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VSTDIGRTAGQKAQRIHWAWVVAAVSFVAILGAAGFRSIPGVMMNPLHHEFGWTHGTVGLAMSVNMMLYG LTAPFAAALMDRFGVRPVLTVSLLLITTGSALSITMTASWQLVLLWGVLVGIGTGSISMGFVATIATRWF EQRRGLVTGVLTAASATGQLIFLPIVAAVTTHHGWRWASLIVAAAALAVVPLVAVFMRNYPADKGLAPYG AEEAQAAAPVVPASSFAAAFDGLRLGARSRAFWLLAASFAICGMTTNGLIATHFIPAANDHGMPTTVAAG LLATIGILDVAGTVFSGWLTDRVDPRVLLLVYYAGRGVSLLLLPSLLSPQAEPSTWVFVVFYGLDWVATV PPTIVLCRDFFGTRSPVVFGWVFASHQVGAAIAAAGAGWLRDLNGNYDMAFYLAAGLCFIAAVFSASIGK SQVSSEEADSVETSALP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5194 | - | - | 100% (437) | integral membrane protein |
| M. smegmatis MC2 155 | MSMEG_4147 | - | 4e-22 | 26.85% (406) | major facilitator superfamily protein MFS_1, putative |
| M. smegmatis MC2 155 | MSMEG_0164 | - | 1e-14 | 24.81% (403) | transmembrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1766c | narK2 | 4e-14 | 24.44% (446) | nitrate/nitrite transporter NarK2 |
| M. gilvum PYR-GCK | Mflv_1096 | - | 2e-26 | 28.12% (384) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1737c | narK2 | 4e-14 | 24.44% (446) | nitrate/nitrite transporter NarK2 |
| M. leprae Br4923 | MLBr_00556 | - | 6e-05 | 23.16% (177) | putative integral membrane drug transport protein |
| M. abscessus ATCC 19977 | MAB_4839c | - | 3e-11 | 24.18% (273) | MFS family transporter |
| M. marinum M | MMAR_1879 | - | 1e-08 | 23.67% (414) | drug-transport integral membrane protein |
| M. avium 104 | MAV_3974 | - | 2e-11 | 24.26% (371) | permease of the major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_0390 | - | 7e-12 | 23.54% (412) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_3826 | - | 9e-07 | 27.72% (184) | hypothetical protein MUL_3826 |
| M. vanbaalenii PYR-1 | Mvan_3219 | - | 2e-12 | 25.26% (380) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4839c|M.abscessus_ATCC_199 ----------MSTAAVHAQPHSITGLRGVLITLCLTEITSWG--VLYYAF
Mvan_3219|M.vanbaalenii_PYR-1 ----------MAESDRADR-------RSVLLTLCLTEITSWG--VLYYAF
Mb1766c|M.bovis_AF2122/97 ----------MRGQAAN-----------LVLATWISVVNFW----AWNLI
Rv1737c|M.tuberculosis_H37Rv ----------MRGQAAN-----------LVLATWISVVNFW----AWNLI
Mflv_1096|M.gilvum_PYR-GCK ----------MGGPVTRFDSAAIAEWRRYGTVPLAAGLGYSMGVIHVYSL
MSMEG_5194|M.smegmatis_MC2_155 ----------MSTDIGRTAGQKAQRIHWAWVVAAVSFVAILGAAGFRSIP
TH_0390|M.thermoresistible__bu -------MNPGRRARTAAGDDDERLAVRPWIVWATGLLAYIVAVLDRTTL
MAV_3974|M.avium_104 ----------------------------------MVALGYG-------VI
MMAR_1879|M.marinum_M ------------MPASPGIRCNAAPVQTHRDTLWAIAIGIFMTSVDDTVV
MLBr_00556|M.leprae_Br4923 ----------MSTRAGR------------RVAISAGSLAVLLGALDTYVV
MUL_3826|M.ulcerans_Agy99 MMRPRATVAAATPTTDLAAGRALITPRRRNFIFVALVLGILLSSLDQTIV
:
MAB_4839c|M.abscessus_ATCC_199 PVLAPRITADTGWSA---PAVTAAFSAALVVAAAAGIGVGRWLDRHGPR-
Mvan_3219|M.vanbaalenii_PYR-1 SVLSPAICADTGWSA---PAVTAAFSAGLVISALLGIPVGRWLDRHGPR-
Mb1766c|M.bovis_AF2122/97 GPLSTSYARDMSLSS---AEASLLVATPILVGALGRIVTGPLTDRFGGR-
Rv1737c|M.tuberculosis_H37Rv GPLSTSYARDMSLSS---AEASLLVATPILVGALGRIVTGPLTDRFGGR-
Mflv_1096|M.gilvum_PYR-GCK GAFMGPLQDEFGWSR---AQASVGLTIVGMAAAVAALPIGLMVDRLGPRR
MSMEG_5194|M.smegmatis_MC2_155 GVMMNPLHHEFGWTH---GTVGLAMSVNMMLYGLTAPFAAALMDRFGVR-
TH_0390|M.thermoresistible__bu GVSGLAAADRFNAAP---AALSTFVVLQVIVYALAQVPAGLLLDRFGSK-
MAV_3974|M.avium_104 SPALPTFARSFGVSI---KAVTFLVTVFSLSRLCFAPISGLLTERLGER-
MMAR_1879|M.marinum_M YVANPSIMAGLNTSY---HMVIWVTSGYVLAYTVPSLVAGRLGDRFGVK-
MLBr_00556|M.leprae_Br4923 VTIMRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKL
MUL_3826|M.ulcerans_Agy99 AIALPTIVADLGEAG----RQSWVVTSYLLASTIATALVGKLGDMFGRK-
. . : . : * :
MAB_4839c|M.abscessus_ATCC_199 --WLMTAGSLWGPAALIGVAMAPNYGWFLAAWLMAG-IAMAAVFYPPAFA
Mvan_3219|M.vanbaalenii_PYR-1 --WIMTGGSVLGSIALAGVAAAPDVVSFTAAWVVAG-VAMSAVFYAPAFA
Mb1766c|M.bovis_AF2122/97 --AMLIAVTLASILPVLAVGVAATMGSYALLVFFGLFLGVAGTIFAVGIP
Rv1737c|M.tuberculosis_H37Rv --AMLIAVTLASILPVLAVGVAATMGSYALLVFFGLFLGVAGTIFAVGIP
Mflv_1096|M.gilvum_PYR-GCK V-GIIGAGLMAGAFALLGTATG-TMGNWILLWSVLA-FACFWVQTTVWTS
MSMEG_5194|M.smegmatis_MC2_155 --PVLTVSLLLITTGSALSITMTASWQLVLLWGVLVGIGTGSISMGFVAT
TH_0390|M.thermoresistible__bu --ALIVAGAAVMATGQLILAFTESLTLAILARAIVG--LGDAVTFISVLR
MAV_3974|M.avium_104 --RIYIGGLLIVAVSTAACAFSQAYWQLMLCRVFSG--VGSTMFYVSALG
MMAR_1879|M.marinum_M --NLYLAGLAVFTVSSLWCGVSGTIEILIAARVAQG--IGAALLYTQTFT
MLBr_00556|M.leprae_Br4923 LLQVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQG--VASGALLPITLA
MUL_3826|M.ulcerans_Agy99 --RVFQVAVLLFVAGSVSCGLTQSMTMLVASRALQG--VGGGAITVTAIA
:
MAB_4839c|M.abscessus_ATCC_199 ALTRWYGPGAVRALMVLTLVAGLASTVFVP-LTAVLASHMD-WRTTYLAL
Mvan_3219|M.vanbaalenii_PYR-1 ALTRYFRPDAVRALTALTLAAGLASTVFAP-LTAAISAHMD-WRETYLVL
Mb1766c|M.bovis_AF2122/97 FANNWYQP-ARRGFSTGVFGMGMVGTALSAFFTPRFVRWFG-LFTTHAIV
Rv1737c|M.tuberculosis_H37Rv FANNWYQP-ARRGFSTGVFGMGMVGTALSAFFTPRFVRWFG-LFTTHAIV
Mflv_1096|M.gilvum_PYR-GCK AVASRFETSRGLAFAVTLSGGSLAAAVFPP-LATLLIGEWG-WRGALFGL
MSMEG_5194|M.smegmatis_MC2_155 IATRWFEQRRGLVTGVLTAASATGQLIFLP-IVAAVTTHHG-WRWASLIV
TH_0390|M.thermoresistible__bu LVPHWFRPRQVPLVTQLTGICGQLGQVLSAVLFLALLTARG-WTPAYLSV
MAV_3974|M.avium_104 LMIHISPADARGRIAGLFTTSFMVGAVGGP-AVGGLAAGWG-LTAPFVVY
MMAR_1879|M.marinum_M IVTRAFPPERRGAAATVWAAAAGFGNLVGPLLGGALVDTLG-WQWIFFVN
MLBr_00556|M.leprae_Br4923 LGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWIN
MUL_3826|M.ulcerans_Agy99 LIGEVVPLRDRGRYQGILGAVIGIATIGGPLLGGYFTDCLG-WRWAFWIN
. . .
MAB_4839c|M.abscessus_ATCC_199 A------------------------------VLLTIITVPAHIIGLRRPW
Mvan_3219|M.vanbaalenii_PYR-1 A------------------------------AAMAVITVPAHFFGLRRPW
Mb1766c|M.bovis_AF2122/97 A------------------------------AALASTAVVAMVVLRDAPY
Rv1737c|M.tuberculosis_H37Rv A------------------------------AALASTAVVAMVVLRDAPY
Mflv_1096|M.gilvum_PYR-GCK GGL---------------------------WGGLVLIVVLLFFRGAQDDK
MSMEG_5194|M.smegmatis_MC2_155 AA-----------------------------AALAVVPLVAVFMRNYPAD
TH_0390|M.thermoresistible__bu VA-----------------------------LGVLTIALTLALVQNTPDG
MAV_3974|M.avium_104 G------------------------------VAMLGVALVLFLGLRNSAL
MMAR_1879|M.marinum_M IPVGIVGLVLAVRFVPALP--THARRFDLIGVGLSGLGLLLIVFGLQQGH
MLBr_00556|M.leprae_Br4923 IPLTAIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQ
MUL_3826|M.ulcerans_Agy99 LPVSAVVICVATAAIPALAATTR---PVIDYAGIMFIGLSLAALTLATSL
: :
MAB_4839c|M.abscessus_ATCC_199 P----------------SLPATHLAESPTRIARS--------RPFISLII
Mvan_3219|M.vanbaalenii_PYR-1 P----------------HIEHHHLVEPPTRIARS--------RQFVALTV
Mb1766c|M.bovis_AF2122/97 F----------------RPNADPVLPRLKAAARLP------VTWEMSFLY
Rv1737c|M.tuberculosis_H37Rv F----------------RPNADPVLPRLKAAARLP------VTWEMSFLY
Mflv_1096|M.gilvum_PYR-GCK K----------------PAPARTVIAPTAAAADLPGVTLAEGLRSATFYK
MSMEG_5194|M.smegmatis_MC2_155 KG-------LAPYGAEEAQAAAPVVPASSFAAAFDG--LRLGARSRAFWL
TH_0390|M.thermoresistible__bu R-----------------AAPATMGTVREIAASLKTVWLRAGTRLGFFTH
MAV_3974|M.avium_104 A-----------------APPPPTRSTVTMREALR---------VRAYQS
MMAR_1879|M.marinum_M AAGWSPWIWAMIAVGVGFVTVFVYWQSVNTSEPLIPLRIFGDRNFALCSF
MLBr_00556|M.leprae_Br4923 PDSKQVLPSYGVPVLVGGIVATVAFAVWERCARTR-LIDPAGVHIRPFLS
MUL_3826|M.ulcerans_Agy99 GGSVYAWGSAPIIGLFTAAGVTLAVFVWVETIAAQPILPIRLFAAPVFSV
MAB_4839c|M.abscessus_ATCC_199 AFALASCASYA------VIVNLVPLMNQRGLDGTVAATALALGGVGQVIG
Mvan_3219|M.vanbaalenii_PYR-1 AFAMAGLASYA------VIVNLVPLMTAHGISTQAAALALGLGGAGQVLG
Mb1766c|M.bovis_AF2122/97 AIVFGGFVAFSNYL--PTYITTIYGFSTVDAGARTAGFALAAVLARPVGG
Rv1737c|M.tuberculosis_H37Rv AIVFGGFVAFSNYL--PTYITTIYGFSTVDAGARTAGFALAAVLARPVGG
Mflv_1096|M.gilvum_PYR-GCK LLVAAGLFAFTTLG---IVVHLVPILRDAGAEPLAAAGTAALVGIFSIVG
MSMEG_5194|M.smegmatis_MC2_155 LAASFAICGMTTNG--LIATHFIPAANDHGMPTTVAAGLLATIGILDVAG
TH_0390|M.thermoresistible__bu MGTQFSVTVFALMWG-VPYLTVGQGLSTQMAGAMLTLSVAVAIVAGVLIG
MAV_3974|M.avium_104 ALLSNFATGWSAFGL-RMALVPLFVSDVMGRGIGTIGVVLAAFAGGNALA
MMAR_1879|M.marinum_M GVAVIAFVAAAMMLPGVFYMQTVRGLSPTRTALLMAPLPIVVGLLTPFIG
MLBr_00556|M.leprae_Br4923 ALGASVAAGAALMVT--LVNVELFGQGVLGMDQTQAAGLLVWFLIALPIG
MUL_3826|M.ulcerans_Agy99 CCVLAFVVGFAMLG--ALIFVPTFMQYVNGVSATASGLRILPMVIGMLIT
:
MAB_4839c|M.abscessus_ATCC_199 RFGYPALAQCIS-VVPRTLLIMGVVAATTAL-----------LGVFA--S
Mvan_3219|M.vanbaalenii_PYR-1 RLGYQRMVRHLS-VVPRTALIMAGVAVTTAL-----------LGLLT--S
Mb1766c|M.bovis_AF2122/97 WLSDRIAPRHVV-LASLAGTALLAFAAALQP-----------PPEVW--S
Rv1737c|M.tuberculosis_H37Rv WLSDRIAPRHVV-LASLAGTALLAFAAALQP-----------PPEVW--S
Mflv_1096|M.gilvum_PYR-GCK RLGVGLLLDRFPGRVVGACAYLVPILGCAAL-----------LIDGS--S
MSMEG_5194|M.smegmatis_MC2_155 TVFSGWLTDRVDPRVLLLVYYAGRGVSLLLL-----------PSLLSPQA
TH_0390|M.thermoresistible__bu IFTGRHPHRRSRLVLAIIASNAAAWTAVLAL-----------PDRAPLWL
MAV_3974|M.avium_104 VVPSGYLSDRMGRRTLLIVGLVTSGAATVWL-----------GFVAS---
MMAR_1879|M.marinum_M KILDRAHPRAVAGFGFSVVAISLIWFSIEMA-----------PATPVWRL
MLBr_00556|M.leprae_Br4923 AVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFS
MUL_3826|M.ulcerans_Agy99 SIGSGSMVGRTGRYKIFPVLGTALMTLAFLLMSR------TDESTSAAVQ
.
MAB_4839c|M.abscessus_ATCC_199 AVSLIAVAVAAGMARGIMTLLQATA-----ITERWGSTHYGHLSGLLTAP
Mvan_3219|M.vanbaalenii_PYR-1 VATLITVAVVAGVVRGVMTLLQATA-----VTERWGITHYGQLSGILSAP
Mb1766c|M.bovis_AF2122/97 AATFITLAVCLGVGTGGVFAWVAR---------RAPAASVGSVTGIVAAA
Rv1737c|M.tuberculosis_H37Rv AATFITLAVCLGVGTGGVFAWVAR---------RAPAASVGSVTGIVAAA
Mflv_1096|M.gilvum_PYR-GCK PLSQTVAAALFGLTLGAEVDVIAYL-----ASRYFGLRNFGGLFGGLVAA
MSMEG_5194|M.smegmatis_MC2_155 EPSTWVFVVFYGLDWVATVPPTIVL-----CRDFFGTRSP-VVFGWVFAS
TH_0390|M.thermoresistible__bu LITLIVVISVGGPGSMVGFDFARTFNPSATLGTAQGMVNMGGFLASLLVM
MAV_3974|M.avium_104 LPVFLVAAGVVGVVTGIYMSPLQAA----VADILGNEARAGLPVATVQMM
MMAR_1879|M.marinum_M AVPIAFLGVGMVFAWPVLTVTATRDLPAELVGASSGVYNAARALGATLGS
MLBr_00556|M.leprae_Br4923 VPTMYADLLVAGLGLGLVIGPLSSATLRVVPTAQHGIASAAVVVARMTGM
MUL_3826|M.ulcerans_Agy99 SVYLLILGSAIGMSSQVLVIIVQNTSEFEDLGVATSGVSLFRTIGGSFGA
.
MAB_4839c|M.abscessus_ATCC_199 IMLTTALAPFTG-AALAQLLHGYPAMFVALGVAGIIGAAAATATNPSQ--
Mvan_3219|M.vanbaalenii_PYR-1 VMLSTALGPFVG-AGLATLLGGYGAMFVVLGAVALAAALLATATRVRPVD
Mb1766c|M.bovis_AF2122/97 GGLGGYFPPLVMGATYDPVDNDYTVGLLLLVATALVACTYTALHAREPVS
Rv1737c|M.tuberculosis_H37Rv GGLGGYFPPLVMGATYDPVDNDYTVGLLLLVATALVACTYTALHAREPVS
Mflv_1096|M.gilvum_PYR-GCK LSLGTAFGPLAAGATSDHFGGYTNFLILTMVLMGLSSMALASLKPPPVWT
MSMEG_5194|M.smegmatis_MC2_155 HQVGAAIAAAGAGWLRDLNGNYDMAFYLAAGLCFIAAVFSASIGKSQVSS
TH_0390|M.thermoresistible__bu QAMGQILDAAGG-YSFDSFRLAWTVQYVVWVVAAVGILITRKKARRQMAL
MAV_3974|M.avium_104 SDLGAIVGSMAVGWAAEQIGYGWGFFISGVVLLIAAVGWVMAPETRTATE
MMAR_1879|M.marinum_M AGMAALMTSRIAAQAPAIHDDAHTSAAAATEGVALQLPEFAREPFSASMS
MLBr_00556|M.leprae_Br4923 LIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMM
MUL_3826|M.ulcerans_Agy99 AIFGSLFVNFLNSRLASALT-ATEVASSPEALHRQSPAVAAPIVHAYAGS
.
MAB_4839c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_3219|M.vanbaalenii_PYR-1 ADG-----------------------------------------------
Mb1766c|M.bovis_AF2122/97 EEASR---------------------------------------------
Rv1737c|M.tuberculosis_H37Rv EEASR---------------------------------------------
Mflv_1096|M.gilvum_PYR-GCK VTSPGEDARADRFPQP----------------------------------
MSMEG_5194|M.smegmatis_MC2_155 EEADSVETSALP--------------------------------------
TH_0390|M.thermoresistible__bu EQERMLLESFEPGPRRHTGPDRTNRPHG----------------------
MAV_3974|M.avium_104 LEADLMAASRTSSRCEQQL-------------------------------
MMAR_1879|M.marinum_M QSLLLPALIALLGVGAALFMSDLRAPRSTLAQGL----------------
MLBr_00556|M.leprae_Br4923 YSDIFMITAIVCVIGALLGLLISSRKEHASEPKVPE--------------
MUL_3826|M.ulcerans_Agy99 LAQVFLCAAPVAAIGFVLALFMREVPLRDIHNRDHDARVPSGDGSGQQNK
MAB_4839c|M.abscessus_ATCC_199 ------------------------------
Mvan_3219|M.vanbaalenii_PYR-1 ------------------------------
Mb1766c|M.bovis_AF2122/97 ------------------------------
Rv1737c|M.tuberculosis_H37Rv ------------------------------
Mflv_1096|M.gilvum_PYR-GCK ------------------------------
MSMEG_5194|M.smegmatis_MC2_155 ------------------------------
TH_0390|M.thermoresistible__bu ------------------------------
MAV_3974|M.avium_104 ------------------------------
MMAR_1879|M.marinum_M ------------------------------
MLBr_00556|M.leprae_Br4923 ------------------------------
MUL_3826|M.ulcerans_Agy99 LEGDLDTGQSVGAPGKEPDFGVDPAMGPVR