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PRVLIADDDTVVRDVVRRYLERDGLDVTIAHDGSEALRLLESEQLDVAVLDVMMPGPDGLSLCRELRKYG DYRLPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRRTSGLTTPAPAELTVGELRVST ASRSVTLSGRPVNLTNREFDLLVFFLTHTDTVFSREDLLKRVWRWDFGDLSTVTVHVKRLRSKLGTHHRV QTVWGRGYLWSGQP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0994 | resD | - | 100% (225) | DNA-binding response regulator ResD |
| M. smegmatis MC2 155 | MSMEG_0244 | - | 8e-43 | 45.58% (226) | two component response transcriptional regulatory protein prra |
| M. smegmatis MC2 155 | MSMEG_2916 | - | 2e-42 | 40.27% (221) | DNA-binding response regulator, PhoP family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1062c | trcR | 2e-44 | 42.53% (221) | two component transcriptional regulator TRCR |
| M. gilvum PYR-GCK | Mflv_0035 | - | 4e-99 | 76.62% (231) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv1033c | trcR | 2e-44 | 42.53% (221) | two component transcriptional regulator TRCR |
| M. leprae Br4923 | MLBr_02123 | - | 2e-40 | 43.50% (223) | two-component response regulator |
| M. abscessus ATCC 19977 | MAB_0956c | - | 9e-42 | 44.05% (227) | transcriptional regulatory protein PrrA |
| M. marinum M | MMAR_4455 | trcR | 6e-44 | 42.53% (221) | two-component transcriptional regulator TrcR |
| M. avium 104 | MAV_0304 | - | 4e-43 | 41.82% (220) | DNA-binding response regulator |
| M. thermoresistible (build 8) | TH_1732 | phoP | 6e-42 | 41.85% (227) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4391 | tcrX | 2e-44 | 43.64% (220) | two component transcriptional regulatory protein TcrX |
| M. vanbaalenii PYR-1 | Mvan_0885 | - | 9e-97 | 78.54% (219) | two component transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1062c|M.bovis_AF2122/97 MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
Rv1033c|M.tuberculosis_H37Rv MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MMAR_4455|M.marinum_M ---MTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MAV_0304|M.avium_104 ---MSQPRAS--------AERVVMCRADGNPINVLVVDDEAVLAEMVSMA
MUL_4391|M.ulcerans_Agy99 -----------------------MCRADGQPVSVLVVDDEPVLADMVSMA
TH_1732|M.thermoresistible__bu -----------------------------VAVRILVVDDDRAVRESLRRS
MLBr_02123|M.leprae_Br4923 ------------------------MDTGVSSPRVLVVDDDSDVLASLERG
MAB_0956c|M.abscessus_ATCC_199 ------------------------MVDGQGSPRVLVVDDDADVLASLERG
Mflv_0035|M.gilvum_PYR-GCK -----------------------------MVTRVLIADDDGVVRDVVRRY
Mvan_0885|M.vanbaalenii_PYR-1 ---------------------------------MLIADDDDVVRDVVRRY
MSMEG_0994|M.smegmatis_MC2_155 ------------------------------MPRVLIADDDTVVRDVVRRY
:*:.**: : :
Mb1062c|M.bovis_AF2122/97 LHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRES
Rv1033c|M.tuberculosis_H37Rv LHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRES
MMAR_4455|M.marinum_M LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
MAV_0304|M.avium_104 LRYEGWNIATASDGASAIAAARNQRPDVVVLDVMLPDMSGLDVLHKLREE
MUL_4391|M.ulcerans_Agy99 LRYEGWNIATASDGASAIASARAERPDVVVLDVMLPDMSGLEVLHRLRKE
TH_1732|M.thermoresistible__bu LSFNGYSVELAEDGVEALDLIANDRPDAVVLDVMMPRLDGLEVCRQLRST
MLBr_02123|M.leprae_Br4923 LRLSGFEVSTAIDGAEALRNATETRPDAIVLDINMPVLDGVSVVTALRAM
MAB_0956c|M.abscessus_ATCC_199 LRLSGFEVNTASDGAEALRCATEHRPDAIVLDINMPVLDGVSVVTALRAM
Mflv_0035|M.gilvum_PYR-GCK LERDGLEVSTAHDGNEALRLLSSQRIDVAVLDVMMPGPDGMALCRRLRQN
Mvan_0885|M.vanbaalenii_PYR-1 LERDGLEVCTAPNGSEALRLLGSRRIDVAVLDVMMPGPDGIALCRNLRKG
MSMEG_0994|M.smegmatis_MC2_155 LERDGLDVTIAHDGSEALRLLESEQLDVAVLDVMMPGPDGLSLCRELRKY
* .* .: * :* .*: *. ***: :* .*: : :*
Mb1062c|M.bovis_AF2122/97 DVY-TPTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRR
Rv1033c|M.tuberculosis_H37Rv DVY-TPTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRR
MMAR_4455|M.marinum_M DAY-TPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRR
MAV_0304|M.avium_104 NPQ-LPVLLLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRR
MUL_4391|M.ulcerans_Agy99 NPR-LPVLLLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEIVLRLRALLRR
TH_1732|M.thermoresistible__bu GDD-LPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRR
MLBr_02123|M.leprae_Br4923 DND-VPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRR
MAB_0956c|M.abscessus_ATCC_199 DND-VPVCVLSARTSVDDRVAGLEAGADDYLTKPFVLAELVARVKALLRR
Mflv_0035|M.gilvum_PYR-GCK GHYSVPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRR
Mvan_0885|M.vanbaalenii_PYR-1 GDYSVPVILLTALGEEQDRIAGLEAGADDYLTKPFSPRELALRVRSVLRR
MSMEG_0994|M.smegmatis_MC2_155 GDYRLPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRR
. * .*:* :*::** :*.***: *** *: *::.:***
Mb1062c|M.bovis_AF2122/97 SSHLERPADEALRVGDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNP
Rv1033c|M.tuberculosis_H37Rv SSHLERPADEALRVGDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNP
MMAR_4455|M.marinum_M SSHLAPPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELLRFLMRNP
MAV_0304|M.avium_104 TGVTTVDSGAQLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRNS
MUL_4391|M.ulcerans_Agy99 TGVTTVDSGAQLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRNS
TH_1732|M.thermoresistible__bu TTPDDAADSQKLTFADLTLDPVTREVTRGNRQISLTRTEFALLELLIANP
MLBr_02123|M.leprae_Br4923 RGATATSSSETIAVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHK
MAB_0956c|M.abscessus_ATCC_199 RGAVATSSTETITVGPLEVEIPGRRARINGVEVDLTKREFDLLAVLAEHK
Mflv_0035|M.gilvum_PYR-GCK SPASIAAHPVDITSGDLTVSTASRSATVGGRTVSLTNREFDLLLFFLTHA
Mvan_0885|M.vanbaalenii_PYR-1 SPATGGVLPVDIRSGDLTVTTASRTVTMAGTPVSLTNREFDLLLFFLTHP
MSMEG_0994|M.smegmatis_MC2_155 TSGLTTPAPAELTVGELRVSTASRSVTLSGRPVNLTNREFDLLVFFLTHT
: . * : : . . :.*: ** ** .: :
Mb1062c|M.bovis_AF2122/97 RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSDREP-MIHTVRG
Rv1033c|M.tuberculosis_H37Rv RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSDREP-MIHTVRG
MMAR_4455|M.marinum_M RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDADREP-MIHTVRG
MAV_0304|M.avium_104 KRVLSKAQILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP-MIHTLRG
MUL_4391|M.ulcerans_Agy99 KRVLSNAQILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP-MIHTLRG
TH_1732|M.thermoresistible__bu RRVLSRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRG
MLBr_02123|M.leprae_Br4923 TTVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEANSGPRLLHTVRG
MAB_0956c|M.abscessus_ATCC_199 TAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRG
Mflv_0035|M.gilvum_PYR-GCK GTVYTREDLLKEVWHWDFG-DLSTVTVHVKRLRSKLGDRHR---VQTVWG
Mvan_0885|M.vanbaalenii_PYR-1 DTVFTREDLLKQVWLWDFG-DLSTVTVHVKRLRSKLGDRHR---VQTVWG
MSMEG_0994|M.smegmatis_MC2_155 DTVFSREDLLKRVWRWDFG-DLSTVTVHVKRLRSKLGTHHR---VQTVWG
. :. :*. ** :** . : :.: ** * ::*: *
Mb1062c|M.bovis_AF2122/97 IGYMLR---------PPE-
Rv1033c|M.tuberculosis_H37Rv IGYMLR---------PPE-
MMAR_4455|M.marinum_M IGYMLR---------PAE-
MAV_0304|M.avium_104 AGYVLK---------PAR-
MUL_4391|M.ulcerans_Agy99 AGYVLK---------PAR-
TH_1732|M.thermoresistible__bu VGYVLR---------ETPP
MLBr_02123|M.leprae_Br4923 VGFVLR---------MQ--
MAB_0956c|M.abscessus_ATCC_199 VGFVLR---------SQ--
Mflv_0035|M.gilvum_PYR-GCK RGYMWAPDEASPGQPDAAG
Mvan_0885|M.vanbaalenii_PYR-1 RGYMWT--------SGAAG
MSMEG_0994|M.smegmatis_MC2_155 RGYLWS---------GQP-
*::