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LTLGLDIGGTKIAAALVDSSGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAADAPIAAVGIASAGPV DLPSGSVSPINIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWLGAGRGARFLLGMVVSTGVGGG LVLDGAPYPGRTGNAGHVGHVVVELDGRPCTCGGHGCVETVASGPSMVRWARENGWSAAPGAGARDLAAA AASDPLAQKAFHRSADALAAMIASVGAVCDLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLDFLSGLTVV PGELGGNAGLIGAARLATLARPAGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4510 | - | - | 100% (306) | sugar kinase |
| M. avium 104 | MAV_3594 | - | 2e-07 | 21.81% (298) | polyphosphate glucokinase |
| M. avium 104 | MAV_4665 | - | 4e-06 | 23.46% (260) | ROK family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0669 | - | 1e-123 | 72.85% (302) | sugar kinase |
| M. gilvum PYR-GCK | Mflv_5102 | - | 1e-110 | 67.45% (298) | ROK family protein |
| M. tuberculosis H37Rv | Rv0650 | - | 1e-123 | 72.85% (302) | sugar kinase |
| M. leprae Br4923 | MLBr_01023 | ppgK | 1e-05 | 22.82% (298) | polyphosphate glucokinase |
| M. abscessus ATCC 19977 | MAB_4059c | - | 2e-08 | 26.77% (254) | hypothetical protein MAB_4059c |
| M. marinum M | MMAR_0987 | - | 1e-123 | 74.09% (301) | carbohydrate kinase |
| M. smegmatis MC2 155 | MSMEG_1363 | - | 1e-113 | 69.57% (299) | glucokinase |
| M. thermoresistible (build 8) | TH_4374 | - | 1e-111 | 66.23% (302) | PUTATIVE glucokinase |
| M. ulcerans Agy99 | MUL_0739 | - | 1e-123 | 74.09% (301) | carbohydrate kinase |
| M. vanbaalenii PYR-1 | Mvan_1251 | - | 1e-113 | 69.02% (297) | ROK family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
Mflv_5102|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1251|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1363|M.smegmatis_MC2_155 --------------------------------------------------
TH_4374|M.thermoresistible__bu --------------------------------------------------
MAB_4059c|M.abscessus_ATCC_199 MTAPVRRPVSRHQIHPPALYIGDSAASSVFRAARVRGPVARDAIAQVTGL
MLBr_01023|M.leprae_Br4923 --------------------------------------------------
Mb0669|M.bovis_AF2122/97 -------------------------------------------MLTLCLD
Rv0650|M.tuberculosis_H37Rv -------------------------------------------MLTLCLD
MMAR_0987|M.marinum_M -------------------------------------------MLTLCLD
MUL_0739|M.ulcerans_Agy99 -------------------------------------------MLTLCLD
MAV_4510|M.avium_104 -------------------------------------------MLTLGLD
Mflv_5102|M.gilvum_PYR-GCK -------------------------------------MALSMSDLTLTLD
Mvan_1251|M.vanbaalenii_PYR-1 -----------------------------------------MNDLVLALD
MSMEG_1363|M.smegmatis_MC2_155 ------------------------------------------MTLTLALD
TH_4374|M.thermoresistible__bu -------------------------------------------VLTLTLD
MAB_4059c|M.abscessus_ATCC_199 SIATVNRQVTALLDAGLLRERADLAVSGAIGRPRVPVELNHEPFLTLGIH
MLBr_01023|M.leprae_Br4923 ---------------------------MIRLRSAAARDRCQVLSLAYRIT
*. :
Mb0669|M.bovis_AF2122/97 IGGTKIAAGLADPAGTLVHTAQRP-----TPAYGGAEQVWAAVAEMIADA
Rv0650|M.tuberculosis_H37Rv IGGTKIAAGLADPAGTLVHTAQRP-----TPAYGGAEQVWAAVAEMIADA
MMAR_0987|M.marinum_M IGGTKVAVGLADADGALVHTAQVP-----TPARCAAEQVWAAVAEAIAEA
MUL_0739|M.ulcerans_Agy99 IGGTKVAVGLADADGALVHTAQVP-----TPARCAAEQVWAAVAEAIAEA
MAV_4510|M.avium_104 IGGTKIAAALVDSSGTLVHTAVRP-----TPNPAPADDVWDVVHALIAEV
Mflv_5102|M.gilvum_PYR-GCK IGGTKLAAGLVDADGNLVRRAQTP-----TPD-GDAETIWDAVASLLAET
Mvan_1251|M.vanbaalenii_PYR-1 IGGTKIAAGLVDADGTLVHRAQQP-----TPD-GDAETVWDTAAALLAET
MSMEG_1363|M.smegmatis_MC2_155 IGGTKIAAGLVDDDGALVHQAQLP-----TPD-GDGELIWNVVDELVTGA
TH_4374|M.thermoresistible__bu IGGTKLAAGLVDGDGGLVHHTHAA-----TPG-GDAEAVWTVLAGLIDDA
MAB_4059c|M.abscessus_ATCC_199 IGARATSIVATDLFGRTLDVVETP-----TPNGPQGAALASLAGSAQRYL
MLBr_01023|M.leprae_Br4923 VAGRCQTVSPHHRQAKVSEQPSLAKEIAITSTDATADTPRTSPPSDTAGT
:.. : . . . *. .
Mb0669|M.bovis_AF2122/97 LGVAGGAVGGVG--IASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVP
Rv0650|M.tuberculosis_H37Rv LGVAGGAVGGVG--IASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVP
MMAR_0987|M.marinum_M LRVADATVAAVG--IASAGPVDLDSGTVSPINIGSWRGFPLRDRVAAMVP
MUL_0739|M.ulcerans_Agy99 LRVADATVAAVG--IASAGPVDLDSGTVSPINIGSWRGFPLRDRVAAMVP
MAV_4510|M.avium_104 VRAADAPIAAVG--IASAGPVDLPSGSVSPINIAGWHRFPLRDKVAAAVP
Mflv_5102|M.gilvum_PYR-GCK RSAADSTIGAVG--IASAGPVDVPAGTVSPINIAEWHRFPIVERVEAAT-
Mvan_1251|M.vanbaalenii_PYR-1 RDAAPGPVSAVG--IGSAGPIDVPGGTVSPINIAEWSHFPIVRRVADLT-
MSMEG_1363|M.smegmatis_MC2_155 LRVADGAVDGVG--IAAAGPIDLPGGTISPINIVEWQRFPIVDRVAAAT-
TH_4374|M.thermoresistible__bu LTRAGGRVRAVG--VGSAGPIDLTAGTVSPINLTAWSRFPLTERVSAALP
MAB_4059c|M.abscessus_ATCC_199 ARWHRRRPLWVG--VATGGVVDGPAGTVDHPRLG-WTEAPVG-RVFADTL
MLBr_01023|M.leprae_Br4923 TSRHRGFGIDIGGSSIKGGIVDLDIGQLIGDRIKLLTPQPATPLAVAKT-
:* .* :* * : .: * .
Mb0669|M.bovis_AF2122/97 GVPVRLGGDGVCMALGEHWLGAGRGARFLLG---LVVSTGVGGGLVLDGA
Rv0650|M.tuberculosis_H37Rv GVPVRLGGDGVCMALGEHWLGAGRGARFLLG---LVVSTGVGGGLVLDGA
MMAR_0987|M.marinum_M DVPVRLGGDGVCMALGEHWLGAGRGARFLLG---MVVSTGVGGGLVLGGV
MUL_0739|M.ulcerans_Agy99 DVPVRLGGDGVCMALGEHWLGAGRGARFLLG---MVVSTGVGGGLVLGGV
MAV_4510|M.avium_104 ATPVVLGGDGLCMALGEQWLGAGRGARFLLG---MVVSTGVGGGLVLDGA
Mflv_5102|M.gilvum_PYR-GCK GLPVYLGGDGLCMAMGEWWRGAGRNRRFMLG---MVVSTGIGGGLVLDGA
Mvan_1251|M.vanbaalenii_PYR-1 GLPVRLGGDGLCMALGEWWRGAGRGAGFLLG---MVVSTGIGGGLVLDGA
MSMEG_1363|M.smegmatis_MC2_155 GLPVRLGGDGLCMALGEHWRGAGRGAQFLLG---MVVSTGVGGGLVLDGA
TH_4374|M.thermoresistible__bu GVPVRLGGDGLCMAMGEQWRGAGRGARFVLG---IVVSTGVGGGLVLDGM
MAB_4059c|M.abscessus_ATCC_199 GLPVSVASHVDAMAGAELLLGLRRFAARSLTSLYVYARETVGFALAIDGR
MLBr_01023|M.leprae_Br4923 -IAEVVNAFGWTAPLGVTYPGVVTQGVVRTAANVDDSWIGTNARDIISAE
. : . . . * . :..
Mb0669|M.bovis_AF2122/97 PCLGRTGNAGHVGHVVVDP--DGSPCPCGGRGCVETIAS--GPSLARWAR
Rv0650|M.tuberculosis_H37Rv PCLGRTGNAGHVGHVVVDP--DGSPCPCGGRGCVETIAS--GPSLARWAR
MMAR_0987|M.marinum_M PYPGRTGNAGHVGHVVVDQ--DGLRCSCGGRGCVETIAA--GPSMVRWAR
MUL_0739|M.ulcerans_Agy99 PYPGRTGNAGHVGHVVVDQ--DGLRCSCGGRGCVETIAA--GPSMVRWAR
MAV_4510|M.avium_104 PYPGRTGNAGHVGHVVVEL--DGRPCTCGGHGCVETVAS--GPSMVRWAR
Mflv_5102|M.gilvum_PYR-GCK PFHGRTGNAGHVGHVVVEP--DGDACTCGGRGCVETVAS--GPHLARWAR
Mvan_1251|M.vanbaalenii_PYR-1 PYHGRSGNAGHVGHVVVEP--GGAPCTCGGRGCVETVAS--GPHLARWAH
MSMEG_1363|M.smegmatis_MC2_155 PYDGRTGNAGHAGHVIVELE-DGDLCTCGGHGCVETVAS--GPNMTRWAR
TH_4374|M.thermoresistible__bu PYQGRTGNAGHVGHVVVDP--RGVACSCGGRGCVETMAA--GPAMVRWAR
MAB_4059c|M.abscessus_ATCC_199 VHSPSSG-PGTIAALPVDS------ELLGGSGKLETTVS--DEAVLAAAR
MLBr_01023|M.leprae_Br4923 LNSQEVTILNDADAAGLAEGRYGAGKNNSGLIVLLTFGTGIGSAVIHNGK
. : .* : * : . : .:
Mb0669|M.bovis_AF2122/97 AN---GWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAV
Rv0650|M.tuberculosis_H37Rv AN---GWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAV
MMAR_0987|M.marinum_M AN---GWSARPEAGARELAAAAAAGDAVALAAFRRGTRGLAAMIASVGAV
MUL_0739|M.ulcerans_Agy99 AN---GWSARPEAGARELAAAAAAGDAVALAAFRRGTRGLAAMIASVGAV
MAV_4510|M.avium_104 EN---GWSAAPGAGARDLAAAAAS-DPLAQKAFHRSADALAAMIASVGAV
Mflv_5102|M.gilvum_PYR-GCK AH---GWEG---ADARELAEAAGRGEDVALRAFARGADAVARTIASVAAV
Mvan_1251|M.vanbaalenii_PYR-1 DN---GWAAAPDADAKDLAEAAGRGDPVALRAFARGADAVARTIASVAAV
MSMEG_1363|M.smegmatis_MC2_155 RQ---GWQAPADADAKELADAANAGDAVALAAYRRGARAVAAMIASVGAV
TH_4374|M.thermoresistible__bu AN---GWNAPPDADAEDLAAAAAAGVPVAVRAYRRGADALAAAISSVAAV
MAB_4059c|M.abscessus_ATCC_199 KLR--IVPAGDGVSVSAVYKAARGGNESARELLSERGRVLGQSVALLRDI
MLBr_01023|M.leprae_Br4923 LIPNTEFGHLEVDGKEAEQRAASSVKDKYKWSYRTWAKQVTRVLVAIENA
. ** : : :
Mb0669|M.bovis_AF2122/97 CDLDLAVIGGGVAKSGRLLFEPLRAALADHARLD--------FLAGLRVV
Rv0650|M.tuberculosis_H37Rv CDLDLAVIGGGVAKSGRLLFEPLRAALADHARLD--------FLAGLRVV
MMAR_0987|M.marinum_M CDLDRVVIGGGVAKAGRLLFDPLRAALADYLGLD--------FLAGLRVV
MUL_0739|M.ulcerans_Agy99 CDLDRVVIGGGVAKAGRLLFDPLRAALADYLGLD--------FLAGLRVV
MAV_4510|M.avium_104 CDLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLD--------FLSGLTVV
Mflv_5102|M.gilvum_PYR-GCK CDLDLVVVGGGVAKAGSLLFDPLHQALRTYAGLD--------FLTDLRVV
Mvan_1251|M.vanbaalenii_PYR-1 CDLDLVVVGGGVAKAGALLFDPLRQALTMYAGLE--------FLRGLRVV
MSMEG_1363|M.smegmatis_MC2_155 CDLDLVVIGGGVAKSGALLFDPIREALKNYAGLD--------FLRTLQVV
TH_4374|M.thermoresistible__bu CDLDLVVIGGGVARSGPVLFDPLAEALTTYTGLS--------FLRGLRVV
MAB_4059c|M.abscessus_ATCC_199 LNPDEVIVGGQAFTEYPEVMNDVETAFLDRSTLSKRDIRVTAFGNRVQEA
MLBr_01023|M.leprae_Br4923 MCPDLFIAGGGISRKADRWIPLLENRTP--------------------MV
* : ** : : .
Mb0669|M.bovis_AF2122/97 PAELGGAAGLVGAARLAAIA------------
Rv0650|M.tuberculosis_H37Rv PAELGGAAGLVGAARLAAIA------------
MMAR_0987|M.marinum_M PAELGGQAGLVGAARLAGLG------------
MUL_0739|M.ulcerans_Agy99 PAELGGQAGLVGAARLAGLG------------
MAV_4510|M.avium_104 PGELGGNAGLIGAARLATLARPAGS-------
Mflv_5102|M.gilvum_PYR-GCK PAELGGDAGLVGAAALAAHHGRFG--------
Mvan_1251|M.vanbaalenii_PYR-1 PAELGGDAGLVGAAALVHDSVRFG--------
MSMEG_1363|M.smegmatis_MC2_155 PAELGGDAGLIGAAALARA-------------
TH_4374|M.thermoresistible__bu PARLGATAGLIGAARLAISAC-----------
MAB_4059c|M.abscessus_ATCC_199 GAGVVSLGGLFADPLGAMRRASARRGEASALA
MLBr_01023|M.leprae_Br4923 AAALQNTAGIVGAAMASTADVTH---------
. : .*:.. .