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IAVARKAGDPPFDADEMAIMEDFAHHAAVALTLCRANEQARRLTVLSDRERIARGDPHAHVIQRLFLAGM DLQGTIARTKSGTVATRLSRTVDDLQSIIDEIRTAIFDLQSPAANAMSFRQRIQASIAAVIDNSSLATTV RISGPIVTVDTKLADGAEAVIPEAVSNAVRHSGATSVTISIDVSDHLEIVVIDNGRGIPDYVERCSGLRN LKTRARRAGGSCEITSSGECGTHVRWSAALRPCKRQL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4614 | - | - | 100% (248) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_3941 | - | e-105 | 82.57% (241) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_5241 | - | 2e-50 | 46.47% (241) | GAF family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 8e-51 | 47.11% (242) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_3844 | - | 2e-52 | 47.72% (241) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 8e-51 | 47.11% (242) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | MLBr_02124 | - | 5e-05 | 42.86% (49) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3890c | - | 2e-43 | 41.49% (241) | histidine kinase response regulator |
| M. marinum M | MMAR_3479 | - | 7e-64 | 52.52% (238) | two-component sensor histidine kinase |
| M. avium 104 | MAV_4108 | - | 2e-68 | 57.68% (241) | GAF family protein |
| M. thermoresistible (build 8) | TH_0388 | - | 3e-52 | 46.47% (241) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. ulcerans Agy99 | MUL_2422 | devS | 2e-50 | 49.78% (227) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_1413 | - | 1e-53 | 45.23% (241) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3479|M.marinum_M -------------------------------------------MHAQLDE
MAV_4108|M.avium_104 ------------------------------------------MTGNRFDE
Mvan_1413|M.vanbaalenii_PYR-1 ------------------------MSNRQQRAFGRRHPADLRRIHEQLDE
MSMEG_4614|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDG---AAMRPLRHTLSQLRLHELLVEVQDRVEQ
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDG---AAMRPLRHTLSQLRLHELLVEVQDRVEQ
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSG---DGLRPLRLTLSQLRLRELLVEVQERVEQ
Mflv_3844|M.gilvum_PYR-GCK -------MHDGAVADADDHRARDGARPVRTTLSQLRLRELLTEVQDRVEQ
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 -------------MVEDVG---AQPNRVTAELAHLQLRELLAEVQGRIEQ
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
MMAR_3479|M.marinum_M LLAA-RDQMEQLLRVIVEIGSDLDLDATLRRIVLAARELTSAPYGALAVR
MAV_4108|M.avium_104 LAAA-RDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVR
Mvan_1413|M.vanbaalenii_PYR-1 LAAD-RDQMGQLLQVAVEIGSDLELNATLQRIVRAARGMTAARYGAIGVW
MSMEG_4614|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 IVEG-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVH
Rv3132c|M.tuberculosis_H37Rv IVEG-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVH
MUL_2422|M.ulcerans_Agy99 IVEG-RDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVH
Mflv_3844|M.gilvum_PYR-GCK IIRG-RDRLDGLVEAMLAVTSGLELDETLRTIVHTAIELVDAQYGALGVR
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 IVDGTRGRMDALLDAVMAVSSGLELDATLREIVCAASELVSARYGALGVV
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
MMAR_3479|M.marinum_M DPEGTLIRFIHAGMDDDVARRIGHLPVGKGVLGVSLVETPALRLDDLTMH
MAV_4108|M.avium_104 DWHANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAH
Mvan_1413|M.vanbaalenii_PYR-1 GTDDLLSDFVHDGMDEGTVQAVGHPPVGKGLLGFLRQGTDPVRLDNAAEH
MSMEG_4614|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 DRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAH
Rv3132c|M.tuberculosis_H37Rv DRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAH
MUL_2422|M.ulcerans_Agy99 DRDKRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQH
Mflv_3844|M.gilvum_PYR-GCK GHDQELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLEDISRH
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 GSDEKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAH
MLBr_02124|M.leprae_Br4923 ----------------------------MNILSRIFARTPSLRTRVVVAT
MMAR_3479|M.marinum_M PAACGFPEHHPPMRAFLAVPITIRGTVFGSLYLTHVDPGRKFSESDEFAA
MAV_4108|M.avium_104 PAAAGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAA
Mvan_1413|M.vanbaalenii_PYR-1 PSAVGFPQHHPAMRAFIGVPIVIRGEPFGSLYLADDRPDFAFAEADEMTV
MSMEG_4614|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 PASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLV
Rv3132c|M.tuberculosis_H37Rv PASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLV
MUL_2422|M.ulcerans_Agy99 PASIGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLV
Mflv_3844|M.gilvum_PYR-GCK ADSVGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLV
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 PASVGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVV
MLBr_02124|M.leprae_Br4923 AIGAAIPVLIVGTVVWVGITNDRKERLDRKLDEAAGFAIPFVPRGLDEIP
MMAR_3479|M.marinum_M RALAFAAGVAIDNAQVFERERTAVKWMEASREITTALMSSTESRREPLQL
MAV_4108|M.avium_104 RALAFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQL
Mvan_1413|M.vanbaalenii_PYR-1 RALASIAAVAIDNARLLDHARATVRWTDAGREITAAVLGGDDPYLRPLQL
MSMEG_4614|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 QALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEP-ATVFRL
Rv3132c|M.tuberculosis_H37Rv QALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEP-ATVFRL
MUL_2422|M.ulcerans_Agy99 QALAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEP-ASVFRL
Mflv_3844|M.gilvum_PYR-GCK QALAAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDP-AGVFRR
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 RALAGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDP-GKALHL
MLBr_02124|M.leprae_Br4923 RSPNDQDAIITVRRGNLVKSNFDITLPKLTNDYADTYLRGVRYRVRTVEI
MMAR_3479|M.marinum_M IAQRACTLTDAEQAIVLVPVESDLATD-EIDTLVVSAAVGLHAEEVVGQQ
MAV_4108|M.avium_104 IAERACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQR
Mvan_1413|M.vanbaalenii_PYR-1 IVGRACELTGAEQGIVLVASDPEQPVD-EVDTLVVSTAAGRYADDVLGQR
MSMEG_4614|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 VAAEALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASTVGRT
Rv3132c|M.tuberculosis_H37Rv VAAEALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASIVGRT
MUL_2422|M.ulcerans_Agy99 VAEEALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCT
Mflv_3844|M.gilvum_PYR-GCK VADRAQKLSGAAATLVAVPDDPDLPVG-EVAELTVAASAGETIAAAHD-P
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 VASSAALLAEADFAFIALPAGDEE----DTAELVVAVCEGKGAEVLNDKL
MLBr_02124|M.leprae_Br4923 PAPEPTSIAVGATYDATVAETNNLHRR-----VLLICGFAIAAAAVFAWL
MMAR_3479|M.marinum_M VPVRGSTCGDVFRSGEPLISEAFSYPIEAFTDVAQRSAIVMPLSAHEKVA
MAV_4108|M.avium_104 VPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVV
Mvan_1413|M.vanbaalenii_PYR-1 VPVHGSTTGAVFQSGRPVITEAFGHSIPFFTDVGERPVVVVPLRSERQNL
MSMEG_4614|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 IPVAGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVA
Rv3132c|M.tuberculosis_H37Rv IPVAGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVA
MUL_2422|M.ulcerans_Agy99 IAVAGTALAEVLLDSAPRQVDKIAVEDVD-ELGDMGPALVLPLRATDAVA
Mflv_3844|M.gilvum_PYR-GCK IPVAGTAIGDAFVHRTPGMTDRADIG----IGATVGPALLLPLRAPDAVP
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 IPIDGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTA
MLBr_02124|M.leprae_Br4923 LAAFAVRPFKQLAQQTRSVDAGGEAPRVEVHGATEAVEIAEAMRG-----
MMAR_3479|M.marinum_M GVIAVARGADQPPFDARCLDLVSQFATHAAIALLLASGREDARQLTILAE
MAV_4108|M.avium_104 GVIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAE
Mvan_1413|M.vanbaalenii_PYR-1 GVLALARNASAPRFQAGDLDLVRDYAYHTAIAIVIARARGTANELAMFTD
MSMEG_4614|M.smegmatis_MC2_155 -MIAVARKAGDPPFDADEMAIMEDFAHHAAVALTLCRANEQARRLTVLSD
Mb3156c|M.bovis_AF2122/97 GVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTD
Rv3132c|M.tuberculosis_H37Rv GVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTD
MUL_2422|M.ulcerans_Agy99 GVVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTE
Mflv_3844|M.gilvum_PYR-GCK GVLIVLRSVGAQPFRSDELDMLAAFADQAAQAWQLASTQHRLRELGILTD
TH_0388|M.thermoresistible__bu -VLVVCRAEEGRPFTDEQLEILVTFADQAALAWQLAATQRRMRELDVLSD
MAB_3890c|M.abscessus_ATCC_199 GVLILLRTVGAIAFDEEQLDMAASFAGQAALALEQAEVRLAKHELDVLAD
MLBr_02124|M.leprae_Br4923 ---MLQRIWNEQNRTKEALASARDFAAVSSHELRTPLT-------AMRTN
: : :* :: : ::
MMAR_3479|M.marinum_M RERIAH-DLHDHVIQRLFASGMDLQGTLARARSPEVIDRLNRTVDDLQTI
MAV_4108|M.avium_104 RERIAH-DLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTI
Mvan_1413|M.vanbaalenii_PYR-1 RERIAH-DLHDQVIQRVFAVGMDLQGVVARVRSPALNERLSNSVDELQAV
MSMEG_4614|M.smegmatis_MC2_155 RERIARGDPHAHVIQRLFLAGMDLQGTIARTKSGTVATRLSRTVDDLQSI
Mb3156c|M.bovis_AF2122/97 RDRIAR-DLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDV
Rv3132c|M.tuberculosis_H37Rv RDRIAR-DLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDV
MUL_2422|M.ulcerans_Agy99 RDRIAR-DLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGV
Mflv_3844|M.gilvum_PYR-GCK RDRIAR-DLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQSV
TH_0388|M.thermoresistible__bu RDRIAR-DLHDHVIQRLFAVGLTLQGTIPRARSTEVQQRLSECIDDLQAV
MAB_3890c|M.abscessus_ATCC_199 RDRIAR-DLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHIDQLHEV
MLBr_02124|M.leprae_Br4923 LEVLATLDLADDQRKEVLGDVIRTQSRIEATLS-ALERLAQGELSTSDDH
: :* * . :.:: : *. . : :. .
MMAR_3479|M.marinum_M IEEIRSTIFQLKSPSGRDGGFRQRIQQVVADLTEHRDVVTTIHMHGPMSA
MAV_4108|M.avium_104 IEEIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTA
Mvan_1413|M.vanbaalenii_PYR-1 ITEIRSTIFNLQKPAEAHGAFAKRIRHAFQRLTEDREMAATLTVSGPMEV
MSMEG_4614|M.smegmatis_MC2_155 IDEIRTAIFDLQSPAANAMSFRQRIQASIAAVIDNSSLATTVRISGPIVT
Mb3156c|M.bovis_AF2122/97 IQEIRTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSV
Rv3132c|M.tuberculosis_H37Rv IQEIRTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSV
MUL_2422|M.ulcerans_Agy99 IQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSV
Mflv_3844|M.gilvum_PYR-GCK IQEIRTAIFDLHGGSSAVTRLRQRLDAAVAAFP-ESGVRTSMQCAGPLSV
TH_0388|M.thermoresistible__bu IGEIRTTIFDLHGGPATGSQIRQRIGEAANQFS-DAGVRTRVQFAGPLSV
MAB_3890c|M.abscessus_ATCC_199 IQEIRTAIFDLHTNDE---SLRATLRSTINELTAETGLRVSVRMSGPLDV
MLBr_02124|M.leprae_Br4923 VPVDITELLDRAAHDATRSYPELKVSLVPSPTCIIVGLPAGLRLAVDNAV
: : : : : . : .
MMAR_3479|M.marinum_M VQGELADHAEAVATEAISNAVRHSGAGRVTLDVSVGDMFSLEVVDDGCG-
MAV_4108|M.avium_104 VGAELAEHAEAVTAEAVSNAVRHSGASRLTVQIGVADMFTLDVIDNGRG-
Mvan_1413|M.vanbaalenii_PYR-1 VAPSLVDDAEAVVLEGLSNAVRHSGAAAVAVEIAVGDDLVVEVCDDGQG-
MSMEG_4614|M.smegmatis_MC2_155 VDTKLADGAEAVIPEAVSNAVRHSGATSVTISIDVSDHLEIVVIDNGRG-
Mb3156c|M.bovis_AF2122/97 VDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRG-
Rv3132c|M.tuberculosis_H37Rv VDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRG-
MUL_2422|M.ulcerans_Agy99 VDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRG-
Mflv_3844|M.gilvum_PYR-GCK VDAGLADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRG-
TH_0388|M.thermoresistible__bu ISAVLADHAEAVVREAVSNAVRHGGATDLSVDVSVDDDLTIEVTDNGRG-
MAB_3890c|M.abscessus_ATCC_199 VPASTSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIG-
MLBr_02124|M.leprae_Br4923 ANAVKHGGATRVQLSAVSSRAGVEIAVDDNGSGVPEDERQVVFERFSRGS
* * ..:*. . * * : . . *
MMAR_3479|M.marinum_M ISPDVSRRSGLANMRSRAEKLGGTCGITTPTEG-GTRISWTVPFGDL---
MAV_4108|M.avium_104 IAAGNTRRSGLANMTRRAEQLGGSCEISSPPGG-GTRVHWTAPLLDH---
Mvan_1413|M.vanbaalenii_PYR-1 IPAESRRRSGLANLAARARAAGGELVIDTPPSG-GTRLIWSVPLART---
MSMEG_4614|M.smegmatis_MC2_155 IPDYVERCSGLRNLKTRARRAGGSCEITSSGEC-GTHVRWSAALRPCKRQ
Mb3156c|M.bovis_AF2122/97 LPD-EFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ----
Rv3132c|M.tuberculosis_H37Rv LPD-EFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ----
MUL_2422|M.ulcerans_Agy99 MPK-TYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ----
Mflv_3844|M.gilvum_PYR-GCK IAA-DVTGSGLANLARRAQDVGGSFSVR-RGAQVGTTLTWRAPLP-----
TH_0388|M.thermoresistible__bu FPEGEVTESGLANLRHRARHAGGTLEVHNRPDG-GARLHWSVPLT-----
MAB_3890c|M.abscessus_ATCC_199 IPD-VVARSGLSGLANRAAQSGGTFSVSAMDTG-GTRLVWSAPLP-----
MLBr_02124|M.leprae_Br4923 TASHSGSGLGLALVAQQAQLHGGTASLETSPLG-GARLLLRISAPS----
. ** : :* ** : *: : .
MMAR_3479|M.marinum_M -
MAV_4108|M.avium_104 -
Mvan_1413|M.vanbaalenii_PYR-1 -
MSMEG_4614|M.smegmatis_MC2_155 L
Mb3156c|M.bovis_AF2122/97 -
Rv3132c|M.tuberculosis_H37Rv -
MUL_2422|M.ulcerans_Agy99 -
Mflv_3844|M.gilvum_PYR-GCK -
TH_0388|M.thermoresistible__bu -
MAB_3890c|M.abscessus_ATCC_199 -
MLBr_02124|M.leprae_Br4923 -