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ELRQLRYFVTVADELNFGRAAERLRIAGPSLSQQIKALERDLKVTLFDRDRRSVTLTSAGSALLPGARAL IAQADELRRQASGLAVSDPVRIGCVQWCPTDWAERAAGVAELRVDTWVMPSHAQAARVADGNLDLAICWV QNADLQAMDLSARLIGVDRLYALDAGSGTGPIRAADTTVLIDDDTTSWSSWNRYAEQFAASTGARVMRTD DGGVTGPTFFEHVRQLRRPMLNNPKGQDDTPPTGLTRRAVVDPSPLWTWSLVWRRGDTNPGVLAIVDEFT RDVGDFGLDSAAVWLPDDDPHHPRHQRGH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5712 | - | - | 100% (310) | LysR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1902 | - | 1e-20 | 39.33% (150) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1895 | - | 1e-17 | 40.41% (146) | HTH-type transcriptional regulator AlsR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 3e-11 | 35.92% (103) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_3565 | - | 3e-17 | 37.74% (159) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 3e-11 | 35.92% (103) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02663 | oxyS | 8e-13 | 37.86% (103) | putative LysR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3208c | - | 3e-16 | 35.09% (171) | LysR family transcriptional regulator |
| M. marinum M | MMAR_0317 | oxyS | 4e-12 | 38.78% (98) | oxidative stress response regulatory protein OxyS |
| M. avium 104 | MAV_5191 | - | 5e-12 | 37.86% (103) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 2e-10 | 42.67% (75) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_4805 | oxyS | 2e-12 | 37.86% (103) | oxidative stress response regulatory protein OxyS |
| M. vanbaalenii PYR-1 | Mvan_4315 | - | 2e-17 | 39.04% (146) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0317|M.marinum_M MKLLGAPKINPELTLAQIPGSDSLVVIPIPRTSGLARRAAPAVQPRCGVT
MUL_4805|M.ulcerans_Agy99 --------------------------------------------------
Mb0121|M.bovis_AF2122/97 --------------------------------------------------
Rv0117|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02663|M.leprae_Br4923 --------------------------------------------------
MAV_5191|M.avium_104 --------------------------------------------------
Mflv_3565|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3208c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3504|M.thermoresistible__bu --------------------------------------------------
Mvan_4315|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5712|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0317|M.marinum_M RTAQWRADLVATVQDLAAQSGTGGRQRSGGGGSLSESVPMTEEVSVLFRQ
MUL_4805|M.ulcerans_Agy99 ---------------------------------------------MLFRQ
Mb0121|M.bovis_AF2122/97 ---------------------------------------------MLFRQ
Rv0117|M.tuberculosis_H37Rv ---------------------------------------------MLFRQ
MLBr_02663|M.leprae_Br4923 ---------------------------------------------MLFRQ
MAV_5191|M.avium_104 ---------------------------------------------MLFRQ
Mflv_3565|M.gilvum_PYR-GCK ---------------------------------------------MELRQ
MAB_3208c|M.abscessus_ATCC_199 ---------------------------------------------MELRQ
TH_3504|M.thermoresistible__bu ----------------------------------------VPSPKIDLRR
Mvan_4315|M.vanbaalenii_PYR-1 -------------------------------------------MDIDFTR
MSMEG_5712|M.smegmatis_MC2_155 ---------------------------------------------MELRQ
: : :
MMAR_0317|M.marinum_M LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MUL_4805|M.ulcerans_Agy99 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELHVTLINRGHSFE
Mb0121|M.bovis_AF2122/97 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
Rv0117|M.tuberculosis_H37Rv LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MLBr_02663|M.leprae_Br4923 LEYFVAVAQERHFARAAERCYVSQPALSSAIAKLERELNVTLINRGHSFE
MAV_5191|M.avium_104 LEYFVAVASERHFARAAEKCFVSQPALSAAIAKLEKELNVTLINRGHSFE
Mflv_3565|M.gilvum_PYR-GCK LEYFVAIVEEGGFTRAASRERVAQPAVSAQIRRLERSVGQPLLTRTSREV
MAB_3208c|M.abscessus_ATCC_199 LEYFLAVAEHANFTRAAEALHVAQPWVSAQVRRLERELGNELFDRSSRVL
TH_3504|M.thermoresistible__bu LAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDVGADLFTRDGRRI
Mvan_4315|M.vanbaalenii_PYR-1 LRYFVAVADELHFKRAADKLMITPPPLSKQIKLLEKELGGPLFERGYHDV
MSMEG_5712|M.smegmatis_MC2_155 LRYFVTVADELNFGRAAERLRIAGPSLSQQIKALERDLKVTLFDRDRRSV
* *:::.. * *** :: :* : **..: *: *
MMAR_0317|M.marinum_M GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVPSAS-TT
MUL_4805|M.ulcerans_Agy99 GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVRSAS-TT
Mb0121|M.bovis_AF2122/97 GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTAS-TT
Rv0117|M.tuberculosis_H37Rv GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTAS-TT
MLBr_02663|M.leprae_Br4923 GLTPEGERLVVWAKRILAEHDAFKAEVHAVRSGITGTLRLGTVPTAS-TT
MAV_5191|M.avium_104 GLTPEGERLVVWARRILAEHDAFKAEVDAVRSGVTGTLRLGTVPTAS-TT
Mflv_3565|M.gilvum_PYR-GCK RLTRAGEALLPHARAALAAVRDGRAAVDDVAGLLRGSVAIGTVTLHP-MN
MAB_3208c|M.abscessus_ATCC_199 RLTEFGKALLPLAGAALRTVGEIRSAADAMAGVLCGQLAIGTVPHPS-PL
TH_3504|M.thermoresistible__bu SLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHYVIGHTPALSGAE
Mvan_4315|M.vanbaalenii_PYR-1 RLTPLGQRLVGPAREILRQVEEFKAVATQAVRGLAPVRVSATAYAPS--D
MSMEG_5712|M.smegmatis_MC2_155 TLTSAGSALLPGARALIAQADELRRQASGLAVSDPVRIGCVQWCPTDWAE
** * *: . : .
MMAR_0317|M.marinum_M ASLVLSDFCSAHPLVKAQICSRLAVTELYRRLRDFELDAAIVYTSSD---
MUL_4805|M.ulcerans_Agy99 ASLVLSDFCSAHPLVKAQICSRLAVTELYRRLRDFERDAAIVYTSSD---
Mb0121|M.bovis_AF2122/97 ASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQ---
Rv0117|M.tuberculosis_H37Rv ASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQ---
MLBr_02663|M.leprae_Br4923 ASLVLSAFCSEHPLIKVQICSRLPVTELHRRLGDFELDAVIVHSAPD---
MAV_5191|M.avium_104 ASLLLSAFCSAHPLVKVQILSRLSAGELYRRLREFELDAAIAHTAPD---
Mflv_3565|M.gilvum_PYR-GCK VAHLIAEFHADHPDVEITLG-TATSDVLIAELGDGRLDLAIVSIAVDE--
MAB_3208c|M.abscessus_ATCC_199 LAEALAAYRRAHPAVTVTLT-EARSDQLATAVVERRLDMAVMAWLAQP--
TH_3504|M.thermoresistible__bu AYALIEPAVTAYPSTSFTLR-QLYPDALTDAVFDGTVQLGLRRGVVP---
Mvan_4315|M.vanbaalenii_PYR-1 LLGELEAAIASLP-VPTEFSVPGSAAEVTAKLIAGQAELGLIHLPAN---
MSMEG_5712|M.smegmatis_MC2_155 RAAGVAELRVDTWVMPSHAQAARVADGNLDLAICWVQNADLQAMDLSARL
: : :
MMAR_0317|M.marinum_M -DGHDVDLVPLYEERYVLLAPPEMLPPGVSTLSWLDAA--QLPLALLSSD
MUL_4805|M.ulcerans_Agy99 -DGHDVDLVPLYEERYVLLAPPEMLPPGVSTLSWLDAA--QLPLALLSSD
Mb0121|M.bovis_AF2122/97 -DSDDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAA--QLPLALLTAD
Rv0117|M.tuberculosis_H37Rv -DSDDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAA--QLPLALLTAD
MLBr_02663|M.leprae_Br4923 -DTHAVDLVPLYHEHYVLVSPADMLPPGASVLAWPEAS--QLPLALLTPD
MAV_5191|M.avium_104 -DIPDVNLVPVYRERYVLLAPADLLASGAATMTWVQAA--QLPLALLTPD
Mflv_3565|M.gilvum_PYR-GCK -DLPGLEVAVITDEAVEAAVADGHPLAHRRSLSLEQLS--RHPLISLPAG
MAB_3208c|M.abscessus_ATCC_199 -PSQ-LRERILAKENIVAVVHRDDPLAGRESVALAELR--DRALISHPQG
TH_3504|M.thermoresistible__bu --TPELATAVIGYHRVRVAFVDSHPLAARESVDITELAREQVALWAPPGT
Mvan_4315|M.vanbaalenii_PYR-1 --DKRLRYKVVASYQGGIAVRFDDPLAAKDLVSIEELRDREVAIDVARPN
MSMEG_5712|M.smegmatis_MC2_155 IGVDRLYALDAGSGTGPIRAADTTVLIDDDTTSWSSWNRYAEQFAASTGA
: . :
MMAR_0317|M.marinum_M MRDRQIIDAAFADHAITVSPQVETDSVASLFAQVATGNSASIVPHTWLWT
MUL_4805|M.ulcerans_Agy99 MRDRQIIDAAFADHAITVSPQVETDSVASLFAQVATGNSASIVPHTWLWT
Mb0121|M.bovis_AF2122/97 MRDRQVIDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWA
Rv0117|M.tuberculosis_H37Rv MRDRQVIDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWA
MLBr_02663|M.leprae_Br4923 MRDRQLIDRAFAGHAITATPQVETDSVASLFAQVATGNWACIVPHTWLWT
MAV_5191|M.avium_104 MRDRQIIDRAFADHGITLHPQVETDSVASLFAQASAGSWASIVPHTWLWA
Mflv_3565|M.gilvum_PYR-GCK TGLRTRLDTACAAAGLRPRIAFEATSPAELAELARHGLGVAILPQSMARG
MAB_3208c|M.abscessus_ATCC_199 CEIRTALDQACLATGFTPRVVFETSSADMMRHLVVRDLGVAVTPRLPREQ
TH_3504|M.thermoresistible__bu SYYSDFLMGACRRAGFEPDYVVSRVQGAATVAAPLTTGGIAFVTAAAGPT
Mvan_4315|M.vanbaalenii_PYR-1 PVVLAGLTRGLNRKGVHRIVRTTNQRGGEVEMATQVFNRHLVAVVSYAPD
MSMEG_5712|M.smegmatis_MC2_155 RVMRTDDGGVTGPTFFEHVRQLRRPMLNNPKGQDDTPPTGLTRRAVVDPS
.
MMAR_0317|M.marinum_M TPAG----GEIRPVQLVSPVVKAQVALATSSTGPGSPVARALMTSAQGLA
MUL_4805|M.ulcerans_Agy99 TPGR----------------------------------------------
Mb0121|M.bovis_AF2122/97 MPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQALA
Rv0117|M.tuberculosis_H37Rv MPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQALA
MLBr_02663|M.leprae_Br4923 TPIG----AEIRAVEMVDPVLKADVALATNSAGPGSPVARALVASAKQLA
MAV_5191|M.avium_104 SPLG----PGIRAVELVDPVLTADVVLAIKSHGPGSPIARALAASAGRLQ
Mflv_3565|M.gilvum_PYR-GCK -------GSGLHALRLAP-ELRGRLVWAWRADG-ANPAARVLGERARAMA
MAB_3208c|M.abscessus_ATCC_199 -------LGRLRQIDLSDRAMSGRLSLLWRGKG-ATLEAVAFAACIDELC
TH_3504|M.thermoresistible__bu MN------GRVQVVDLTPPLLVP-VQALWQRHTLSAIRDRILEGLG----
Mvan_4315|M.vanbaalenii_PYR-1 SFIG-----KIFSPPEFKLIPLDESTWAPAEIALAWVPERVQARLTEVEL
MSMEG_5712|M.smegmatis_MC2_155 PLWTWSLVWRRGDTNPGVLAIVDEFTRDVGDFGLDSAAVWLPDDDPHHPR
MMAR_0317|M.marinum_M LDEFFQTRLMEISRRR
MUL_4805|M.ulcerans_Agy99 ----------------
Mb0121|M.bovis_AF2122/97 LNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv LNEFFDTQLRGITRRR
MLBr_02663|M.leprae_Br4923 LNEFFEAQLAGITRRR
MAV_5191|M.avium_104 LNDFFDAQLLGVTRRR
Mflv_3565|M.gilvum_PYR-GCK VSPGSGAPAVVPGA--
MAB_3208c|M.abscessus_ATCC_199 RKDAN----LVS----
TH_3504|M.thermoresistible__bu ----------------
Mvan_4315|M.vanbaalenii_PYR-1 MVEQIADRLGPVHRGA
MSMEG_5712|M.smegmatis_MC2_155 HQRGH-----------