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M. smegmatis MC2 155 MSMEG_5190 (-)

AGERPGGRTAAVRRAVLSAAEDLLIEAGFDGLELTVVAERAGVGKSTVYRRWGTVPALVADLLTDMAEQS
LPRADTGSLRGDLQANARLVRRTLADARQGRLFKAMIAAATCDPRTAEALEDFYARRIAEWSGCVTDAIA
RGEAPAGTDAAAAIRQVSAPLYYQFLTSTKRLTTADADRAAEAAVAAIDAGVYTARG*

Operon Prediction Model: Genebank

Paralogs

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_5190	-	-	100% (198)	TetR-family protein transcriptional regulator
M. smegmatis MC2 155	MSMEG_3834	-	4e-18	32.12% (193)	putative TetR-family protein transcriptional regulator
M. smegmatis MC2 155	MSMEG_5340	-	6e-18	33.70% (184)	TetR-family protein transcriptional regulator

Closest Orthologs (e-value cutoff: 1e-4)

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	Mb3192c	-	3e-11	28.22% (163)	TetR family transcriptional regulator
M. gilvum PYR-GCK	Mflv_1535	-	2e-17	30.57% (193)	TetR family transcriptional regulator
M. tuberculosis H37Rv	Rv3167c	-	3e-11	28.22% (163)	TetR family transcriptional regulator
M. leprae Br4923	-	-	-	-	-
M. abscessus ATCC 19977	MAB_3565	-	2e-25	33.16% (196)	TetR family transcriptional regulator
M. marinum M	MMAR_0340	-	3e-10	25.79% (190)	TetR family transcriptional regulator
M. avium 104	MAV_5267	-	2e-18	32.46% (191)	transcriptional regulator, TetR family protein
M. thermoresistible (build 8)	TH_0688	-	7e-12	28.11% (185)	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY
M. ulcerans Agy99	MUL_4780	-	5e-10	27.46% (193)	TetR family transcriptional regulator
M. vanbaalenii PYR-1	Mvan_5223	-	3e-18	30.60% (183)	TetR family transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_5190|M.smegmatis_MC2_155      ---------MAGERPGGRTAAVRRAVLSAAEDLLIEAGFDGLELTVVAER
MAB_3565|M.abscessus_ATCC_1997      ---MANRQTVQGVRTGGRSARVREAILDAAFGELIDRGYAELTMEAVASR
Mflv_1535|M.gilvum_PYR-GCK          ---------MASRRGRPRSEAVRSAVLTAAAELALAGGPAAASVEAIARR
Mvan_5223|M.vanbaalenii_PYR-1       ----MVEAGSAARRGRPRSEAARSAVLTAAAELALEGGPAAATVEAIAKR
Mb3192c|M.bovis_AF2122/97           MKADLPSLDKAPGAGRPRDPRIDSAILSATAELLVQIGYSNLSLAAVAER
Rv3167c|M.tuberculosis_H37Rv        MKADLPSLDKAPGAGRPRDPRIDSAILSATAELLVQIGYSNLSLAAVAER
TH_0688|M.thermoresistible__bu      MTTNSTSVDKAAGAGRPRDPRIDGAILRATADLLVEIGYSNLTMSAVAER
MMAR_0340|M.marinum_M               ---------MVADFGRPRDPRIDGAVLRATVELLAETGYAGLLVSAIAKR
MUL_4780|M.ulcerans_Agy99           ---------MVADFGRPRDPRIDGAVLRATVELLAETGYAGLLVSAIAKR
MAV_5267|M.avium_104                ----MPTDPNGPAAPRRRSEKSRTAIVTATRELLLERGFDGLTIEAVAAR
                                                     *      *:: *:       *     : .:* *

MSMEG_5190|M.smegmatis_MC2_155      AGVGKSTVYRRWGTVPALVADLLTDMAEQSLPRAD-TGSLRGDLQANARL
MAB_3565|M.abscessus_ATCC_1997      AGVNKTTIYRRWPTLEDLLVEALTTWSLEAIPIPE-TGSIESDLLSTGRE
Mflv_1535|M.gilvum_PYR-GCK          AEVSRTTIYKWWPSAPAIVLEGLLDSVRDSITRPP-GSTSVEAVVHHVCA
Mvan_5223|M.vanbaalenii_PYR-1       AHVSRTTIYKWWPSAASIVLEGLLDAVRASITRPS-GSTSVQALVHHVSS
Mb3192c|M.bovis_AF2122/97           AGTTKSALYRRWSSKAELVHEAAFPAAPTALQAA--AGDIAADIRMMIAA
Rv3167c|M.tuberculosis_H37Rv        AGTTKSALYRRWSSKAELVHEAAFPAAPTALQAA--AGDIAADIRMMIAA
TH_0688|M.thermoresistible__bu      AGTTKTALYRRWSSKPELVYAATAPTDPVDTVES--SDDVAGIVRALIER
MMAR_0340|M.marinum_M               AGTSKPAIYRRWPSKAHLVHEAVFPIDAATAVPD--TGSPVDDLREMVRR
MUL_4780|M.ulcerans_Agy99           AGTSKPAIYRRWPSKAHLVHEAVFPIDAATAVPD--TGSPVDDLREMVRR
MAV_5267|M.avium_104                AGVGKQTIYRWWPTRPALVADVMLEDADRLLASVEHSGDLAADLVGWVGK
                                    * . : ::*: * :   ::                  .     :      

MSMEG_5190|M.smegmatis_MC2_155      VRRTLADARQGRLFKAMIAAATCDPRTAEALED-FYARRIAEWSGCVTDA
MAB_3565|M.abscessus_ATCC_1997      LAAVLNDGVGRQVAALVLTAGLRSAPLREATRR-YFDHQVLRAAPVVRQA
Mflv_1535|M.gilvum_PYR-GCK          LNAILVDPTVGPLLRNVIAASASDPAIQQALCDQWIAPRRAAVAATVRDA
Mvan_5223|M.vanbaalenii_PYR-1       LNAILADPAVGPLLRNVIAASTSDPAIERAVLDQWIAPRRAAVAVTLREA
Mb3192c|M.bovis_AF2122/97           TRDVFTTPVVRAALPGLVADMTADAELNARVLARFADLF-AAVRMRLREA
Rv3167c|M.tuberculosis_H37Rv        TRDVFTTPVVRAALPGLVADMTADAELNARVLARFADLF-AAVRMRLREA
TH_0688|M.thermoresistible__bu      NRQITATPAARAAMPGLLVDMAADPRLHRGLLGRVGSLV-EALRRRLAEA
MMAR_0340|M.marinum_M               TTAVLSTPAAKAALPGLIGEMAADPTLHSALLVRFGEIFGHGLTTWLDNA
MUL_4780|M.ulcerans_Agy99           TTAVLSTPAAKAAQPGLIGEMAADPTLHSALLVRFGEIFGHGLTTWLDNA
MAV_5267|M.avium_104                LVTSLTTPRGSAMLRTLTVACMEHEDTAVKLRAGFSAPLHDSVRARLLAE
                                                    :                             :   

MSMEG_5190|M.smegmatis_MC2_155      IARGEAPAGTDAAAAIRQVSAPLYYQFLTSTKRL----TTADADRAAEAA
MAB_3565|M.abscessus_ATCC_1997      IDRGELPADCDVDMLLTTFRAPLFYRTITTGDPI----DDALIIHATQIT
Mflv_1535|M.gilvum_PYR-GCK          VEGGELRDDVDVEVVVDAVVSPPYYRLVLGMPPL----DDRAIDGLVRAV
Mvan_5223|M.vanbaalenii_PYR-1       VDRGELPGDVDIEVAVDALVSPPYYRLVLGMPPL----AAEAVDRLVETV
Mb3192c|M.bovis_AF2122/97           VDRGEAHPDVDPDRLIELIGGATMLRMLLYPDDM---LDDAWVDQTTAIV
Rv3167c|M.tuberculosis_H37Rv        VDRGEAHPDVDPDRLIELIGGATMLRMLLYPDDM---LDDAWVDQTTAIV
TH_0688|M.thermoresistible__bu      AGRGEVQSGVDADRLTELIGGSVMFRMVLHPDEP---ITERWADEVAAIL
MMAR_0340|M.marinum_M               AARGQVRADVTAPELAEAIAGIVLIGLLTRPGELEPGVGDAWIDRTTTLL
MUL_4780|M.ulcerans_Agy99           AARGQVRADVTAPELAEAIAGIVLIGLLTRPGELEPGVGDAWIDRTTTLL
MAV_5267|M.avium_104                G-----VDAATAESAADAIVGGVVYPILSGAQRY----SRRRAEHTTRLI
                                                      . .      :                  .   

MSMEG_5190|M.smegmatis_MC2_155      VAAIDAGVYTARG-
MAB_3565|M.abscessus_ATCC_1997      LTAARAGLLSA---
Mflv_1535|M.gilvum_PYR-GCK          WRGYRH--------
Mvan_5223|M.vanbaalenii_PYR-1       WSGCRH--------
Mb3192c|M.bovis_AF2122/97           VRGVHRAAPGGSVV
Rv3167c|M.tuberculosis_H37Rv        VRGVHRAAPGGSVV
TH_0688|M.thermoresistible__bu      IRGVTKEG------
MMAR_0340|M.marinum_M               LKGIRKGTPQ----
MUL_4780|M.ulcerans_Agy99           LKGIRKGTPQ----
MAV_5267|M.avium_104                VAALTAG-------
                                      .