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SETRPLAMVTGASSGIGFELAMLLADDGYDLIVAADDEAIYPAADKLGTECATVQAVQVDLRKPADVERL YRSSSGRVPDVVVLNAGSVRAGSFIEGDLDADLSIIDLNVRSTVHLAKRVLRDMTAKGSGKVLFTSSIVA AMPGSLQSIYNASKSFIQSLAEALQDELRDTDVTVTALMPGPTDTNLFARNHMENTVLARWIPKDDPAQV AKQGYDAMMNGRRRVVASSISSKALGLINTVLPDMVKAKLNRFIASPVRGN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5402 | - | - | 100% (262) | dehydrogenase DhgA |
| M. smegmatis MC2 155 | MSMEG_2895 | - | 7e-22 | 29.84% (248) | short chain oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4722 | - | 5e-21 | 31.66% (259) | short-chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1571 | - | 2e-21 | 33.04% (224) | ketoacyl reductase |
| M. gilvum PYR-GCK | Mflv_0138 | - | 3e-24 | 32.30% (226) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1544 | - | 2e-21 | 33.04% (224) | ketoacyl reductase |
| M. leprae Br4923 | MLBr_00429 | - | 5e-19 | 28.92% (249) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4261c | - | 3e-19 | 27.91% (258) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0254 | - | 6e-27 | 32.02% (253) | ketoacyl reductase |
| M. avium 104 | MAV_3259 | - | 5e-74 | 57.09% (254) | dehydrogenase DhgA |
| M. thermoresistible (build 8) | TH_2749 | - | 2e-20 | 28.88% (232) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4860 | - | 2e-25 | 31.23% (253) | ketoacyl reductase |
| M. vanbaalenii PYR-1 | Mvan_0661 | - | 5e-20 | 34.62% (208) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5402|M.smegmatis_MC2_155 ----MSETRPLAMVTGASSGIGFELAMLLADDGYDLIVAADD-EAIYPAA
MAV_3259|M.avium_104 --------MALAMITGASSGIGLELAELFAQRGYDLVVAAEN-DGIYPAS
Mb1571|M.bovis_AF2122/97 MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRERLDELA
Rv1544|M.tuberculosis_H37Rv MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRERLDELA
MLBr_00429|M.leprae_Br4923 MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVIARREDVLVDLA
MMAR_0254|M.marinum_M MALPPPGKDRAAIVTGASSGIGEEFARILSQRGYQVVLVARSADRLEALA
MUL_4860|M.ulcerans_Agy99 MALPPPGKDRAAIVTGASSGIGEEFARILSQRGYQVVLVARSADRLEALA
Mflv_0138|M.gilvum_PYR-GCK MGLPTPSPTTTAVVTGASSGIGADLARELAARGHGVTLVARREDRLRALA
MAB_4261c|M.abscessus_ATCC_199 -MAATNSARPVALITGPTSGLGGGFARKYASQGYDVVLVARDEQRLGALA
Mvan_0661|M.vanbaalenii_PYR-1 ------MSRPVALITGPTSGLGEGFARRYAVDGFDLVLVARDVERLNRLA
TH_2749|M.thermoresistible__bu -VTDLTRYGPTAVIAGGSEGVGAEFARLLADAGIDLVLIARKPGPLEDTA
.:::* :..:* :* : * : : * : :
MSMEG_5402|M.smegmatis_MC2_155 DKLGTEC-ATVQAVQVDLRKPADVERLYRSSS--GRVPDVVVLNAGSVRA
MAV_3259|M.avium_104 DSLSRWG-VDVRPVQVDLRTPDGVEKLYREATEGGRGLDAAALNAGVGGG
Mb1571|M.bovis_AF2122/97 DQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIA--GLCNSAGFGTS
Rv1544|M.tuberculosis_H37Rv DQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIA--GLCNSAGFGTS
MLBr_00429|M.leprae_Br4923 ARLADKYRVAVEVRPADLTDPSERVKLADELTVRPIS--ILCANAGTATF
MMAR_0254|M.marinum_M GRLGS----DTHPLPADLSVRSDRAGLVDRVAALGLVPDILINNAGLSTL
MUL_4860|M.ulcerans_Agy99 GRLGS----DTHPLPADLSVRSDRAGLVDRVAALGLVPDILINNAGLSTL
Mflv_0138|M.gilvum_PYR-GCK DELSSSN-VRVEVVACDVADADARAGLFPEIERRGLTVDVLVNNAGIGTI
MAB_4261c|M.abscessus_ATCC_199 DELTCRFGVYAEALPADLADAADRARVADRLAA-GVS--VLVNNAGFATA
Mvan_0661|M.vanbaalenii_PYR-1 AELHDEAGTNVEVIRADLADAADRAVVADRLRA-GVR--VLVNNAGFGTS
TH_2749|M.thermoresistible__bu ADCRARG-VEVRTISADLTDPAAVHRVLAECAGLEVG--LLIYNAGANTC
.. *: : .**
MSMEG_5402|M.smegmatis_MC2_155 -GSFIEGDLDADLSIIDLNVRSTVHLAKRVLRDMTAKGSGKVLFTSSIVA
MAV_3259|M.avium_104 -GSFVEGELAHDLSIIDLNVRSTVHLAKLVLRNMTRRNTGKVLFTSSLAS
Mb1571|M.bovis_AF2122/97 -GRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAG
Rv1544|M.tuberculosis_H37Rv -GRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAG
MLBr_00429|M.leprae_Br4923 -GPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAG
MMAR_0254|M.marinum_M -GPVAKSVPEQELNLVEVDVAAVVDLCSRFLPAMVERGRGAVLNVASVAG
MUL_4860|M.ulcerans_Agy99 -GPVAKSVPEQEFNLAEVDVAAVVDLCSRFLPAMVERGRGAVFNVASVAG
Mflv_0138|M.gilvum_PYR-GCK -GPVVDSTPEAEIGQVRVNVEAVIDLTTRAVQQMVPRGRGAILNVGSTAG
MAB_4261c|M.abscessus_ATCC_199 -GEFWTAAPELLHSQLDVNVTAVMELTRAALPSMIEAGAGTVINVASVAG
Mvan_0661|M.vanbaalenii_PYR-1 -GEFWSADYALLQTQLDVNVTAVMQFTHAALPPMLAAGEGTVLNVASVAG
TH_2749|M.thermoresistible__bu SEEFLDGELADFDKVLRLNIDTMLTLVQHFGRPMRERRSGGILLVGSMAG
. :: : : * * :: .* ..
MSMEG_5402|M.smegmatis_MC2_155 AMPGSLQSIYNASKSFIQSLAEALQDELRDTDVTVTALMPGPTDTNLFAR
MAV_3259|M.avium_104 MAPGPFEAVYHASKSFVQSFAAALRDELRDTGITVTSLMPGTIETNFFSR
Mb1571|M.bovis_AF2122/97 FQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEI
Rv1544|M.tuberculosis_H37Rv FQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEI
MLBr_00429|M.leprae_Br4923 NSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPGPVRTELPDH
MMAR_0254|M.marinum_M FAPLPGQAAYGAAKAFVLSYTHSLRGELHGSGVSVTALSPGPVDTSFGDV
MUL_4860|M.ulcerans_Agy99 FAPLPGQAAYGAAKAFVLSYTHSLRGELHGSGVSVTALSPGPVDTSFGDV
Mflv_0138|M.gilvum_PYR-GCK FQPFPGQSGYAATKAFVRTYTDGLRGELAGTGVTVTALHPGPVRTEFLDT
MAB_4261c|M.abscessus_ATCC_199 LVSGRG-STYSASKAWVVSFTEGLANGLLGTGVGMHVLCPGFIHTEFHER
Mvan_0661|M.vanbaalenii_PYR-1 LLPGRG-STYSASKAWVVSFSEGLANGLGGTGVGVHALCPGFVHTEFHER
TH_2749|M.thermoresistible__bu YLGSARHTVYGGVKAFGRIFAESLWLELRDHGVDVLELVLGVTRTPAMER
: * . *:: : .: * . .: : * * *
MSMEG_5402|M.smegmatis_MC2_155 NHMENTVLARWIPKD---DPAQVAKQGYDAMMNGRRRVVASSISSKALGL
MAV_3259|M.avium_104 AGMDQTR-AGQKPKD---DPAEVARQGFEAMMRGHRKVVGGSLTTKTVGV
Mb1571|M.bovis_AF2122/97 ASA-----ERFSIPLAQVSPHDVAEAAIAGMLSGKRTVVPG-IVPKFVST
Rv1544|M.tuberculosis_H37Rv ASA-----ERFSIPLAQVSPHDVAEAAIAGMLSGKRTVVPG-IVPKFVST
MLBr_00429|M.leprae_Br4923 DEASL--VEKLVPDFLWISTEHTARLSLDALERNKMRVVPG-LTSKAMSV
MMAR_0254|M.marinum_M AGFTQQETES-LPKIMWKSVDQVAQAGIDGLAAGKAVVVPG-LANRISAE
MUL_4860|M.ulcerans_Agy99 AGFTPQETES-LPKIMWKSVDQVAQAGIDGLAAGKAVVVPG-LANRISAE
Mflv_0138|M.gilvum_PYR-GCK AGMDERTFASAFPKFLWIESREVAEKGIDGLAADRGSVIPG-LQNEIPAR
MAB_4261c|M.abscessus_ATCC_199 AGIE----MGTIPEFMWLQVDDVVNACLHDIAAGKVLIVPG-VQYKAITS
Mvan_0661|M.vanbaalenii_PYR-1 AGID----MAGTASFLWLEVDDVVRETMASIAKHKVVIIPG-LQYKALTT
TH_2749|M.thermoresistible__bu AGLN-----FDVPGLRVADPADVAREGLERLPHGPVHVAGG--NAEDVAR
. .... : : . .
MSMEG_5402|M.smegmatis_MC2_155 INTVLPDMVKAKLNRFIASPVRGN---
MAV_3259|M.avium_104 ALRFLPDSWKAAASRVNSTPAGRR---
Mb1571|M.bovis_AF2122/97 SGRFAPRSLLLPAIR-IGNRLRGGPSR
Rv1544|M.tuberculosis_H37Rv SGRFAPRSLLLPAIR-IGNRLRGGPSR
MLBr_00429|M.leprae_Br4923 ASRYAPRAIVASIVGNFYKKLGGG---
MMAR_0254|M.marinum_M LIRVTPPDWMGSIMARIHPAMKRQ---
MUL_4860|M.ulcerans_Agy99 LIRVTPPDWMGSIMARIHPAMKRQ---
Mflv_0138|M.gilvum_PYR-GCK VFEFLPRRILLPLIRNQHPALRRSRS-
MAB_4261c|M.abscessus_ATCC_199 VTRLIPRGLVRKYNSVVGRGRGRT---
Mvan_0661|M.vanbaalenii_PYR-1 GGRMVPRNLVRALTKVVGKGRGRT---
TH_2749|M.thermoresistible__bu RNDPDRAKVVLGAHRFVQKLIGQA---