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MPRSVLVTGATGTLGHHVVPEATQAGHAVRALSRRPRVGYTGVHWQQGDLSDAGTLDAALDGIDTVVHCA TQPTGDKDIVAARNLTNAVRRNNVGHLIYVSIVGIDKIPLPYYRTKLRVEQLLADSGVPHTIQRATQFHE LIKRIFDIQRFSPVLVALRDVRFQPIDTRDVASRLVELIDQEPGGRVTDMGGPEVVEHPDLAQMYLAAHS SRRRVVRFTPPGRIAAGYRSGAHLTPDNAVGTVTFQQYLASGT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_5504 | - | - | 100% (253) | hypothetical protein MSMEG_5504 |
M. smegmatis MC2 155 | MSMEG_2353 | - | 6e-23 | 32.05% (259) | secreted protein |
M. smegmatis MC2 155 | MSMEG_4426 | - | 2e-21 | 34.25% (219) | secreted protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1136c | - | 2e-08 | 31.58% (114) | cholesterol dehydrogenase |
M. gilvum PYR-GCK | Mflv_1635 | - | 8e-19 | 30.38% (237) | NAD-dependent epimerase/dehydratase |
M. tuberculosis H37Rv | Rv1106c | - | 2e-08 | 31.58% (114) | cholesterol dehydrogenase |
M. leprae Br4923 | MLBr_01942 | - | 5e-07 | 27.33% (161) | putative cholesterol dehydrogenase |
M. abscessus ATCC 19977 | MAB_3360c | - | 5e-21 | 34.11% (214) | hypothetical protein MAB_3360c |
M. marinum M | MMAR_4766 | - | 7e-22 | 30.50% (259) | hypothetical protein MMAR_4766 |
M. avium 104 | MAV_4078 | - | 2e-17 | 31.58% (247) | hypothetical protein MAV_4078 |
M. thermoresistible (build 8) | TH_3570 | - | 1e-22 | 36.32% (223) | PUTATIVE secreted protein |
M. ulcerans Agy99 | MUL_2265 | - | 1e-08 | 25.00% (240) | hypothetical protein MUL_2265 |
M. vanbaalenii PYR-1 | Mvan_2101 | - | 1e-22 | 32.54% (252) | dTDP-4-dehydrorhamnose reductase |
CLUSTAL 2.0.9 multiple sequence alignment MAB_3360c|M.abscessus_ATCC_199 --------------MKITVVGATGQIGSRVVSLLIADGHDVVAASLS--- Mvan_2101|M.vanbaalenii_PYR-1 --------------MKISVIGATGLIGSKVVDLLQRDGHHVVAASRA--- TH_3570|M.thermoresistible__bu ---------VEGAVMRITVFGATGRIGSEVVALLRADGHDVVPASLS--- MMAR_4766|M.marinum_M --------------MKILVIGGSGLIGSQVVAQLTGLAHQAVAASPR--- MSMEG_5504|M.smegmatis_MC2_155 ------------MPRSVLVTGATGTLGHHVVPEATQAGHAVRALSRRPRV Mb1136c|M.bovis_AF2122/97 MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPSL Rv1106c|M.tuberculosis_H37Rv MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPSL MLBr_01942|M.leprae_Br4923 MLRGVGNASLTTELGRVLVTGGSGFVGANLVTALLERGYQVRSFDRAPMP MAV_4078|M.avium_104 ----------MRALTTIAVIGATGTAGSRVVARLRPRDVAVVEISRA--- Mflv_1635|M.gilvum_PYR-GCK ---------MPGNDVRCVVTGATGYIGGRLVPELLARGLQVRAMARTPSK MUL_2265|M.ulcerans_Agy99 --------------MRVAVTGAGGVLGRGLASRLLSQGHEVVGMSRRRPD * *. * * :. . MAB_3360c|M.abscessus_ATCC_199 -------SGANVLTGEG-----------LVDALTGSAVVIDVVNSPSFED Mvan_2101|M.vanbaalenii_PYR-1 -------SGADVLTGEG-----------LTDALAGADVLVDVTNSPSFDD TH_3570|M.thermoresistible__bu -------TGADVVTGAG-----------LADSLSGADVLVDVVNSPSFAD MMAR_4766|M.marinum_M -------SGVNALTGEG-----------LADAVAGADAVVDVSNSPSFAD MSMEG_5504|M.smegmatis_MC2_155 G-----YTGVHWQQGD------------LSDAGTLDAALDGIDTVVHCAT Mb1136c|M.bovis_AF2122/97 LP---AHPQLEVLQGDITDADVCAAAVDGIDTIFHTAAIIELMGGASVTD Rv1106c|M.tuberculosis_H37Rv LP---AHPQLEVLQGDITDADVCAAAVDGIDTIFHTAAIIELMGGASVTD MLBr_01942|M.leprae_Br4923 LP---QHPQLEVLQGDITDATVCTTAMDSIDTVFHTAAIIELMGGASVTD MAV_4078|M.avium_104 -------QGVDVFDAPG-----------LTRALEGVDVVIDVSNPVPPDG Mflv_1635|M.gilvum_PYR-GCK LDRTEWRDRVEVVRGDLT----------EADSLTAAFNGADVVYYLVHSM MUL_2265|M.ulcerans_Agy99 SWP----SQADFVAGDIR------DAAAVRRAITGADVVAHCAWARNPGP . . : MAB_3360c|M.abscessus_ATCC_199 GPVMDFFTA---SARNLVDAAKATGVGHYVALS-----------IVGADG Mvan_2101|M.vanbaalenii_PYR-1 DAVMDFFTR---SSANLVSAAEESGVRHYVALS-----------IVGADG TH_3570|M.thermoresistible__bu GPVSEFFTA---AALNLTAAARAAGVGHHVALS-----------IVGCDE MMAR_4766|M.marinum_M DDVLHFFTT---STKNLLAAEQTAGVRHHVALS-----------IVGTDR MSMEG_5504|M.smegmatis_MC2_155 QPTGDKDIV---AARNLTNAVRRNNVGHLIYVS-----------IVGIDK Mb1136c|M.bovis_AF2122/97 EYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGDET Rv1106c|M.tuberculosis_H37Rv EYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGDET MLBr_01942|M.leprae_Br4923 EYRQRSYTVNVGGTENLLRAGQKSGVKRFVYTASNSVVMGGTPITGGDET MAV_4078|M.avium_104 RSDIRQTLAT--AARNIMGACATQEVQRLVVLT-----------IAGIED Mflv_1635|M.gilvum_PYR-GCK GTSRDFVAEERRSAHNVVEAAKKAGVRRIVYLSG-----------LHPDR MUL_2265|M.ulcerans_Agy99 DGRISQQIN-IDGTRNVLDAMAACGTGRIVFPSSPHVYRPGLPMPATEHG .: *: * . : : : . MAB_3360c|M.abscessus_ATCC_199 LPESG-----YMRAKVAQEKIIVGSGLP----------------YTIVRA Mvan_2101|M.vanbaalenii_PYR-1 LPESG-----YMRAKVVQEKTIAGSDVP----------------HSIVRA TH_3570|M.thermoresistible__bu LPDSG-----YMRAKAAQERIIAESGLP----------------YTIVRA MMAR_4766|M.marinum_M VPNSG-----YLRAKCAQEKLIKESDLP----------------YSIVRA MSMEG_5504|M.smegmatis_MC2_155 IPLP------YYRTKLRVEQLLADSGVP----------------HTIQRA Mb1136c|M.bovis_AF2122/97 LPYTDRFNDLYTETKVVAERFVLAQNGV-DG--MLTCAIRPSGIWGNGDQ Rv1106c|M.tuberculosis_H37Rv LPYTDRFNDLYTETKVVAERFVLAQNGV-DG--MLTCAIRPSGIWGNGDQ MLBr_01942|M.leprae_Br4923 MPYTKRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIRPSGIWGRGDQ MAV_4078|M.avium_104 PVFDEFP---YYQAKREAKEILLDGPVP----------------TTVVKS Mflv_1635|M.gilvum_PYR-GCK KELSR-----HLASRVEVGEILMQSGIETVVLQAG---------IVIGSG MUL_2265|M.ulcerans_Agy99 AVAPAS---AEGRHKAGVEQMLQESGAQ---------------WVAVRSA : . : MAB_3360c|M.abscessus_ATCC_199 TQFQEFAEAITD---TLVVGDEVRVPD-ARIQLIAVDDVSTQVAHAAAAA Mvan_2101|M.vanbaalenii_PYR-1 TQFHEFADAIVG---TLEADDEVRVPD-ARIQPIAADDVAAEVFRAAVGS TH_3570|M.thermoresistible__bu TQFDEFAEAIVE---SLIVGAEVRVPD-GSIQPIAAADVAAEVAARAVAE MMAR_4766|M.marinum_M TQFFEFVIGIAD---SATDGDTVRLSHTAAIQPIAASDVATGVTRAAISD MSMEG_5504|M.smegmatis_MC2_155 TQFHELIKRIFD---IQRFSPVLVALRDVRFQPIDTRDVASRLVELIDQE Mb1136c|M.bovis_AF2122/97 TMFRKLFESVLKGHVKVLVGRKSARLDNSYVHNLIHGFILAAAHLVPDGT Rv1106c|M.tuberculosis_H37Rv TMFRKLFESVLKGHVKVLVGRKSARLDNSYVHNLIHGFILAAAHLVPDGT MLBr_01942|M.leprae_Br4923 TMFRKAFESVVSGHVKVLIGSKNAKLDNSYVHNLVHGLILAAEHLVPGGT MAV_4078|M.avium_104 TQWYEFATNHDA----VSCDDNEVIVEDWLIQPIAADTVADVLVETALAQ Mflv_1635|M.gilvum_PYR-GCK SASFEMVRHLTD----RLPVMTTPKWVHNKIQPISISDVLHYLAEAATAE MUL_2265|M.ulcerans_Agy99 LIVGRNIDNWVRR--LFALPAFPDGSADDVLQVVHLDDVLRLLTRAVSDV . .: : : MAB_3360c|M.abscessus_ATCC_199 PR-NGIINIGGPEKFSFADMAGAVLAARGDDRPVVVDSGATY------FG Mvan_2101|M.vanbaalenii_PYR-1 PV-DGVINIGGPDKISFADLARAVLARRGADKTVVIDPQATY------FG TH_3570|M.thermoresistible__bu PA-GGVVNIGGPDRMSFADLARTVLAHQHRRTPVVIDPQATY------FG MMAR_4766|M.marinum_M PL-NGTTNIAGPDKFGMDDFVRMGLAAHGDSRQVRTDPNARY------FG MSMEG_5504|M.smegmatis_MC2_155 PG-GRVTDMGGPEVVEHPDLAQMYLAAHSSRRRVVRFTPPGR------IA Mb1136c|M.bovis_AF2122/97 AP-GQAYFINDAEPINMFEFARPVLEACGQRWPKMRISGPAVRWVMTGWQ Rv1106c|M.tuberculosis_H37Rv AP-GQAYFINDAEPINMFEFARPVLEACGQRWPKMRISGPAVRWVMTGWQ MLBr_01942|M.leprae_Br4923 AP-GQAYFINDGEPINFFDFMGPIIKACGENWPRVRISGRLVRNVMAVWQ MAV_4078|M.avium_104 T--HTPRTITGPDAIRLPELTSKLLVRQGDRRAVRSVEPAVSALG----A Mflv_1635|M.gilvum_PYR-GCK FGESRTWDIGGPDVMEYGDAMQGYADVAGLRRRVMVVLPFLTPTIASWWV MUL_2265|M.ulcerans_Agy99 GAGTGPVNLAAPGLPTLREIATALRRPILPVGAALRRIGSVAEFQLVQGV : : MAB_3360c|M.abscessus_ATCC_199 TPVD------DFSLVT--GDDGVLTQTRFADWMARR-------------- Mvan_2101|M.vanbaalenii_PYR-1 TPLD------QNSLVT--GDGAVLGAVRFADHH----------------- TH_3570|M.thermoresistible__bu TRID------DTSLVT--GAGAVIAGTPLAAVLAPPASD----------- MMAR_4766|M.marinum_M AVLD------GHSIVPTDGEDVTIYPTHFSDWLAAG-------------- MSMEG_5504|M.smegmatis_MC2_155 AGYR------SGAHLT---PDNAVGTVTFQQYLASGT------------- Mb1136c|M.bovis_AF2122/97 RLHF------RFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTT Rv1106c|M.tuberculosis_H37Rv RLHF------RFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTT MLBr_01942|M.leprae_Br4923 RLHF------GFGLPKPPMEPLAVERVYLDNYFSIEKAHKELGYRPLFTT MAV_4078|M.avium_104 GALL------ASGHAVVVGPDVDTWLQTLAPPGGDGHRGRDGDGHRGADG Mflv_1635|M.gilvum_PYR-GCK GLVTPIPSGLARPLVESLECDAICHEHDIDAVIPPPKGGLIGYREAVAKE MUL_2265|M.ulcerans_Agy99 PVMDTARLHDEWKFQPAFTAEESVEDFALAVRGRVSLGRRVVSLPWRLAN : MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 QQALTECLPYYVSLFEQMKNEAR--AEKTAATVKP--------------- Rv1106c|M.tuberculosis_H37Rv QQALTECLPYYVSLFEQMKNEAR--AEKTAATVKP--------------- MLBr_01942|M.leprae_Br4923 EQAMAECLPYYTELFEQIKVAAKPHLASIAATPRPE-------------- MAV_4078|M.avium_104 DHRGADGDGKPRRG------------------------------------ Mflv_1635|M.gilvum_PYR-GCK LRSEGGSSAGRRHLLRFSPAASD--------------------------- MUL_2265|M.ulcerans_Agy99 IQDLPAIDASAQDGVVPRLAGPEGVNGEFDTPIDPRFPTFLATNLSEALP MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 GPFSPSSASVTVRGLRAGGVGIAERLRPGGVIQREIAMRTVAVFAHRLYG MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 AITSAHFMAETVPFAKPAMIVSNSGFFGPSMGSLPIFGEERPPAESSFVR MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 RQLCTVRNIGVFGVNLVGLSAGSALDTNDFIADVDRLEQLAGGDVTTLDD MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 RRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRAVSGRDTAPAAGPE MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 LVSARSVEAVQRLVDAARHDEAVIRLLSEPGDRLGKLAVAAPHFYDAVRQ MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 ELSLIGHRGPAEVEMMSTSYADNPELLVGMVAKTLSTSSVPQPPQPSIPL MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 QAKPIAVLAARQLRDREARRDKMVRAIWVLRALLREHGRRLAEAGVLHAS MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 DDVFYLLVDEVDALPADVAELVARRRAEQRRLTAVVPPTVFSGKWEPSTA MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 SAAALTAEGTLRGVGVCGGRVRGRVRIVRPETIDELEPGEILVAEVTDVG MAB_3360c|M.abscessus_ATCC_199 -------------------------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3570|M.thermoresistible__bu -------------------------------------------------- MMAR_4766|M.marinum_M -------------------------------------------------- MSMEG_5504|M.smegmatis_MC2_155 -------------------------------------------------- Mb1136c|M.bovis_AF2122/97 -------------------------------------------------- Rv1106c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01942|M.leprae_Br4923 -------------------------------------------------- MAV_4078|M.avium_104 -------------------------------------------------- Mflv_1635|M.gilvum_PYR-GCK -------------------------------------------------- MUL_2265|M.ulcerans_Agy99 YTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALI MAB_3360c|M.abscessus_ATCC_199 ------------------------------- Mvan_2101|M.vanbaalenii_PYR-1 ------------------------------- TH_3570|M.thermoresistible__bu ------------------------------- MMAR_4766|M.marinum_M ------------------------------- MSMEG_5504|M.smegmatis_MC2_155 ------------------------------- Mb1136c|M.bovis_AF2122/97 ------------------------------- Rv1106c|M.tuberculosis_H37Rv ------------------------------- MLBr_01942|M.leprae_Br4923 ------------------------------- MAV_4078|M.avium_104 ------------------------------- Mflv_1635|M.gilvum_PYR-GCK ------------------------------- MUL_2265|M.ulcerans_Agy99 EVDGTTGEIQVLELAAEGDSSVTQSDPADLA