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ALAMITGASSGIGLELAELFAQRGYDLVVAAENDGIYPASDSLSRWGVDVRPVQVDLRTPDGVEKLYREA TEGGRGLDAAALNAGVGGGGSFVEGELAHDLSIIDLNVRSTVHLAKLVLRNMTRRNTGKVLFTSSLASMA PGPFEAVYHASKSFVQSFAAALRDELRDTGITVTSLMPGTIETNFFSRAGMDQTRAGQKPKDDPAEVARQ GFEAMMRGHRKVVGGSLTTKTVGVALRFLPDSWKAAASRVNSTPAGRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3259 | - | - | 100% (259) | dehydrogenase DhgA |
| M. avium 104 | MAV_3226 | - | 9e-25 | 32.68% (254) | ketoacyl reductase |
| M. avium 104 | MAV_1666 | - | 4e-21 | 31.15% (244) | short-chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1571 | - | 9e-26 | 33.46% (257) | ketoacyl reductase |
| M. gilvum PYR-GCK | Mflv_0138 | - | 6e-30 | 34.10% (261) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1544 | - | 9e-26 | 33.46% (257) | ketoacyl reductase |
| M. leprae Br4923 | MLBr_00429 | - | 5e-22 | 31.58% (247) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1537c | - | 1e-22 | 33.33% (249) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0254 | - | 1e-28 | 33.20% (244) | ketoacyl reductase |
| M. smegmatis MC2 155 | MSMEG_5402 | - | 6e-74 | 57.09% (254) | dehydrogenase DhgA |
| M. thermoresistible (build 8) | TH_2749 | - | 3e-25 | 35.37% (229) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1543 | - | 4e-27 | 33.59% (259) | ketoacyl reductase |
| M. vanbaalenii PYR-1 | Mvan_3113 | - | 2e-26 | 36.25% (251) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00429|M.leprae_Br4923 MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVIARREDVLVDLA
MAB_1537c|M.abscessus_ATCC_199 MPIPAPSPDARAVVTGASQGIGAALAEELAARGHNLIITARRGEILNDLA
Mb1571|M.bovis_AF2122/97 MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRERLDELA
Rv1544|M.tuberculosis_H37Rv MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRERLDELA
MUL_1543|M.ulcerans_Agy99 MTLPKPNKQATVVITGASSGIGVELARGLAGRGFPLMLVARRRERLEELA
Mvan_3113|M.vanbaalenii_PYR-1 MSLAKPSAGTTVVITGASSGIGEHIARGLARRGYSLTLIARRRDRLEALS
Mflv_0138|M.gilvum_PYR-GCK MGLPTPSPTTTAVVTGASSGIGADLARELAARGHGVTLVARREDRLRALA
MMAR_0254|M.marinum_M MALPPPGKDRAAIVTGASSGIGEEFARILSQRGYQVVLVARSADRLEALA
MAV_3259|M.avium_104 --------MALAMITGASSGIGLELAELFAQRGYDLVVAAE-NDGIYPAS
MSMEG_5402|M.smegmatis_MC2_155 ----MSETRPLAMVTGASSGIGFELAMLLADDGYDLIVAAD-DEAIYPAA
TH_2749|M.thermoresistible__bu -VTDLTRYGPTAVIAGGSEGVGAEFARLLADAGIDLVLIARKPGPLEDTA
.:::*.*..:* :* :: * : : * : :
MLBr_00429|M.leprae_Br4923 ARLADKYRVAVEVRPADLTDPSERVKLADELTVRPISI--LCANAGTATF
MAB_1537c|M.abscessus_ATCC_199 NALSEKTGVIVEVRAVDLADPGARDALCTELSERNISI--LCNNAGTATF
Mb1571|M.bovis_AF2122/97 DQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAG--LCNSAGFGTS
Rv1544|M.tuberculosis_H37Rv DQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAG--LCNSAGFGTS
MUL_1543|M.ulcerans_Agy99 DDLRDKFSIAVEVLPLDLSDAQARTQLADRLRSDSIAG--LCNSAGFGTS
Mvan_3113|M.vanbaalenii_PYR-1 DELCRARSISVDVVALDLNEQSARAEAVERLRSGAVAG--LVNSAGFGTN
Mflv_0138|M.gilvum_PYR-GCK DELSSSN-VRVEVVACDVADADARAGLFPEIERRGLTVDVLVNNAGIGTI
MMAR_0254|M.marinum_M GRLGS----DTHPLPADLSVRSDRAGLVDRVAALGLVPDILINNAGLSTL
MAV_3259|M.avium_104 DSLSRWG-VDVRPVQVDLRTPDGVEKLYREATEGGRGLDAAALNAGVGGG
MSMEG_5402|M.smegmatis_MC2_155 DKLGTEC-ATVQAVQVDLRKPADVERLYRSSS--GRVPDVVVLNAGSVRA
TH_2749|M.thermoresistible__bu ADCRARG-VEVRTISADLTDPAAVHRVLAECAGLEVGL--LIYNAGANTC
. *: .**
MLBr_00429|M.leprae_Br4923 -GPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAG
MAB_1537c|M.abscessus_ATCC_199 -GPIRGLDPAGERKQVQLNAVAVHDLTLAVLPGMLARGAGGILISGSAAG
Mb1571|M.bovis_AF2122/97 -GRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAG
Rv1544|M.tuberculosis_H37Rv -GRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAG
MUL_1543|M.ulcerans_Agy99 -GRFCELPPERESEQVTLNALALMEFTRAALPGMVERGAGAVLNIASIAG
Mvan_3113|M.vanbaalenii_PYR-1 -GLLQDLPPDRERDQVIVNVLALTELTHAVLPQMVERGAGAVLNIGSIAG
Mflv_0138|M.gilvum_PYR-GCK -GPVVDSTPEAEIGQVRVNVEAVIDLTTRAVQQMVPRGRGAILNVGSTAG
MMAR_0254|M.marinum_M -GPVAKSVPEQELNLVEVDVAAVVDLCSRFLPAMVERGRGAVLNVASVAG
MAV_3259|M.avium_104 -GSFVEGELAHDLSIIDLNVRSTVHLAKLVLRNMTRRNTGKVLFTSSLAS
MSMEG_5402|M.smegmatis_MC2_155 -GSFIEGDLDADLSIIDLNVRSTVHLAKRVLRDMTAKGSGKVLFTSSIVA
TH_2749|M.thermoresistible__bu SEEFLDGELADFDKVLRLNIDTMLTLVQHFGRPMRERRSGGILLVGSMAG
. : :: : : * : * :* .* ..
MLBr_00429|M.leprae_Br4923 NSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPGPVRTELPDH
MAB_1537c|M.abscessus_ATCC_199 NSPIPNNATYAATKAFANTFSESLRGELKGTGVHVTLLAPGPVRTVEPDP
Mb1571|M.bovis_AF2122/97 FQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEI
Rv1544|M.tuberculosis_H37Rv FQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEI
MUL_1543|M.ulcerans_Agy99 FQPIPFMAVYSASKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEI
Mvan_3113|M.vanbaalenii_PYR-1 FQPLPGAAVYSATKAYVQTFSEAVHEGLHGTGVSCTALCPGPVPTEWWEI
Mflv_0138|M.gilvum_PYR-GCK FQPFPGQSGYAATKAFVRTYTDGLRGELAGTGVTVTALHPGPVRTEFLDT
MMAR_0254|M.marinum_M FAPLPGQAAYGAAKAFVLSYTHSLRGELHGSGVSVTALSPGPVDTSFGDV
MAV_3259|M.avium_104 MAPGPFEAVYHASKSFVQSFAAALRDELRDTGITVTSLMPGTIETNFFSR
MSMEG_5402|M.smegmatis_MC2_155 AMPGSLQSIYNASKSFIQSLAEALQDELRDTDVTVTALMPGPTDTNLFAR
TH_2749|M.thermoresistible__bu YLGSARHTVYGGVKAFGRIFAESLWLELRDHGVDVLELVLGVTRTPAMER
. : * . *:: : .: * . .: * * *
MLBr_00429|M.leprae_Br4923 DEASLVEKLVP--DFLWISTEHTARLSLDALERNKMRVVPG-LTSKAMSV
MAB_1537c|M.abscessus_ATCC_199 AEASIVDKVVP--DFLWINGEYTARVSLNALERNKMRVVPG-ITSKAMSV
Mb1571|M.bovis_AF2122/97 ASAERFSIPL-----AQVSPHDVAEAAIAGMLSGKRTVVPG-IVPKFVST
Rv1544|M.tuberculosis_H37Rv ASAERFSIPL-----AQVSPHDVAEAAIAGMLSGKRTVVPG-IVPKFVST
MUL_1543|M.ulcerans_Agy99 ASAERFSIPL-----ARVSPHDVAEAAIEGMLTGKRTVVPG-VVPKFVST
Mvan_3113|M.vanbaalenii_PYR-1 AG-EKPPGGK-----VAVSVEEVAEAGIAAMREGKRLVVPG-LVPKLTGL
Mflv_0138|M.gilvum_PYR-GCK AGMDERTFASAFPKFLWIESREVAEKGIDGLAADRGSVIPG-LQNEIPAR
MMAR_0254|M.marinum_M AGFTQQETES-LPKIMWKSVDQVAQAGIDGLAAGKAVVVPG-LANRISAE
MAV_3259|M.avium_104 AGMDQTR-AGQKP---KDDPAEVARQGFEAMMRGHRKVVGGSLTTKTVGV
MSMEG_5402|M.smegmatis_MC2_155 NHMENTVLARWIP---KDDPAQVAKQGYDAMMNGRRRVVASSISSKALGL
TH_2749|M.thermoresistible__bu AGLNFDVPGLR-----VADPADVAREGLERLPHGPVHVAGG--NAEDVAR
. .*. . : . * . . .
MLBr_00429|M.leprae_Br4923 ASRYAPRAIVASIVGNFYKKLGGG---
MAB_1537c|M.abscessus_ATCC_199 AAGYAPRAVVAPIVGSFYKKLGD----
Mb1571|M.bovis_AF2122/97 SGRFAPRSLLLPAIR-IGNRLRGGPSR
Rv1544|M.tuberculosis_H37Rv SGRFAPRSLLLPAIR-IGNRLRGGPSR
MUL_1543|M.ulcerans_Agy99 SGRYLPRSVLLPAIR-IGNKLRGGPSH
Mvan_3113|M.vanbaalenii_PYR-1 GGRFTPRALLLPALR-MAAARRR----
Mflv_0138|M.gilvum_PYR-GCK VFEFLPRRILLPLIRNQHPALRRSRS-
MMAR_0254|M.marinum_M LIRVTPPDWMGSIMARIHPAMKRQ---
MAV_3259|M.avium_104 ALRFLPDSWKAAASRVNSTPAGRR---
MSMEG_5402|M.smegmatis_MC2_155 INTVLPDMVKAKLNRFIASPVRGN---
TH_2749|M.thermoresistible__bu RNDPDRAKVVLGAHRFVQKLIGQA---