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MPDLATYGPWAVIAGGSEGVGAEFARLLAEAGVNLVLIARKPGPLQDTAQRCREIGVDVRTVATDLLDPT AVEQITGATAGLDVGLLIYNAGASTCNEPFLDAPLDDFRKVLDLNVTRMMELVQHYARPMVARQRGGVLI VGSLSGYMGADRHSVYGGAKAFSRIFAESLWLELREHNVDVVELVLGVTRTPAMERVGLNFDVPGMIVND PADVAAEGLANLANGPVHIAGGNAAIAAANNAPDRAKVVLQAHERMRRLINRGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2895 | - | - | 100% (264) | short chain oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_6592 | - | 2e-45 | 43.16% (234) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_5402 | - | 8e-22 | 29.84% (248) | dehydrogenase DhgA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2537 | - | 1e-17 | 33.15% (184) | putative short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_4545 | - | 1e-105 | 72.73% (253) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2509 | - | 1e-17 | 33.15% (184) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00429 | - | 3e-16 | 32.07% (184) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1537c | - | 7e-20 | 35.71% (182) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3509 | - | 2e-82 | 68.00% (225) | short-chain alcohol dehydrogenase |
| M. avium 104 | MAV_5238 | - | 1e-43 | 41.49% (241) | oxidoreductase, short-chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_2749 | - | 1e-101 | 68.85% (260) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0124 | - | 1e-19 | 30.91% (220) | ketoacyl reductase |
| M. vanbaalenii PYR-1 | Mvan_2633 | - | 5e-98 | 67.83% (258) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2895|M.smegmatis_MC2_155 ------------MPDLATYGPWAVIAGGSEGVGAEFARLLAEAGVNLVLI
Mflv_4545|M.gilvum_PYR-GCK ---------------MTKYGPWAVIAGGSEGVGAEFAKALAEDGANLVLI
MMAR_3509|M.marinum_M -----------------------------------------------MLI
TH_2749|M.thermoresistible__bu ------------VTDLTRYGPTAVIAGGSEGVGAEFARLLADAGIDLVLI
Mvan_2633|M.vanbaalenii_PYR-1 MLPDTRRGDDVTVTDLTGYGPWAVVAGGSEGVGAEFAAQLARAGVNLVLV
MAV_5238|M.avium_104 ------------MSFAARYGPWALVAGASDGVGAAFAEGLAERGVNVALL
Mb2537|M.bovis_AF2122/97 -----------MPIPAPSPDARAVVTGASQNIGAALATELAARGHHLIVT
Rv2509|M.tuberculosis_H37Rv -----------MPIPAPSPDARAVVTGASQNIGAALATELAARGHHLIVT
MLBr_00429|M.leprae_Br4923 -----------MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVI
MAB_1537c|M.abscessus_ATCC_199 -----------MPIPAPSPDARAVVTGASQGIGAALAEELAARGHNLIIT
MUL_0124|M.ulcerans_Agy99 -----------MPRPV------ALITGPTSGIGAGYARRYAQDGYDLILV
:
MSMEG_2895|M.smegmatis_MC2_155 ARKPGPLQDTAQRCREIG-VDVRTVATDLLDPTAVEQITGATAGLDVGLL
Mflv_4545|M.gilvum_PYR-GCK ARKPQPLDETAQECRRLG-AQVRTIALDLLDADSTSRIVDATSDVEVGLL
MMAR_3509|M.marinum_M ARAPGPLADTARRCRETG-VHVRTIAVDLVDPEAVALICSETADLEVGLL
TH_2749|M.thermoresistible__bu ARKPGPLEDTAADCRARG-VEVRTISADLTDPAAVHRVLAECAGLEVGLL
Mvan_2633|M.vanbaalenii_PYR-1 ARTPEPLERTAARCREFG-VQTRTLAVDLVD--ATHEVIAATADLEVGLL
MAV_5238|M.avium_104 ARRQDVLDRVAARIRARTSAQTRTLAIDLAHPGAAKAIAAATADVTIGML
Mb2537|M.bovis_AF2122/97 ARREDVLTELAARLADKYRVTVDVRPADLADPQERSKLADELAARPISIL
Rv2509|M.tuberculosis_H37Rv ARREDVLTELAARLADKYRVTVDVRPADLADPQERSKLADELAARPISIL
MLBr_00429|M.leprae_Br4923 ARREDVLVDLAARLADKYRVAVEVRPADLTDPSERVKLADELTVRPISIL
MAB_1537c|M.abscessus_ATCC_199 ARRGEILNDLANALSEKTGVIVEVRAVDLADPGARDALCTELSERNISIL
MUL_0124|M.ulcerans_Agy99 ARDVDRLTQSAVELEDDAG-NVEILPADLADAAGRDKVAERLS-RGVRVL
** * * . . ** . : : : :*
MSMEG_2895|M.smegmatis_MC2_155 IYNAGASTCNEPFLDAPLDDFRKVLDLNVTRMMELVQHYARPMVARQRGG
Mflv_4545|M.gilvum_PYR-GCK IYNAGASTCNERFLDAELSEFGKVIDLNTTRMLELTQHFGRRMAAMSRGG
MMAR_3509|M.marinum_M IYNAGANTCREQFLDAELTELGRVIDLNVTRMLELVQHFGRPMRARRRGG
TH_2749|M.thermoresistible__bu IYNAGANTCSEEFLDGELADFDKVLRLNIDTMLTLVQHFGRPMRERRSGG
Mvan_2633|M.vanbaalenii_PYR-1 IYNAGANTCSEEFLDADLAEFGRVVDLNVTAMMTLVQHYGRPMRERRRGG
MAV_5238|M.avium_104 VYCAGADPDFKPFLANRIEAAEAMVQRNCMVPMQLCHHYAPAMVERGAGG
Mb2537|M.bovis_AF2122/97 CANAGT-ATFGPIASLDLAGEKTQVQLNAVAVHDLTLAVLPGMIERKAGG
Rv2509|M.tuberculosis_H37Rv CANAGT-ATFGPIASLDLAGEKTQVQLNAVAVHDLTLAVLPGMIERKAGG
MLBr_00429|M.leprae_Br4923 CANAGT-ATFGPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGG
MAB_1537c|M.abscessus_ATCC_199 CNNAGT-ATFGPIRGLDPAGERKQVQLNAVAVHDLTLAVLPGMLARGAGG
MUL_0124|M.ulcerans_Agy99 VNNAGF-ATSGEFWETEPAALQAQLDVNVTAVMQLTRAALPPMLAAGAGT
** . . : * * * *
MSMEG_2895|M.smegmatis_MC2_155 VLIVGSLSGYMGADRHSVYGGAKAFSRIFAESLWLELREHNVDVVELVLG
Mflv_4545|M.gilvum_PYR-GCK IVLVGSLSGYMGAERHSVYAGAKAFSRVFAESLWLELREHGVDVLELVLG
MMAR_3509|M.marinum_M IVLVGSTAATYGAMRQSAYAGAKAFSRLFAESLWLELRETGVDVLELVLG
TH_2749|M.thermoresistible__bu ILLVGSMAGYLGSARHTVYGGVKAFGRIFAESLWLELRDHGVDVLELVLG
Mvan_2633|M.vanbaalenii_PYR-1 ILLVGSMAGYLGSVRHTVYGGVKAFGRIFAEGLWLELRDHDVHVLELVLG
MAV_5238|M.avium_104 IVLFGSGAGLAGGPNMVAYGASKAFDMVFAEALWAELHDKGVDVLGLILG
Mb2537|M.bovis_AF2122/97 ILISGSAAGNSPIPYNATYAATKAFVNTFSESLRGELRGSGVHVTVLAPG
Rv2509|M.tuberculosis_H37Rv ILISGSAAGNSPIPYNATYAATKAFVNTFSESLRGELRGSGVHVTVLAPG
MLBr_00429|M.leprae_Br4923 ILISGSAAGNSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPG
MAB_1537c|M.abscessus_ATCC_199 ILISGSAAGNSPIPNNATYAATKAFANTFSESLRGELKGTGVHVTLLAPG
MUL_0124|M.ulcerans_Agy99 VINIASVAG-LLSGRGSTYSASKAWVISFSEGLSTGLEGTGVGVHAVCPG
:: .* :. .*.. **: *:*.* *. .* * : *
MSMEG_2895|M.smegmatis_MC2_155 VTRTPAMERVGLN---FDVPGMIVNDPA---DVAAEGLANLANGPVHIAG
Mflv_4545|M.gilvum_PYR-GCK VTRTPAMERAGLN---FDAPGIIVNDPA---DVAREGLRHIADGPVFIAG
MMAR_3509|M.marinum_M VTRTPAMQRAGLN---FDAPGISVSDPA---DVAREGLDNLANGPVVIAG
TH_2749|M.thermoresistible__bu VTRTPAMERAGLN---FDVPGLRVADPA---DVAREGLERLPHGPVHVAG
Mvan_2633|M.vanbaalenii_PYR-1 VTRTPAMERVGLN---FDVPGLRVSEPA---EVAAEGLRQLPHGPVHVVN
MAV_5238|M.avium_104 KTDTPALRALEYSRGQIASPDQAPSDAAAVSDVIAEAFENLGNGPTLMVG
Mb2537|M.bovis_AF2122/97 PVRTELPDASEASLVEKLVPDFLWISTE---HTARVSLNALERNKMRVVP
Rv2509|M.tuberculosis_H37Rv PVRTELPDASEASLVEKLVPDFLWISTE---HTARVSLNALERNKMRVVP
MLBr_00429|M.leprae_Br4923 PVRTELPDHDEASLVEKLVPDFLWISTE---HTARLSLDALERNKMRVVP
MAB_1537c|M.abscessus_ATCC_199 PVRTVEPDPAEASIVDKVVPDFLWINGE---YTARVSLNALERNKMRVVP
MUL_0124|M.ulcerans_Agy99 YVHTEF--HARAGIDMTKLPSFMWLDVD---DVIQESLADIADGKVIGIP
. * . *. . . .: : .
MSMEG_2895|M.smegmatis_MC2_155 GNAAIAAANNA-PDRAKVVLQAHERMRRLINRGA--------
Mflv_4545|M.gilvum_PYR-GCK GNAERAARSSA-PDRAAVVLGSHEMIKRLRGMRP--------
MMAR_3509|M.marinum_M DNAAHVHRGSG-ADRAAIVLRAHRAMQALIGSPPPPPKGDRA
TH_2749|M.thermoresistible__bu GNAEDVARRND-PDRAKVVLGAHRFVQKLIGQA---------
Mvan_2633|M.vanbaalenii_PYR-1 GNEDDVARRND-PDRARVVLGAHRFMQKLIGGRGHR------
MAV_5238|M.avium_104 DTMRAAAQLLASLSRNQAVELFAQAAAAAMGPDD--------
Mb2537|M.bovis_AF2122/97 GLTSKAMSVASQYAPRAIVAPIVGAFYKRLGGS---------
Rv2509|M.tuberculosis_H37Rv GLTSKAMSVASQYAPRAIVAPIVGAFYKRLGGS---------
MLBr_00429|M.leprae_Br4923 GLTSKAMSVASRYAPRAIVASIVGNFYKKLGGG---------
MAB_1537c|M.abscessus_ATCC_199 GITSKAMSVAAGYAPRAVVAPIVGSFYKKLGD----------
MUL_0124|M.ulcerans_Agy99 GVQYKALVGAGRMIPRGLLRAVMKRVGGGRGRT---------
. . : .