | 7e-19 | 25.85% (294) | carbohydrate kinase |
| M. vanbaalenii PYR-1 | Mvan_4888 | - | 1e-141 | 67.90% (377) | ROK family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1841|M.gilvum_PYR-GCK --------------------------------------MSSPRTAVPTSV
Mvan_4888|M.vanbaalenii_PYR-1 --------------------------------------MALFRTSSASSV
MSMEG_0316|M.smegmatis_MC2_155 -----------------------------------MEAMPPPATLVSPTP
MAB_4059c|M.abscessus_ATCC_199 ----------------------MTAP-VRRP-VSRHQIHPPALYIGDSAA
TH_0877|M.thermoresistible__bu VARTANTVSTPRTASSLLRPAGVTASRTRRPLVSRQRVVAPSLRVADAAA
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
MLBr_01023|M.leprae_Br4923 -----------------------------------------MIRLRSAAA
Mflv_1841|M.gilvum_PYR-GCK GDIYALIRAKRGLTRSEVGALSGLSRTAVNARVSELTSRGLVVED--QHA
Mvan_4888|M.vanbaalenii_PYR-1 GDVFALIRHKRDLTRTEIGRLTGLSRTAVTARVSELTSRDLVVER--EQA
MSMEG_0316|M.smegmatis_MC2_155 GEVFALIRDRRATTRGELGRLTGLSRTAVTARVAALEAGGLVIER--DQA
MAB_4059c|M.abscessus_ATCC_199 SSVFRAARVRGPVARDAIAQVTGLSIATVNRQVTALLDAGLLRERADLAV
TH_0877|M.thermoresistible__bu ASVFEAARLRGPIARDAIAKATGLSIATVNRQVIALLEAGLLRERPDLAV
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
MLBr_01023|M.leprae_Br4923 RDRCQVLSLAYRITVAGRCQTVSPHHRQAKVSEQPSLAKEIAITSTDATA
Mflv_1841|M.gilvum_PYR-GCK PSTGGRPAAVLRFNAAAGIVLTAAVGGSRTRLGVCDLAGDALATADIDQE
Mvan_4888|M.vanbaalenii_PYR-1 PSTGGRPAALLSFNADAGVVLTAAVGGSRTRLAVCNLAGDVLTAADIDQE
MSMEG_0316|M.smegmatis_MC2_155 -STGGRPAAQLMFNVDAGVVFSAAIGRSRTQLAVCNLDGTILASTDIDQE
MAB_4059c|M.abscessus_ATCC_199 SGAIGRPRVPVELNHEPFLTLGIHIGARATSIVATDLFGRTLDVVETPTP
TH_0877|M.thermoresistible__bu SGAIGRPRVPVEVDHDPYLTLGIHIGARTTSIAATDLFGRTLDVVETPTP
Mb0669|M.bovis_AF2122/97 -----------------MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTP
Rv0650|M.tuberculosis_H37Rv -----------------MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTP
MMAR_0987|M.marinum_M -----------------MLTLCLDIGGTKVAVGLADADGALVHTAQVPTP
MUL_0739|M.ulcerans_Agy99 -----------------MLTLCLDIGGTKVAVGLADADGALVHTAQVPTP
MAV_4510|M.avium_104 -----------------MLTLGLDIGGTKIAAALVDSSGTLVHTAVRPTP
MLBr_01023|M.leprae_Br4923 DTPRTSPPSDTAGTTSRHRGFGIDIGGSSIKGGIVDLDIGQLIGDRIKLL
: :* : :
Mflv_1841|M.gilvum_PYR-GCK PGQGPASLMPDIVGRLDLLLSEADRRDARIFGVGLSLPGTVDPVRGTSID
Mvan_4888|M.vanbaalenii_PYR-1 PGLGPQDLMPQVVKGLEVLLAESGHSDA-VYGVGLSLPGTVDQERGSSID
MSMEG_0316|M.smegmatis_MC2_155 PGIAPDDLLPDLVKRLDMLLDESARRDAHIFGVGLSLPGTVDQRTGASLD
MAB_4059c|M.abscessus_ATCC_199 NGPQG-AALASLAGSAQRYLARWHRRRP--LWVGVATGGVVDGPAG-TVD
TH_0877|M.thermoresistible__bu RGAQP-GAVASLAESARRYLSRWHRRRP--LWVGVAAGGVFDVTTG-HLD
Mb0669|M.bovis_AF2122/97 AYGGAEQVWAAVAEMIADALGVAGGAVG---GVGIASAGPIDLHSG-RVS
Rv0650|M.tuberculosis_H37Rv AYGGAEQVWAAVAEMIADALGVAGGAVG---GVGIASAGPIDLHSG-RVS
MMAR_0987|M.marinum_M ARCAAEQVWAAVAEAIAEALRVADATVA---AVGIASAGPVDLDSG-TVS
MUL_0739|M.ulcerans_Agy99 ARCAAEQVWAAVAEAIAEALRVADATVA---AVGIASAGPVDLDSG-TVS
MAV_4510|M.avium_104 NPAPADDVWDVVHALIAEVVRAADAPIA---AVGIASAGPVDLPSG-SVS
MLBr_01023|M.leprae_Br4923 T--PQPATPLAVAKTIAEVVNAFGWTAP----LGVTYPGVVTQGVVRTAA
: : :*:: * .
Mflv_1841|M.gilvum_PYR-GCK TPVLSGWDGAPLFP-YFRDLTPAPVVLGNDANVIALAEWREGAGR---AF
Mvan_4888|M.vanbaalenii_PYR-1 TPVLSGWDGAPLIP-YFRQLTEAPVVLGNDANVIALAEWRAGAGR---GF
MSMEG_0316|M.smegmatis_MC2_155 SPNMSGWDGVPLAP-YFTSLTDAPVVIDNDANAIAVAERRGGYG----EY
MAB_4059c|M.abscessus_ATCC_199 HPRLG-WTEAPVGR-VFADTLGLPVSVASHVDAMAGAELLLGLRRFAARS
TH_0877|M.thermoresistible__bu HPLLG-WTDAPVGP-VLAETLGLPVSVAPHLDAMAAAELLLGRSR--RRG
Mb0669|M.bovis_AF2122/97 PINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGR---GA
Rv0650|M.tuberculosis_H37Rv PINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGR---GA
MMAR_0987|M.marinum_M PINIGSWRGFPLRDRVAAMVPDVPVRLGGDGVCMALGEHWLGAGR---GA
MUL_0739|M.ulcerans_Agy99 PINIGSWRGFPLRDRVAAMVPDVPVRLGGDGVCMALGEHWLGAGR---GA
MAV_4510|M.avium_104 PINIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWLGAGR---GA
MLBr_01023|M.leprae_Br4923 N-VDDSWIGTNARDIISAELNSQEVTILNDADAAGLAEGRYGAGK--NNS
* * : . . .* *
Mflv_1841|M.gilvum_PYR-GCK DDLLVIKASTGLGAGIILGGVLQVGSIRAAGEFGHNKTAAAAGRACRCGD
Mvan_4888|M.vanbaalenii_PYR-1 DDLLVVKASTGLGAGIIAGGAPQRGAIRAAGEFGHNKTPAAEGRPCRCGD
MSMEG_0316|M.smegmatis_MC2_155 DDMLVVKASTGLAAGIIMGGQLQRGAVQAAGEFGHSKTAAAAGVHCRCGD
MAB_4059c|M.abscessus_ATCC_199 LTSLYVYARETVGFALAIDGRVHSPSSGPGTIAALPVDSELLGGSGKLET
TH_0877|M.thermoresistible__bu TTSLFMYARETVGYALSIAGRVHSPAAGPGTIAALPVNSDLLGGTGQLET
Mb0669|M.bovis_AF2122/97 RFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVGH-VVVDPDGSPCPCGG
Rv0650|M.tuberculosis_H37Rv RFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVGH-VVVDPDGSPCPCGG
MMAR_0987|M.marinum_M RFLLGMVVSTGVGGGLVLGGVPYPGRTGNAGHVGH-VVVDQDGLRCSCGG
MUL_0739|M.ulcerans_Agy99 RFLLGMVVSTGVGGGLVLGGVPYPGRTGNAGHVGH-VVVDQDGLRCSCGG
MAV_4510|M.avium_104 RFLLGMVVSTGVGGGLVLDGAPYPGRTGNAGHVGH-VVVELDGRPCTCGG
MLBr_01023|M.leprae_Br4923 GLIVLLTFGTGIGSAVIHNGKLIPN-----TEFGH---------------
: : :. .: * .
Mflv_1841|M.gilvum_PYR-GCK VGCLETVAGGWALVRALREDGRTVEN---LRDVVVLAHTGDALARRLIRD
Mvan_4888|M.vanbaalenii_PYR-1 TGCLETVAGGWALVRTLAQEGRPVRN---LRDLVELAHSGDALARRQIRD
MSMEG_0316|M.smegmatis_MC2_155 TGCLEAIAGGWALVRALQRDGRAVNH---LRDVVALAHTGDPEARRMIRE
MAB_4059c|M.abscessus_ATCC_199 TVSDEAVLAAARKLRIVP-AGDGVS----VSAVYKAARGGNESARELLSE
TH_0877|M.thermoresistible__bu TVSDQAVVTAARRLNVIPPEGPAST----IAAVLRAAQRGDSTARELLDE
Mb0669|M.bovis_AF2122/97 RGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRR
Rv0650|M.tuberculosis_H37Rv RGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRR
MMAR_0987|M.marinum_M RGCVETIAAGPSMVRWARANGWSARPEAGARELAAAAAAGDAVALAAFRR
MUL_0739|M.ulcerans_Agy99 RGCVETIAAGPSMVRWARANGWSARPEAGARELAAAAAAGDAVALAAFRR
MAV_4510|M.avium_104 HGCVETVASGPSMVRWARENGWSAAPGAGARDLAAAAAS-DPLAQKAFHR
MLBr_01023|M.leprae_Br4923 ----------------LEVDGKEAEQ--------RAASSVKDKYKWSYRT
* * .
Mflv_1841|M.gilvum_PYR-GCK SGRHVGKVLAAAVNLLNPAALVVAGDVAGAYDIFVAGLRETLYGNATALA
Mvan_4888|M.vanbaalenii_PYR-1 SGRYIGEVLAGAVNLLNPAALVVAGDAAGAYDIFVAGLRETLYGNATALA
MSMEG_0316|M.smegmatis_MC2_155 SGRHIGEVLAAAVNLLNPAVLVIAGDMVGAYDLFVAGLRETLYGNATALA
MAB_4059c|M.abscessus_ATCC_199 RGRVLGQSVALLRDILNPDEVIVGGQAFTEYPEVMNDVETAFLDRSTLSK
TH_0877|M.thermoresistible__bu RARVLGESLALLRDMLNPDEVVVGGQAFTDYPAGMETLTAAFTTRSVLPP
Mb0669|M.bovis_AF2122/97 GAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDF
Rv0650|M.tuberculosis_H37Rv GAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDF
MMAR_0987|M.marinum_M GTRGLAAMIASVGAVCDLDRVVIGGGVAKAGRLLFDPLRAALADYLGLDF
MUL_0739|M.ulcerans_Agy99 GTRGLAAMIASVGAVCDLDRVVIGGGVAKAGRLLFDPLRAALADYLGLDF
MAV_4510|M.avium_104 SADALAAMIASVGAVCDLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLDF
MLBr_01023|M.leprae_Br4923 WAKQVTRVLVAIENAMCPDLFIAGGGISRKADRWIPLLENRTP-------
: :. : .* . :
Mflv_1841|M.gilvum_PYR-GCK TKNLDVLPAALGDRSGGIGSATMVLDEVLGP------RAVDALVTTS---
Mvan_4888|M.vanbaalenii_PYR-1 TRVLEIRPAQLGDRGGSIGSAMMVLDQVLGP------RAVDALVAA----
MSMEG_0316|M.smegmatis_MC2_155 TRTLQIVPSIHRERSSMVGCATNVLDRVLSP------DAVDAAMYGD---
MAB_4059c|M.abscessus_ATCC_199 ---RDIRVTAFGNRVQEAGAGVVSLGGLFADPLGAMRRAS-ARRGEASAL
TH_0877|M.thermoresistible__bu ---LEIRTTAFGNRVQEAGAGVVSLGSLYADPIGAMRRALDAPRTSARVL
Mb0669|M.bovis_AF2122/97 LAGLRVVPAELGGAAGLVGAARLAAIA-----------------------
Rv0650|M.tuberculosis_H37Rv LAGLRVVPAELGGAAGLVGAARLAAIA-----------------------
MMAR_0987|M.marinum_M LAGLRVVPAELGGQAGLVGAARLAGLG-----------------------
MUL_0739|M.ulcerans_Agy99 LAGLRVVPAELGGQAGLVGAARLAGLG-----------------------
MAV_4510|M.avium_104 LSGLTVVPGELGGNAGLIGAARLATLARPAGS------------------
MLBr_01023|M.leprae_Br4923 -----MVAAALQNTAGIVGAAMASTADVTH--------------------
: *..
Mflv_1841|M.gilvum_PYR-GCK -------
Mvan_4888|M.vanbaalenii_PYR-1 -------
MSMEG_0316|M.smegmatis_MC2_155 -------
MAB_4059c|M.abscessus_ATCC_199 A------
TH_0877|M.thermoresistible__bu TGQHATG
Mb0669|M.bovis_AF2122/97 -------
Rv0650|M.tuberculosis_H37Rv -------
MMAR_0987|M.marinum_M -------
MUL_0739|M.ulcerans_Agy99 -------
MAV_4510|M.avium_104 -------
MLBr_01023|M.leprae_Br4923 -------