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MDIDFTRLRYFVAVADELHFKRAADKLMITPPPLSKQIKLLEKELGGPLFERGYHDVRLTPLGQRLVGPA REILRQVEEFKAVATQAVRGLAPVRVSATAYAPSDLLGELEAAIASLPVPTEFSVPGSAAEVTAKLIAGQ AELGLIHLPANDKRLRYKVVASYQGGIAVRFDDPLAAKDLVSIEELRDREVAIDVARPNPVVLAGLTRGL NRKGVHRIVRTTNQRGGEVEMATQVFNRHLVAVVSYAPDSFIGKIFSPPEFKLIPLDESTWAPAEIALAW VPERVQARLTEVELMVEQIADRLGPVHRGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4315 | - | - | 100% (310) | LysR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 7e-16 | 39.73% (146) | LysR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4518 | - | 1e-15 | 28.33% (293) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 4e-12 | 48.72% (78) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_2332 | - | 1e-162 | 92.26% (310) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 4e-12 | 48.72% (78) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02663 | oxyS | 2e-13 | 48.72% (78) | putative LysR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3208c | - | 1e-18 | 31.75% (189) | LysR family transcriptional regulator |
| M. marinum M | MMAR_0317 | oxyS | 5e-13 | 48.72% (78) | oxidative stress response regulatory protein OxyS |
| M. avium 104 | MAV_5191 | - | 7e-15 | 37.50% (152) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_1902 | - | 1e-129 | 73.86% (306) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_3504 | - | 3e-12 | 30.50% (200) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_4805 | oxyS | 5e-13 | 48.72% (78) | oxidative stress response regulatory protein OxyS |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0317|M.marinum_M MKLLGAPKINPELTLAQIPGSDSLVVIPIPRTSGLARRAAPAVQPRCGVT
MUL_4805|M.ulcerans_Agy99 --------------------------------------------------
Mb0121|M.bovis_AF2122/97 --------------------------------------------------
Rv0117|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02663|M.leprae_Br4923 --------------------------------------------------
MAV_5191|M.avium_104 --------------------------------------------------
Mvan_4315|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2332|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1902|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3208c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3504|M.thermoresistible__bu --------------------------------------------------
MMAR_0317|M.marinum_M RTAQWRADLVATVQDLAAQSGTGGRQRSGGGGSLSESVPMTEEVSVLFRQ
MUL_4805|M.ulcerans_Agy99 ---------------------------------------------MLFRQ
Mb0121|M.bovis_AF2122/97 ---------------------------------------------MLFRQ
Rv0117|M.tuberculosis_H37Rv ---------------------------------------------MLFRQ
MLBr_02663|M.leprae_Br4923 ---------------------------------------------MLFRQ
MAV_5191|M.avium_104 ---------------------------------------------MLFRQ
Mvan_4315|M.vanbaalenii_PYR-1 -------------------------------------------MDIDFTR
Mflv_2332|M.gilvum_PYR-GCK -------------------------------------------MDIDFTR
MSMEG_1902|M.smegmatis_MC2_155 -------------------------------------------MEIDFTR
MAB_3208c|M.abscessus_ATCC_199 ---------------------------------------------MELRQ
TH_3504|M.thermoresistible__bu ----------------------------------------VPSPKIDLRR
: : :
MMAR_0317|M.marinum_M LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MUL_4805|M.ulcerans_Agy99 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELHVTLINRGHSFE
Mb0121|M.bovis_AF2122/97 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
Rv0117|M.tuberculosis_H37Rv LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MLBr_02663|M.leprae_Br4923 LEYFVAVAQERHFARAAERCYVSQPALSSAIAKLERELNVTLINRGHSFE
MAV_5191|M.avium_104 LEYFVAVASERHFARAAEKCFVSQPALSAAIAKLEKELNVTLINRGHSFE
Mvan_4315|M.vanbaalenii_PYR-1 LRYFVAVADELHFKRAADKLMITPPPLSKQIKLLEKELGGPLFERGYHDV
Mflv_2332|M.gilvum_PYR-GCK LRYFVAVADELHFKRAADKLRITPPPLSKQIKLLEKELGGPLFERGYHEV
MSMEG_1902|M.smegmatis_MC2_155 LRYFVAVAEELHFKRAADRLMITPPPLSKQIKLLEKELGGQLFERNYHEV
MAB_3208c|M.abscessus_ATCC_199 LEYFLAVAEHANFTRAAEALHVAQPWVSAQVRRLERELGNELFDRSSRVL
TH_3504|M.thermoresistible__bu LAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDVGADLFTRDGRRI
* *:***. * *** :: :* : **.:: *: *.
MMAR_0317|M.marinum_M GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVPSAS-TT
MUL_4805|M.ulcerans_Agy99 GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVRSAS-TT
Mb0121|M.bovis_AF2122/97 GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTAS-TT
Rv0117|M.tuberculosis_H37Rv GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTAS-TT
MLBr_02663|M.leprae_Br4923 GLTPEGERLVVWAKRILAEHDAFKAEVHAVRSGITGTLRLGTVPTAS-TT
MAV_5191|M.avium_104 GLTPEGERLVVWARRILAEHDAFKAEVDAVRSGVTGTLRLGTVPTAS-TT
Mvan_4315|M.vanbaalenii_PYR-1 RLTPLGQRLVGPAREILRQVEEFKAVATQAVRGLA-PVRVSATAYAP-SD
Mflv_2332|M.gilvum_PYR-GCK RLSPLGERLVGPAREILRQVEDFKAAATQGVRGLA-PLRVSATAYAP-SD
MSMEG_1902|M.smegmatis_MC2_155 RLTPLGEKLLGPARDILARVEDLKATASRITQGVA-PVRVGATAYAP-SD
MAB_3208c|M.abscessus_ATCC_199 RLTEFGKALLPLAGAALRTVGEIRSAADAMAGVLCGQLAIGTVPHPS-PL
TH_3504|M.thermoresistible__bu SLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHYVIGHTPALSGAE
*: *. *: . : . . :. . . .
MMAR_0317|M.marinum_M ASLVLSDFCSAHPLVKAQICSRLAVTELYRRLRDFELDAAIVYTS-SDDG
MUL_4805|M.ulcerans_Agy99 ASLVLSDFCSAHPLVKAQICSRLAVTELYRRLRDFERDAAIVYTS-SDDG
Mb0121|M.bovis_AF2122/97 ASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPE-TQDS
Rv0117|M.tuberculosis_H37Rv ASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPE-TQDS
MLBr_02663|M.leprae_Br4923 ASLVLSAFCSEHPLIKVQICSRLPVTELHRRLGDFELDAVIVHSA-PDDT
MAV_5191|M.avium_104 ASLLLSAFCSAHPLVKVQILSRLSAGELYRRLREFELDAAIAHTA-PDDI
Mvan_4315|M.vanbaalenii_PYR-1 LLGELEAAIASLPVPTEFSVPGSAAEVTAKLIAGQAELGLIHLPA-NDKR
Mflv_2332|M.gilvum_PYR-GCK LLGELEAVLAGLPGPTEFSVPGSAAEVTAKLIAGQSELGLIHLPA-TDKR
MSMEG_1902|M.smegmatis_MC2_155 FLARLEKAVAGLAAPTQFSVPGSAAEVTAKLVSGHLDIGLIHLPS-ADKR
MAB_3208c|M.abscessus_ATCC_199 LAEALAAYRRAHPAVTVTLTEARSDQLATAVVERRLDMAVMAWLAQPPSQ
TH_3504|M.thermoresistible__bu AYALIEPAVTAYPSTSFTLRQLYPDALTDAVFDGTVQLGLRRGVV-PTPE
: . . . . .
MMAR_0317|M.marinum_M HDVDLVPLYEERYVLLAPPEMLPPGVSTLSWLDAAQLPLALLSSDMRDRQ
MUL_4805|M.ulcerans_Agy99 HDVDLVPLYEERYVLLAPPEMLPPGVSTLSWLDAAQLPLALLSSDMRDRQ
Mb0121|M.bovis_AF2122/97 DDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQ
Rv0117|M.tuberculosis_H37Rv DDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQ
MLBr_02663|M.leprae_Br4923 HAVDLVPLYHEHYVLVSPADMLPPGASVLAWPEASQLPLALLTPDMRDRQ
MAV_5191|M.avium_104 PDVNLVPVYRERYVLLAPADLLASGAATMTWVQAAQLPLALLTPDMRDRQ
Mvan_4315|M.vanbaalenii_PYR-1 LRYKVVASYQGGIAVRFDDPLAAKDLVSIEELRDREVAIDVARPNPVVLA
Mflv_2332|M.gilvum_PYR-GCK LRHRVVASYQGGVAVRFDDPLAAKDLVSIEELRDREVAIDFARPNPVVLA
MSMEG_1902|M.smegmatis_MC2_155 LRHRVVARYQGAIAVRFDDPLAAKDVVAIEELRDREVVIDFARPNPVVLA
MAB_3208c|M.abscessus_ATCC_199 LRERILAKENIVAVVHRDDPLAGRESVALAELRDRALISHPQGCEIR--T
TH_3504|M.thermoresistible__bu LATAVIGYHRVRVAFVDSHPLAARESVDITELAREQVALWAPPGTSYYSD
:: . .. : : :
MMAR_0317|M.marinum_M IIDAAFADHAITVSPQVETDSVASLFAQVATGNSASIVPHTWLWTTPAG-
MUL_4805|M.ulcerans_Agy99 IIDAAFADHAITVSPQVETDSVASLFAQVATGNSASIVPHTWLWTTPGR-
Mb0121|M.bovis_AF2122/97 VIDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWAMPMSG
Rv0117|M.tuberculosis_H37Rv VIDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWAMPMSG
MLBr_02663|M.leprae_Br4923 LIDRAFAGHAITATPQVETDSVASLFAQVATGNWACIVPHTWLWTTPIG-
MAV_5191|M.avium_104 IIDRAFADHGITLHPQVETDSVASLFAQASAGSWASIVPHTWLWASPLG-
Mvan_4315|M.vanbaalenii_PYR-1 GLTRGLNRKGVHRIVRTTNQRGGEVEMATQVFNRHLVAVVSYAPDSFIGK
Mflv_2332|M.gilvum_PYR-GCK GLTRRLNRKGVHHIVRTTNQRGGEVEMATQVFNRHLVAVVSYAPESFIGK
MSMEG_1902|M.smegmatis_MC2_155 GLTRGLNAKGVTKIVRAINQLGGELEMATQVFNRHLVAMVTYAPESMIGR
MAB_3208c|M.abscessus_ATCC_199 ALDQACLATGFT--PRVVFETSSADMMRHLVVRDLGVAVTPRLPREQLG-
TH_3504|M.thermoresistible__bu FLMGACRRAGFEPDYVVSRVQGAATVAAPLTTGGIAFVTAAAGP-TMNG-
: .. . . . .. .
MMAR_0317|M.marinum_M ----GEIRPVQLVSPVVK-AQVALATSSTGPGSPVARALMTSAQGLALDE
MUL_4805|M.ulcerans_Agy99 --------------------------------------------------
Mb0121|M.bovis_AF2122/97 PTG-GEIRAVELVDPVLK-AQIALATNALGPGSPVARALITCAQALALNE
Rv0117|M.tuberculosis_H37Rv PTG-GEIRAVELVDPVLK-AQIALATNALGPGSPVARALITCAQALALNE
MLBr_02663|M.leprae_Br4923 ----AEIRAVEMVDPVLK-ADVALATNSAGPGSPVARALVASAKQLALNE
MAV_5191|M.avium_104 ----PGIRAVELVDPVLT-ADVVLAIKSHGPGSPIARALAASAGRLQLND
Mvan_4315|M.vanbaalenii_PYR-1 IFSPPEFKLIPLDESTWAPAEIALAWVPERVQAR-------LTEVELMVE
Mflv_2332|M.gilvum_PYR-GCK IFSPPEFKLIPVDESTWAPAEIALAWVPERVQGR-------LAEVELMVE
MSMEG_1902|M.smegmatis_MC2_155 IFSPPEFKLIPIDEATWAPAQIALAWAPDRLSDRRSERVLRPAEIEALVD
MAB_3208c|M.abscessus_ATCC_199 -----RLRQIDLSDRAMS-GRLSLLWRGKG-------ATLEAVAFAACID
TH_3504|M.thermoresistible__bu -----RVQVVDLTPPLLVPVQALWQR----------------HTLSAIRD
MMAR_0317|M.marinum_M FFQTRLMEISRRR
MUL_4805|M.ulcerans_Agy99 -------------
Mb0121|M.bovis_AF2122/97 FFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv FFDTQLRGITRRR
MLBr_02663|M.leprae_Br4923 FFEAQLAGITRRR
MAV_5191|M.avium_104 FFDAQLLGVTRRR
Mvan_4315|M.vanbaalenii_PYR-1 QIADRLGPVHRGA
Mflv_2332|M.gilvum_PYR-GCK QIADRLGPVHRGA
MSMEG_1902|M.smegmatis_MC2_155 ELERAVARPAGGA
MAB_3208c|M.abscessus_ATCC_199 ELCRKDANLVS--
TH_3504|M.thermoresistible__bu RILEGLG------